Endothelial mechanotransduction

Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues

Volumn 9780521895231, Issue , 2013, Pages 20-60

  Davies, Peter F ^a   Helmke, Brian P ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b University of Virginia   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; HISTOLOGY; MAMMALS; MICROCIRCULATION; SHEAR FLOW; TRANSPORT PROPERTIES;

BLOOD FLOW; CELLULARS; FLOW FORCES; HIGH FLOW; HIGH PRESSURE; MECHANOTRANSDUCTION; STRUCTURAL RELATIONSHIP; TRANSPORT SYSTEMS; VASCULAR TRANSPORT; VESSEL WALLS;

TISSUE;

EID: 77957257918     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9781139195874.003     Document Type: Chapter

References (145)

1. LaBarbera M. Principles of design of fluid transport systems in zoology. Science 1990; 249: 992-1000.
2. Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, et al Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis 2007; 195: 225-35.
3. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol. Rev. 1995; 75: 519-60.
4. Nerem RM. Hemodynamics and the vascular endothelium. J. Biomech. Eng. 1993; 115: 510-14.
5. Resnick N, Gimbrone MA, Jr. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 1995; 9: 874-82.
6. Davies PF, Polacek DC, Handen JS, Helmke BP, DePaola N. A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis. Trends Biotechnol. 1999; 17: 347-51.
7. Shyy JYJ, Chien S. Role of integrins in endothelial mechanosensing of shear stress. Circ. Res. 2002; 91: 769-75.
8. Koller A, Sun D, Kaley G. Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro. Circ. Res. 1993; 72: 1276-84.
9. + current in vascular endothelial cells. Nature 1988; 331: 168-70.
10. Gudi SR, Nolan JP, Frangos JA. Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition. Proc. Natl. Acad. Sci. USA 1998; 95: 2515-19.
11. Butler PJ, Norwich G, Weinbaum S, Chien S. Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity. Am. J. Physiol. 2001; 280: C962-9.
12. Aird WC, ed. Endothelial Biomedicine. New York: Cambridge University Press, 2007.
13. Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986; 8: 37-44.
14. Moncada S. Adventures in vascular biology: A tale of two mediators. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006; 361: 735-59.
15. Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ. Res. 1996; 79: 984-91.
16. Griffith TM. Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective. Biorheology 2002; 39: 307-18.
17. Langille BL, O’Donnell F. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science 1986; 231: 405-7.
18. Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, et al Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev. Cell 2006; 11: 845-57.
19. Glagov S, Zarins CK, Giddens DP, Ku DN. Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries. Arch. Pathol. Lab. Med. 1988; 112: 1018-31.
20. Ku DN, Giddens DP. Pulsatile flow in a model carotid bifurcation. Arteriosclerosis 1983; 3: 31-9.
21. Steinberg D. Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime. Nat. Med. 2002; 8: 1211-17.
22. Helmke BP, Rosen AB, Davies PF. Mapping mechanical strain of an endogenous cytoskeletal network in living endothelial cells. Biophys. J. 2003; 84: 2691-9.
23. 2+) coupling in vascular endothelial cells. Am. J. Physiol. 1991; 261: H149-H54.
24. Choi H, Ferrara K, Barakat A. Modulation of ATP/ADP concentration at the endothelial surface by shear stress: Effect of flow recirculation. Ann. Biomed. Eng. 2007; 35: 505-16.
25. Dull RO, Tarbell JM, Davies PF. Mechanisms of flow-mediated signal transduction in endothelial cells: Kinetics of ATP surface concentrations. J. Vasc. Res. 1992; 29: 410-19.
26. Davies PF, Reidy MA, Goode TB, Bowyer DE. Scanning electron microscopy in the evaluation of endothelial integrity of the fatty lesion in atherosclerosis. Atherosclerosis 1976; 25: 125-30.
27. Dewey CF, Jr., Bussolari SR, Gimbrone MA, Jr., Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J. Biomech. Eng. 1981; 103: 177-88.
