Freeze-drying of polycaprolactone and poly(D,L-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 50, Issue 3, 2000, Pages 379-387

  Saez, A ^a   Guzman M ^a   Molpeceres, J ^a   Aberturas, M R ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Cryoprotectives; Freeze drying; Nanoparticles; Pharmacokinetics, Cyclosporine

Indexed keywords

CYCLOSPORIN A; GELATIN; GLUCOSE; POLYCAPROLACTONE; POLYGLACTIN; RESOMER RG 504; SUCROSE; TREHALOSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FECES LEVEL; DRUG MANUFACTURE; DRUG RELEASE; DRUG STABILITY; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FLUORESCENCE POLARIZATION IMMUNOASSAY; FREEZE DRYING; KIDNEY; LIVER; MALE; NANOPARTICLE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; RAT; SPLEEN; TEMPERATURE;

ADMINISTRATION, ORAL; ANIMAL; BIOCOMPATIBLE MATERIALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYOPROTECTIVE AGENTS; CYCLOSPORINE; DRUG CARRIERS; DRUG STABILITY; ENTROPY; FREEZE DRYING; IMMUNOSUPPRESSIVE AGENTS; LACTIC ACID; MALE; PARTICLE SIZE; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION;

EID: 0033790335     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(00)00125-9     Document Type: Article

References (31)

1. Nanoparticles and microparticles for drug and vaccine delivery
2. Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia
3. Stability of cyclosporin-loaded poly-ε-caprolactone nanoparticles
4. Formulation and lyoprotection of poly (lactic acid-co-ethylene oxide) nanoparticles: Influence on physical stability and in vitro cell uptake
5. Stability study of nanoparticles of poly(ε-caprolactone), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide)
6. Is Trehalose special for preserving dry materials?
7. Freeze-drying of liposomes with free and membrane-bound cryoprotectives - the background of protection and damaging process
8. Cryoprotective mechanism of saccharides on freeze-drying of liposome
9. The cryopreservation of liposomes. 1. A differential scanning calorimetry study of the thermal behaviour of a liposome dispersion containing mannitol during freezing/thawing
10. Lyophilisation de vecteurs colloIdaux submicroniques
11. Gastro-intestinal tolerance study of a freeze-dried oral dosage form of indomethacin-loaded nanocapsules
12. Freeze-drying of itraconazole-loaded nanosphere suspensions: a feasibility study
13. Formulation and evaluation of zinc phthalocyanine-loaded poly(DL-lactic acid) nanoparticles
14. On shelf stability of freeze-dried poly(methylidene malonate, 2.1.2) nanoparticles
15. Influence of the stabilizer coating layer on the purification and freeze-drying of poly(D,L-lactic acid) nanoparticles prepared by an emulsion-diffusion technique
16. Thermal analysis of freeze dried liposome-carbohydrate mixtures with modulated differential scanning calorimetry
17. Stability and freeze-drying of cyclosporine loaded poly(D,L-lactide-glycolide) carriers
18. Increased oral bioavailability of cyclosporine incorporated in polycaprolactone nanoparticles
19. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency
20. Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement
21. Optimized preparation of poly DL(lactic-glycolic) microspheres and nanoparticles for oral administration
22. The uptake and translocation of latex nanopheres and microspheres after oral administration to rats
23. Formation and characterization of cyclosporine-loaded nanoparticles
24. Dependency of cyclosporine tissue distribution and metabolism on the age and gender of rats after a single intravenous dose
25. Thermische Analyse in der pharmazie
26. Optimisation de parametres de lyophilisation par analyse calorimetrique differentielle
27. Measurement of glass transition temperatures of freeze-concentrated solutes by differential scanning calorimetry
28. Electrolyte-induced changes in glass transition temperatures of freeze-concentrated solutes
29. Characteristics and significance of the amorphous state in pharmaceutical systems
30. Comparacion de los perfiles de liberacion de ciclosporina a partir de nanopartIculas de PECL y PLGA frente a formulaciones comerciales: Sandimmun y Sandimmun Neoral
31. Biodegradable nanoparticles as a delivery system for cyclosporine: preparation and characterization