Chapter 1 Intestinal fermentation: dietary and microbial interactions

Biology of Growing Animals

Volumn 4, Issue C, 2006, Pages 3-31

  Piva, A ^a   Galvano, F ^b   Biagi, G ^a   Casadei, G ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957111763     PISSN: 18771823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1877-1823(09)70088-8     Document Type: Article

References (169)

1. Anderson D.B., McCracken V.J., Aminov R.I., Simpson J.M., Mackie R.I., Verstegen M.W.A., and Gaskins H.R. Gut microbiology and growth-promoting antibiotics in swine. Nutr. Abst. Rev. 70 (2000) 101-108
2. Ange K.D., Eisemann J.H., Argenzio R.A., Almond G.W., and Blikslager A.T. Effects of feed physical form and buffering solutes on water disappearance and proximal stomach pH in swine. J. Anim. Sci. 78 9 (2000) 2344-2352
3. Arbuckle J.B.R. The distribution of certain Escherichia coli strains in pigs and their environment. Br. Vet. J. 124 (1968) 152-159
4. Audia J.P., Webb C.C., and Foster J.W. Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria. Int. J. Med. Microbiol. 291 2 (2001) 97-106
5. Bach Knudsen K.E., Wiske E., Daniel M., Feldheim W., and Eggum B.O. Digestibility of energy, protein, fat and non-starch polysaccharides in mixed diets: comparative studies between man and the rat. Br. J. Nutr. 71 4 (1994) 471-487
6. Bager F., Madsen M., Christensen J., and Aarestrup F.M. Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms. Prev. Vet. Med. 31 1-32 (1997) 95-112
7. Bardocz S., Grant G., Brown D.S., Ralph A., and Pusztai A. Polyamines in food - implication for growth and health. J. Nutr. Biochem. 4 (1993) 66-71
8. Bardocz S., White A., Grant G., Walker T.J., Brown D.W., and Pusztai A. The role of polyamines in intestinal function and gut maturation. In: Piva A., Bach Knudsen K.E., and Lindberg J.E. (Eds). Gut Environment of Pigs (2001), Nottingham University Press, Loughborough 29-42
9. Barnett K.L., Kornegay E.T., Risley C.R., Lindemann M.D., and Schurig G.G. Characterization of creep feed consumption and its subsequent effects on immune response, scouring index and performance of weanling pigs. J. Anim. Sci. 67 (1989) 2698-2708
10. Bartho L., Petho G., Antal A., Holzer P., and Szolcsanyi J. Two types of relaxation due to capsaicin in the guinea pig isolated ileum. Neurosci. Lett. 81 (1987) 146-150
11. Baume P.E., Nicholls A., and Baxter C.H. Inhibition of gastric acid secretion by a purified bacterial lipopolysaccharide. Nature 215 (1967) 59-60
12. Bearson S., Bearson B., and Foster J.W. Acid stress responses in enterobacteria. FEMS Microbiol. Lett. 147 (1997) 173-180
13. Berggren A.M., Bjorck I.M., Nyman E.M., and Eggum B.O. Short-chain fatty acid content and pH in caecum of rats given various sources of carbohydrates. J. Sci. Food Agric. 63 (1993) 397-406
14. Bermudez A.J., and Firman J.D. Effects of biogenic amines in broiler chickens. Avian Dis. 42 1 (1998) 199-203
15. Berry R.D., and Paraskeva C. Expression of a carcinoembryonic antigen by the adenoma and carcinoma derived epithelial cell lines: possible marker of tumor progression and modulation of expression by sodium butyrate. Carcinogenesis 9 (1988) 447-450
16. Biagi, G, 2000. Alternative strategies to the use of antibiotics as growth promoters in swine. PhD Thesis. School of Veterinary Medicine, University of Bologna, Italy.
17. Biagi, G, Piva, A, Hill, T, Schneider, D.K, Crenshaw, T.D, 2003. Low buffering capacity diets with added organic acids as a substitute for antibiotics in diets for weaned pigs. In: Ball, R.O. (Ed.), Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 2, pp. 217-32.
