-
1
-
-
0036629238
-
The use of imaging to accelerate drug development
-
Aboagye E. The use of imaging to accelerate drug development. Drug Discov Today 2002;7:706-7.
-
(2002)
Drug Discov Today
, vol.7
, pp. 706-707
-
-
Aboagye, E.1
-
2
-
-
33846453304
-
Imaging in drug development
-
Aboagye EO. Imaging in drug development. Clin Adv Hematol Oncol 2006;4:902-4.
-
(2006)
Clin Adv Hematol Oncol
, vol.4
, pp. 902-904
-
-
Aboagye, E.O.1
-
3
-
-
33646457229
-
Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies
-
Workman P, Aboagye EO, Chung YL, Griffiths JR, Hart R, Leach MO, et al. Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. J Natl Cancer Inst 2006;98:580-98.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 580-598
-
-
Workman, P.1
Aboagye, E.O.2
Chung, Y.L.3
Griffiths, J.R.4
Hart, R.5
Leach, M.O.6
-
4
-
-
66149108022
-
Monitoring predominantly cytostatic treatment response with 18F-FDG PET
-
Contractor KB, Aboagye EO. Monitoring predominantly cytostatic treatment response with 18F-FDG PET. J Nucl Med 2009;50 Suppl 1:97S-105S.
-
(2009)
J Nucl Med
, vol.50
, Issue.SUPPL. 1
-
-
Contractor, K.B.1
Aboagye, E.O.2
-
5
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008;321:1801-6.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
7
-
-
35548986989
-
From combinatorial chemistry to cancer-targeting peptides
-
Aina OH, Liu R, Sutcliffe JL, Marik J, Pan CX, Lam KS. From combinatorial chemistry to cancer-targeting peptides. Mol Pharm 2007;4:631-51.
-
(2007)
Mol Pharm
, vol.4
, pp. 631-651
-
-
Aina, O.H.1
Liu, R.2
Sutcliffe, J.L.3
Marik, J.4
Pan, C.X.5
Lam, K.S.6
-
8
-
-
70449570521
-
High-throughput in vivo screening of targeted molecular imaging agents
-
Gagnon MK, Hausner SH, Marik J, Abbey CK, Marshall JF, Sutcliffe JL. High-throughput in vivo screening of targeted molecular imaging agents. Proc Natl Acad Sci U S A 2009;106:17904-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 17904-17909
-
-
Gagnon, M.K.1
Hausner, S.H.2
Marik, J.3
Abbey, C.K.4
Marshall, J.F.5
Sutcliffe, J.L.6
-
9
-
-
35748953087
-
11C]Carbon monoxide, a versatile and useful precursor in labelling chemistry for PET-ligand development
-
11C]Carbon monoxide, a versatile and useful precursor in labelling chemistry for PET-ligand development. J Labelled Comp Radiopharm 2007;50:794-810.
-
(2007)
J Labelled Comp Radiopharm
, vol.50
, pp. 794-810
-
-
Långström, B.1
Itsenko, O.2
Rahman, O.3
-
10
-
-
77449084007
-
Peptide-based probes for targeted molecular imaging
-
Lee S, Xie J, Chen X. Peptide-based probes for targeted molecular imaging. Biochemistry 2010;49:1364-76.
-
(2010)
Biochemistry
, vol.49
, pp. 1364-1376
-
-
Lee, S.1
Xie, J.2
Chen, X.3
-
11
-
-
58149090677
-
Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F] fluoroethylazide
-
Smith G, Glaser M, Perumal M, Nguyen QD, Shan B, Arstad E, et al. Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F] fluoroethylazide. J Med Chem 2008;51:8057-67.
-
(2008)
J Med Chem
, vol.51
, pp. 8057-8067
-
-
Smith, G.1
Glaser, M.2
Perumal, M.3
Nguyen, Q.D.4
Shan, B.5
Arstad, E.6
-
12
-
-
0036389509
-
Radiopharmaceutical chemistry for positron emission tomography
-
Elsinga PH. Radiopharmaceutical chemistry for positron emission tomography. Methods 2002;27:208-17.
-
(2002)
Methods
, vol.27
, pp. 208-217
-
-
Elsinga, P.H.1
-
13
-
-
28144443339
-
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: Synthesis, in vitro activity, and molecular modeling studies
-
Chu W, Zhang J, Zeng C, Rothfuss J, Tu Z, Chu Y, et al. N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J Med Chem 2005;48:7637-47.
