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Volumn 28, Issue 4, 2000, Pages 604-614

Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFκB activation offering protection against chemically induced diabetes

Author keywords

Antioxidants; Free radicals; IDDM; NF B; Spin trap

Indexed keywords

ALLOXAN; ANTIOXIDANT; FREE RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N TERT BUTYL ALPHA PHENYLNITRONE; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN;

EID: 0034652424     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00271-3     Document Type: Article
Times cited : (62)

References (50)
  • 1
    • 0025825811 scopus 로고
    • Conference summary: Diet as an environmental factor in development of insulin-dependent diabetes mellitus
    • Scott F.W., Marliss E.B. Conference summary diet as an environmental factor in development of insulin-dependent diabetes mellitus. Can. J. Physiol. Pharmacol. 69:1991;311-319.
    • (1991) Can. J. Physiol. Pharmacol. , vol.69 , pp. 311-319
    • Scott, F.W.1    Marliss, E.B.2
  • 2
    • 0017086041 scopus 로고
    • Inheritance of diabetes mellitus
    • Zonana J., Rimoin D.L. Inheritance of diabetes mellitus. N. Engl. J. Med. 295:1976;603-605.
    • (1976) N. Engl. J. Med. , vol.295 , pp. 603-605
    • Zonana, J.1    Rimoin, D.L.2
  • 3
  • 4
    • 0023770113 scopus 로고
    • Free radicals and diabetes
    • Oberley L.W. Free radicals and diabetes. Free Radic. Biol. Med. 5:1988;113-124.
    • (1988) Free Radic. Biol. Med. , vol.5 , pp. 113-124
    • Oberley, L.W.1
  • 5
    • 0026510118 scopus 로고
    • Cytotoxic effects of cytokines on rat islets: Evidence for involvement of free radicals and lipid peroxidation
    • Rabinovitch A., Suarez W.L., Thomas P.D., Strynadka K., Simpson I. Cytotoxic effects of cytokines on rat islets evidence for involvement of free radicals and lipid peroxidation. Diabetologia. 35:1992;409-413.
    • (1992) Diabetologia , vol.35 , pp. 409-413
    • Rabinovitch, A.1    Suarez, W.L.2    Thomas, P.D.3    Strynadka, K.4    Simpson, I.5
  • 6
    • 0026719297 scopus 로고
    • Free radicals as mediators of pancreatic islet beta-cell injury in autoimmune diabetes (editorial; Comment)
    • Rabinovitch A. Free radicals as mediators of pancreatic islet beta-cell injury in autoimmune diabetes (editorial; comment). J. Lab. Clin. Med. 119:1992;455-456.
    • (1992) J. Lab. Clin. Med. , vol.119 , pp. 455-456
    • Rabinovitch, A.1
  • 7
    • 0026683354 scopus 로고
    • Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM
    • Corbett, J. A.; McDaniel, M. L. Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. Diabetes 41:897-903; 1992.
    • (1992) Diabetes , vol.41 , pp. 897-903
    • Corbett, J.A.1    McDaniel, M.L.2
  • 8
    • 0017254918 scopus 로고
    • Alloxan-induced diabetes-evidence for hydroxyl radical as a cytotoxic intermediate
    • Heikkila R.E., Winston B., Cohen G. Alloxan-induced diabetes-evidence for hydroxyl radical as a cytotoxic intermediate. Biochem. Pharmacol. 25:1976;1085-1092.
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 1085-1092
    • Heikkila, R.E.1    Winston, B.2    Cohen, G.3
  • 9
    • 0032492540 scopus 로고    scopus 로고
    • Generation of nitric oxide from streptozotocin (STZ) in the presence of copper(II) plus ascorbate: Implication for the development of STZ-induced diabetes
    • Tsuji A., Sakurai H. Generation of nitric oxide from streptozotocin (STZ) in the presence of copper(II) plus ascorbate implication for the development of STZ-induced diabetes. Biochem. Biophys. Res. Commun. 245:1998;11-16.
    • (1998) Biochem. Biophys. Res. Commun. , vol.245 , pp. 11-16
    • Tsuji, A.1    Sakurai, H.2
  • 10
    • 0029257151 scopus 로고
    • Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage
    • Kroncke, K. D.; Fehsel, K.; Sommer, A.; Rodriguez, M. L.; Kolb-Bachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage. Biol. Chem. Hoppe. Seyler. 376:179-185; 1995.