18. Blank R., Mosenthin R., Sauer W.C., and Huang S. Effect of fumaric acid and dietary buffering capacity on ileal and fecal amino acid digestibilities in early-weaned pigs. J. Anim. Sci. 77 11 (1999) 2974-2984
19. Blechea F., Pollmann D.S., and Nichols D.A. Weaning pigs at an early age decreases cellular immunity. J. Anim. Sci. 56 (1983) 396-400
20. Bolduan G., Jung H., Schneider R., Block J., and Klenke B. Die Wirkung von Propion- und Ameisensäure in der Ferkelzucht. J. Anim. Physiol. Anim. Nutr. 59 (1988) 72-78
21. Brighenti F., Testolin G., Canzi E., Ferrari A., Wolever T.M.S., Ciappellano S., Porrini M., and Simonetti P. Influence of long-term feeding of different purified dietary fibers on the volatile fatty acid (VFA) profile, pH and fiber-degrading activity of the cecal contents in rats. Nutr. Res. 9 (1989) 761-772
22. Burrin, D.G, Stoll, B, 2003. Enhancing intestinal function to improve growth and efficiency. In: Ball, R.O. (Ed.), Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 1, pp. 121-32.
23. Canibe N., and Jensen B.B. Fermented and nonfermented liquid feed to growing pigs: effect on aspects of gastrointestinal ecology and growth performance. J. Anim. Sci. 81 8 (2003) 2019-2031
24. Clausen M.R., Bonnen H., and Mortensen P.B. Colonic fermentation of dietary fibre to short chain fatty acids in patients with adenomatous polyps and colonic cancer. Gut 32 8 (1991) 923-928
25. Cook G.M., and Russell J.B. The effect of extracellular pH and lactic acid on pH homeostasis in Lactococcus lactis and Streptococcus bovis. Curr. Microbiol. 28 (1994) 165-168
26. Cranwell P.D., and Moughan P.J. Biological limitations imposed by the digestive system to the growth performance of weaned pigs. In: Barnett J.L., and Hennessy D.P. (Eds). Manipulating Pig Production II (1989), Australian Pig Science Association, Werribee 140-159
27. Cranwell P.D., Noakes D.E., and Hill K.J. Gastric secretion and fermentation in the suckling pig. Br. J. Nutr. 36 (1976) 71-86
28. DANMAP (Danish Integrated Antimicrobial Resistance Monitoring and Research Programme), 2002. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark. ISSN 1600-32. Copenhagen: Danish Veterinary Laboratory. Available at: URL: http://www.svs.dk
29. Decuypere, J, Van der Heyde, H, 1972. Study of the gastrointestinal microflora of suckling piglets and early weaned piglets reared using different feeding systems. Zentralbl. Bakteriol. Parasitenkd. Infektionskrankheiten Hyg. I(A221), 492-32.
30. Decuypere, J, De Bruyn, M, Dierick, N, 1997. Influence of the buffering capacity of the feed on the precaecal digestibility in pigs. In: Laplace, J.P, Fevrier, C, Barbeau, A. (Eds.), Proceedings of the 8th Int. Symposium on Digestive Physiology in Pigs. Saint Malo, France 88, pp. 391-32.
31. Dharmaraj H.P., Grimble G.K., and Silk D.B.A. Lacitol, a new hydrogenated lactose derivative: intestinal absorption and laxative threshold in normal human subjects. Br. J. Nutr. 57 (1987) 195-199
32. Dierick N.A., Vervaeke I.J., Decupyere J.A., and Henderickx H.K. Influence of the gut flora and of some growth-promoting feed additives on nitrogen metabolism in pigs. I. Studies in vitro. Livest. Prod. Sci. 14 (1986) 161-176
33. Dufour C., Dandrifosse G., Forget P., Vermesse F., Romain N., and Lepoint P. Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology 1 (1988) 112-116
34. Easter R.A. Acidification of diets for pigs. In: Haresign W., and Cole D.J.A. (Eds). Recent Advances in Animal Nutrition (1988), Butterworths, London 61-72
35. Eisemann J.H., and Nienaber J.A. Tissue and whole-body oxygen uptake in fed and fasted steers. Br. J. Nutr. 64 (1990) 399-411
36. Favier, C, Lalles, J.P, Seve, B, 2003. Intestinal variations in the caecal microbiota of piglets at the time of weaning. In: Ball, R.O. (Ed.), Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 2, pp. 102-32.
37. Fernandez I.M., Silva M., Schuch R., Walker W.A., Siber A.M., Maurelli A.T., and McCormick B.A. Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling. J. Infect. Dis. 184 6 (2001) 743-753
38. Fleming S.E., and Gill R. Aging stimulates fatty acid oxidation in rat colonocytes but does not influence the response to dietary fiber. J. Gerontol. A. Biol. Sci. Med. Sci. 52A (1997) B318-B330
39. Galfi P., and Bokori J. Feeding trial in pigs with a diet containing sodium n-butyrate. Acta Vet. Hung. 38 1 (1990) 3-17
40. Gallaher D.D., and Khil J. The effect of synbiotics on colon carcinogenesis in rats. J. Nutr. 129 7 Suppl. (1999) 1483S-1487S
41. Gaskins, H.R, 2003. The commensal microbiota and development of mucosal defense in the mammalian intestine. In: Ball, R.O. (Ed.), Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 1, pp. 57-32.
