Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

Life Sciences

Volumn 82, Issue 13-14, 2008, Pages 741-751

  Yi, Li Tao ^a   Li, Jian Mei ^a   Li, Yu Cheng ^a   Pan, Ying ^a   Xu, Qun ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

5 Hydroxyindoleacetic acid; Adenylyl cyclase; Antidepressant; Apigenin; Corticosterone; Dopamine; Serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ADENYLATE CYCLASE; ANTIDEPRESSANT AGENT; APIGENIN; DOPAMINE; NEUROTRANSMITTER; SEROTONIN; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BRAIN REGION; CHRONIC STRESS; CITRUS FRUIT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION; MALE; NONHUMAN; RAT;

ADENYLATE CYCLASE; ADMINISTRATION, ORAL; ANIMALS; ANTIDEPRESSIVE AGENTS; APIGENIN; BEHAVIOR, ANIMAL; BIOGENIC MONOAMINES; BRAIN; BRAIN CHEMISTRY; CITRUS; CORTICOSTERONE; MALE; MICE; MICE, INBRED ICR; RATS; RATS, WISTAR; STRESS, PSYCHOLOGICAL; SWIMMING;

CITRUS; MUS; RATTUS; RATTUS NORVEGICUS;

EID: 40649126076     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.01.007     Document Type: Article

References (66)

