Drug design with a new transition state analog of the hydrated carbonyl: Silicon-based inhibitors of the HIV protease

Chemistry and Biology

Volumn 8, Issue 12, 2001, Pages 1161-1166

  Chen, Chien An ^a   Sieburth, Scott McN ^a,c   Glekas, Athanasios ^a   Hewitt, Gregory W ^a   Trainor, George L ^b   Erickson Viitanen, Susan ^b   Garber, Sena S ^b   Cordova, Beverly ^b   Jeffry, Susan ^b   Klabe, Ronald M ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c Temple University   (United States)

Author keywords

Drug design; HIV; Organosilane; Protease inhibitor; Silanediol

Indexed keywords

ORGANOSILICON DERIVATIVE; PROTEINASE INHIBITOR;

ARTICLE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1;

CELLS, CULTURED; DRUG DESIGN; HIV PROTEASE INHIBITORS; HIV-1; HUMAN; MODELS, MOLECULAR; ORGANOSILICON COMPOUNDS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 18044404491     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00079-5     Document Type: Article

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