42. Gaskins H.R., and Kelley K.W. Immunology and neonatal mortality. In: Varley M.A. (Ed). The Neonatal Pig: Development and Survival (1995), CAB International, Wallingford 39-55
43. Gedek B., Roth F.X., Kirchgessner M., Wiehler S., Bott A., and Eidelsburger U. Zum Einfluß von Fumarsäure, Salzsäure, Natriumformat, Tylosin und Toyocerin auf die Keimzahlen der Mikroflora und deren Zusammensetzung in verschiedenen Segmenten des Gastrointestinaltraktes. J. Anim. Physiol. Anim. Nutr. 68 (1992) 209-217
44. Gibson G.R., and Roberfroid M.B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 125 (1995) 1401-1412
45. Goodson M., and Rowbury R.J. Habituation to normal lethal acidity by prior growth of Escherichia coli at a sublethal acid pH value. Lett. Appl. Microbiol. 8 (1989) 70-77
46. Guilfoyle D.E., and Hirshfield I.N. The survival benefit of short-chain fatty acids and the inducible arginine and lysine decarboxylase genes for Escherichia coli. Lett. Appl. Microbiol. 22 (1996) 1-4
47. Hampson D.J. Alterations in piglet small intestinal structure at weaning. Res. Vet. Sci. 40 (1986) 32-40
48. Hartemink, R, Rombouts, F.M, 1997. Gas formation from oligosaccharides by the intestinal microflora. In: Hartemink, R. (Ed.), Proceeding of the International Symposium "Non-Digestible Oligosaccharides: Healthy Food for the Colon?". Wageningen, The Netherlands, pp. 57-32.
49. Heby O. Role of polyamines in the control of cell proliferation and differentiation. Differentiation 19 1 (1981) 1-20
50. Heby O., and Persson L. Molecular genetics of polyamine synthesis in eukaryotic cells. Trends Biochem. Sci. 15 4 (1990) 153-158
51. Henningsson A.M., Bjorck I.M., and Nyman E.M. Combinations of indigestible carbohydrates affect short-chain fatty acid formation in the hindgut of rats. J. Nutr. 132 10 (2002) 3098-3104
52. Henry Y. Effects of dietary tryptophan deficiency in finishing pigs, according to age or weight at slaughter or live weight gain. Livest. Prod. Sci. 41 (1995) 63-76
53. Hodin R.A., Shei A., and Meng S. Transcriptional activation of the human villin gene during enterocyte differentiation. J. Gastrointest. Surg. 1 5 (1997) 433-438
54. Houdijk, J.G.M, Hartemink, R, Van Laere, K.M.J, Williams, B.A, 1997. Fructooligosaccharides and transgalactooligosaccharides in weaner pigs' diet. In: Hartemink, R. (Ed.), Proceeding of the International Symposium "Non-Digestible Oligosaccharides: Healthy Food for the Colon?" Wageningen, The Netherlands, pp. 69-32.
55. Howard M.D., Gordon D.T., Pace L.W., Garleb K.A., and Kerley M.S. Effects of dietary supplementation with fructooligosaccharides on colonic microbiota populations and epithelial cell proliferation in neonatal pigs. J. Pediatr. Gastroenterol. Nutr. 21 (1993) 297-303
56. Jacobasch G., Schmiedl D., Kruschewski M., and Schmehl K. Dietary resistant starch and chronic inflammatory bowel diseases. Int. J. Colorectal Dis. 14 4-32 (1999) 201-211
57. Jacobs C. Life in the balance: cell walls and antibiotic resistance. Science 278 (1997) 1731-1732
58. Jensen, B.B, 1988. Effect of diet composition and virginiamycin on microbial activity in the digestive tract of pigs. In: Buraczewska, L, Buraczewski, S, Pastuszewska, B, Zebrowska, T. (Eds.), Proceedings, 4th International Seminar on Digestive Physiology in the Pig. Polish Academy of Science, Jablonna, Poland, pp. 392-32.
59. Jensen, B.B, 1993. The possibility of manipulating the microbial activity in the digestive tract of monogastric animals. In: Proceedings of the 44th Meeting of European Association for Animal Production. Aarhus, Denmark, pp. 1-32.
