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Volumn , Issue , 2006, Pages 25-50

Control of endothelial cell adhesion by mechanotransmission from cytoskeleton to substrate

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EID: 84882482117     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369392-1/50003-6     Document Type: Chapter
Times cited : (2)

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    • Reviews integrin-activated signaling networks activated by substrate stretch.
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    • Proposes molecular mechanisms that regulate cytoskeletal mechanics in response to changes in shear stress profile.
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    • Reviews patial organization of signaling molecules and proposes that signaling networks function can be regulated by mechanical coupling through the cytoskeleton.
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    • Proposes that inflammatory mechanisms mediate atherosclerosis.
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    • Proposes that the spatial distribution of eNOS activity correlates with defects in vasodilatory activity observed in regions of atherosclerotic lesions.
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    • Reviews the shear stress-mediated activation and assembly of focal adhesion-associated signaling proteins.


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