Mixture effects of dietary flavonoids on steroid hormone synthesis in the human adrenocortical H295R cell line

Food and Chemical Toxicology

Volumn 48, Issue 11, 2010, Pages 3194-3200

  Ohlsson, Åsa ^a   Ullerås, Erik ^a   Cedergreen, Nina ^b   Oskarsson, Agneta ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aldosterone; Cortisol; Endocrine disruption; Flavonoids; Oestradiol; Testosterone

Indexed keywords

ALDOSTERONE; APIGENIN; DAIDZEIN; ESTRADIOL; GENISTEIN; HYDROCORTISONE; TESTOSTERONE;

ADRENAL CORTEX CELL; ALDOSTERONE RELEASE; ARTICLE; CONTROLLED STUDY; DIET; ESTROGEN RELEASE; FOOD POISONING; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; PREDICTION; TESTOSTERONE RELEASE;

ADRENAL CORTEX; ALDOSTERONE; APIGENIN; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ESTRADIOL; GENISTEIN; HUMANS; HYDROCORTISONE; ISOFLAVONES; STEROIDS; TESTOSTERONE;

EID: 77957345391     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.08.021     Document Type: Article

References (35)

1. Ajdzanovic V., Sosic-Jurjevic B., Filipovic B., Trifunovic S., Manojlovic-Stojanoski M., Sekulic M., Milosevic V. Genistein-induced histomorphometric and hormone secreting changes in the adrenal cortex in middle-aged rats. Exp. Biol. Med. (Maywood) 2009, 234:148-156.
2. Backhaus T., Arrhenius A., Blanck H. Toxicity of a mixture of dissimilarly acting substances to natural algal communities: predictive power and limitations of independent action and concentration addition. Environ. Sci. Technol. 2004, 38:6363-6370.
3. Backhaus T., Faust M., Scholze M., Gramatica P., Vighi M., Grimme L.H. Joint algal toxicity of phenylurea herbicides is equally predictable by concentration addition and independent action. Environ. Toxicol. Chem. 2004, 23:258-264.
4. Bliss C.I. The toxicity of poisons applied jointly. Ann. J. Appl. Biol. 1939, 26:585-615.
5. Chang H.C., Churchwell M.I., Delclos K.B., Newbold R.R., Doerge D.R. Mass spectrometric-determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats. J. Nutr. 2000, 130:1963-1970.
6. Gracia T., Hilscherova K., Jones P.D., Newsted J.L., Higley E.B., Zhang X., Hecker M., Murphy M.B., Yu R.M., Lam P.K., Wu R.S., Giesy J.P. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicol. Appl. Pharmacol. 2007, 225:142-153.
7. Harvey P.W., Everett D.J., Springall C.J. Adrenal toxicology: a strategy for assessment of functional toxicity to the adrenal cortex and steroidogenesis. J. Appl. Toxicol. 2007, 27:103-115.
8. Heald C.L., Bolton-Smith C., Ritchie M.R., Morton M.S., Alexander F.E. Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men. Eur. J. Clin. Nutr. 2006, 60:129-135.
9. Kortenkamp A. Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals. Environ. Health Perspect. 2007, 115(Suppl. 1):98-105.
10. Le Bail J.C., Champavier Y., Chulia A.J., Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci. 2000, 66:1281-1291.
11. Loewe S., Muischnek H. Über Kombinationswirkungen I. Mitteilung: Hilfsmittel der Fragestellung. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 1926, 114:313-326. (in German).
12. Manach C., Scalbert A., Morand C., Remesy C., Jimenez L. Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 2004, 79:727-747.
13. Mesiano S., Katz S.L., Lee J.Y., Jaffe R.B. Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells. J. Clin. Endocrinol. Metab. 1999, 84:2443-2448.
14. Mortensen A., Kulling S.E., Schwartz H., Rowland I., Ruefer C.E., Rimbach G., Cassidy A., Magee P., Millar J., Hall W.L., Kramer Birkved F., Sorensen I.K., Sontag G. Analytical and compositional aspects of isoflavones in food and their biological effects. Mol. Nutr. Food Res. 2009, 53(Suppl. 2):S266-309.