60. Jensen B.B. The impact of feed additives on the microbial ecology of the gut in young pigs. J. Anim. Feed Sci. 7 Suppl. 1 (1998) 45-64
61. Jensen B.B., and Mikkelsen L.L. Feeding liquid diets to pigs. In: Garnsworthy P.G., and Wiseman J. (Eds). Recent Advances in Animal Nutrition (1998), Nottingham University Press, Loughborough 107-126
62. Jensen, B.B., Hojberg, O., Mikkelsen, L.L., Hedemann, M.S., Canibe, N., 2003. Enhancing intestinal function to treat and prevent intestinal disease. In: Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 1, pp. 103-32.
63. Jukes T.H., and Williams W.L. Nutritional effects of antibiotics. Pharmacol. Rev. 5 (1953) 381-396
64. Jukes T.H., Stokstad E.L.R., Taylor R.R., Cunha T.J., Edwards H.M., and Meadows G.B. Growth promoting effect of aureomycin on pigs. Arch. Biochem. 26 (1950) 324-331
65. Kaback H.R. Active transport: membrane vesicles, bioenergetics, molecules and mechanisms. In: Sokatch J.R., Ornston L.N., and Krulwich T.A. (Eds). Bacterial Energetics XII (1990), Academic Press Inc, New York 151-193 The Bacteria: a Treatise on Structure and Function
66. Kajikawa H., and Russell J.B. Effect of ionophores on proton flux in the ruminal bacterium, Streptococcus bovis. Curr. Microbiol. 25 (1992) 327-330
67. Kidder D.E., and Manners M.J. Digestion in the Pig (1978), Kingston Press, Bath
68. Knarreborg A., Miquel N., Granli T., and Jensen B.B. Establishment and application of an in vitro methodology to study the effects of organic acids on coliforms and lactic acid bacteria on the proximal part of the gastrointestinal tract of piglets. Anim. Feed Sci. Technol. 99 (2002) 131-140
69. Kohler H., Rodrigues S.P., Maurelli A.T., and McCormick B.A. Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine. J. Infect. Dis. 186 8 (2002) 1122-1130
70. Kroll R.G., and Booth I.R. The relationship between intracellular pH, the pH gradient, and potassium transport in Escherichia coli. Biochem. J. 216 (1983) 709-716
71. Laerke, N.H., Jensen, B.B., 2003. Continuous measurement of gastric pH in young pigs. In: Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 2, pp. 3133.
72. Levrat M.A., Remesy C., and Demigne C. High propionic acid fermentations and mineral accumulation in the cecum of rats adapted to different levels of inulin. J. Nutr. 121 11 (1991) 1730-1737
73. Lin J., Lee I.S., Frey J., Slonozewski J.L., and Foster J.W. Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri and Escherichia coli. J. Bacteriol. 177 (1995) 4097-4104
74. Lopez S., Valdes C., Newbold C.J., and Wallace R.J. Influence of sodium fumarate addition on rumen fermentation in vitro. Br. J. Nutr. 81 1 (1999) 59-64
75. Loubiere P., Salou P., Leroy M.J., Lindley N.D., and Pareilleux A. Electrogenic malate uptake and improved growth energetics of the malolactic bacterium Leuconostoc oenos grown on glucose-malate mixtures. J. Bacteriol. 174 (1992) 5302-5308
76. Luchansky, J.B., 2000. Use of biotherapeutics to enhance animal well being and food safety. In: Piva, G., Masoero, F. (Eds.), Proc. 6th Int. Feed Production Conference, Piacenza, Italy, pp. 188-32.