-
(2005)
J Med Chem
, vol.48
, pp. 7637-7647
-
-
Chu, W.1
Zhang, J.2
Zeng, C.3
Rothfuss, J.4
Tu, Z.5
Chu, Y.6
-
14
-
-
62949137154
-
Fluorinated isatin derivatives. Part 1: Synthesis of new N-substituted (S)-5-[1-(2-methoxymethyl-pyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors
-
Podichetty AK, Faust A, Kopka K, Wagner S, Schober O, Schafers M, et al. Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethyl-pyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors. Bioorg Med Chem 2009;17:2680-8.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2680-2688
-
-
Podichetty, A.K.1
Faust, A.2
Kopka, K.3
Wagner, S.4
Schober, O.5
Schafers, M.6
-
15
-
-
66749129069
-
Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis
-
Podichetty AK, Wagner S, Schroer S, Faust A, Schafers M, Schober O, et al. Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J Med Chem 2009;52:3484-95.
-
(2009)
J Med Chem
, vol.52
, pp. 3484-3495
-
-
Podichetty, A.K.1
Wagner, S.2
Schroer, S.3
Faust, A.4
Schafers, M.5
Schober, O.6
-
17
-
-
14644412456
-
Do inducers of apoptosis trigger caspase-independent cell death?
-
Chipuk JE, Green DR. Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol 2005;6:268-75.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 268-275
-
-
Chipuk, J.E.1
Green, D.R.2
-
18
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002;108:153-64.
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
19
-
-
46749092088
-
In vivo detection of apoptosis
-
Blankenberg FG. In vivo detection of apoptosis. J Nucl Med 2008;49 Suppl 2:81S-95S.
-
(2008)
J Nucl Med
, vol.49
, Issue.SUPPL. 2
-
-
Blankenberg, F.G.1
-
20
-
-
0242329769
-
In vivo, selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope
-
Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, et al. In vivo, selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope. Br J Cancer 2003;89:1327-33.
-
(2003)
Br J Cancer
, vol.89
, pp. 1327-1333
-
-
Collingridge, D.R.1
Glaser, M.2
Osman, S.3
Barthel, H.4
Hutchinson, O.C.5
Luthra, S.K.6
-
21
-
-
1642358348
-
Production of [F-18]fluoroannexin for imaging apoptosis with PET
-
Grierson JR, Yagle KJ, Eary JF, Tait JF, Gibson DF, Lewellen B, et al. Production of [F-18]fluoroannexin for imaging apoptosis with PET. Bioconjug Chem 2004;15:373-9.
-
(2004)
Bioconjug Chem
, vol.15
, pp. 373-379
-
-
Grierson, J.R.1
Yagle, K.J.2
Eary, J.F.3
Tait, J.F.4
Gibson, D.F.5
Lewellen, B.6
-
22
-
-
33644977266
-
ApoSense: A novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis
-
Damianovich M, Ziv I, Heyman SN, Rosen S, Shina A, Kidron D, et al. ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. Eur J Nucl Med Mol Imaging 2006;33:281-91.
-
(2006)
Eur J Nucl Med Mol Imaging
, vol.33
, pp. 281-291
-
-
Damianovich, M.1
Ziv, I.2
Heyman, S.N.3
Rosen, S.4
Shina, A.5
Kidron, D.6
-
24
-
-
34548058938
-
Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry
-
Aulabaugh A, Kapoor B, Huang X, Dollings P, Hum WT, Banker A, et al. Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry. Biochemistry 2007;46:9462-71.
-
(2007)
Biochemistry
, vol.46
, pp. 9462-9471
-
-
Aulabaugh, A.1
Kapoor, B.2
Huang, X.3
Dollings, P.4
Hum, W.T.5
Banker, A.6
-
25
-
-
0034717269
-
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
-
Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, et al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem 2000;275:16007-14.
-
(2000)
J Biol Chem
, vol.275
, pp. 16007-16014
-
-
Lee, D.1
Long, S.A.2
Adams, J.L.3
Chan, G.4
Vaidya, K.S.5
Francis, T.A.6
-
26
-
-
34347338806
-
"Click labelling" with 2-[18f]fluoroethylazide for positron emission tomography
-
Glaser M, Arstad E. "Click labelling" with 2-[18f] fluoroethylazide for positron emission tomography. Bioconjug Chem 2007;18:989-93.
