Dishevelled interacts with p65 and acts as a repressor of NF-B-mediated transcription

Cell Research

Volumn 20, Issue 10, 2010, Pages 1117-1127

  Deng, Ning ^a   Ye, Yanger ^a   Wang, Wei ^a   Li, Lin ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Dishevelled (Dvl); NF B p65; transcriptional suppressor; Wnt signaling

Indexed keywords

BETA CATENIN; DISHEVELLED PROTEINS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOPROTEIN; RELA PROTEIN, HUMAN; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; WNT PROTEIN;

APOPTOSIS; ARTICLE; CELL LINE; CELL NUCLEUS; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PROMOTER REGION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BETA CATENIN; CELL LINE; CELL NUCLEUS; HUMANS; NF-KAPPA B; PHOSPHOPROTEINS; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; WNT PROTEINS;

EID: 77957561749     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.108     Document Type: Article

References (41)

1. Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 2000; 287:1606-1609.
2. Goldstein B, Takeshita H, Mizumoto K, Sawa H. Wnt signals can function as positional cues in establishing cell polarity. Dev Cell 2006; 10:391-396.
3. Moon RT, Brown JD, Torres M. WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 1997; 13:157-162.
4. Fuerer C, Nusse R, Ten Berge D. Wnt signalling in development and disease. EMBO Rep 2008; 9:134-138.
5. Van Amerongen R, Nusse R.Towards an integrated view of Wnt signaling in development. Development 2009; 136:3205-3214.
6. Itoh K, Brott BK, Bae GU, Ratcliffe MJ, Sokol SY. Nuclear localization is required for Dishevelled function in Wnt/ β-catenin signaling. J Biol 2005; 4:3.
7. Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L. Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabilization of β-catenin-TCF interaction. J Cell Biol 2008; 180:1087-1100.
8. Boutros M, Mlodzik M. Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech Dev 1999; 831:27-37.
9. Veeman MT, Axelrod JD, Moon RT. A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 2003; 5:367-377.
10. Wharton KA Jr. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their signifcance to Wnt signal transduc-tion. Dev Biol 2003; 253:1-17.
11. Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996; 14:649-683.
12. Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evo-lutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16:225-260.
13. Baeuerle PA, Baichwal VR. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol 1997; 65:111-137.
14. Mercurio F, Manning AM. NF-κB as a primary regulator of the stress response. Oncogene 1999; 18:6163-6171.
15. Hayden MS, Ghosh S. Signaling to NF-κB. Genes Dev 2004; 18:2195-2224.
16. Barnes PJ, Karin M. Nuclear factor-κB: a pivotal transcription factor in chronic infammatory diseases. N Engl J Med 1997; 336:1066-1071.
17. Gilmore TD, Koedood M, Piffat KA, White DW. Rel/NF-κB/ IκB proteins and cancer. Oncogene 1996; 13:1367-1378.
18. Rayet B, Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 1999; 18:6938-6947.
19. Sussman DJ, Klingensmith J, Salinas P, Adams PS, Nusse R, Perrimon N. Isolation and characterization of a mouse ho-molog of the Drosophila segment polarity gene dishevelled. Dev Biol 1994; 166:73-86. (Pubitemid 24374748)
20. Klingensmith J, Yang Y, Axelrod JD, Beier DR, Perrimon N, Sussman DJ. Conservation of dishevelled structure and function between fies and mice: isolation and characterization of Dvl2. Mech Dev 1996; 58:15-26.
21. Tsang M, Lijam N, Yang Y, Beier DR, Wynshaw-Boris A, Sussman DJ. Isolation and characterization of mouse dishev-elled-3. Dev Dyn 1996; 207:253-262.
22. Li L, Yuan H, Xie W, et al. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-termi-nal kinase in mammalian cells. J Biol Chem 1999; 274:129-134.
23. Wallingford JB, Habas R. The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 2005; 132:4421-4436.
24. Masui O, Ueda Y, Tsumura A, Koyanagi M, Hijikata M, Shimotohno K. RelA suppresses the Wnt/β-catenin pathway without exerting trans-acting transcriptional ability. Int J Mol Med 2002; 9:489-493.
25. Deng J, Miller SA, Wang HY, et al. β-catenin interacts with and inhibits NF-κB in human colon and breast cancer. Cancer Cell 2002; 2:323-334.
26. Strovel ET, Sussman DJ. Transient overexpression of murine dishevelled genes results in apoptotic cell death. Exp Cell Res 1999; 253:637-648.
27. Minden A, Karin M. Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta 1997; 1332:85-104.
28. Karin M. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 1999; 18:6867-6874.
29. Jaattela M, Mouritzen H, Elling F, Bastholm L. A20 zinc fn-ger protein inhibits TNF and IL-1 signaling. J Immunol 1996; 156:1166-1173.
30. Song HY, Rothe M, Goeddel DV. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/ TRAF2 and inhibits NF-κB activation. Proc Natl Acad Sci USA 1996; 93:6721-6725.
31. Kovalenko A, Chable-Bessia C, Cantarella G, Israël A, Wal-lach D, Courtois G. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 2003; 424:801-805.
32. Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ash-worth A, Mosialos G. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 2003; 424:793-796.
33. Sosi? D, Richardson JA, Yu K, Ornitz DM, Olson EN. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-κB activity. Cell 2003; 112:169-180.
34. Gao H, Sun Y, Wu Y, et al. Identifcation of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways. Mol Cell 2004; 14:303-317.
35. Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ. β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα. Proc Natl Acad Sci USA 2004; 101:8603-8607.
36. Liu B, Yang R, Wong KA, et al. Negative regulation of NF-κB signaling by PIAS1. Mol Cell Biol 2005; 25:1113-1123.
37. Liu B, Yang Y, Chernishof V, et al. Proinfammatory stimuli induce IKKα-mediated phosphorylation of PIAS1 to restrict infammation and immunity. Cell 2007; 129:903-914.
38. Malewicz M, Zeller N, Yilmaz ZB, Weih F. NF-κB controls the balance between Fas and tumor necrosis factor cell death pathways during T cell receptor-induced apoptosis via the expression of its target gene A20. J Biol Chem 2003; 278:32825-32833.
39. Zazzeroni F, Papa S, Algeciras-Schimnich A, et al. Gadd45 β mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood 2003; 102:3270-3279.
40. Mao J, Wang J, Liu B, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001; 7:801-809.
41. Sun S, Tang Y, Lou X, et al. UXT is a novel and essential co-factor in the NF-κB transcriptional enhanceosome. J Cell Biol 2007; 178:231-244.