Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues

Journal of Investigative Medicine

Volumn 44, Issue 2, 1996, Pages 42-46

  Stewart, Mark J ^a   Malek, Kevin ^a   Crabb, David W ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaldehyde; Aldehyde dehydrogenase; Gene expression; Liver; Northern blotting

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN; DIAGNOSTIC AGENT; ISOENZYME; MESSENGER RNA;

ADULT; ARTICLE; DNA PROBE; FETUS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; NORTHERN BLOTTING; PHYSIOLOGY; TISSUE DISTRIBUTION;

ADULT; ALDEHYDE DEHYDROGENASE; BLOTTING, NORTHERN; DNA PROBES; FETUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0030077380     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Crabb DW, Bosron WF, Li T-K. Ethanol metabolism. Pharmacol Ther 1987;34:59-73.
2. Estonius M, Danielsson O, Karlsson C, Person H, Jornvall H, Hoog J-O. Distribution of alcohol and sorbitol dehydrogenases. Assessment of mRNA species in mammalian tissues. Eur J Biochem 1993;215:497-503.
3. Canto MF, Oliva MM, Potter JJ, Mezey E, Yang VW. Enhancer site downstream binding protein activity is enriched in rat tissues that express the class I alcohol dehydrogenase gene. Biochem Biophys Res Commun 1992;188:689-94.
4. Shimizu M, Lasker JM, Tsutsumi M, Lieber CS. Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract. Gastroenterology 1990;99:1044-53.
5. Lindahl R. Aldehyde dehydrogenases and their role in carcinogenesis. Crit Rev Biochem Mol Biol 1992;27:283-335.
6. Crabb DW, Edenberg HJ, Bosron WF, Li T-K. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2*2 allele is dominant. J Clin Invest 1989;83:314-6.
7. Goedde HW, Agarwal DP, Harada S, Meier-Tackmann D, Ruofo D, Bienzle U, Kroeger A, Hussein L. Population genetic studies of aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Am J Hum Genet 1983;35:769-72.
8. Enomoto N, Takase S, Yasuhara M, Takada A. Acetaldehyde metabolism in different aldehyde dehydrogenase 2 genotypes. Alcohol Clin Exp Res 1991;15:141-44.
9. Kurys G, Ambrosiak W, Pietruszko R. Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for γ-aminobutyraldehyde. J Biol Chem 1989;264:4715-21.
10. Kurys G, Shah PC, Kikonyogo A, Reed D, Ambrosiak W, Pietruszko R. Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde. Eur J Biochem 1993;218:311-20.
11. Hsu LC, Chang WC. Cloning and characterization of a new functional human aldehyde dehydrogenase gene. J Biol Chem 1991;266:12257-65.
12. Stewart MJ, Malek K, Xiao Q, Dipple KM, Crabb DW. The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 1995;211:144-51.
13. Hartley DP, Ruth JA, Petersen DR. The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione-S-transferase. Arch Biochem Biophys 1995;316:197-205.
14. Rekha GK, Sreerama L, Sladek NE. Intrinsic cellular resistance to oxazophosphorines exhibited by a human colon cancer cell line expressing relatively large amounts of class 3 aldehyde dehydrogenase. Biochem Pharmacol 1994;48:1943-52.
15. Duley JA, Harris O, Holmes RS. Analysis of human alcohol- and aldehyde-metabolizing isozymes by electrophoresis and isoelectric focusing. Alcohol Clin Exp Res 1985;9:263-271.
16. Goedde HW, Agarwal DP, Harada S. Alcohol metabolizing enzymes: studies of isozymes in human biopsies and cultured fibroblasts. Clin Genet 1979;16:29-33.
17. Harada S, Agarwal DP, Goedde HW. Isozyme variations in acetaldehyde dehydrogenase (E.C.1.2.1.3) in human tissues. Hum Genet 1978;44:181-5.
18. Harada S, Agarwal DP, Goedde HW. Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues. Life Sci 1980;26:1773-80.
19. Dipple KM, Crabb DW. The mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is expressed in a tissue-specific manner. Biochem Biophys Res Commun 1993;193:420-7.
20. Farres J, Guan K-L, Weiner H. Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences. Eur J Biochem 1989;180:67-74.
21. Hsu L, Chang W-C, Yoshida A. Genomic structure of the human cytosolic aldehyde dehydrogenase gene. Genomics 1989;5:857-65.
22. Hsu LC, Tani K, Fujiyoshi T, Kurachi K, Yoshida A. Cloning of cDNAs for human ALDHs 1 and 2. Proc Natl Acad Sci USA 1985;82:3771-5.
23. Greenfield NJ, Pietruszko R. Two aldehyde dehydrogenases from human liver: isolation via affinity chromatography and characterization of the isozymes. Biochim Biophys Acta 1977;483:35-45.
24. Westlund P, Fylling AC, Cederlund E, Jornvall H. 11-hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase. FEBS Lett 1994;345:99-103.
25. Chen M, Achkar C, Gudas LJ. Enzymatic conversion of retinaldehyde to retinoic acid by cloned murine cytosolic and mitochondrial aldehyde dehydrogenases. Mol Pharmacol 1994;46:88-96.
26. Watanabe T. Mechanism of ethanol-induced bronchoconstriction in Japanese asthmatic patients. Arerugi 1991;40:1210-7.
27. Preedy VR, Peters TJ. Alcohol and skeletal muscle disease. Alcohol Alcohol 1990;25:177-87.
28. Martin F, Ward K, Slavin G, Levi J, Peters TJ. Alcoholic skeletal myopathy, a clinical and pathological study. Q J Med 1985;218:233-51.
29. Meier-Tackmann D, Korenke GC, Agarwal DP, Goedde HW. Human placental aldehyde dehydrogenase: subcellular distribution and properties. Enzyme 1985;33:153-61.
30. Algar EM, Cheung B, Hayes J, Holmes RS, Beacham IR. Bovine corneal aldehyde dehydrogenases: evidence for multiple gene products (ALDH3 and ALDHx). Adv Exp Med Biol 1993;328:153-7.