-
(2007)
Bioconjug Chem
, vol.18
, pp. 989-993
-
-
Glaser, M.1
Arstad, E.2
-
27
-
-
70349481530
-
Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide
-
Nguyen QD, Smith G, Glaser M, Perumal M, Arstad E, Aboagye EO. Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide. Proc Natl Acad Sci U S A 2009;106:16375-80.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16375-16380
-
-
Nguyen, Q.D.1
Smith, G.2
Glaser, M.3
Perumal, M.4
Arstad, E.5
Aboagye, E.O.6
-
28
-
-
0035393729
-
Extraction of 5-fluorouracil by tumor and liver: A noninvasive positron emission tomography study of patients with gastrointestinal cancer
-
Aboagye EO, Saleem A, Cunningham VJ, Osman S, Price PM. Extraction of 5-fluorouracil by tumor and liver: a noninvasive positron emission tomography study of patients with gastrointestinal cancer. Cancer Res 2001;61:4937-41.
-
(2001)
Cancer Res
, vol.61
, pp. 4937-4941
-
-
Aboagye, E.O.1
Saleem, A.2
Cunningham, V.J.3
Osman, S.4
Price, P.M.5
-
29
-
-
24944515476
-
Fluorine-18-labelled fluoropyridines: Advances in radiopharmaceutical design
-
DOI 10.2174/138161205774424645
-
Dolle F. Fluorine-18-labelled fluoropyridines: advances in radiopharmaceutical design. Curr Pharm Des 2005;11:3221-35. (Pubitemid 41300773)
-
(2005)
Current Pharmaceutical Design
, vol.11
, Issue.25
, pp. 3221-3235
-
-
Dolle, F.1
-
30
-
-
0034679322
-
Modulation of fluorouracil tissue pharmacokinetics by eniluracil: In-vivo imaging of drug action
-
Saleem A, Yap J, Osman S, Brady F, Suttle B, Lucas SV, et al. Modulation of fluorouracil tissue pharmacokinetics by eniluracil: in-vivo imaging of drug action. Lancet 2000;355:2125-31.
-
(2000)
Lancet
, vol.355
, pp. 2125-2131
-
-
Saleem, A.1
Yap, J.2
Osman, S.3
Brady, F.4
Suttle, B.5
Lucas, S.V.6
-
31
-
-
18044404491
-
Drug design with a new transition state analog of the hydrated carbonyl: Silicon-based inhibitors of the HIV protease
-
Chen CA, Sieburth SM, Glekas A, Hewitt GW, Trainor GL, Erickson-Viitanen S, et al. Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease. Chem Biol 2001;8:1161-6.
-
(2001)
Chem Biol
, vol.8
, pp. 1161-1166
-
-
Chen, C.A.1
Sieburth, S.M.2
Glekas, A.3
Hewitt, G.W.4
Trainor, G.L.5
Erickson-Viitanen, S.6
-
32
-
-
0023808041
-
Mechanistic positron emission tomography studies: Demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain
-
Fowler JS, Wolf AP, MacGregor RR, Dewey SL, Logan J, Schlyer DJ, et al. Mechanistic positron emission tomography studies: demonstration of a deuterium isotope effect in the monoamine oxidase-catalyzed binding of [11C]L-deprenyl in living baboon brain. J Neurochem 1988;51:1524-34.
-
(1988)
J Neurochem
, vol.51
, pp. 1524-1534
-
-
Fowler, J.S.1
Wolf, A.P.2
MacGregor, R.R.3
Dewey, S.L.4
Logan, J.5
Schlyer, D.J.6
-
33
-
-
0034534949
-
Equilibrium modeling of 5-HT(2A) receptors with [18F]deuteroaltanserin and PET: Feasibility of a constant infusion paradigm
-
van Dyck CH, Soares JC, Tan PZ, Staley JK, Baldwin RM, Amici LA, et al. Equilibrium modeling of 5-HT(2A) receptors with [18F]deuteroaltanserin and PET: feasibility of a constant infusion paradigm. Nucl Med Biol 2000;27:715-22.
-
(2000)
Nucl Med Biol
, vol.27
, pp. 715-722
-
-
Van Dyck, C.H.1
Soares, J.C.2
Tan, P.Z.3
Staley, J.K.4
Baldwin, R.M.5
Amici, L.A.6
-
34
-
-
70350244594
-
[18F]fluoromethyl-[1,2-2H4]-choline: A novel radiotracer for imaging choline metabolism in tumors by positron emission tomography
-
Leyton J, Smith G, Zhao Y, Perumal M, Nguyen QD, Robins E, et al. [18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography. Cancer Res 2009;69:7721-8.
-
(2009)
Cancer Res
, vol.69
, pp. 7721-7728
-
-
Leyton, J.1
Smith, G.2
Zhao, Y.3
Perumal, M.4
Nguyen, Q.D.5
Robins, E.6
-
35
-
-
0038311920
-
11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer
-
discussion 38-9
-
11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer. Eur Urol 2003;44:32-8; discussion 38-9.