15. Ohlsson Å., Ullerås E., Oskarsson A. A biphasic effect of the fungicide prochloraz on aldosterone, but not cortisol, secretion in human adrenal H295R cells - underlying mechanisms. Toxicol. Lett. 2009, 191:174-180.
16. Ohno S., Shinoda S., Toyoshima S., Nakazawa H., Makino T., Nakajin S. Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. J. Steroid Biochem. Mol. Biol. 2002, 80:355-363.
17. Ohno S., Nakajima Y., Inoue K., Nakazawa H., Nakajin S. Genistein administration decreases serum corticosterone and testosterone levels in rats. Life Sci. 2003, 74:733-742.
18. Ohno S., Matsumoto N., Watanabe M., Nakajin S. Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II. J. Steroid Biochem. Mol. Biol. 2004, 88:175-182.
19. Oskarsson A., Ullerås E., Plant K.E., Hinson J.P., Goldfarb P.S. Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J. Appl. Toxicol. 2006, 26:484-492.
20. Patisaul H.B., Jefferson W. The pros and cons of phytoestrogens. Front. Neuroendocrinol. 2010, 10.1016/j.yfrne.2010.03.003.
21. R Development Core Team R: A Language and Environment for Statistical Computing 2004, R Foundation for Statistical Computing, Vienna.
22. Ritz C., Streibig J.C. Bioassay analysis using R. J. Stat. Softw. 2005, 12:1-22.
23. Ross J.A., Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr. 2002, 22:19-34.
24. Sanderson J.T., Hordijk J., Denison M.S., Springsteel M.F., Nantz M.H., van den Berg M. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol. Sci. 2004, 82:70-79.
25. Scalbert A., Manach C., Morand C., Remesy C., Jimenez L. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 2005, 45:287-306.
26. Scott H.M., Mason J.I., Sharpe R.M. Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr. Rev. 2009, 30:883-925.
27. Setchell K.D., Brown N.M., Desai P., Zimmer-Nechemias L., Wolfe B.E., Brashear W.T., Kirschner A.S., Cassidy A., Heubi J.E. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J. Nutr. 2001, 131:1362S-1375S.
28. Sotoca A.M., Ratman D., van der Saag P., Strom A., Gustafsson J.A., Vervoort J., Rietjens I.M., Murk A.J. Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERalpha/ERbeta ratio. J. Steroid Biochem. Mol. Biol. 2008, 112:171-178.
29. Streibig J.C., Rudemo M., Jensen J.E. Dose-response curves and statistical models. Herbicide Bioassays 1993, 29-55. CRC Press, Boca Raton. J.C. Streibig, P. Kudsk (Eds.).
30. Tanaka M., Fujimoto K., Chihara Y., Torimoto K., Yoneda T., Tanaka N., Hirayama A., Miyanaga N., Akaza H., Hirao Y. Isoflavone supplements stimulated the production of serum equol and decreased the serum dihydrotestosterone levels in healthy male volunteers. Prostate Cancer Prostatic Dis. 2009, 12:247-252.
31. Taxvig C., Elleby A., Sonne-Hansen K., Bonefeld-Jorgensen E.C., Vinggaard A.M., Lykkesfeldt A.E., Nellemann C. Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity. Nutr. Cancer 2010, 62:122-131.
32. Ullerås E., Ohlsson Å., Oskarsson A. Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption - screening of 30 selected chemicals in the human H295R cell model. J. Appl. Toxicol. 2008, 28:1045-1053.
33. Valles S.L., Dolz-Gaiton P., Gambini J., Borras C., Lloret A., Pallardo F.V., Vina J. Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes. Brain Res. 2010, 1312:138-144.
34. Whitehead S.A., Rice S. Endocrine-disrupting chemicals as modulators of sex steroid synthesis. Best Pract. Res. Clin. Endocrinol. Metab. 2006, 20:45-61.
35. Yi L.T., Li J.M., Li Y.C., Pan Y., Xu Q., Kong L.D. Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin. Life Sci. 2008, 82:741-751.