Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure

Clinical Science

Volumn 99, Issue 6, 2000, Pages 541-546

  Totsune, K ^a   Takahashi, K ^a   Mackenzie, H S ^a   Murakami, O ^a   Arihara, Z ^a   Sone, M ^a   Mouri, T ^a   Brenner, B M ^a   Ito, S ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenomedullin; Calcitonin receptor like receptor; Heart failure; Kidney; Receptor activity modifying protein 2

Indexed keywords

ADRENOMEDULLIN; CALCITONIN RECEPTOR LIKE RECEPTOR; HORMONE RECEPTOR; RECEPTOR ACTIVITY MODIFYING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HEART VENTRICLE; KIDNEY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADRENAL MEDULLA; ANIMALS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENE EXPRESSION; HEART FAILURE, CONGESTIVE; KIDNEY; MALE; MYOCARDIUM; RATS; RATS, WISTAR; RECEPTORS, CALCITONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, RNA; VASODILATION;

EID: 0034546522     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20000108     Document Type: Article

References (33)

1. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
2. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide
3. Endothelial cells actively synthesize and secrete adrenomedullin
4. Production and secretion of adrenomedullin from vascular smooth muscle cells: Augmented production by tumor necrosis factor-α
5. Immunocytochemical localization of adrenomedullin in canine heart and aorta
6. Adrenomedullin production in fibroblasts: Its possible function as a growth regulator of Swiss 3T3 cells
7. Gene transcription and synthesis of adrenomedullin by cultured human renal cells
8. Adrenomedullin in monocytes and macrophages: Possible involvement of macrophage-derived adrenomedullin in atherogenesis
9. Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma
10. Immunocytochemical localization of adrenomedullin-like immunoreactivity in the human hypothalamus and the adrenal gland
11. Increased secretion of adrenomedullin from cultured human astrocytes by cytokines
12. Adrenomedullin expression in human tumor cell lines
13. Expression of adrenomedullin mRNA in adrenocortical tumors and secretion of adrenomedullin by cultured adrenocortical carcinoma cells
14. Expression of adrenomedullin and adrenomedullin mRNA in ectopic ACTH-secreting tumors
15. Immunohistochemical identification of adrenomedullin in human, rat, and porcine tissue
16. Elevation of circulating and ventricular adrenomedullin in human congestive heart failure
17. Increased plasma levels of adrenomedullin in patients with heart failure
18. Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: Blunted effect in experimental hypertension
19. Cardiac production and secretion of adrenomedullin are increased in heart failure
20. Differential regulation of ventricular adrenomedullin and atrial natriuretic peptide gene expression in pressure and volume overload in the rat
21. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
22. CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues
23. Renal effects of high-dose natriuretic peptide receptor blockade in rats with congestive heart failure
24. Upregulation of atrial natriuretic peptide gene expression in remnant kidney of rats with reduced renal mass
25. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
26. Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure
27. Cardiovascular actions of adrenomedullin in conscious sheep
28. Inotropic effect of adrenomedullin in the isolated perfused rat heart
29. Adrenomedullin: A possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes
30. Adrenomedullin gene expression is developmentally regulated and induced in rat ventricular cardiac myocytes
31. Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells
32. Induction of a myocardial adrenomedullin signaling system during ischemic heart failure in rats
33. A receptor activity modifying protein (RAMP) 2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when co-expressed with human RAMP1