-
(2003)
Eur Urol
, vol.44
, pp. 32-38
-
-
De Jong, I.J.1
Pruim, J.2
Elsinga, P.H.3
Vaalburg, W.4
Mensink, H.J.5
-
36
-
-
77952561404
-
Does computed tomography or positron emission tomography/computed tomography contribute to detection of small focal cancers in the prostate?
-
Li MM, Rybalov M, Haider MA, de Jong IJ. Does computed tomography or positron emission tomography/computed tomography contribute to detection of small focal cancers in the prostate? J Endourol 2010;24:693-700.
-
(2010)
J Endourol
, vol.24
, pp. 693-700
-
-
Li, M.M.1
Rybalov, M.2
Haider, M.A.3
De Jong, I.J.4
-
38
-
-
0032893756
-
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
-
Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999;59:80-4.
-
(1999)
Cancer Res
, vol.59
, pp. 80-84
-
-
Aboagye, E.O.1
Bhujwalla, Z.M.2
-
39
-
-
69949091374
-
[11C]choline positron emission tomography in estrogen receptor-positive breast cancer
-
Contractor KB, Kenny LM, Stebbing J, Al-Nahhas A, Palmieri C, Sinnett D, et al. [11C]choline positron emission tomography in estrogen receptor-positive breast cancer. Clin Cancer Res 2009;15:5503-10.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5503-5510
-
-
Contractor, K.B.1
Kenny, L.M.2
Stebbing, J.3
Al-Nahhas, A.4
Palmieri, C.5
Sinnett, D.6
-
40
-
-
77950279249
-
Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells
-
Iorio E, Ricci A, Bagnoli M, Pisanu ME, Castellano G, Di Vito M, et al. Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells. Cancer Res 70;2126-35.
-
Cancer Res
, vol.70
, pp. 2126-2135
-
-
Iorio, E.1
Ricci, A.2
Bagnoli, M.3
Pisanu, M.E.4
Castellano, G.5
Di Vito, M.6
-
41
-
-
34748827371
-
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: A retrospective study
-
Ramirez de Molina A, Sarmentero-Estrada J, Belda-Iniesta C, Taron M, Ramirez de Molina V, Cejas P, et al. Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol 2007;8:889-97.
-
(2007)
Lancet Oncol
, vol.8
, pp. 889-897
-
-
Ramirez De Molina, A.1
Sarmentero-Estrada, J.2
Belda-Iniesta, C.3
Taron, M.4
Ramirez De Molina, V.5
Cejas, P.6
-
42
-
-
0031790264
-
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography
-
Shields AF, Grierson JR, Dohmen BM, Machulla HJ, Stayanoff JC, Lawhorn-Crews JM, et al. Imaging proliferation in vivo with [F-18]FLT and positron emission tomography. Nat Med 1998;4:1334-6.
-
(1998)
Nat Med
, vol.4
, pp. 1334-1336
-
-
Shields, A.F.1
Grierson, J.R.2
Dohmen, B.M.3
Machulla, H.J.4
Stayanoff, J.C.5
Lawhorn-Crews, J.M.6
-
43
-
-
68449095057
-
NCI-sponsored trial for the evaluation of safety and preliminary efficacy of 3′-deoxy-3′-[18F] fluorothymidine (FLT) as a marker of proliferation in patients with recurrent gliomas: Preliminary efficacy studies
-
Spence AM, Muzi M, Link JM, O'Sullivan F, Eary JF, Hoffman JM, et al. NCI-sponsored trial for the evaluation of safety and preliminary efficacy of 3′-deoxy-3′-[18F] fluorothymidine (FLT) as a marker of proliferation in patients with recurrent gliomas: preliminary efficacy studies. Mol Imaging Biol 2009;11:343-55.
-
(2009)
Mol Imaging Biol
, vol.11
, pp. 343-355
-
-
Spence, A.M.1
Muzi, M.2
Link, J.M.3
O'Sullivan, F.4
Eary, J.F.5
Hoffman, J.M.6
-
44
-
-
17644392076
-
The uptake of 3′-deoxy-3′-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels
-
Barthel H, Perumal M, Latigo J, He Q, Brady F, Luthra SK, et al. The uptake of 3′-deoxy-3′-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels. Eur J Nucl Med Mol Imaging 2005;32:257-63.
