Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) in head and neck cancer patients before and early after initiation of chemoradiation therapy

Journal of Nuclear Medicine

Volumn 50, Issue 7, 2009, Pages 1028-1035

  Menda, Yusuf ^a   Boles Ponto, Laura L ^a   Dornfeld, Kenneth J ^b   Tewson, Timothy J ^a   Watkins, G Leonard ^a   Schultz, Michael K ^b   Sunderland, John J ^a   Graham, Michael M ^a   Buatti, John M ^b  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

3 deoxy 3 18F fluorothymidine; 18F FLT; Head and neck cancer

Indexed keywords

3' FLUOROTHYMIDINE F 18; CARBOPLATIN; CISPLATIN; PACLITAXEL;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CERVICAL LYMPH NODE; CLINICAL ARTICLE; CLINICAL TRIAL; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG UPTAKE; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; SQUAMOUS CELL CARCINOMA;

ADULT; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; COMPUTER SIMULATION; DIDEOXYNUCLEOSIDES; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; KINETICS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MODELS, BIOLOGICAL; RADIOPHARMACEUTICALS; RADIOTHERAPY, ADJUVANT;

EID: 67650067335     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.058495     Document Type: Article

References (21)

1. Rasey JS, Grierson JR, Wiens LW, et al. Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells. J Nucl Med. 2002;43:1210-1217.
2. 18F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors. Clin Cancer Res. 2002;8:3315-3323.
3. Buck AK, Bommer M, Stilgenbauer S, et al. Molecular imaging of proliferation in malignant lymphoma. Cancer Res. 2006;66:11055-11061.
4. 18F-FDG. J Nucl Med. 2005;46:945-952.
5. 18F-FDG PET. J Nucl Med. 2004;45:226-231.
6. 18F-FDG in primary head and neck cancer correlates with survival. Nuklearmedizin. 2008;47:80-85.
7. 18F-FLT PET does not discriminate between reactive and metastatic lymph nodes in primary head and neck cancer patients. J Nucl Med. 2007;48:726-735.
8. 18F]fluorothymidine-positron emission tomography imaging: evaluation of analytical methods. Cancer Res. 2005;65:10104-10112.
9. 18F]FLT). J Radioanal Nucl Chem. 2000;24:843-846.
10. 18F]3′-deoxy-3′-fluorothymidine metabolism and retention. Eur J Nucl Med Mol Imaging. 2005;32:1269-1275.
11. Muzi M, Mankoff DA, Grierson JR, et al. Kinetic modeling of 3′-deoxy-3′-fluorothymidine in somatic tumors: mathematical studies. J Nucl Med. 2005;46:371-380.
12. 18F-fluorothymidine kinetics of malignant brain tumors. Eur J Nucl Med Mol Imaging. 2007;34:1003-1011.
13. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-tobrain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983;3:1-7.
14. Haveman J, Sigmond J, van Bree C, et al. Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation. Oncol Rep. 2006;16:901-905.
15. Waf1. Cell Growth Differ. 1998;9:887-896.
16. Zackrisson B, Flygare P, Gustafsson H, et al. Cell kinetic changes in human squamous cell carcinomas during radiotherapy studied using the in vivo administration of two halogenated pyrimidines. Eur J Cancer. 2002;38:1100-1106.
17. Valente G, Orecchia R, Gandolfo S, et al. Can Ki67 immunostaining predict response to radiotherapy in oral squamous cell carcinoma? J Clin Pathol. 1994;47:109-112.
18. Bading JR, Shields AF. Imaging of cell proliferation: status and prospects. J Nucl Med. 2008;49(suppl 2):64S-80S.
19. Muzi M, Vesselle H, Grierson JR, et al. Kinetic analysis of 3′-deoxy-3′-fluorothymidine PET studies: validation studies in patients with lung cancer. J Nucl Med. 2005;46:274-282.
20. 18FLT utilisation in colorectal cancer. Eur J Nucl Med Mol Imaging. 2004;31:169-178.
21. 18F-FDG for differentiating tumor from inflammation in a rodent model. J Nucl Med. 2004;45:695-700.