77. Lundstrom K., Malmfors B., Stern S., Rydhmer L., Eliasson-Selling L., Mortensen A.B., and Mortensen H.P. Skatole levels in pigs selected for high lean tissue growth rate on different dietary protein levels. Livest. Prod. Sci. 38 (1994) 125-132
78. Lutgens M., and Gottschalk G. Why a co-substrate is required for anaerobic growth of Escherichia coli on citrate. J. Gen. Microbiol. 119 (1980) 63-70
79. Lyons D.E., Beery J.T., Lyons S.A., and Taylor S.L. Cadaverine and aminoguanidine potentiate the uptake of histamine in vitro in perfused intestinal segments of rats. Toxicol. Appl. Pharmacol. 70 3 (1983) 445-458
80. Maribo H., Jensen B.B., and Hedemann M.S. Different doses of organic acids to piglets (2000), The National Committee for Pig Production, Copenhagen Publication no. 469
81. Marty-Teysset C., Posthuma C., Lolkema J.S., Schmitt P., Divies C., and Konings W.N. Proton motive force generation by citrolactic fermentation in Leuconostoc mesenteroides. J. Bacteriol. 178 (1996) 2178-2185
82. McDougall E.I. Studies on ruminant saliva. 1. The composition and output of sheep's saliva. Biochem. J. 43 (1948) 99-109
83. Menke K.H., Raab L., Salewski A., Steingass H., Fritz H., and Schneider W. The estimation of digestibility and metabolizable energy content of ruminant feedingstuffs from the gas production when they are incubated with rumen liquor in vitro. J. Agric. Sci. 93 (1979) 217-222
84. Meyer J.H., and Kelly G.A. Canine pancreatic responses to intestinally perfused proteins and protein digests. Am. J. Physiol. 231 3 (1976) 682-691
85. Mikkelsen, L.L., Jensen, B.B., 2003. The stomach as a barrier that reduces the occurrence of pathogenic bacteria in pigs. In: Proceedings of the 9th Int. Symposium on Digestive Physiology in Pigs. Banff, Canada, Vol. 2, pp. 22-32.
86. Mitsuoka T. Intestinal Bacteria and Health (1993), Harcourt Brace Jovanovich Japan, Inc, Tokyo
87. Morrel V. Antibiotic resistance: road of no return. Science 278 (1997) 575-576
88. Mroz Z., Moeser A.J., Vreman K., van Diepen J.T., van Kempen T., Canh T.T., and Jongbloed A.W. Effects of dietary carbohydrates and buffering capacity on nutrient digestibility and manure characteristics in finishing pigs. J. Anim. Sci. 78 12 (2000) 3096-3106
89. Murphy C., Carroll C., and Jordan K.N. Identification of a novel stress resistance mechanism in Campylobacter jejuni. J. Appl. Microbiol. 95 4 (2003) 704-708
90. Nabuurs M.J., Hoogendoorn A., Van der Molen E.J., and van Osta A.L. Villus height and crypt depth in weaned and unweaned pigs, reared under various circumstances in The Netherlands. Res. Vet. Sci. 55 1 (1993) 78-84
91. Nousiainen J. Comparative observations on selected probiotics and olaquindox as feed additives for piglets around weaning. 2. Effect on villus length and crypt depth in the jejunum, ileum, caecum and colon. J. Anim. Physiol. Anim. Nutr. 66 (1991) 224-230
92. Nousiainen, J.T, Setälä, J.K, 1992. Feed for promoting the growth and intestinal function of animals. European Patent Application 91108549.6, publication number 4,435,389.
93. O'Driscoll B., Gahan C.G., and Hill C. Adaptive acid tolerance response in Listeria monocytogenes: isolation of an acid-tolerant mutant which demonstrates increased virulence. Appl. Environ. Microbiol. 62 5 (1996) 1693-1698
94. Orskov E.R., Fraser C., Mason V.C., and Mann S.O. Influence of starch digestion in the large intestine of sheep on caecal fermentation, caecal microflora and faecal nitrogen excretion. Br. J. Nutr. 24 (1970) 671-682
95. Osman N.E., Westrom B., Wang Q., Persson L., and Karlsson B. Spermine affects intestinal in vitro permeability to different-sized molecules in rats. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 120 2 (1998) 211-216
96. Park Y.K., Bearson B., Bang S.H., Bang I.S., and Foster J.W. Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium. Mol. Microbiol. 20 (1996) 605-611
97. Partanen K. Organic acids - their efficacy and modes of action in pigs. In: Piva A., Bach Knudsen K.E., and Lindberg J.E. (Eds). Gut Environment of Pigs (2001), Nottingham University Press, Loughborough 201-217
98. Partanen K.H., and Mroz Z. Organic acids for performance enhancement in pig diets. Nutr. Res. Rev. 12 (1999) 117-145
99. Pegg A.E. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J. 234 (1986) 240-262
100. Pignata S., Di Luccia A., Lamanda R., Menchise A., and D'Agostino L. Interaction of putrescine with nuclear oligopeptides in the enterocyte-like Caco-2 cells. Digestion 60 3 (1999) 255-261
101. Piva, A, 2000. Alternatives to antibiotics. In: Proceedings of the Animal Nutrition Association of Canada - Eastern Nutrition Conference, Montreal, Canada, pp. 81-32.
