Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract

European Journal of Biochemistry

Volumn 270, Issue 12, 2003, Pages 2652-2662

  Vaglenova, Julia ^a,c   Martínez, Susana E ^a,d   Porté, Sergio ^a   Duester, Gregg ^b   Farrés, Jaume ^a   Parés, Xavier ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b BURNHAM INSTITUTE   (United States)

^c AUBURN UNIVERSITY   (United States)

^d BOSTON COLLEGE   (United States)

Author keywords

Ethanol; Immunohistochemistry; In situ hybridization; Retinoic acid; Retinol

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE (NAD(P)); ALCOHOL DEHYDROGENASE 1; ALCOHOL DEHYDROGENASE 4; ENZYME; RETINOL DEHYDROGENASE; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL OXIDATION; ANIMAL TISSUE; ARTICLE; CELL TYPE; COLON; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ESOPHAGUS; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE; MALE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYLORUS; RAT; RECTUM; STOMACH; VITAMIN METABOLISM; WESTERN BLOTTING;

ALCOHOL DEHYDROGENASE; ANIMALS; DIGESTIVE SYSTEM; ESOPHAGUS; ILEUM; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINAL MUCOSA; ISOENZYMES; JEJUNUM; RATS; TONGUE;

ANIMALIA;

EID: 0038650796     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03642.x     Document Type: Article

References (68)