1. Abdel-Razaq W., Bates T.E., and Kendall D.A. The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochemical Pharmacology 73 12 (2007) 1995-2003
2. Aihara M., Ida I., Yuuki N., Oshima A., Kumano H., Takahashi K., Fukuda M., Oriuchi N., Endo K., Matsuda H., and Mikuni M. HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions. Psychiatry Research 155 3 (2007) 245-256
3. Avallone R., Zanoli P., Puia G., Kleinschnitz M., Schreier P., and Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemical Pharmacology 59 11 (2000) 1387-1394
4. Ayensu W.K., Pucilowski O., Mason G.A., Overstreet D.H., Rezvani A.H., and Janowsky D.S. Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats. Physiology & Behavior 57 1 (1995) 165-169
5. Barden N., Reul J.M., and Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?. Trends in Neurosciences 18 1 (1995) 6-11
6. Bekris S., Antoniou K., Daskas S., and Papadopoulou-Daifoti Z. Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behavioural Brain Research 161 1 (2005) 45-59
7. Chen D., Daniel K.G., Chen M.S., Kuhn D.J., Landis-Piwowar K.R., and Dou Q.P. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochemical Pharmacology 69 10 (2005) 1421-1432
8. Cowburn R.F., Marcusson J.O., Eriksson A., Wiehager B., and O'Neill C. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Research 633 1-2 (1994) 297-304
9. Coyle J.T., and Duman R.S. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38 2 (2003) 157-160
10. Curzon G., and Green A.R. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain. British Journal of Pharmacology 39 3 (1970) 653-655
11. Czyz J., Madeja Z., Irmer U., Korohoda W., and Hulser D.F. Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. International Journal of Cancer 114 1 (2005) 12-18
12. Di Chiara G., Loddo P., and Tanda G. Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression. Biological Psychiatry 46 12 (1999) 1624-1633
13. Donati R.J., and Rasenick M.M. G protein signaling and the molecular basis of antidepressant action. Life Sciences 73 1 (2003) 1-17
14. Duman R.S. Novel therapeutic approaches beyond the serotonin receptor. Biological Psychiatry 44 5 (1998) 324-335
15. Duman R.S., Heninger G.R., and Nestler E.J. A molecular and cellular theory of depression. Archives of General Psychiatry 54 7 (1997) 597-606
16. Fang J., Xia C., Cao Z., Zheng J.Z., Reed E., and Jiang B.H. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB Journal 19 3 (2005) 342-353
17. Gainotti G., Antonucci G., Marra C., and Paolucci S. Relation between depression after stroke, antidepressant therapy, and functional recovery. Journal of Neurology Neurosurgery and Psychiatry 71 2 (2001) 258-261
18. Garg A., Garg S., Zaneveld L.J., and Singla A.K. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytotherapy Research 15 8 (2001) 655-669
19. Grippo A.J., Beltz T.G., Weiss R.M., and Johnson A.K. The effects of chronic fluoxetine treatment on chronic mild stress-induced cardiovascular changes and anhedonia. Biological Psychiatry 59 4 (2006) 309-316
20. Han X.H., Hong S.S., Hwang J.S., Lee M.K., Hwang B.Y., and Ro J.S. Monoamine oxidase inhibitory components from Cayratia japonica. Archives of Pharmacal Research 30 1 (2007) 13-17
21. Heuser I.J., Schweiger U., Gotthardt U., Schmider J., Lammers C.H., Dettling M., Yassouridis A., and Holsboer F. Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. The American Journal of Psychiatry 153 1 (1996) 93-99
22. Hines L.M., and Tabakoff B. Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use. Biological Psychiatry 58 12 (2005) 955-962
23. Hougee S., Sanders A., Faber J., Graus Y.M., van den Berg W.B., Garssen J., Smit H.F., and Hoijer M.A. Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. Biochemical Pharmacology 69 2 (2005) 241-248
24. Ito N., Nagai T., Yabe T., Nunome S., Hanawa T., and Yamada H. Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis. Phytomedicine 13 9-10 (2006) 658-667
25. Kanazawa I. Short review on monoamine oxidase and its inhibitors. European Neurology 34 Suppl 3 (1994) 36-39
26. Keeney A., Jessop D.S., Harbuz M.S., Marsden C.A., Hogg S., and Blackburn-Munro R.E. Differential effects of acute and chronic social defeat stress on hypothalamic-pituitary-adrenal axis function and hippocampal serotonin release in mice. Journal of Neuroendocrinology 18 (2006) 330-338
27. Komiya M., Takeuchi T., and Harada E. Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behavioural Brain Research 172 2 (2006) 240-249
28. Komori T., Fujiwara R., Tanida M., and Nomura J. Potential antidepressant effects of lemon odor in rats. European Neuropsychopharmacology 5 4 (1995) 477-480
29. Komori T., Fujiwara R., Tanida M., and Nomura J. Application of fragrances to treatments for depression. Nihon Shinkei Seishin Yakurigaku Zasshi 15 1 (1995) 39-42
30. Komori T., Fujiwara R., Tanida M., Nomura J., and Yokovama M.M. Effects of citrus fragrance on immune function and depressive states. Neuroimmunomodulation 2 3 (1995) 174-180
31. Kulkarni S.K., and Dhir A. Effect of various classes of antidepressants in behavioral paradigms of despair. Progress in Neuro-Psychopharmacology & Biological Psychiatry 31 6 (2007) 1248-1254
32. Li J.M., Kong L.D., Wang Y.M., Cheng C.H., Zhang W.Y., and Tan W.Z. Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sciences 74 1 (2003) 55-73
33. Lorenzo P.S., Rubio M.C., Medina J.H., and Adler-Graschinsky E. Involvement of monoamine oxidase and noradrenaline uptake in the positive chronotropic effects of apigenin in rat atria. European Journal of Pharmacology 312 2 (1996) 203-207
34. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193 1 (1951) 265-275
35. MacSweeney C.P., Lesourd M., and Gandon J.M. Antidepressant-like effects of alnespirone (S 20499) in the learned helplessness test in rats. European Journal of Pharmacology 345 2 (1998) 133-137
36. Manthey J.A., and Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. Journal of Agricultural and Food Chemistry 50 21 (2002) 5837-5843
37. Menninger J.A., and Tabakoff B. Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression. Biological Psychiatry 42 1 (1997) 30-38
38. Morel I., Lescoat G., Cogrel P., Sergent O., Pasdeloup N., Brissot P., Cillard P., and Cillard J. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochemical Pharmacology 45 1 (1993) 13-19
39. Muñoz C., and Papp M. Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression. Pharmacology Biochemistry and Behavior 63 4 (1999) 647-653
40. Muscat R., and Willner P. Suppression of sucrose drinking by chronic mild unpredictable stress: a methodological analysis. Neuroscience and Biobehavioral Reviews 16 4 (1992) 507-517
41. Nakazawa T., Yasuda T., Ueda J., and Ohsawa K. Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. Biological & Pharmaceutical Bulletin 26 4 (2003) 474-480
42. Nestler E.J. Antidepressant treatments in the 21st century. Biological Psychiatry 44 7 (1998) 526-533
43. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., and Monteggia L.M. Neurobiology of depression. Neuron 34 1 (2002) 13-25
44. Nestler E.J., Gould E., Manji H., Buncan M., Duman R.S., and Greshenfeld H. Preclinical models: status of basic research in depression. Biological Psychiatry 52 6 (2002) 503-528
45. Nickel T., Sonntag A., Schill J., Zobel A.W., Ackl N., Brunnauer A., Murck H., Ising M., Yassouridis A., Steiger A., Zihl J., and Holsboer F. Clinical and neurobiological effects of tianeptine and paroxetine in major depression. Journal of Clinical Psychopharmacology 23 2 (2003) 155-168
46. Pan Y., Kong L., Xia X., Zhang W., Xia Z., and Jiang F. Antidepressant-like effect of icariin and its possible mechanism in mice. Pharmacology Biochemistry and Behavior 82 4 (2005) 686-694
47. Pan Y., Kong L.D., Li Y.C., Xia X., Kung H.F., and Jiang F.X. Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats. Pharmacology Biochemistry and Behavior 87 1 (2007) 130-140
48. Porsolt R.D., Le Pichon M., and Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266 5604 (1977) 730-732
49. Porsolt R.D., Anton G., Blavet N., and Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. European Journal of Pharmacology 47 4 (1978) 379-391
50. Price M.L., and Lucki I. Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing factor. Journal of Neuroscience 21 8 (2001) 2833-2841
51. Reiach J.S., Li P.P., Warsh J.J., Kish S.J., and Young L.T. Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims. Journal of Affective Disorders 56 2-3 (1999) 141-151
52. Risbrough V.B., and Stein M.B. Role of corticotropin releasing factor in anxiety disorders: a translational research perspective. Hormones and Behavior 50 4 (2006) 550-561
53. Salah N., Miller N.J., Paganga G., Tijburg L., Bolwell G.P., and Riceevans C. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Archives of Biochemistry and Biophysics 322 2 (1995) 339-346
54. Skolnick P. Antidepressants for the new millennium. European Journal of Pharmacology 375 1-3 (1999) 31-40
55. Struckmann J.R., and Nicolaides A.N. Flavonoids. A review of the pharmacology and therapeutic efficacy of Daflon 500 mg in patients with chronic venous insufficiency and related disorders. Angiology 45 6 (1994) 419-428
56. Torres I.L., Gamaro G.D., Vasconcellos A.P., Silveira R., and Dalmaz C. Effects of chronic restraint stress on feeding behavior and on monoamine levels in different brain structures in rats. Neurochemical Research 27 6 (2002) 519-525
57. Valentino R.J., and Commons K.G. Peptides that fine-tune the serotonin system. Neuropeptides 39 1 (2005) 1-8
58. 1A-sensitive adenylyl cyclase of rodent hippocampal neurons: effects of antidepressant treatments and chronic stimulation with agonists. Journal of Pharmacology and Experimental Therapeutics 257 1 (1991) 433-438
59. Welch A.S., and Welch B.L. Solvent extraction method for simultaneous determination of norepinephrine, dopamine, serotonin, and 5-hydroxyindoleacetic acid in a single mouse brain. Analytical Biochemistry 30 2 (1969) 161-179
60. Willner P., Towell A., Sampson D., Sophokleous S., and Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93 3 (1987) 358-364
61. Wong M.L., and Licinio J. Research and treatment approaches to depression. Nature Reviews Neuroscience 2 5 (2001) 343-351
62. Wouters J. Structural aspects of monoamine oxidase and its reversible inhibition. Current Medicinal Chemistry 5 2 (1998) 137-162
63. Xu Y., Ku B.S., Tie L., Yao H.Y., Jiang W.G., Ma X., and Li X.J. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Research 1122 1 (2006) 56-64
64. Xu Y., Ku B.S., Cui L., Li X.J., Barish P.A., Foster T.C., and Ogle W.O. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Research 1162 (2007) 9-18
65. Young E.A., Altemus M., Lopez J.F., Kocsis J.H., Schatzberg A.F., DeBattista C., and Zubieta J.K. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 29 9 (2004) 1198-1204
66. Zanoli P., Avallone R., and Baraldi M. Behavioral characterization of the flavonoids apigenin and chrysin. Fitoterapia 71 Suppl. 1 (2000) S117-S123