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Bioorganic and Medicinal Chemistry

Volumn 18, Issue 20, 2010, Pages 7212-7220

Synthesis and biological evaluation of a series of aromatic bisphosphonates

(5) Barney, Rocky J a Wasko, Brian M b Dudakovic, Amel c Hohl, Raymond J b,c Wiemer, David F a,c

a The University of Iowa (United States)

b UNIVERSITY OF IOWA (United States)

c UNIVERSITY OF IOWA (United States)

Author keywords

Bisphosphonate; Enzyme inhibitor; Geranylgeranyl diphosphate; GGDPS; Isoprenoid biosynthesis; Protein prenylation

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; DIALKYLBISPHOSPHONATE; FARNESYL TRANS TRANSFERASE; TETRAETHYL BISPHOSPHONATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LEUKEMIA CELL;

BINDING SITES; CELL LINE, TUMOR; DIPHOSPHONATES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GERANYLTRANSTRANSFERASE; HUMANS;

EID: 77957586255 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.08.036 Document Type: Article

Times cited : (25)

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