Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: A crystallographic and computational investigation

Journal of Medicinal Chemistry

Volumn 51, Issue 18, 2008, Pages 5594-5607

  Chen, Cammy K M ^a,b   Hudock, Michael P ^c   Zhang, Yonghui ^e   Guo, Rey Ting ^b,d   Cao, Rong ^c   Joo, Hwan No ^c   Liang, Po Huang ^a,b   Ko, Tzu Ping ^b   Chang, Tao Hsin ^b,d   Chang, Shiou Chi ^e   Song, Yongcheng ^e   Axelson, Jordan ^e   Kumar, Anup ^e   Wang, Andrew H J ^a,b,d   Oldfield, Eric ^c,e  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d ACADEMIA SINICA   (Taiwan)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; FARNESYL TRANS TRANSFERASE; MAGNESIUM ION;

ARTICLE; BINDING SITE; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; IC 50; MOLECULAR DOCKING; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHONATES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52449099606     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800325y     Document Type: Article

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