102. Piva A., Panciroli A., Meola E., and Formigoni A. Lactitol enhances short-chain-fatty acid and gas production by swine cecal microflora to a greater extent when fermenting low rather than high fiber diets. J. Nutr. 126 (1996) 280-289
103. Piva A., Meola E., Panciroli A., and Formigoni A. In vitro intestinal fermentation and modelling. J. Anim. Sci. 74 Suppl. 1 (1996) 173
104. Piva A., Anfossi P., Meola E., Pietri A., Panciroli A., Bertuzzi T., and Formigoni A. Effect of microencapsulation on absorption processes in swine. Livest. Prod. Sci. 51 (1997) 53-61
105. Piva, A, Meola, E, Fomigoni, A, Panciroli, A, Bertuzzi, T, Pietri, A, Mordenti, A, 1997b. Lactitol controls indole and 3-methylindole production by swine cecal microflora. In: Laplace, J.P, Fevrier, C, Barbeau, A, (Eds.), Proceedings of the 8th Int. Symposium on Digestive Physiology in Pigs. Saint Malo, France, 88, 470-32.
106. Piva A., Biagi G., Meola E., Panciroli A., and Formigoni A. Dairy whey influences swine cecal fermentation. J. Anim. Sci. 76 Suppl. 1 (1998) 172
107. Piva A., Morlacchini M., Casadei G., Biagi G., and Prandini A. Sodium butyrate improves growth performance of weaning piglets. Ital. J. Anim. Sci. 1 (2002) 35-41
108. Piva A., Prandini A., Fiorentini L., Morlacchini M., Galvano F., and Luchansky J.B. Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs. J. Anim. Sci. 80 3 (2002) 670-680
109. Piva A., Casadei G., and Biagi G. An organic acid blend can modulate swine intestinal fermentation and reduce microbial proteolysis. Can. J. Anim. Sci. 82 4 (2002) 527-532
110. Piva, A, Casadei, G, Gatta, P.P, Luchansky, J.B, Biagi, G, 2005. Effect of a synbiotic on intestinal proteolysis in vitro and feed efficiency in weaned pigs. Can. J. Anim. Sci. (in press).
111. Pluske R.P., Hampson D.J., and Williams I.H. Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livest. Prod. Sci. 51 (1997) 215-236
112. Raithel M., Matek M., Beankler H.W., Jorde W., and Hahn E.G. Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy. Int. Arch. Allergy Immunol. 108 (1995) 127-133
113. Regina D.C., Eisemann J.H., Lang J.A., and Argenzio R.A. Changes in gastric contents in pigs fed a finely ground and pelleted or coarsely ground meal diet. J. Anim. Sci. 77 10 (1999) 2721-2729
114. Renault P., Gaillardin C., and Heslot H. Role of malolactic fermentation in lactic acid bacteria. Biochimie 70 (1988) 375-379
115. Rerat A.A. Digestion and absorption of nutrients in the pig. World Rev. Nutr. Dietet. 37 (1981) 229-287
116. Roberfroid M.B. Prebiotics and synbiotics: concepts and nutritional properties. Br. J. Nutr. 80 4 (1998) S197-S202
117. Russell J.B., and Diez-Gonzalez F. The effects of fermentation acids on bacterial growth. Adv. Microb. Physiol. 39 (1998) 205-234
118. Russell J.B., Sniffen C.J., and van Soest P.J. Effect of carbohydrate limitation on degradation and utilization of casein by mixed rumen bacteria. J. Dairy Sci. 66 (1983) 763-775
119. Rychen G., and Nunes C.S. Effects of three microbial probiotics on postprandial porto-arterial concentration differences of glucose, galactose and amino-nitrogen in the young pig. Br. J. Nutr. 74 1 (1995) 19-26
120. Sakata, T, 1988. Chemical and physical trophic effects of dietary fibre on the intestine of monogastric animals. In: Buraczewska, L, Buraczewski, S, Pastuszewska, B, Zebrowska, T. (Eds.), Proceedings, 4th International Seminar on Digestive Physiology in the Pig. Polish Academy of Science, Jablonna, Poland, pp. 128-32.
