Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages

European Journal of Immunology

Volumn 40, Issue 10, 2010, Pages 2797-2803

  McCoy, Andrea J ^a,e   Koizumi, Yukiko ^a   Toma, Claudia ^a   Higa, Naomi ^a   Dixit, Vishva ^b   Taniguchi, Shun'ichiro ^c   Tschopp, Jürg ^d   Suzuki, Toshihiko ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b GENENTECH INC   (United States)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e NAVAL MEDICAL RESEARCH CENTER   (United States)

Author keywords

Aeromonas; Caspase 1; Nod like receptor

Indexed keywords

AEROLYSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CRYOPYRIN; CYTOTOXIN; HEMOLYSIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE;

AEROMONAS HYDROPHILA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; ENZYME ACTIVATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AEROMONAS HYDROPHILA; ANIMALS; BACTERIAL TOXINS; CARRIER PROTEINS; CASPASE 1; CASPASES; CELL DEATH; CYTOTOXINS; ENZYME ACTIVATION; GRAM-NEGATIVE BACTERIAL INFECTIONS; HEMOLYSIN PROTEINS; IMMUNOBLOTTING; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PORE FORMING CYTOTOXIC PROTEINS;

EID: 77957165746     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040490     Document Type: Article

References (26)

1. Janda, J. M. and Abbott, S. L., Evolving concepts regarding the genus Aeromonas: an expanding Panorama of species, disease presentations, and unanswered questions. Clin. Infect. Dis. 1998. 27: 332-344.
2. Janda, J. M. and Abbott, S. L., The genus Aeromonas: taxonomy, pathogenicity, and infection. Clin. Microbiol. Rev. 2010. 23: 35-73.
3. Krzyminska, S., Kaznowski, A. and Chodysz, M., Aeromonas spp. human isolates induce apoptosis of murine macrophages. Curr. Microbiol. 2009. 58: 252-257.
4. Majumdar, T., Chattopadhyay, P., Saha, D. R., Sau, S. and Mazumder, S., Virulence plasmid of Aeromonas hydrophila induces macrophage apoptosis and helps in developing systemic infection in mice. Microb. Pathog. 2009. 46: 98-107.
5. Bergsbaken, T., Fink, S. L. and Cookson, B. T., Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 2009. 7: 99-109.
6. Abdul-Sater, A. A., Koo, E., Hacker, G. and Ojcius, D. M., Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. J. Biol. Chem. 2009. 284: 26789-26796.
7. Duncan, J. A., Gao, X., Huang, M. T., O'Connor, B. P., Thomas, C. E., Willingham, S. B., Bergstralh, D. T. et al., Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J. Immunol. 2009. 182: 6460-6469.
8. Harder, J., Franchi, L., Munoz-Planillo, R., Park, J. H., Reimer, T. and Nunez, G., Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappaB activation but proceeds independently of TLR signaling and P2X7 receptor. J. Immunol. 2009. 183: 5823-5829.
9. Craven, R. R., Gao, X., Allen, I. C., Gris, D., Bubeck Wardenburg, J., McElvania-Tekippe, E., Ting, J. P. et al., Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One 2009. 4: e7446.
10. Munoz-Planillo, R., Franchi, L., Miller, L. S. and Nunez, G., A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome. J. Immunol. 2009. 183: 3942-3948.
11. Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H. et al., The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 2009. 30: 556-565.
12. Ichinohe, T., Lee, H. K., Ogura, Y., Flavell, R. and Iwasaki, A., Inflammasome recognition of influenza virus is essential for adaptive immune responses. J. Exp. Med. 2009. 206: 79-87.
13. Thomas, P. G., Dash, P., Aldridge, J. R., Jr., Ellebedy, A. H., Reynolds, C., Funk, A. J., Martin, W. J. et al., The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 2009. 30: 566-575.
14. Joly, S., Ma, N., Sadler, J. J., Soll, D. R., Cassel, S. L. and Sutterwala, F. S., Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J. Immunol. 2009. 183: 3578-3581.
15. Delaloye, J., Roger, T., Steiner-Tardivel, Q. G., Le Roy, D., Knaup Reymond, M., Akira, S., Petrilli, V. et al., Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog. 2009. 5: e1000480.
16. Gross, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschlager, N., Endres, S., Hartmann, G. et al., Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009. 459: 433-436.
17. Hise, A. G., Tomalka, J., Ganesan, S., Patel, K., Hall, B. A., Brown, G. D. and Fitzgerald, K. A., An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 2009. 5: 487-497.
18. Franchi, L., Eigenbrod, T., Munoz-Planillo, R. and Nunez, G., The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 2009. 10: 241-247.
19. Lamkanfi, M. and Dixit, V. M., Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 2009. 227: 95-105.
20. Buckley, J. T., Purification of cloned proaerolysin released by a low protease mutant of Aeromonas salmonicida. Biochem. Cell. Biol. 1990. 68: 221-224.
21. Gurcel, L., Abrami, L., Girardin, S., Tschopp, J. and van der Goot, F. G., Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006. 126: 1135-1145.
22. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. and Tschopp, J., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006. 440: 237-241.
23. Galindo, C. L., Sha, J., Ribardo, D. A., Fadl, A. A., Pillai, L. and Chopra, A. K., Identification of Aeromonas hydrophila cytotoxic enterotoxin-induced genes in macrophages using microarrays. J. Biol. Chem. 2003. 278: 40198-40212.
24. Galindo, C. L., Fadl, A. A., Sha, J., Gutierrez Jr C., Popov, V. L., Boldogh, I., Aggarwal, B. B. et al., Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelial cells. J. Biol. Chem. 2004. 279: 37597-37612.
25. Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M. et al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004. 430: 213-218.
26. Yamamoto, M., Yaginuma, K., Tsutsui, H., Sagara, J., Guan, X., Seki, E., Yasuda, K. et al., ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells 2004. 9: 1055-1067.