-
(2005)
Eur J Nucl Med Mol Imaging
, vol.32
, pp. 257-263
-
-
Barthel, H.1
Perumal, M.2
Latigo, J.3
He, Q.4
Brady, F.5
Luthra, S.K.6
-
45
-
-
33748992895
-
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography
-
Perumal M, Pillai RG, Barthel H, Leyton J, Latigo JR, Forster M, et al. Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography. Cancer Res 2006;66:8558-64.
-
(2006)
Cancer Res
, vol.66
, pp. 8558-8564
-
-
Perumal, M.1
Pillai, R.G.2
Barthel, H.3
Leyton, J.4
Latigo, J.R.5
Forster, M.6
-
46
-
-
0036732034
-
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells
-
Rasey JS, Grierson JR, Wiens LW, Kolb PD, Schwartz JL. Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells. J Nucl Med 2002;43:1210-7.
-
(2002)
J Nucl Med
, vol.43
, pp. 1210-1217
-
-
Rasey, J.S.1
Grierson, J.R.2
Wiens, L.W.3
Kolb, P.D.4
Schwartz, J.L.5
-
47
-
-
0026315964
-
Cell cycle regulation of thymidine kinase: Residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis
-
Kauffman MG, Kelly TJ. Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis. Mol Cell Biol 1991;11:2538-46.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 2538-2546
-
-
Kauffman, M.G.1
Kelly, T.J.2
-
48
-
-
0029889149
-
Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells
-
Sutterluety H, Bartl S, Karlseder J, Wintersberger E, Seiser C. Carboxy-terminal residues of mouse thymidine kinase are essential for rapid degradation in quiescent cells. J Mol Biol 1996;259:383-92.
-
(1996)
J Mol Biol
, vol.259
, pp. 383-392
-
-
Sutterluety, H.1
Bartl, S.2
Karlseder, J.3
Wintersberger, E.4
Seiser, C.5
-
49
-
-
0347986676
-
Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway
-
Ke PY, Chang ZF. Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway. Mol Cell Biol 2004;24:514-26.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 514-526
-
-
Ke, P.Y.1
Chang, Z.F.2
-
50
-
-
0347694727
-
Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site
-
Li CL, Lu CY, Ke PY, Chang ZF. Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site. Biochem Biophys Res Commun 2004;313:587-93.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 587-593
-
-
Li, C.L.1
Lu, C.Y.2
Ke, P.Y.3
Chang, Z.F.4
-
51
-
-
0032524346
-
Serine 13 is the site of mitotic phosphorylation of human thymidine kinase
-
Chang ZF, Huang DY, Chi LM. Serine 13 is the site of mitotic phosphorylation of human thymidine kinase. J Biol Chem 1998;273:12095-100.
-
(1998)
J Biol Chem
, vol.273
, pp. 12095-12100
-
-
Chang, Z.F.1
Huang, D.Y.2
Chi, L.M.3
-
52
-
-
0142181279
-
Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG
-
Buck AK, Halter G, Schirrmeister H, Kotzerke J, Wurzinger I, Glatting G, et al. Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG. J Nucl Med 2003;44:1426-31.
-
(2003)
J Nucl Med
, vol.44
, pp. 1426-1431
-
-
Buck, A.K.1
Halter, G.2
Schirrmeister, H.3
Kotzerke, J.4
Wurzinger, I.5
Glatting, G.6
-
53
-
-
27544449023
-
Quantification of cellular proliferation in tumor and normal tissues of patients with breast cancer by [18F]fluorothymidine-positron emission tomography imaging: Evaluation of analytical methods
-
Kenny LM, Vigushin DM, Al-Nahhas A, Osman S, Luthra SK, Shousha S, et al. Quantification of cellular proliferation in tumor and normal tissues of patients with breast cancer by [18F]fluorothymidine-positron emission tomography imaging: evaluation of analytical methods. Cancer Res 2005;65:10104-12.
-
(2005)
Cancer Res
, vol.65
, pp. 10104-10112
-
-
Kenny, L.M.1
Vigushin, D.M.2
Al-Nahhas, A.3
Osman, S.4
Luthra, S.K.5
Shousha, S.6
-
54
-
-
15844426940
-
Kinetic modeling of 3′-deoxy-3′-fluorothymidine in somatic tumors: Mathematical studies
-
Muzi M, Mankoff DA, Grierson JR, Wells JM, Vesselle H, Krohn KA. Kinetic modeling of 3′-deoxy-3′-fluorothymidine in somatic tumors: mathematical studies. J Nucl Med 2005;46:371-80.