    • (1995) Biol. Chem. Hoppe. Seyler. , vol.376 , pp. 179-185
    • Kroncke, K.D.1    Fehsel, K.2    Sommer, A.3    Rodriguez, M.L.4    Kolb-Bachofen, V.5
  • 12
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S., Drinkgern J., Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. 20:1996;463-466.
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 13
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • Tiedge M., Lortz S., Drinkgern J., Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 46:1997;1733-1742.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 15
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin A.S. Jr. The NF-kappa B and I kappa B proteins new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin A.S. Jr1
  • 16
    • 0029101772 scopus 로고
    • Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers
    • Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules NF-kappa B and cytokine-inducible enhancers. FASEB J. 9:1995;899-909.
    • (1995) FASEB J. , vol.9 , pp. 899-909
    • Collins, T.1    Read, M.A.2    Neish, A.S.3    Whitley, M.Z.4    Thanos, D.5    Maniatis, T.6
  • 17
    • 0024584166 scopus 로고
    • Kappa B-specific DNA binding proteins: Role in the regulation of human interleukin-2 gene expression
    • Hoyos B., Ballard D.W., Bohnlein E., Siekevitz M., Greene W.C. Kappa B-specific DNA binding proteins role in the regulation of human interleukin-2 gene expression. Science. 244:1989;457-460.
    • (1989) Science , vol.244 , pp. 457-460
    • Hoyos, B.1    Ballard, D.W.2    Bohnlein, E.3    Siekevitz, M.4    Greene, W.C.5
  • 18
    • 0025343895 scopus 로고
    • Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
    • Libermann T.A., Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol. Cell. Biol. 10:1990;2327-2334.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2327-2334
    • Libermann, T.A.1    Baltimore, D.2
  • 19
    • 0025186678 scopus 로고
    • Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
    • Shakhov A.N., Collart M.A., Vassalli P., Nedospasov S.A., Jongeneel C.V. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J. Exp. Med. 171:1990;35-47.
    • (1990) J. Exp. Med. , vol.171 , pp. 35-47
    • Shakhov, A.N.1    Collart, M.A.2    Vassalli, P.3    Nedospasov, S.A.4    Jongeneel, C.V.5
  • 20
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie Q.W., Kashiwabara Y., Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:1994;4705-4708.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4705-4708
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 21
    • 0028889292 scopus 로고
    • Spin trapping agent, phenyl N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice
    • Miyajima T., Kotake Y. Spin trapping agent, phenyl N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice. Biochem. Biophys. Res. Commun. 215:1995;114-121.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 114-121
    • Miyajima, T.1    Kotake, Y.2
  • 22
    • 0025932511 scopus 로고
    • Protection against oxidative damage to CNS by alpha-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers
    • Carney J.M., Floyd R.A. Protection against oxidative damage to CNS by alpha-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents a novel series of nonlipid free radical scavengers. J. Mol. Neurosci. 3:1991;47-57.
    • (1991) J. Mol. Neurosci. , vol.3 , pp. 47-57
    • Carney, J.M.1    Floyd, R.A.2
  • 23
    • 0026647763 scopus 로고
    • Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress
    • Floyd R.A., Carney J.M. Free radical damage to protein and DNA mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32:1992;S22-S27.
    • (1992) Ann. Neurol. , vol.32
    • Floyd, R.A.1    Carney, J.M.2
  • 24
    • 0021989345 scopus 로고
    • Low dose streptozotocin induced diabetes in mice. Metabolic, light microscopical, histochemical, immunofluorescence microscopical, electron microscopical and morphometrical findings