121. Sakata T., and Setoyama H. Bi-phasic allometric growth of the small intestine, cecum and the proximal, middle, and distal colon of rats (Rattus norvegicus Berkenhout, 1764) before and after weaning. Comp. Biochem. Physiol. A. Physiol. 118 3 (1997) 897-902
122. Santos J., Saperas E., Nogueiras C., Mourelle M., Antolin M., Cadahia A., and Malagelada J.R. Release of mast cell mediators into the jejunum by cold pain stress in humans. Gastroenterology 114 (1998) 640-648
123. Scheppach W., Sommer H., Kirchner T., Paganelli G.M., Bartram P., Christl S., Richter F., Dusel G., and Kasper H. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 103 1 (1992) 51-56
124. Schofield P., Pitt R.E., and Pell A.N. Kinetics of fiber digestion from in vitro gas production. J. Anim. Sci. 72 (1994) 2980-2991
125. Scholten R.H., Van der Peet-Schwering C.M., den Hartog L.A., Balk M., Schrama J.W., and Verstegen M.W. Fermented wheat in liquid diets: effects on gastrointestinal characteristics in weanling piglets. J. Anim. Sci. 80 5 (2002) 1179-1186
126. Seild A., Tunici P., Ewen S.W.B., Grant G., Pusztai A., Bardoc S., and Perin A. Ileal mucosal growth during intraluminal infusion of ethylamine or putrescine. Am. J. Physiol. 249 (1985) G434-G438
127. Shi X.S., and Noblet J. Contribution of the hindgut to digestion of diets in growing pigs and adult sows: effect of diet composition. Livest. Prod. Sci. 34 (1993) 237-252
128. Sinkovics G., and Juhasz B. Development of the intestinal flora in suckling pigs. Acta Vet. Acad. Sci. Hung. 24 (1974) 375-381
129. Sissons J.W. Potential of probiotic organisms to prevent diarrhoea and promote digestion in farm animals - a review. J. Sci. Food Agric. 49 (1989) 1-13
130. Smith H.W., and Jones J.E.T. Observations on the alimentary tract and its bacterial flora in healthy and diseased pigs. J. Pathol. Bacteriol. 86 (1963) 387-412
131. Stewart C.S., and Bryant M.P. The rumen bacteria. In: Hobson P.N. (Ed). The Rumen Microbial Ecosystem (1988), Elsevier, Essex 21-76
132. Stokstad E.L.R. Antibiotics in animal nutrition. Physiol. Rev. 34 (1954) 25-38
133. Stokstad E.L.R., and Jukes T.H. Further observations on the animal protein factor. Proc. Soc. Biol. Exp. Med. 73 (1949) 523-526
134. Stokstad E.L.R., and Jukes T.H. The growth promoting effect of aureomycin on turkey poults. Poult. Sci. 29 (1950) 611-615
135. Stoll B., Burrin D.G., Henry J., Yu H., Jahoor F., and Reeds P.J. Substrate oxidation by the portal drained viscera of fed piglets. Am. J. Physiol. 277 1 Pt 1 (1999) E168-E175
136. Sutton, A.L, Matthew, A.G, Scheidt, A.B, Patterson, J.A, Kelly, D.T, 1991. Effects of carbohydrate sources and organic acids on intestinal microflora and performance of the weanling pig. In: Proceedings of the 5th International Symposium on Digestive Physiology in Pigs. Wageningen, The Netherlands, pp. 422-32.
137. Tabor C.W., and Tabor H. Polyamines. Annu. Rev. Biochem. 53 (1984) 749-790
138. Tannock G.W. Probiotics: A Critical Review (1999), Horizon Scientific Press, Wymondham
139. Taylor W.H. Studies on gastric proteolysis. 4. Proteinase activity of gastric juice and gastric mucosal extracts at pH 6 to 8. Biochem. J. 71 (1959) 626-632
140. Taylor W.H. Proteinases of the stomach in health and disease. Physiol. Rev. 42 (1962) 519-553
141. Thomlinson J.R., and Lawrence T.L.J. Dietary manipulation of gastric pH in the prophylaxis of enteric disease in weaned pigs: some field observations. Vet. Rec. 109 (1981) 120-122
142. Tielens A.G., and van Hellemond J.J. The electron transport chain in anaerobically functioning eukaryotes. Biochim. Biophys. Acta 1365 (1998) 71-78
143. Toledo H., Valenzuela M., Rivas A., and Jerez C.A. Acid stress response in Helicobacter pylori. FEMS Microbiol. Lett. 213 1 (2002) 67-72
144. Tran Q.H., Bongaerts J., Vlad D., and Unden G. Requirement for the proton pumping NADH dehydrogenase I of Escherichia coli in respiration of NADH to fumarate and its bioenergetic implications. Eur. J. Biochem. 244 (1997) 155-160