28. Davies PF, Dewey CF, Jr., Bussolari SR, Gordon EJ, Gimbrone MA, Jr. Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells. J. Clin. Invest. 1984; 73: 1121-9.
29. Davies PF, Remuzzi A, Gordon EJ, Dewey CF, Gimbrone MA. Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc. Natl. Acad. Sci. USA 1986; 83: 2114-17.
30. Sprague EA, Steinbach BL, Nerem RM, Schwartz CJ. Influence of a laminar steady-state fluid-imposed wall shear stress on the binding, internalization, and degradation of low-density lipoproteins by cultured arterial endothelium. Circulation 1987; 76: 648-56.
31. Ingber D. Integrins as mechanochemical transducers. Curr. Opin. Cell Biol. 1991; 3: 841-18.
32. Sims JR, Karp S, Ingber DE. Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape. J. Cell Sci. 1992; 103: 1215-22.
33. Davies PF, Robotewskyj A, Griem ML. Endothelial cell adhesion in real time. Measurements in vitro by tandem scanning confocal image analysis. J. Clin. Invest. 1993; 91: 2640-52.
34. Davies PF, Robotewskyj A, Griem ML. Quantitative studies of endothelial cell adhesion: Directional remodeling of focal adhesion sites in response to flow forces. J. Clin. Invest. 1994; 93: 2031-8.
35. Liu Y, Chen BPC, Lu M, Zhu Y, Stemerman MB, Chien S, et al Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler. Thromb. Vasc. Biol. 2002; 22: 76-81.
36. Fujiwara K, Masuda M, Osawa M, Kano Y, Katoh K. Is PECAM-1 a mechanoresponsive molecule? Cell Struct. Funct. 2001; 26: 11-17.
37. Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, et al A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005; 437: 426-31.
38. Helmke BP, Goldman RD, Davies PF. Rapid displacement of vimentin intermediate filaments in living endothelial cells exposed to flow. Circ. Res. 2000; 86: 745-52.
39. Helmke BP, Thakker DB, Goldman RD, Davies PF. Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells. Biophys. J. 2001; 80: 184-94.
40. Mott RE, Helmke BP. Mapping the dynamics of shear stress-induced structural changes in endothelial cells. Am. J. Physiol. 2007; 293: C1616-26.
41. Davies PF, Tripathi SC. Mechanical stress mechanisms and the cell: An endothelial paradigm. Circ. Res. 1993; 72: 239-45.
42. Helmke BP, Davies PF. The cytoskeleton under external fluid mechanical forces: Hemodynamic forces acting on the endothelium. Ann. Biomed. Eng. 2002; 30: 284-96.
43. Jacobs ER, Cheliakine C, Gebremedhin D, Davies PF, Harder DR. Shear activated channels in cell attached patches of vascular endothelial cells. Pflügers Arch. 1995; 431: 129-31.
44. Barbee KA, Davies PF, Lal R. Shear stress-induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy. Circ. Res. 1994; 74: 163-71.
45. Barbee KA, Davies PF, Lal R. Subcellular distribution of shear stress at the surface of flow aligned and non-aligned endothelial monolayers. Am. J. Physiol. 1995; 268: H1765-72.
46. Weinbaum S, Tarbell JM, Damiano ER. The structure and function of the endothelial glycocalyx layer. Annu. Rev. Biomed. Eng. 2007; 9: 121-67.
47. Malek AM, Izumo S. Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress. J. Cell Sci. 1996; 109: 713-26.
48. Helmke BP. Molecular control of cytoskeletal mechanics by hemodynamic forces. Physiology 2005; 20: 43-53.
49. Hu S, Chen J, Fabry B, Numaguchi Y, Gouldstone A, Ingber D., et al Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am. J. Physiol. 2003; 285: C1082-90.
50. Hu S, Wang N. Control of stress propagation in the cytoplasm by prestress and loading frequency. Mol. Cell. Biomech. 2006; 3: 49-60.
51. Janmey PA, Euteneuer U, Traub P, Schliwa M. Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J. Cell Biol. 1991; 113: 155-60.