    • Cossel L., Schneider E., Kuttler B., Schmidt S., Wohlrab F., Schade J., Bochmann C. Low dose streptozotocin induced diabetes in mice. Metabolic, light microscopical, histochemical, immunofluorescence microscopical, electron microscopical and morphometrical findings. Exp. Clin. Endocrinol. 85:1985;7-26.
    • (1985) Exp. Clin. Endocrinol. , vol.85 , pp. 7-26
    • Cossel, L.1    Schneider, E.2    Kuttler, B.3    Schmidt, S.4    Wohlrab, F.5    Schade, J.6    Bochmann, C.7
  • 25
    • 0028334949 scopus 로고
    • A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues
    • Deryckere F., Gannon F. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques. 16:1994;405.
    • (1994) Biotechniques , vol.16 , pp. 405
    • Deryckere, F.1    Gannon, F.2
  • 28
    • 0032844258 scopus 로고    scopus 로고
    • Supplementation of N-Acetylcysteine inhibits NFkB activation and protects against alloxan-induced diabetes in CD-1 mice
    • Ho E., Chen G., Bray T. Supplementation of N-Acetylcysteine inhibits NFkB activation and protects against alloxan-induced diabetes in CD-1 mice. FASEB J. 13:1999;1845-1854.
    • (1999) FASEB J. , vol.13 , pp. 1845-1854
    • Ho, E.1    Chen, G.2    Bray, T.3
  • 29
    • 0031899972 scopus 로고    scopus 로고
    • Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1 beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells
    • Kwon G., Corbett J.A., Hauser S., Hill J.R., Turk J., McDaniel M.L. Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1 beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes. 47:1998;583-591.
    • (1998) Diabetes , vol.47 , pp. 583-591
    • Kwon, G.1    Corbett, J.A.2    Hauser, S.3    Hill, J.R.4    Turk, J.5    McDaniel, M.L.6
  • 30
    • 0025173450 scopus 로고
    • Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats
    • Chen G.M., Bray T.M., Janzen E.G., McCay P.B. Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats. Free Radic. Res. Commun. 9:1990;317-323.
    • (1990) Free Radic. Res. Commun. , vol.9 , pp. 317-323
    • Chen, G.M.1    Bray, T.M.2    Janzen, E.G.3    McCay, P.B.4
  • 31
    • 0020382491 scopus 로고
    • Alloxan toxicity to the pancreatic B-cell. A new hypothesis
    • Malaisse W.J. Alloxan toxicity to the pancreatic B-cell. A new hypothesis. Biochem. Pharmacol. 31:1982;3527-3534.
    • (1982) Biochem. Pharmacol. , vol.31 , pp. 3527-3534
    • Malaisse, W.J.1
  • 33
    • 0021134461 scopus 로고
    • Alloxan-induced free radical production in isolated cells. Selective effect on islet cells
    • Asayama K., Nyfeler F., English D., Pilkis S.J., Burr I.M. Alloxan-induced free radical production in isolated cells. Selective effect on islet cells. Diabetes. 33:1984;1008-1011.
    • (1984) Diabetes , vol.33 , pp. 1008-1011
    • Asayama, K.1    Nyfeler, F.2    English, D.3    Pilkis, S.J.4    Burr, I.M.5
  • 34
    • 0032171411 scopus 로고    scopus 로고
    • Metal-mediated DNA damage induced by diabetogenic alloxan in the presence of NADH
    • Murata M., Imada M., Inoue S., Kawanishi S. Metal-mediated DNA damage induced by diabetogenic alloxan in the presence of NADH. Free Radic. Biol. Med. 25:1998;586-595.
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 586-595
    • Murata, M.1    Imada, M.2    Inoue, S.3    Kawanishi, S.4
  • 35
    • 0026530490 scopus 로고
    • Stabilities of hydroxyl radical spin adducts of PBN-type spin traps
    • Janzen E.G., Kotake Y., Hinton R.D. Stabilities of hydroxyl radical spin adducts of PBN-type spin traps. Free Radic. Biol. Med. 12:1992;169-173.
    • (1992) Free Radic. Biol. Med. , vol.12 , pp. 169-173
    • Janzen, E.G.1    Kotake, Y.2    Hinton, R.D.3
  • 36
    • 0019783833 scopus 로고
    • Superoxide dismutase is a prophylactic against alloxan diabetes
    • Grankvist K., Marklund S., Taljedal I.B. Superoxide dismutase is a prophylactic against alloxan diabetes. Nature. 294:1981;158-160.
    • (1981) Nature , vol.294 , pp. 158-160
    • Grankvist, K.1    Marklund, S.2    Taljedal, I.B.3
  • 37
    • 0345593812 scopus 로고    scopus 로고
