High-throughput in vivo screening of targeted molecular imaging agents

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 42, 2009, Pages 17904-17909

  Gagnon, M Karen J ^a   Hausner, Sven H ^a   Marik, Jan ^a   Abbey, Craig K ^a,b   Marshall, John F ^c   Sutcliffe, Julie L ^a,d  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

High throughput screening; In vivo imaging; MicroPET; Positron emission tomography; Radiolabeled peptides

Indexed keywords

4 FLUOROBENZOIC ACID F 18; ALPHA INTEGRIN; ARGINYLASPARTYLASPARTYLLEUCYLMETHIONYLTYROSYLLEUCYLARGININE; ARGINYLLEUCYLASPARTYLLEUCYLGLUTAMINYLPROLYLLEUCYLISOLEUCINE; ARGINYLSERYLASPARTYLLEUCYLTHREONYLPROLYLLEUCYLPHENYLALANINE; ARGINYLTHREONYLASPARTYLLEUCYLLYSYLLYSYLLEUCYLLEUCINE; ARGINYLVALYLASPARTYLLEUCYLMETHIONYLTYROSYLLEUCYLARGININE; BETA INTEGRIN; CONTRAST MEDIUM; LYSYLLEUCYLASPARTYLLEUCYLHISTIDYLTHREONYLLEUCYLGLUTAMIC ACID; PEPTIDE; PROLYLGLYCYLASPARTYLLEUCYLALANYLVALYLLEUCYLALANINE; PROLYLMETHIONYLASPARTYLLEUCYLALANYLTYROSYLLEUCYLARGININE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; IC 50; IN VIVO STUDY; ISOTOPE LABELING; MOLECULAR IMAGING; PEPTIDE ANALYSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SOLID;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; FLUORINE RADIOISOTOPES; MICE; NEOPLASMS, EXPERIMENTAL; OLIGOPEPTIDES; PEPTIDE LIBRARY; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

ANIMALIA;

EID: 70449570521     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906925106     Document Type: Article

References (38)