1. Li, T.-K. (1983) The absorption, distribution and metabolism of ethanol and its effects on nutrition and hepatic function. In Medical and Social Aspects of Ethanol. Abuse (Tabakoff, B., Sutker, P.B. & Randall, C.L., eds), pp. 47-77. Plenum Press, New york.
2. Boleda, M.D., Julià, P., Moreno, A. & Parés, X. (1989) Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism. Arch. Biochem. Biophys. 274, 74-81.
3. Brändén, C.I., Jörnvall, H., Eklund, H. & Furugren, B. (1975) Alcohol dehydrogenase. In The Enzymes, Vol. 11, 3rd edn. (Boyer, P.D., ed.), pp. 103-190. Academic Press, New York.
4. Nordling, E., Persson, B. & Jörnvall, H. (2002) Differential multiplicity of MDR alcohol dehydrogenases: enzyme genes in the human genome versus those in organisms initially studied. Cell. Mol. Life Sci. 59, 1070-1075.
5. Jörnvall, H. & Höög, J.-O. (1995) Nomenclature of alcohol dehydrogenases. Alcohol 30, 153-161.
6. Duester, G., Farrés, J., Felder, M.R., Holmes, R.S., Höög, J.-O., Parés, X., Plapp, B.V., Yin, S.-J. & Jörnvall, H. (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem. Pharmacol. 58, 389-395.
7. Julià, P., Farrés, J. & Parés, X. (1987) Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties. Eur. J. Biochem. 162, 179-189.
8. Svensson, S., Stromberg, P. & Höög, J.-O. (1999) A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro (47) and Ser (182) modulate hydride transfer in the mouse enzyme. J. Biol. Chem. 274, 29712-29719.
9. Farrés, J., Moreno, A., Crosas, B., Peralba, J.M., Allali-Hassani, A., Hjelmqvist, L., Jörnvall, H. & Parés, X. (1994) Alcohol dehydrogenase of class IV (σσ-ADH) from human stomach. cDNA sequence and structure/function relationships. Eur. J. Biochem. 224, 549-557.
10. Allali-Hassani, A., Martínez, S.E., Peralba, J.M., Vaglenova, J., Vidal, F., Richart, C., Farrés, J. & Parés, X. (1997) Alcohol dehydrogenase of human and rat blood vessels. Role in ethanol metabolism. FEBS Lett. 405, 26-30.
11. Martínez, S.E., Vaglenova, J., Sabrià, J., Martínez, M.C., Farrés, J. & Parés, X. (2001) Distribution of alcohol dehydrogenase mRNA in the rat central nervous system: Consequences for brain ethanol and retinoid metabolism. Eur. J. Biochem. 268, 5045-5056.
12. 2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase. FEBS Lett. 426, 362-366.
13. Boleda, M.D., Saubi, N., Farrés, J. & Parés, X. (1993) Physiological substrates for rat alcohol dehydrogenase classes: Aldehydes of lipid peroxidation, ω-hydroxyfatty acids, and retinoids. Arch. Biochem. Biophys. 307, 85-90.
14. Crosas, B., Allali-Hassani, A., Martínez, S.E., Martras, S., Persson, B., Jörnvall, H., Parés, X. & Farrés, J. (2000) Molecular basis for differential substrate specificity in class IV alcohol dehydrogenases: a conserved function in retinoid metabolism but not in ethanol metabolism. J. Biol. Chem. 275, 25180-25187.
15. Kedishvili, N.Y., Bosron, W.F., Stone, C.L., Hurley, T.D., Peggs, C.F., Thomasson, H.R., Popov, K.M., Carr, L.G., Edenberg, H. & Li, T.-K. (1995) Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. J. Biol. Chem. 270, 3625-3620.
16. Molotkov, A., Fan, X., Deltour, L., Foglio, M.H., Martras, S., Farrés, J., Parés, X. & Duester, G. (2002) Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase, Adh3. Proc. Natl Acad. Sci. USA 99, 5337-5342.
17. Yang, Z.-N., Davis, G.J., Hurley, T.D., Stone, C.L., Li, T.-K. & Bosron, W.F. (1994) Catalytic efficiency of human alcohol dehydrogenase for retinol oxidation and retinal reduction. Alcohol. Clin. Exp. Res. 18, 587-591.
18. Deltour, L., Foglio, M.H. & Duester, G. (1999) Metabolic deficiencies in alcohol dehydrogenase Adhl, Adh3, and Adh4 null mutant mice. J. Biol. Chem. 274, 16796-16801.
19. Deltour, L., Foglio, M.H. & Duester, G. (1999) Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice. Dev. Genet. 25, 1-10.
20. Estonius, M., Danielsson, O., Karlsson, C., Persson, H., Jörnvall, H. & Höög, J.-O. (1993) Distribution of alcohol and sorbitol dehydrogenases. Assessment of mRNA species in mammalian tissues. Eur. J. Biochem. 215, 497-503.
21. Haselbeck, R.J. & Duester, G. (1997) Regional restriction of alcohol/retinol dehydrogenases along the mouse gastrointestinal epithelium. Alcohol. Clin. Exp. Res. 21, 1484-1490.
22. Koivisto, T. & Salaspuro, M. (1996) Aldehyde dehydrogenases of the rat colon: comparison with other tissues of the alimentary tract and the liver. Alcohol. Clin. Exp. Res. 20, 551-555.
