Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds

Toxicology and Applied Pharmacology

Volumn 225, Issue 2, 2007, Pages 142-153

  Gracia, Tannia ^a   Hilscherova, Klara ^b   Jones, Paul D ^a   Newsted, John L ^c   Higley, Eric B ^a   Zhang, Xiaowei ^a,d   Hecker, Markus ^a   Murphy, Margaret B ^d   Yu, Richard M K ^d   Lam, Paul K S ^d   Wu, Rudolf S S ^d   Giesy, John P ^a,d,e  

^a National Food Safety and Toxicology Center   (United States)

^b MASARYK UNIVERSITY   (Czech Republic)

^c ENTRIX INC   (United States)

^d CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Bioassay; Dose response; Drug mixtures; Endocrine disruptors; Pharmaceuticals; Steroidogenesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3BETA HYDROXYSTEROID DEHYDROGENASE 2; ALDOSTERONE SYNTHASE; AMOXICILLIN; ANTIBIOTIC AGENT; AROMATASE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CEFALEXIN; CLOFIBRATE; CYPROTERONE; CYTOCHROME P450 11BETA1; CYTOCHROME P450 17; DEXAMETHASONE; DIETHYLTOLUAMIDE; DOXYCYCLINE; ENDOCRINE DISRUPTOR; ERYTHROMYCIN; ESTRADIOL; ETHINYLESTRADIOL; FLUOXETINE; IBUPROFEN; PARACETAMOL; PROGESTERONE; SALBUTAMOL; STEROID HORMONE; TESTOSTERONE; TRENBOLONE; TRIMETHOPRIM; TYLOSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROIDOGENESIS; UNITED STATES; UPREGULATION;

3-HYDROXYSTEROID DEHYDROGENASES; ADRENOCORTICAL CARCINOMA; ALDOSTERONE SYNTHASE; AROMATASE; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOCRINE DISRUPTORS; ESTRADIOL; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; HUMANS; PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; TESTOSTERONE;

EID: 36048929219     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.07.013     Document Type: Article

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