52. Janmey PA, Euteneuer U, Traub P, Schliwa M. Viscoelasticity of intermediate filament networks. Sub-Cellular Biochem. 1998; 31: 381-97.
53. Schmid-Schönbein GW, Sung K-LP, Tözeren H, Skalak R, Chien S. Passive mechanical properties of human leukocytes. Biophys. J. 1981; 36: 243-56.
54. Theret DP, Levesque MJ, Sato M, Nerem RM, Wheeler LT. The application of a homogeneous half-space model in the analysis of endothelial cell micropipette measurements. J. Biomech. Eng. 1988; 110: 190-9.
55. Sato M, Theret DP, Wheeler LT, Ohshima N, Nerem RM. Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties. J. Biomech. Eng. 1990; 112: 263-8.
56. Colangelo S, Langille BL, Steiner G, Gotlieb AI. Alterations in endothelial F-actin microfilaments in rabbit aorta in hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 1998; 18: 52-6.
57. Galbraith CG, Skalak R, Chien S. Shear stress induces spatial reorganization of the endothelial cell cytoskeleton. Cell Motil. Cytoskel. 1998; 40: 317-30.
58. Sato M, Ohshima N, Nerem RM. Viscoelastic properties of cultured porcine aortic endothelial cells exposed to shear stress. J. Biomech. 1996; 29: 461-7.
59. Satcher RL, Jr., Dewey CF, Jr. Theoretical estimates of mechanical properties of the endothelial cell cytoskeleton. Biophys. J. 1996; 71: 109-18.
60. Ferko MC, Bhatnagar A, Garcia MB, Butler PJ. Finite-element stress analysis of a multicomponent model of sheared and focally-adhered endothelial cells. Ann. Biomed. Eng. 2007; 35: 208-23.
61. Fuller RB. Tensegrity. Portfolio Art News Annu. 1961; 4: 112-27.
62. Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science 1993; 260: 1124-7.
63. Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Fredberg JJ. Scaling the microrheology of living cells. Phys. Rev. Lett. 2001; 87:148102.
64. Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Taback NA, et al Time scale and other invariants of integrative mechanical behavior in living cells. Phys. Rev. E 2003; 68(4 pt. 1):041914.
65. Bursac P, Lenormand G, Fabry B, Oliver M, Weitz DA, Viasnoff V, et al Cytoskeletal remodeling and slow dynamics in the living cell. Nat. Mater. 2005; 4: 557-61.
66. Wootton DM, Ku DN. Fluid mechanics of vascular systems, diseases, and thrombosis. Annu. Rev. Biomed. Eng. 1999; 1: 299-329.
67. Friedman MH, Giddens DP. Blood flow in major blood vessels-Modeling and experiments. Ann. Biomed. Eng. 2005; 33: 1710-13.
68. Fung YC, Liu SQ. Elementary mechanics of the endothelium of blood vessels. J. Biomech. Eng. 1993; 115: 1-12.
69. Haidekker MA, L’Heureux N, Frangos JA. Fluid shear stress increases membrane fluidity in endothelial cells: A study with DCVJ fluorescence. Am. J. Physiol. 2000; 278: H1401-6.
70. Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, et al Functional expression of Kir2.x in human aortic endothelial cells: The dominant role of Kir2.2. Am. J. Physiol. 2005; 289: C1134-44.
71. Sukharev SI, Sigurdson WJ, Kung C, Sachs F. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. J. Gen. Physiol. 1999; 113: 525-40.
72. Hamill OP, Martinac B. Molecular basis of mechanotransduction in living cells. Physiol. Rev. 2001; 81: 685-740.
73. Martinac B, Hamill OP. Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness. Proc. Natl. Acad. Sci. USA 2002; 99: 4308-12.
74. Chachisvilis M, Zhang Y-L, Frangos JA. G protein-coupled receptors sense fluid shear stress in endothelial cells. Proc. Natl. Acad. Sci. USA 2006; 103: 15463-8.
