Expression-System-Dependent Modulation of HIV-1 Envelope Glycoprotein Antigenicity and Immunogenicity

Journal of Molecular Biology

Volumn 403, Issue 1, 2010, Pages 131-147

  Kong, Leopold ^a,b   Sheppard, Neil C ^a   Stewart Jones, Guillaume B E ^c   Robson, Cynthia L ^a   Chen, Hongying ^d   Xu, Xiaodong ^d   Krashias, George ^a   Bonomelli, Camille ^e   Scanlan, Christopher N ^e   Kwong, Peter D ^b   Jeffs, Simon A ^f   Jones, Ian M ^d   Sattentau, Quentin J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF READING   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

B cell immunogenicity; Computational modeling; Glycan type; HIV 1 gp120; Mass spectrometry

Indexed keywords

CD4 ANTIGEN; GLYCAN; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN G2; KIFUNENSINE; GLYCOPROTEIN; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN G; POLYSACCHARIDE; PROTEIN BINDING; RECOMBINANT PROTEIN; VIRUS ANTIGEN;

ANIMAL CELL; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION SYSTEM; GLYCOSYLATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; IMMUNOGENICITY; MASS SPECTROMETRY; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SURFACE CHARGE; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CULTURE TECHNIQUE; DNA SEQUENCE; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN TERTIARY STRUCTURE; SPODOPTERA; STATIC ELECTRICITY;

HEXAPODA; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; SPODOPTERA FRUGIPERDA;

ANIMALS; ANTIGENS, CD4; ANTIGENS, VIRAL; CELL CULTURE TECHNIQUES; CELL LINE; GENETIC VECTORS; GLYCOPROTEINS; GLYCOSYLATION; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SPODOPTERA; STATIC ELECTRICITY;

EID: 77957271989     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.08.033     Document Type: Article

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