-
(2005)
J Nucl Med
, vol.46
, pp. 371-380
-
-
Muzi, M.1
Mankoff, D.A.2
Grierson, J.R.3
Wells, J.M.4
Vesselle, H.5
Krohn, K.A.6
-
55
-
-
34249280302
-
Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine in patients with gliomas
-
Muzi M, Spence AM, O'Sullivan F, Mankoff DA, Wells JM, Grierson JR, et al. Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine in patients with gliomas. J Nucl Med 2006;47:1612-21.
-
(2006)
J Nucl Med
, vol.47
, pp. 1612-1621
-
-
Muzi, M.1
Spence, A.M.2
O'Sullivan, F.3
Mankoff, D.A.4
Wells, J.M.5
Grierson, J.R.6
-
56
-
-
15844427289
-
Kinetic analysis of 3′-deoxy-3′-fluorothymidine PET studies: Validation studies in patients with lung cancer
-
Muzi M, Vesselle H, Grierson JR, Mankoff DA, Schmidt RA, Peterson L, et al. Kinetic analysis of 3′-deoxy-3′-fluorothymidine PET studies: validation studies in patients with lung cancer. J Nucl Med 2005;46:274-82.
-
(2005)
J Nucl Med
, vol.46
, pp. 274-282
-
-
Muzi, M.1
Vesselle, H.2
Grierson, J.R.3
Mankoff, D.A.4
Schmidt, R.A.5
Peterson, L.6
-
57
-
-
42249098076
-
Glioma proliferation as assessed by 3′-fluoro-3′-deoxy-L- Thymidine positron emission tomography in patients with newly diagnosed high-grade glioma
-
DOI 10.1158/1078-0432.CCR-07-1553
-
Ullrich R, Backes H, Li H, Kracht L, Miletic H, Kesper K, et al. Glioma proliferation as assessed by 3′-fluoro-3′-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma. Clin Cancer Res 2008;14:2049-55. (Pubitemid 351551115)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.7
, pp. 2049-2055
-
-
Ullrich, R.1
Backes, H.2
Li, H.3
Kracht, L.4
Miletic, H.5
Kesper, K.6
Neumaier, B.7
Heiss, W.-D.8
Wienhard, K.9
Jacobs, A.H.10
-
58
-
-
67650067335
-
Kinetic analysis of 3′-deoxy-3′-(18)F-fluorothymidine ((18)F-FLT) in head and neck cancer patients before and early after initiation of chemoradiation therapy
-
Menda Y, Boles Ponto LL, Dornfeld KJ, Tewson TJ, Watkins GL, Schultz MK, et al. Kinetic analysis of 3′-deoxy-3′-(18)F-fluorothymidine ((18)F-FLT) in head and neck cancer patients before and early after initiation of chemoradiation therapy. J Nucl Med 2009;50:1028-35.
-
(2009)
J Nucl Med
, vol.50
, pp. 1028-1035
-
-
Menda, Y.1
Boles Ponto, L.L.2
Dornfeld, K.J.3
Tewson, T.J.4
Watkins, G.L.5
Schultz, M.K.6
-
59
-
-
27744467582
-
A simplified analysis of [F-18]3′-deoxy-3 ′-fluorothymidine metabolism and retention
-
Shields AF, Briston DA, Chandupatla S, Douglas KA, Lawhorn-Crews J, Collins JM, et al. A simplified analysis of [F-18]3′-deoxy-3 ′-fluorothymidine metabolism and retention. Eur J Nucl Med Mol Imaging 2005;32:1269-75.
-
(2005)
Eur J Nucl Med Mol Imaging
, vol.32
, pp. 1269-1275
-
-
Shields, A.F.1
Briston, D.A.2
Chandupatla, S.3
Douglas, K.A.4
Lawhorn-Crews, J.5
Collins, J.M.6
-
60
-
-
70350719346
-
Altered tissue 3′-deoxy-3′-[18F]fluorothymidine pharmacokinetics in human breast cancer following capecitabine treatment detected by positron emission tomography
-
Kenny LM, Contractor KB, Stebbing J, Al-Nahhas A, Palmieri C, Shousha S, et al. Altered tissue 3′-deoxy-3′-[18F]fluorothymidine pharmacokinetics in human breast cancer following capecitabine treatment detected by positron emission tomography. Clin Cancer Res 2009;15:6649-57.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6649-6657
-
-
Kenny, L.M.1
Contractor, K.B.2
Stebbing, J.3
Al-Nahhas, A.4
Palmieri, C.5
Shousha, S.6
-
61
-
-
45549089324
-
Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945
-
Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, et al. Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945. Cancer Res 2008;68:3827-34.