75. Romanenko VG, Davies PF, Levitan I. Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells. Am. J. Physiol. 2002; 282: C708-18.
76. Balaban NQ, Schwarz US, Riveline D, Goichberg P, Tzur G, Sabanay I, et al Force and focal adhesion assembly: A close relationship studied using elastic micropatterned substrates. Nat. Cell Biol. 2001; 3: 466-72.
77. Reitsma S, Slaaf D, Vink H, van Zandvoort M, oude Egbrink M. The endothelial glycocalyx: Composition, functions, and visualization. Pflügers Arch. 2007; 454: 345-59.
78. Smith ML, Long DS, Damiano ER, Ley K. Near-wall μ-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo. Biophys. J. 2003; 85: 637-45.
79. Weinbaum S, Zhang X, Han Y, Vink H, Cowin SC. Mechanotransduction and flow across the endothelial glycocalyx. Proc. Natl. Acad. Sci. USA 2003; 100: 7988-95.
80. Thi MM, Tarbell JM, Weinbaum S, Spray DC. The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: A “bumper-car” model. Proc. Natl. Acad. Sci. USA 2004; 101: 16483-8.
81. van den Berg BM, Spaan JA., Rolf TM, Vink H. Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation. Am. J. Physiol. 2006; 290: H915-20.
82. Vink H, Constantinescu AA, Spaan JA. Oxidized lipoproteins degrade the endothelial surface layer: Implications for platelet-endothelial cell adhesion. Circulation 2000; 101: 1500-2.
83. Pohl U, Herlan K, Huang A, Bassenge E. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am. J. Physiol. 1991; 261: H2016-23.
84. Hecker M, Mulsch A, Bassenge E, Busse R. Vasoconstriction and increased flow: Two principal mechanisms of shear stress-dependent endothelial autacoid release. Am. J. Physiol. 1993; 265: H828-33.
85. Pahakis MY, Kosky JR, Dull RO, Tarbell JM. The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress. Biochem. Biophys. Res. Comm. 2007; 355: 228-33.
86. Florian JA, Kosky JR, Ainslie K, Pang Z, Dull RO, Tarbell JM. Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circ. Res. 2003; 93:14.
87. Gouverneur M, Spaan JA., Pannekoek H, Fontijn RD, Vink H. Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx. Am. J. Physiol. 2006; 290: H458-2.
88. Yao Y, Rabodzey A, Dewey CF, Jr. Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stress. Am. J. Physiol. 2007; 293: H1023-30.
89. Kojimahara M. Endothelial cilia in rat mesenteric arteries and intramyocardial capillaries. Z. Mikrosk. Anat. Forsch. 1990; 104: 412-6.
90. Iomini C, Tejada K, Mo W, Vaananen H, Piperno G. Primary cilia of human endothelial cells disassemble under laminar shear stress. J. Cell Biol. 2004; 164: 811-17.
91. van der Heiden K, Groenendijk BCW, Hierck BP, Hogers B, Koerten HK, Mommaas AM, et al Monocilia on chicken embryonic endocardium in low shear stress areas. Developmental Dynamics 2006; 235: 19-28.
92. van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, et al Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis. Atherosclerosis 2007; DOI:10.1016/j.atherosclerosis.2007.05.030.
93. Ando J, Komatsuda T, Kamiya A. Cytoplasmic calcium response to fluid shear stress in cultured vascular endothelial cells. In Vitro Cell. Dev. Biol. 1988; 24: 871-7.
94. 2+ waves preferentially originate at specific loci in caveolin-rich cell edges. Proc. Natl. Acad. Sci. USA 1998; 95: 5009-14.
95. 2+ wave initiation move with caveolae to the trailing edge of migrating cells. J. Cell Sci. 2002; 115: 475-84.
96. Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, et al Visualizing the mechanical activation of Src. Nature 2005; 434: 1040-5.
97. Tzima E, del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, et al Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J. 2002; 21: 6791-800.
98. Yamada S, Wirtz D, Kuo SC. Mechanics of living cells measured by laser tracking microrheology. Biophys. J. 2000; 78: 1736-47.