23. Dong, Y.J., Peng, T.K. & Yin, S.J. (1996) Expression and activities of class TV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth. Alcohol 13, 257-262.
24. Estonius, M., Svensson, S. & Höög, J.-O. (1996) Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme. FEBS Lett. 397, 338-342.
25. Parés, X. & Farrés, J. (1996) Alcohol and aldehyde dehydrogenases in the gastrointestinal tract. In Alcohol and the Gastrointestinal Tract (Preedy, V.R. & Watson, R.R., eds), pp. 41-56. CRC Press, Boca Raton.
26. Parés, X., Martínez, S.E., Allali-Hassani, A., Borràs, E., Farrés, J., Martras, S., Rosell, A. & Vaglenova, J. (2001) Distribution of alcohol dehydrogenase in human organs. Relevance for alcohol metabolism and pathology. In Alcohol in Health and Disease (Agarwal, D. P. & Seitz H. K., eds), pp. 87-102. Marcel Dekker Inc., New York.
27. Pestalozzi, D.M., Bühler, R., von Wartburg, J.P. & Hess, M. (1983) Immunohistochemical localization of alcohol dehydrogenase in the human gastrointestinal tract. Gastroenterology 85, 1011-1016.
28. Seitz, H.K., Egerer, G., Oneta, C., Kramer, S., Sieg, A., Klee, F. & Simanowski, U.A. (1996) Alcohol dehydrogenase in the human colon and rectum. Digestion 57, 105-108.
29. Yin, S.J., Chou, F.J., Chao, S.F., Tsai, S.F., Liao, C.S., Wang, S.L., Wu, C.W. & Lee, S.C. (1993) Alcohol and aldehyde dehydrogenases in human esophagus: comparison with the stomach enzyme activities. Alcohol. Clin. Exp. Res. 17, 376-381.
30. Yin, S.J., Liao, C.S., Wu, C.W., Li, T.T., Chen, L.L., Lai, C.L. & Tsao, T.Y. (1997) Human stomach alcohol and aldehyde dehydrogenases: comparison of expression pattern and activities in alimentary tract. Gastroenterology 112, 766-775.
31. Crabb, D.W., Bosron, W.F. & Li, T.K. (1983) Steady-state kinetic properties of purified rat liver alcohol dehydrogenase: application to predicting alcohol elimination rates in vivo. Arch. Biochem. Biophys. 224, 299-309.
32. Bradford, M.M. (1976) A rapid and sensitive method for the quantitative determination of microgram quantifies of protein utilising the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
33. Young, B. & Heath, J.W. (2000) Wheater's Functional Histology, 4th edn. Churchill Livingstone, Edinburgh.
34. Ang, H.L., Deltour, L., Zgombic-Knight, M., Wagner, M.A. & Duester, G. (1996) Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis. Alcohol. Clin. Exp. Res. 20, 1050-1064.
35. Zgombic-Knight, M., Ang, H.L., Foglio, M.H. & Duester, G. (1995) Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family. J. Biol. Chem. 270, 10868-10877.
36. Crow, J.A. & Ong, D.E. (1985) Cell-specific immunohistochemical localization of a cellular retinol-binding protein (type two) in the small intestine of rat. Proc. Natl Acad. Sci. USA 82, 4707-4711.
37. Dowlatshahi, K., Mehta, R.G., Levin, B., Cerny, W.L., Skinner, D.B. & Moon, R.C. (1984) Retinoic-acid-binding protein in normal and neoplastic human esophagus. Cancer 54, 308-311.
38. Inagami, S. & Ong, D.E. (1992) Purification and partial characterization of cellular retinol-binding protein, type two, from human small intestine. J. Nutr. 122, 450-456.
39. Jiang, S.Y., Shen, S.R. & Shyu, R.Y., Yu, J.C., Ham, H.J., Yeh, M.Y., Lee, M.M. & Chang, Y.C. (1999) Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization. Br. J. Cancer 80, 206-214.
40. Kato, S., Mano, H., Kumazawa, T., Yoshizawa, Y., Kojima, R. & Masushige, S. (1992) Effect of retinoid status on alpha, beta and gamma retinoic acid receptor mRNA levels in various rat tissues. Biochem. J. 286, 755-760.
41. Bhat, P.V. (1998) Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency. FEBS Lett. 426, 260-262.
42. Frota-Ruchon, A., Marcinkiewicz, M. & Bhat, P.V. (2000) Localization of retinal dehydrogenase type 1 in the stomach and intestine. Cell Tissue Res. 302, 397-400.
43. Molotkov, A., Deltour, L., Foglio, M.H., Cuenca, A.E. & Duester, G. (2002) Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. J. Biol. Chem. 277, 13804-13811.
44. Crabb, D.W., Pinairs, J., Hasanadka, R., Fang, M., Leo, M.A., Lieber, C.S., Tsukamoto, H., Motomura, K., Miyahara, T., Ohata, M., Bosron, W.F., Sanghani, S., Kedishvili, N., Shiraishi, H., Yokoyama, H., Miyagi, M., Ishii, H., Bergheim, I., Menzl, I., Parlesak, A. & Bode, C. (2001) Alcohol and retinoids. Alcohol. Clin. Exp. Res. 25, 207S-217S.
