Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart

Circulation Research

Volumn 105, Issue 11, 2009, Pages 1118-1127

  Endo, Jin ^a,b   Sano, Motoaki ^a,d   Katayama, Takaharu ^a,b   Hishiki, Takako ^c   Shinmura, Ken ^a   Morizane, Shintaro ^a   Matsuhashi, Tomohiro ^a   Katsumata, Yoshinori ^a,b   Zhang, Yan ^a   Ito, Hideyuki ^a   Nagahata, Yoshiko ^c   Marchitti, Satori ^f   Nishimaki, Kiyomi ^e   Wolf, Alexander Martin ^e   Nakanishi, Hiroki ^g   Hattori, Fumiyuki ^a   Vasiliou, Vasilis ^f   Adachi, Takeshi ^c   Ohsawa, Ikuroh ^e   Taguchi, Ryo ^g   Hirabayashi, Yoshio ^h   Ohta, Shigeo ^e   Suematsu, Makoto ^c   Ogawa, Satoshi ^b   Fukuda, Keiichi ^a   more..

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Department of Internal Medicine

^c Department of Biochemistry and Integrative Medical Biology ^*

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e NIPPON MEDICAL SCHOOL   (Japan)

^f UNIVERSITY OF COLORADO   (United States)

^g UNIVERSITY OF TOKYO   (Japan)

^h RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Aldehyde; Cardiac metabolism; Oxidative stress; Stress response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; GLUTATHIONE; INITIATION FACTOR 2; PENTOSE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; ATF4 PROTEIN, MOUSE; GLUCOSE;

AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE INDUCTION; GLUTATHIONE METABOLISM; HEART LEFT VENTRICLE FUNCTION; HEART STIMULATION; HEART STRESS; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ADAPTATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; DNA MICROARRAY; ECHOCARDIOGRAPHY; ECHOGRAPHY; ENZYME ACTIVATION; ENZYME INDUCTION; GENETIC TRANSCRIPTION; GENETICS; HEART MUSCLE; METABOLISM; METABOLOME; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ADAPTATION, PHYSIOLOGICAL; ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANIMALS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME INDUCTION; GLUCOSE; GLUTATHIONE; METABOLOME; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; TRANSCRIPTION, GENETIC;

EID: 73349110116     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.206607     Document Type: Article

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