99. Crocker JC, Hoffman BD. Multiple-particle tracking and two-point microrheology in cells. Meth. Cell Biol. 2007; 83: 141-78.
100. Panorchan P, Lee JSH, Daniels BR, Kole TP, Tseng Y, Wirtz D. Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology. Meth. Cell Biol. 2007; 83: 115-40.
101. Stamenovic D, Mijailovich SM, Tolic-Norrelykke IM, Chen J, Wang N. Cell prestress. II. Contribution of microtubules. Am. J. Physiol. 2002; 282: C617-C24.
102. Wang N, Stamenovic D. Contribution of intermediate filaments to cell stiffness, stiffening, and growth. Am. J. Physiol. 2000; 279: C188-94.
103. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285: 1028-33.
104. Davies PF, Barbee KA, Volin MV, Robotewskyj A, Chen J, Joseph L, et al Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu. Rev. Physiol. 1997; 59: 527-49.
105. Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, et al Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J. Biol. Chem. 1997; 272: 30455-62.
106. Chen K-D, Li Y-S, Kim M, Li S, Yuan S, Chien S, et al Mechanotransduction in response to shear stress: Roles of receptor tyrosine kinases, integrins, and Shc. J. Biol. Chem. 1999; 274: 18393-400.
107. Jalali S, del Pozo MA, Chen K-D, Miao H, Li Y-S, Schwartz MA, et al Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc. Natl. Acad. Sci. USA 2001; 98: 1042-6.
108. Hu Y-L, Chien S. Dynamic motion of paxillin on actin filaments in living endothelial cells. Biochem. Biophys. Res. Comm. 2007; 357: 871-6.
109. Tai L-K, Okuda M, Abe J-I, Yan C, Berk BC. Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway. Arterioscler. Thromb. Vasc. Biol. 2002; 22: 1790-6.
110. Rizzo V, Morton C, DePaola N, Schnitzer JE, Davies PF. Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro. Am. J. Physiol. 2003; 285: H1720-H9.
111. Radel C, Rizzo V. Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization. Am. J. Physiol. 2005; 288: H936-H45.
112. Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 2001; 20: 4639-47.
113. Ren XD, Kiosses WB, Sieg DJ, Otey CA, Schlaepfer DD, Schwartz MA. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J. Cell Sci. 2000; 113: 3673-8.
114. Arthur WT, Burridge K. RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol. Biol. Cell 2001; 12: 2711-20.
115. Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, et al Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 1999; 285: 895-8.
116. Orr AW, Sanders JM, Bevard M, Coleman E, Sarembock IJ, Schwartz MA. The subendothelial extracellular matrix modulates NF-κB activation by flow: A potential role in atherosclerosis. J. Cell Biol. 2005; 169: 191-202.
117. Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific suppression of integrin activation in shear stress signaling. Mol. Biol. Cell 2006; 17: 4686-97.
118. Orr AW, Stockton R, Simmers MB, Sanders JM, Sarembock IJ, Blackman BR, et al Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J. Cell Biol. 2007; 176: 719-27.
119. Kano Y, Katoh K, Masuda M, Fujiwara K. Macromolecular composition of stress fiber-plasma membrane attachment sites in endothelial cells in situ. Circ. Res. 1996; 79: 1000-6.
120. Osawa M, Masuda M, Kusano K-i, Fujiwara K. Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: Is it a mechanoresponsive molecule? J. Cell Biol. 2002; 158: 773-85.
121. Tai L-k, Zheng Q, Pan S, Jin Z-G, Berk BC. Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2. J. Biol. Chem. 2005; 280: 29620-4.
122. Shay-Salit A, Shushy M, Wolfovitz E, Yahav H, Breviario F, Dejana E, et al VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 2002; 99: 9462-7.
123. Cornhill JF, Roach MR. A quantitative study of the localization of atherosclerotic lesions in the rabbit aorta. Atherosclerosis 1976; 23: 489-501.