45. Yokoyama, H., Matsumoto, M., Shiraishi, H., Miyagi, M., Kato, S. & Ishii, H. (2001) Nicotinamide adenine dinucleotide-dependent retinoic acid formation from retinol in the human gastric mucosa: inhibition by ethanol, acetaldehyde, and H2 blockers. Alcohol. Clin. Exp. Res. 2, 24S-28S.
46. Wyss, A., Wirtz, G.M., Woggon, W.D., Brugger, R., Wyss, M., Friedlein, A., Riss, G., Bachmann, H. & Hunziker, W. (2001) Expression pattern and localization of beta,beta-carotene 15,15′-dioxygenase in different tissues. Biochem. J. 354, 521-529.
47. Kakkad, B.P. & Ong, D.E. (1988) Reduction of retinaldehyde bound to cellular retinol-binding protein (type II) by microsomes from rat small intestine. J. Biol. Chem. 263, 12916-12919.
48. Kedishvili, N.Y., Chumakova, O.V., Chetyrkin, S.V., Belyaeva, O.V., Lapshina, E.A., Lin, D.W., Matsumura, M. & Nelson, P.S. (2002) Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). J. Biol. Chem. 277, 28909-28915.
49. Caballería, J., Barahona, E. & Lieber, C.S. (1986) The contribution of the stomach to ethanol oxidation in the rat. Life Sci. 41, 1021-1027.
50. Caballería, J., Frezza, M., Hernández-Muñoz, R., DiPadova, C., Korsten, M.A., Barahona, E. & Lieber, C.S. (1989) Gastric origin of the first-pass metabolism of ethanol in humans: effect of gastrectomy. Gastroenterology 97, 1205-1209.
51. Han, C.-L., Liao, C.-S., Wu, C.-W., Hwong, C.-L., Lee, A.-R. & Yin, S.-J. (1998) Contribution to first-pass metabolism of ethanol and inhibition by ethanol for retinol oxidation in human alcohol dehydrogenase family. Eur. J. Biochem. 254, 25-31.
52. Lim, R.T., Gentry, R.T. Jr, Itio, D., Yokoyama, H., Baraona, E. & Lieber, C.S. (1993) First-pass metabolism of ethanol is predominantly gastric. Alcohol. Clin. Exp. Res. 17, 1337-1344.
53. Oneta, C.M., Simanowski, U.A., Martinez, M., Allali-Hassani, A., Parés, X., Homann, N., Conradt, C., Waldherr, R., Fiehn, W., Coutelle, C. & Seitz, H.K. (1998) First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying. Gut 43, 612-619.
54. Krebs, H.A. & Perkins, J.R. (1970) The physiological role of liver alcohol dehydrogenase. Biochem. J. 118, 635-644.
55. Baraona, E., Julkunen, R., Tannenbaum, L. & Lieber, C.S. (1986) Role of intestinal bacterial overgrowth in ethanol production and metabolism in rats. Gastroenterology 90, 103-110.
56. Nosova, T., Jokelainen, K., Kaihovaara, P., Jousimies-Somer, H., Siitonen, A., Heine, R. & Salaspuro, M. (1996) Aldehyde dehydrogenase activity and acetate production by aerobic bacteria representing the normal flora of human large intestine Alcohol Alcohol. 31, 555-564.
57. Longnecker, M.P. (1995) Alcohol consumption and risk of cancer in humans: an overview. Alcohol 12, 87-96.
58. Seitz, H.K., Matsuzaki, S., Yokoyama, A., Homann, N., Vakevainen, S. & Wang, X.D. (2001) Alcohol and cancer. Alcohol. Clin. Exp. Res. 25, 137S-143S.
59. Maier, H., Weidauer, H., Zoller, J., Seitz, H.K., Flentje, M., Mall, G. & Born, I.A. (1994) Effect of chronic alcohol consumption on the morphology of the oral mucosa. Alcohol. Clin. Exp. Res. 18, 387-391.
60. Love, J.M. & Gudas, L.J. (1994) Vitamin A, differentiation and cancer. Curr. Opin. Cell Biol. 6, 825-831.
61. Mak, K.M., Leo, M.A. & Lieber, C.S. (1987) Effect of ethanol and vitamin A deficiency on epithelial cell proliferation and structure in the rat esophagus. Gastroenterology 93, 362-370.
62. Wald, N., Boreham, J. & Bailey, A. (1986) Serum retinol and subsequent risk of cancer. Br. J. Cancer 54, 957-961.
63. Julià, P., Farrés, J. & Parés, X. (1986) Ocular alcohol dehydrogenase in the rat: Regional distribution and kinetics of the ADH-1 isoenzyme with retinol and retinal. Exp. Eye Res. 42, 305-314.
64. Kedishvili, N.Y., Gough, W.H., Wilhelmina, I.D., Parsons, S., Li, T.-K. & Bosron, W.F. (1998) Effect of cellular retinol-binding protein on retinol oxidation by human class IV retinol/alcohol dehydrogenase and inhibition by ethanol. Biochem. Biophys. Res. Commun. 249, 191-196.
65. Mezey, E. & Holt, P.R. (1971) The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina. Exp. Mol. Pathol. 15, 148-156.
66. Molotkov, A. & Duester, G. (2002) Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase. J. Biol. Chem. 277, 22553-22557.
67. Napoli, J.L. (1999) Interactions of retinoid proteins and enzymes in retinoid metabolism. Biochim. Biophys. Acta 1440, 139-162.
68. Duester, G. (2000) Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur. J. Biochem. 267, 4315-4324.