-
(2008)
Cancer Res
, vol.68
, pp. 3827-3834
-
-
Pillai, R.G.1
Forster, M.2
Perumal, M.3
Mitchell, F.4
Leyton, J.5
Aibgirhio, F.I.6
-
62
-
-
0037742189
-
3′-deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
-
Barthel H, Cleij MC, Collingridge DR, Hutchinson OC, Osman S, He Q, et al. 3′-deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. Cancer Res 2003;63:3791-8.
-
(2003)
Cancer Res
, vol.63
, pp. 3791-3798
-
-
Barthel, H.1
Cleij, M.C.2
Collingridge, D.R.3
Hutchinson, O.C.4
Osman, S.5
He, Q.6
-
63
-
-
0742271315
-
Small-animal imaging of tumour proliferation with PET
-
DOI 10.1016/S1470-2045(04)01383-X, PII S147020450401383X
-
Barthel H, Price P, Aboagye EO. Small-animal imaging of tumour proliferation with PET. Lancet Oncol 2004;5:100. (Pubitemid 38145892)
-
(2004)
Lancet Oncology
, vol.5
, Issue.2
, pp. 100
-
-
Barthel, H.1
Price, P.2
Aboagye, E.O.3
-
64
-
-
33747893488
-
In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography
-
Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, et al. In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography. Cancer Res 2006;66:7621-9.
-
(2006)
Cancer Res
, vol.66
, pp. 7621-7629
-
-
Leyton, J.1
Alao, J.P.2
Da Costa, M.3
Stavropoulou, A.V.4
Latigo, J.R.5
Perumal, M.6
-
65
-
-
20144366731
-
Early detection of tumor response to chemotherapy by 3′-deoxy- 3′-[18F]fluorothymidine positron emission tomography: The effect of cisplatin on a fibrosarcoma tumor model in vivo
-
Leyton J, Latigo JR, Perumal M, Dhaliwal H, He Q, Aboagye EO. Early detection of tumor response to chemotherapy by 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo. Cancer Res 2005;65:4202-10.
-
(2005)
Cancer Res
, vol.65
, pp. 4202-4210
-
-
Leyton, J.1
Latigo, J.R.2
Perumal, M.3
Dhaliwal, H.4
He, Q.5
Aboagye, E.O.6
-
66
-
-
33749467859
-
Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography imaging
-
Leyton J, Lockley M, Aerts JL, Baird SK, Aboagye EO, Lemoine NR, et al. Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography imaging. Cancer Res 2006;66:9178-85.
-
(2006)
Cancer Res
, vol.66
, pp. 9178-9185
-
-
Leyton, J.1
Lockley, M.2
Aerts, J.L.3
Baird, S.K.4
Aboagye, E.O.5
Lemoine, N.R.6
-
67
-
-
77957678083
-
3′-Deoxy-3′-[18F]fluorothymidine and 2-[18F]fluoro-2-deoxy-D- glucose as markers of response to cisplatin therapy in vivo
-
Leyton J, Perumal M, Dhaliwal H, Latigo J, Aboagye EO. 3′-Deoxy-3′-[18F]fluorothymidine and 2-[18F]fluoro-2-deoxy-D-glucose as markers of response to cisplatin therapy in vivo. Br J Cancer 2004;91:S45.
-
(2004)
Br J Cancer
, vol.91
-
-
Leyton, J.1
Perumal, M.2
Dhaliwal, H.3
Latigo, J.4
Aboagye, E.O.5
-
68
-
-
54049121486
-
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901
-
Leyton J, Smith G, Lees M, Perumal M, Nguyen QD, Aigbirhio FI, et al. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901. Mol Cancer Ther 2008;7:3112-21.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3112-3121
-
-
Leyton, J.1
Smith, G.2
Lees, M.3
Perumal, M.4
Nguyen, Q.D.5
Aigbirhio, F.I.6
-
69
-
-
37049013325
-
3′-deoxy-3′-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition
-
Solit DB, Santos E, Pratilas CA, Lobo J, Moroz M, Cai S, et al. 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition. Cancer Res 2007;67:11463-9.
-
(2007)
Cancer Res
, vol.67
, pp. 11463-11469
-
-
Solit, D.B.1
Santos, E.2
Pratilas, C.A.3
Lobo, J.4
Moroz, M.5
Cai, S.6
-
70
-
-
34548173711
-
Imaging early changes in proliferation at 1 week post chemotherapy: A pilot study in breast cancer patients with 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography
-
Kenny L, Coombes RC, Vigushin DM, Al-Nahhas A, Shousha S, Aboagye EO. Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography. Eur J Nucl Med Mol Imaging 2007;34:1339-47.