124. Steinman DA. Image-based computational fluid dynamics modeling in realistic arterial geometries. Ann. Biomed. Eng. 2002; 30: 483-97.
125. Caro CG, Fitz-Gerald JM, Schroter RC. Arterial wall shear and distribution of early atheroma in man. Nature 1969; 223: 1159-61.
126. Lutz RJ, Cannon JN, Bischoff KB, Dedrick RL, Stiles RK, Fry DL. Wall shear stress distribution in a model canine artery during steady flow. Circ. Res. 1977; 41: 391-9.
127. Suo J, Ferrara DE, Sorescu D, Guldberg RE, Taylor WR, Giddens DP. Hemodynamic shear stresses in mouse aortas: Implications for atherogenesis. Arterioscler. Thromb. Vasc. Biol. 2007; 27: 346-51.
128. Passerini AG, Polacek DC, Shi C, Francesco NM, Manduchi E, Grant GR, et al Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc. Natl. Acad. Sci. USA 2004; 101: 2482-7.
129. Volger OL, Fledderus JO, Kisters N, Fontijn RD, Moerland PD, Kuiper J, et al Distinctive expression of chemokines and transforming growth factor-β signaling in human arterial endothelium during atherosclerosis. Am. J. Pathol. 2007; 171: 326-37.
130. Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circ. Res. 2005; 96: 792-9.
131. Magid R, Davies PF. Endothelial protein kinase C isoform identity and differential activity of PKCζ in an athero-susceptible region of porcine aorta. Circ. Res. 2005; 97: 443-9.
132. Boon RA, Fledderus JO, Volger OL, van Wanrooij EJA, Pardali E, Weesie F, et al KLF2 suppresses TGF-β signaling in endothelium through induction of Smad7 and inhibition of AP-1. Arterioscler. Thromb. Vasc. Biol. 2007; 27: 532-9.
133. Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA, Jr. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ. Res. 2007; 101: 723-33.
134. Hajra L, Evans AI, Chen M, Hyduk SJ, Collins T, Cybulsky MI. The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc. Natl. Acad. Sci. USA 2000; 97: 9052-7.
135. Dekker RJ, van Soest S, Fontijn RD, Salamanca S, de Groot PG, VanBavel E, et al Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). Blood 2002; 100: 1689-98.
136. Dekker RJ, Boon RA, Rondaij MG, Kragt A, Volger OL, Elderkamp YW, et al KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood 2006; 107: 4354-63.
137. Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, et al Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. J. Clin. Invest. 2006; 116: 49-58.
138. Cheng C, van Haperen R, de Waard M, van Damme LCA, Tempel D, Hanemaaijer L, et al Shear stress affects the intracellular distribution of eNOS: Direct demonstration by a novel in vivo technique. Blood 2005; 106: 3691-8.
139. Schoen FJ, Levy RJ. Tissue heart valves: Current challenges and future research perspectives. J. Biomed. Mater. Res. 1999; 47: 439-65.
140. Poggianti E, Venneri L, Chubuchny V, Jambrik Z, Baroncini LA, Picano E. Aortic valve sclerosis is associated with systemic endothelial dysfunction. J. Amer. Coll. Cardiol. 2003; 41: 136-41.
141. Sacks MS, Yoganathan AP. Heart valve function: A biomechanical perspective. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2007; 362: 1369-91.
142. Davies PF, Mundel T, Barbee KA. A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro. J. Biomech. 1995; 28: 1553-60.
143. Mott RE, Helmke BP. Control of endothelial cell adhesion by mechanotransmission from cytoskeleton to substrate. In: King MR, ed. Principles of Cellular Engineering: Understanding the Biomolecular Interface. Burlington, MA: Elsevier; 2006: 25-50.
144. Karino T, Goldsmith HL. Particle flow behavior in models of branching vessels. II. Effects of branching angle and diameter ratio on flow patterns. Biorheology 1985; 22: 87-104.
145. Steinman D, Taylor C. Flow imaging and computing: Large artery hemodynamics. Ann. Biomed. Eng. 2005; 33: 1704-9.