Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant

Journal of Biological Chemistry

Volumn 280, Issue 34, 2005, Pages 30550-30556

  Larson, Heather N ^a   Weiner, Henry ^b   Hurley, Thomas D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CATALYSIS; CRYSTAL STRUCTURE; DIMERS; HYDROGEN BONDS; OLIGOMERS;

ALDEHYDE DEHYDROGENASE (ALDH); COENZYME BINDING; OLIGOMERIZATION;

ENZYMES;

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ARGININE; DIMER; GLUTAMIC ACID; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CATALYSIS; COENZYME; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; ROTATION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

ALDEHYDE DEHYDROGENASE; ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA, COMPLEMENTARY; GLUTAMIC ACID; HUMANS; HYDROGEN BONDING; KINETICS; LYSINE; MITOCHONDRIA; MODELS, MOLECULAR; NAD; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 24044510433     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M502345200     Document Type: Article

References (33)

1. Hurley, T. D., Edenberg, H. J., and Li, T. K. (2002) in Pharmacogenomics: The Search for Individualized Therapies (Licinio, J., and Wong, M., eds) pp. 417-441, Wiley-VCH, Weinheim, Germany
2. Chen, Z., Zhang, J., and Stamler, J. S. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8306-8311
3. Seitz, H. K., Matsuzaki, S., Yokoyama, A., Homann, N., Vakevainen, S., and Wang, X. D. (2001) Alcohol. Clin. Exp. Res. 25, 137S-143S
4. Peng, G. S., Wang, M. F., Chen, C. Y., Luu, S. U., Chou, H. C., Li, T. K., and Yin, S. J. (1999) Pharmacogenetics 9, 463-476
5. Enomoto, N., Takase, S., Takada, N., and Takada, A. (1991) Hepatology 13, 1071-1075
6. Yokoyama, A., Muramatsu, T., Omori, T., Matsushita, S., Yoshimizu, H., Higuchi, S., Yokoyama, T., Maruyama, K., and Ishii, H. (1999) Alcohol. Clin. Exp. Res. 23, 1705-1710
7. Farres, J., Wang, X., Takahashi, K., Cunningham, S. J., Wang, T. T., and Weiner, H. (1994) J. Biol. Chem. 269, 13854-13860
8. Steinmetz, C. G., Xie, P., Weiner, H., and Hurley, T. D. (1997) Structure 5, 701-711
9. Ni, L., Zhou, J., Hurley, T. D., and Weiner, H. (1999) Protein Sci. 8, 2784-2790
10. Weiner, H., Hu, J. H., and Sanny, C. G. (1976) J. Biol. Chem. 251, 3853-3855
11. Zhou, J., and Weiner, H. (2000) Biochemistry 39, 12019-12024
12. Perez-Miller, S., and Hurley, T. D. (2003) Biochemistry 42, 7100-7109
13. Hammen, P. K., Allali-Hassani, A., Hallenga, K., Hurley, T. D., and Weiner, H. (2002) Biochemistry 41, 7156-7168
14. Moore, S. A., Baker, H. M., Blythe, T. J., Kitson, K. E., Kitson, T. M., and Baker, E. N. (1998) Structure 6, 1541-1551
15. Hurley, T., Perez-Miller, S., and Breen, H. (2001) Chem. Biol. Interact. 130-132, 3-14
16. Zheng, C. F., Wang, T. T., and Weiner, H. (1993) Alcohol. Clin. Exp. Res. 17, 828-831
17. Jeng, J. J., and Weiner, H. (1991) Arch. Biochem. Biophys. 289, 214-222
18. Ghenbot, G., and Weiner, H. (1992) Protein Expression Purif. 3, 470-478
19. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
20. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
21. Navaza, J. (1994) Acta Crystallogr. A 50, 157-163
22. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
23. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
24. Hayward, S., and Berendsen, H. J. C. (1998) Proteins 30, 144-154
25. Kabsch, W. (1976) Acta Crystallogr. Sect. A 32, 922-923
26. Lamb, A. L., and Newcomer, M. E. (1999) Biochemistry 38, 6003-6011
27. Bordelon, T., Montegudo, S. K., Pakhomova, S., Oldham, M. L., and Newcomer, M. E. (2004) J. Biol. Chem. 279, 43085-43091
28. Greenbaum, A. L., Gumaa, K. A., and McLean, P. (1971) Arch. Biochem. Biophys. 143, 617-663
29. Ni, L., Sheikh, S., and Weiner, H. (1997) J. Biol. Chem. 272, 18823-18826
30. Ambroziak, W., Kosley, L. L., and Pietruszko, R. (1989) Biochemistry 28, 5367-5373
31. Takahashi, K., Weiner, H., and Hu, J. H. (1980) Arch. Biochem. Biophys. 205, 571-578
32. Bross, P., Jespersen, C., Jensen, T. G., Andresen, B. S., Kristensen, M. J., Winter, V., Nandy, A., Krautle, F., Ghisla, S., Bolund, L., Kim, J.-J. P., and Gregersen, N. (1994) J. Biol. Chem. 270, 10284-10290
33. Kim, J. J., and Wu, J. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 6677-6681