pH-Dependent dissolution in Vitro and absorption in Vivo of weakly basic drugs: Development of a canine model

Pharmaceutical Research

Volumn 22, Issue 2, 2005, Pages 188-192

  Zhou, Rong ^a   Moench, Paul ^a   Heran, Christopher ^a   Lu, Xujin ^a   Mathias, Neil ^a   Faria, Teresa N ^a   Wall, Doris A ^a   Hussain, Munir A ^a   Smith, Ronald L ^a   Sun, Duxin ^a,b  

^a BRISTOL MYERS SQUIBB   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Absorption; Bioavailability; Canine; Dissolution; pH dependence

Indexed keywords

DIPYRIDAMOLE; FAMOTIDINE; KETOCONAZOLE; PENTAGASTRIN;

AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG EXPOSURE; DRUG FORMULATION; FIBER OPTICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MEDICAL RESEARCH; NONHUMAN; PH; PRIORITY JOURNAL; SCREENING TEST; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; DOGS; FEMALE; GASTRIC ACID; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; MALE; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 20144387782     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-1185-3     Document Type: Article

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