Intrinsic retinoic acid receptor α-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells

Stem Cells

Volumn 25, Issue 10, 2007, Pages 2628-2637

  Luo, Peihua ^a   Wang, Anxun ^a   Payne, Kimberly J ^a,c   Peng, Hui ^a   Wang, Jian Guang ^a   Parrish, Yasmin K ^a   Rogerio, Jaqueline W ^a   Triche, Timothy J ^a,c   He, Qiaojun ^b   Wu, Lingtao ^a,c,d  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Cell cycle G1 exit; Normal granulopoiesis; Proliferation differentiation transition; Retinoid dependent signaling

Indexed keywords

ALDEHYDE DEHYDROGENASE; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; P21 ACTIVATED KINASE; RETINOIC ACID RECEPTOR ALPHA; RING FINGER PROTEIN MAT1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CD34 SELECTION; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GRANULOCYTE PRECURSOR; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYELOID LEUKEMIA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ALDEHYDE DEHYDROGENASE; ALDEHYDE OXIDOREDUCTASES; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; G1 PHASE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GRANULOCYTES; HEMATOPOIETIC STEM CELLS; HUMANS; MULTIENZYME COMPLEXES; MYELOID CELLS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, RETINOIC ACID; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TRETINOIN;

EID: 35348891363     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0264     Document Type: Article

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