Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 437-442

  Miller, Philip S ^a   Barwell, James ^b   Poyner, David R ^b   Wigglesworth, Mark J ^c   Garland, Stephen L ^c   Donnelly, Dan ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ASTON UNIVERSITY   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antagonist; CGRP; GPCR; Migraine; Pharmacology; Receptor

Indexed keywords

ALANINE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CALCITONIN RECEPTOR LIKE RECEPTOR; METHIONINE; OLCEGEPANT; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; TELCAGEPANT; TRYPTOPHAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHIMERA; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; MUTAGENIC ACTIVITY; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE;

AZEPINES; HUMANS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; METHIONINE; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; RECEPTORS, CALCITONIN; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; TRYPTOPHAN;

EID: 72949116357     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.076     Document Type: Article

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