Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity

Nutrition and Cancer

Volumn 62, Issue 1, 2010, Pages 122-131

  Taxvig, Camilla ^a   Elleby, Anders ^a   Sonne Hansen, Katrine ^b   Bonefeld Jrgensen, Eva C ^c   Vinggaard, Anne Marie ^a   Lykkesfeldt, Anne E ^b   Nellemann, Christine ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; AROMATASE; COUMESTROL; DAIDZEIN; ENTERODIOL; ENTEROLACTONE; EQUOL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; FORMONONETIN; GENISTEIN; ISOFLAVONOID; LARICIRESINOL; MATAIRESINOL; PHYTOESTROGEN; PINORESINOL; PROGESTERONE RECEPTOR; SECOISOLARICI RESINOL; TESTOSTERONE; UNCLASSIFIED DRUG;

ADRENAL CORTEX CARCINOMA; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CHORIOCARCINOMA; CONTROLLED STUDY; DIET; DOWN REGULATION; ENDOCRINE FUNCTION; ENZYME ACTIVITY; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STEROIDOGENESIS; UPREGULATION;

ADRENAL CORTEX NEOPLASMS; AROMATASE; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; ENDOCRINE DISRUPTORS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FLAVONOIDS; FOOD; HUMANS; PHYTOESTROGENS; PLANTS, EDIBLE; RECEPTORS, ANDROGEN; RECEPTORS, PROGESTERONE; STEROIDS; TESTOSTERONE;

VERTEBRATA;

EID: 74249089484     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580903191577     Document Type: Article

References (34)

1. Setchell KD: Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs). J Am Coll Nutr 20, 354S-362S, 381S-383S, 2001.
2. Ibarreta D, Daxenberger A, and Meyer HH: Possible health impact of phytoestrogens and xenoestrogens in food. Apmis 109, 161-184, 2001.
3. Magee PJ and Rowland IR: Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 91, 513-531, 2004.
4. Le Bail JC, Champavier Y, Chulia AJ, and Habrioux G: Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Life Sci 66, 1281-1291, 2000.
5. Power KA, Saarinen NM, Chen JM, and Thompson LU: Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. Int J Cancer 118, 1316-1320, 2006.
6. Krista A and Power LUT: Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer? Mol Nutr Food Res 51, 845-856, 2007.
7. Tham DM, Gardner CD, and Haskell WL: Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, andmechanistic evidence. J Clin Endocrinol Metab 83, 2223-2235, 1998.
8. Yang J, Nakagawa H, Tsuta K, and Tsubura A: Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett 149, 171-179, 2000.
9. Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M, and Clarke R: Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep 6, 1089-1095, 1999.
10. Allred CD, Ju YH, Allred KF, Chang J, and Helferich WG: Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22, 1667-1673, 2001.
11. De Lemos ML: Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann Pharmacother 35, 1118-1121, 2001.
12. Hedelin M, Klint A, Chang ET, Bellocco R, Johansson JE, et al.: Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the cancer prostate Sweden study (Sweden). Cancer Causes Control 17, 169-180, 2006.
13. Adlercreutz H, Mazur W, Bartels P, Elomaa VV, Watanabe S, et al.: Phytoestrogens and Prostate Disease. J. Nutr 130, 658S-658S, 2000.
14. Jian-Ping Yuan J-HWXL: Metabolism of dietary soy isoflavones to equol by human intestinal microflora-implications for health. Mol Nutr Food Res 51, 765-781, 2007.
15. Almstrup K, Fernandez MF, Petersen JH, Olea N, Skakkebaek NE, et al.: Dual effects of phytoestrogens result in u-shaped dose-response curves. Environ Health Perspect 110, 743-748, 2002.
16. Simpson ER and Davis SR: Minireview: aromatase and the regulation of estrogen biosynthesis-some new perspectives. Endocrinology 142, 4589-4594, 2001.
17. Rice S, Mason HD, and Whitehead SA: Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. J Steroid Biochem Mol Biol 101, 216-225, 2006.
18. Adlercreutz H: Phyto-oestrogens and cancer. Lancet Oncol 3, 364-373, 2002.
19. Benassayag C, Perrot-Applanat M, and Ferre F: Phytoestrogens as modulators of steroid action in target cells. J Chromatogr B Analyt Technol Biomed Life Sci 777, 233-248, 2002.
20. Kinoshita Y and Chen S: Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor {alpha}. Cancer Res 63, 3546-3555, 2003.
21. Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, et al.: Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci 82, 70-79, 2004.
22. Edmunds KM, Holloway AC, Crankshaw DJ, Agarwal SK, and Foster WG: The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells. Reprod Nutr Dev 45, 709-720, 2005.
23. Horwitz KB and McGuire WL: Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor. J Biol Chem 253, 2223-2228, 1978.
24. Lundholt BK, Briand P, and Lykkesfeldt AE: Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways. Breast Cancer Res Treat 67, 199-214, 2001.
25. Rasmussen LM, Zaveri NT, Stenvang J, Peters RH, and Lykkesfeldt AE: A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer. Breast Cancer Res Treat 106, 191-203, 2007.
26. Bonefeld-Jorgensen EC, Long M, Hofmeister MV, and Vinggaard AM: Endocrine-disrupting potential of bisphenol A, bisphenolAdimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review. Environ Health Perspect 115(1Suppl), 69-76, 2007.
27. Bonefeld-Jorgensen EC, Grunfeld HT, and Gjermandsen IM: Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells. Mol Cell Endocrinol 244, 20-30,2005.
28. Vinggaard AM, Joergensen EC, and Larsen JC: Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals. Toxicol Appl Pharmacol 155, 150-160, 1999.
29. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, et al.: Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. Embo J 9, 1603-1614, 1990.
30. Grünfeld HT and Bonefeld-Jorgensen EC: Effect of in vitro estrogenic pesticides on human estrogen receptor alpha and beta mRNA levels. Toxicol Lett 151, 467-480, 2004.
31. Jensen BL, Skouv J, Lundholt BK, and Lykkesfeldt AE: Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6. Br J Cancer 79, 386-392, 1999.
32. Ohno S, Shinoda S, Toyoshima S, Nakazawa H, Makino T, et al.: Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells. J Steroid Biochem Mol Biol 80, 355-363, 2002.
33. van Meeuwen JA, Ter Burg W, Piersma AH, van den Berg M, and Sanderson JT: Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells. Food Chem Toxicol 45, 2319-2330, 2007.
34. Ying C, Hsu J-T, Yang C-D, Hsung S-J,Wang L-K, et al.: The combination effects of phytoestrogens on cell proliferation, cell cycle progression and estrogen receptor alpha. J Food Drug Anal 13, 30-37, 2005.