1. Lam KS, Lebl M, Krchnak V (1997) The "one-bead-one-compound" combinatorial library method. Chem Rev 97:411-448.
2. Geysen HM, Schoenen F, Wagner D, Wagner R (2003) Combinatorial compound libraries for drug discovery: An ongoing challenge. Nat Rev Drug Discov 2:222-230. (Pubitemid 37361667)
3. Szardenings M (2003) Phage display of random peptide libraries: Applications, limits, and potential. J Recept Sig Transd 23:307-349. (Pubitemid 38018399)
4. Uttamchandani M, Wang J, Yao SQ (2006) Protein and small molecule microarrays: Powerful tools for high-throughput proteomics. Mol BioSyst 2:58-68.
5. Melnick JS, et al. (2006) An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci USA 103:3153-3158.
6. Inglese J, et al. (2006) Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci USA 103:11473-11478. (Pubitemid 44182476)
7. Nicholson RL, Welch M, Ladlow M, Spring DR (2007) Small-molecule screening: Advances in microarraying and cell-imaging technologies. Chem Biol 2:24-30. (Pubitemid 47490239)
8. Gomez-Hens A, Aguilar-Caballos MP (2007) Modern analytical approaches to highthroughput drug discovery. Trends Anal Chem 26:171-182. (Pubitemid 46343663)
9. Dittrich PS, Manz A (2006) Lab-on-a-chip: Microfluidics in drug discovery. Nat Rev Drug Discov 5:210-218.
10. Edwards BS, Kuckuck FW, Prossnitz ER, Ransom JT, Sklar LA (2001) HTPS flow cytometry: A novel platform for automated high throughput drug discovery and characterization. J Biomol Screen 6:83-90.
11. Edwards BS, Oprea T, Prossnitz ER, Sklar LA (2004) Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol 8:392-398. (Pubitemid 38993732)
12. Hogemann D, Ntziachristos V, Josephson L, Weissleder R (2002) High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjugate Chem 13:116-121. (Pubitemid 34119642)
13. Bock NA, Konyer NB, Henkelman RM (2003) Multiple-mouse MRI. Magn Reson Med 49:158-167.
14. Dazai J, et al. (2004) Multiple mouse biological loading and monitoring system for MRI. Magn Reson Med 52:709-715. (Pubitemid 39314971)
15. Bock NA, Nieman BJ, Bishop JB, Henkelman RM (2005) In vivo multiple-mouse MRI at 7 tesla. Magn Reson Med 54:1311-1316.
16. McConville P, Moody JB, Moffat BA (2005) High-throughput magnetic resonance imaging in mice for phenotyping and therapeutic evaluation. Curr Opin Chem Biol 9:413-420. (Pubitemid 41019689)
17. Melgar S, Gillberg P-G, Hockings PD, Olsson LE (2007) High-throughput magnetic resonance imaging in murine colonic inflammation. Biochem Bioph Res Co 355:1102-1107. (Pubitemid 46366941)
18. Ramirez MS, Bankson JA (2007) A practical method for 2D multiple-animal MRI. J Magn Reson Imaging 26:1162-1166.
19. Ramirez MS, Ragan DK, Kundra V, Bankson JA (2007) Feasibility of multiple-mouse dynamic contrast-enhanced MRI. Magn Reson Med 58:610-615. (Pubitemid 350154973)
20. Esparza-Coss E, Ramirez MS, Bankson JA (2008) Wireless self-gated multiple-mouse cardiac cine MRI. Magn Reson Med 59:1203-1206. (Pubitemid 351590536)
21. Hofmann M, Weitzel T, Krause T (2006) Ga-68-DOTATOC: Feasibility of high throughput screening by small animal PET using a clinical high-resolution PET/CT scanner. Nucl Instrum Meth A 569:522-524. (Pubitemid 44820479)
22. Aina OH, et al. (2007) From combinatorial chemistry to cancer-targeting peptides. Mol Pharm 4:631-651.
23. Peng L, et al. (2006) Combinatorial chemistry identifies high-affinity peptidomimetics against α4β1 integrin for in vivo tumor imaging. Nat Chem Biol 2:381-389. (Pubitemid 43936939)
24. Aina OH, Sroka TC, Chen ML, Lam KS (2002) Therapeutic cancer targeting peptides. Biopolymers 66:184-199.
25. Sutcliffe-Goulden JL, et al. (2002) Rapid solid phase synthesis and biodistribution of 18F-labeled linear peptides. Eur J Nucl Med Mol Imaging 29:754-759. (Pubitemid 34591691)
26. 18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin αvβ6 expression with positron emission tomography. Cancer Res 67:7833-7840.
27. 6 as a prognostic biomarker for non-small cell lung cancer. Cancer Res 67:5889-5895.
28. Bates RC, et al. (2005) Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 115:339-347.
29. 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. J Pathol 212:316-324.
30. 6 acts as a prognostic indicator in gastric carcinoma. Clin Oncol 20:61-66.
31. Kraft S, et al. (1999) Definition of an unexpected ligand recognition motif for αvβ6 integrin. J Biol Chem 274:1979-1985. (Pubitemid 29061346)
32. Lau DH, et al. (2002) Identifying peptide ligands for cell surface receptors using cell-growth-on-bead assay and one-bead-one-compound combinatorial library. Biotechnol Lett 24:497-500.
33. Zasadny KR, Wahl RL (1993) Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: Variations with body weight and a method for correction. Radiology 189:847-850.
34. Pierschbacher MD, Ruoslahti E (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30-33.
35. 18F]galacto-RGD. PLoS Med 2:0244-0252.
36. 6-specific peptide. Mol Imaging 8:111-121.
37. 6 with and improved radiotracer and its relevance in a pancreatic tumor model. Cancer Res 69:5843-5850.
38. 18F] fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU). Appl Radiat Isot 65:199-203.