-
(2007)
Eur J Nucl Med Mol Imaging
, vol.34
, pp. 1339-1347
-
-
Kenny, L.1
Coombes, R.C.2
Vigushin, D.M.3
Al-Nahhas, A.4
Shousha, S.5
Aboagye, E.O.6
-
71
-
-
58149337441
-
[18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lung
-
Sohn HJ, Yang YJ, Ryu JS, Oh SJ, Im KC, Moon DH, et al. [18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lung. Clin Cancer Res 2008;14:7423-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7423-7429
-
-
Sohn, H.J.1
Yang, Y.J.2
Ryu, J.S.3
Oh, S.J.4
Im, K.C.5
Moon, D.H.6
-
72
-
-
36048955738
-
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: A pilot study
-
Chen W, Delaloye S, Silverman DH, Geist C, Czernin J, Sayre J, et al. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol 2007;25:4714-21.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4714-4721
-
-
Chen, W.1
Delaloye, S.2
Silverman, D.H.3
Geist, C.4
Czernin, J.5
Sayre, J.6
-
73
-
-
33645826040
-
Usefulness of 3′-[18F]fluoro-3′-deoxythymidine with positron emission tomography in predicting breast cancer response to therapy
-
Pio BS, Park CK, Pietras R, Hsueh W-A, Satyamurthy N, Pegram MD, et al. Usefulness of 3′-[18F]fluoro-3′-deoxythymidine with positron emission tomography in predicting breast cancer response to therapy. Mol Imaging Biol 2006;8:36.
-
(2006)
Mol Imaging Biol
, vol.8
, pp. 36
-
-
Pio, B.S.1
Park, C.K.2
Pietras, R.3
Hsueh, W.-A.4
Satyamurthy, N.5
Pegram, M.D.6
-
74
-
-
34250373777
-
18F-fluorothymidine kinetics of malignant brain tumors
-
Schiepers C, Chen W, Dahlbom M, Cloughesy T, Hoh CK, Huang SC. 18F-fluorothymidine kinetics of malignant brain tumors. Eur J Nucl Med Mol Imaging 2007;34:1003-11.
-
(2007)
Eur J Nucl Med Mol Imaging
, vol.34
, pp. 1003-1011
-
-
Schiepers, C.1
Chen, W.2
Dahlbom, M.3
Cloughesy, T.4
Hoh, C.K.5
Huang, S.C.6
-
75
-
-
60549104389
-
Reproducibility of quantitative 18F-3′-deoxy-3′- fluorothymidine measurements using positron emission tomography
-
de Langen AJ, Klabbers B, Lubberink M, Boellaard R, Spreeuwenberg MD, Slotman BJ, et al. Reproducibility of quantitative 18F-3′-deoxy-3′- fluorothymidine measurements using positron emission tomography. Eur J Nucl Med Mol Imaging 2009;36:389-95.
-
(2009)
Eur J Nucl Med Mol Imaging
, vol.36
, pp. 389-395
-
-
De Langen, A.J.1
Klabbers, B.2
Lubberink, M.3
Boellaard, R.4
Spreeuwenberg, M.D.5
Slotman, B.J.6
-
76
-
-
51649089704
-
Analysis and reproducibility of 3′-Deoxy-3′-[18F] fluorothymidine positron emission tomography imaging in patients with non-small cell lung cancer
-
Shields AF, Lawhorn-Crews JM, Briston DA, Zalzala S, Gadgeel S, Douglas KA, et al. Analysis and reproducibility of 3′-Deoxy-3′-[18F] fluorothymidine positron emission tomography imaging in patients with non-small cell lung cancer. Clin Cancer Res 2008;14:4463-8.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4463-4468
-
-
Shields, A.F.1
Lawhorn-Crews, J.M.2
Briston, D.A.3
Zalzala, S.4
Gadgeel, S.5
Douglas, K.A.6
-
77
-
-
0032716268
-
Reproducibility of metabolic measurements in malignant tumors using FDG PET
-
Weber WA, Ziegler SI, Thodtmann R, Hanauske AR, Schwaiger M. Reproducibility of metabolic measurements in malignant tumors using FDG PET. J Nucl Med 1999;40:1771-7. (Pubitemid 29523568)
-
(1999)
Journal of Nuclear Medicine
, vol.40
, Issue.11
, pp. 1771-1777
-
-
Weber, W.A.1
Ziegler, S.I.2
Thodtmann, R.3
Hanauske, A.-R.4
Schwaiger, M.5
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