    • Effect of superoxide dismutase, catalase chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro
    • Jorns A., Tiedge M., Lenzen S., Munday R. Effect of superoxide dismutase, catalase chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro. Free Radic. Biol. Med. 26:1999;1300-1304.
    • (1999) Free Radic. Biol. Med. , vol.26 , pp. 1300-1304
    • Jorns, A.1    Tiedge, M.2    Lenzen, S.3    Munday, R.4
  • 38
    • 0019800333 scopus 로고
    • DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin
    • Yamamoto H., Uchigata Y., Okamoto H. DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin. Biochem. Biophys. Res. Commun. 103:1981;1014-1020.
    • (1981) Biochem. Biophys. Res. Commun. , vol.103 , pp. 1014-1020
    • Yamamoto, H.1    Uchigata, Y.2    Okamoto, H.3
  • 39
    • 0019812690 scopus 로고
    • Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets
    • Yamamoto H., Uchigata Y., Okamoto H. Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets. Nature. 294:1981;284-286.
    • (1981) Nature , vol.294 , pp. 284-286
    • Yamamoto, H.1    Uchigata, Y.2    Okamoto, H.3
  • 40
    • 0031589133 scopus 로고    scopus 로고
    • Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus
    • Tabatabaie T., Kotake Y., Wallis G., Jacob J.M., Floyd R.A. Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus. FEBS Lett. 407:1997;148-152.
    • (1997) FEBS Lett. , vol.407 , pp. 148-152
    • Tabatabaie, T.1    Kotake, Y.2    Wallis, G.3    Jacob, J.M.4    Floyd, R.A.5
  • 41
    • 0032547909 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN)
    • Kotake Y., Sang H., Miyajima T., Wallis G.L. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN). Biochim. Biophys. Acta. 1448:1998;77-84.
    • (1998) Biochim. Biophys. Acta. , vol.1448 , pp. 77-84
    • Kotake, Y.1    Sang, H.2    Miyajima, T.3    Wallis, G.L.4
  • 42
    • 0031757934 scopus 로고    scopus 로고
    • Nuclear factor kappa B: Important transcription factor and therapeutic target
    • Lee J.I., Burckart G.J. Nuclear factor kappa B important transcription factor and therapeutic target. J. Clin. Pharmacol. 38:1998;981-993.
    • (1998) J. Clin. Pharmacol. , vol.38 , pp. 981-993
    • Lee, J.I.1    Burckart, G.J.2
  • 47
    • 0031459881 scopus 로고    scopus 로고
    • Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation
    • De Bosscher K., Schmitz M.L., Vanden Berghe W., Plaisance S., Fiers W., Haegeman G. Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA. 94:1997;13504-13509.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13504-13509
    • De Bosscher, K.1    Schmitz, M.L.2    Vanden Berghe, W.3    Plaisance, S.4    Fiers, W.5    Haegeman, G.6
  • 48
    • 0030805604 scopus 로고    scopus 로고
    • Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-kappaB activation
    • Meyer S., Kohler N.G., Joly A. Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-kappaB activation. FEBS Lett. 413:1997;354-358.
    • (1997) FEBS Lett. , vol.413 , pp. 354-358
    • Meyer, S.1    Kohler, N.G.2    Joly, A.3
  • 49
    • 0029038108 scopus 로고
    • Deoxyspergualin inhibits kappa light chain expression in 70Z/3 pre-B cells by blocking lipopolysaccharide-induced NF-kappa B activation
    • Tepper M.A., Nadler S.G., Esselstyn J.M., Sterbenz K.G. Deoxyspergualin inhibits kappa light chain expression in 70Z/3 pre-B cells by blocking lipopolysaccharide-induced NF-kappa B activation. J. Immunol. 155:1995;2427-2436.
    • (1995) J. Immunol. , vol.155 , pp. 2427-2436
    • Tepper, M.A.1    Nadler, S.G.2    Esselstyn, J.M.3    Sterbenz, K.G.4
  • 50
    • 0031982964 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation
    • Schwenger P., Alpert D., Skolnik E.Y., Vilcek J. Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation. Mol. Cell. Biol. 18:1998;78-84.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 78-84
    • Schwenger, P.1    Alpert, D.2    Skolnik, E.Y.3    Vilcek, J.4


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