145. Treem W.R., Ahsan N., Shoup M., and Hyams J.S. Fecal short-chain fatty acids in children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. 18 2 (1994) 159-164
146. Tsiloyiannis V.K., Kyriakis S.C., Vlemmas J., and Sarris K. The effect of organic acids on the control of porcine post-weaning diarrhoea. Res. Vet. Sci. 70 3 (2001) 287-293
147. Tsuji K., Uehara A., Okumura T., Taniguchi Y., Kitamori S., Takasugi Y., and Namiki M. The gastric antisecretory action of lipopolysaccharide is blocked by indomethacin. Eur. J. Pharmacol. 210 2 (1992) 213-215
148. Uehara A., Okumura T., Okamura K., Takasugi Y., and Namiki M. Lipopolysaccharide-induced inhibition of gastric acid and pepsin secretion in rats. Eur. J. Pharmacol. 181 1-32 (1990) 141-145
149. Uehara A., Okumura T., Tsuji K., Taniguchi Y., Kitamori S., Takasugi Y., and Namiki M. Evidence that gastric antisecretory action of lipopolysaccharide is not due to a toxic effect on gastric parietal cells. Dig. Dis. Sci. 37 7 (1992) 1039-1044
150. Van Soest P.J. Nutritional Ecology of the Ruminants (1982), Comstock Publishing Associates, Cornell University Press, Ithaca, New York
151. Van Soest P.J., Robertson J.B., and Lewis B.A. Methods for dietary fiber, neutral detergent fiber and nonstarch polysaccharides in relation to animal nutrition. J. Dairy Sci. 74 (1991) 3583-3597
152. Vaughan E.E., Schut F., Heilig H.G., Zoetendal E.G., de Vos W.M., and Akkermans A.D. A molecular view of the intestinal ecosystem. Curr. Issues Intest. Microbiol. 1 1 (2000) 1-12
153. Vervaeke I.J., Dierick N.A., Demeyer D.I., and Decupyere J.A. Approach to the energetic importance of fiber digestion in pigs. II. An experimental approach to hindgut digestion. Anim. Feed Sci. Technol. 23 (1989) 169-194
154. Villarreal L., Heredia N.L., and Garcia S. Changes in protein synthesis and acid tolerance in Clostridium perfringens type A in response to acid shock. Int. Microbiol. 3 2 (2000) 113-116
155. Visek W.J. Diet and cell growth modulation by ammonia. Am. J. Clin. Nutr. 31 Suppl. 10 (1978) 216-220
156. Visek W.J. Ammonia: its effects on biological systems, metabolic hormones, and reproduction. J. Dairy Sci. 67 (1984) 481-498
157. Wallace H.M. The physiological role of the polyamines. Eur. J. Clin. Invest. 30 1 (2000) 1-3
158. Walton J.R. Modes of action of growth promoting agents. Vet. Res. Comm. 7 (1983) 1-7
159. Wang Y.Z., Cooke H.J., Su H.C., and Fertel R. Histamine augments colonic secretion in guinea pig distal colon. Am. J. Physiol. 258 (1990) 432-439
160. White A., and Bardocz S. Estimation of the polyamine body pool: contribution by de novo biosynthesis, diet and luminal bacteria. In: Bardocz S., and White A. (Eds). Polyamines in Health and Nutrition (1999), Kluwer Academic Publishers, Boston 117-122
161. White F., Wenham G., Sharman G.A.M., Jones A.S., Rattray E.A.S., and McDonald I. Stomach fermentation in relation to scour syndrome in the piglet. Br. J. Nutr. 23 (1969) 847-850
162. WHO, 1997. The medical impact of the use of antimicrobials in food animals, Berlin 13-32 October 1997.
163. Wingren U., Hallert C., Norrby K., and Enerback L. Histamine and mucosal mast cells in gluten enteropathy. Agents Actions 18 (1986) 266-268
164. Witte W. Medical consequences of antibiotic use in agriculture. Science 279 (1998) 996-997
165. Wondra K.J., Hancock J.D., Behnke K.C., and Hines R.H. Effects of dietary buffers on growth performance, nutrient digestibility, and stomach morphology in finishing pigs. J. Anim. Sci. 73 2 (1995) 414-420
166. Wyllie J.H., Limbosch J.M., and Nyhus L.M. Inhibition of gastric acid secretion by bacterial lipopolysaccharide. Nature 215 (1967) 879
167. Ziprin R.L., and Deloach J.R. Comparison of probiotics maintained by in vivo passage through laying hens and broilers. Poult. Sci. 72 4 (1993) 628-635
168. Zwietering M.H., Jongenburger I., Rombouts F.M., and van't Riet K. Modelling the bacterial growth curve. Appl. Environ. Microbiol. 56 (1990) 1875-1881
169. Zwietering M.H., Rombouts F.M., and van't Riet K. Comparison of definitions of the lag phase and the exponential phase in bacterial growth. J. Appl. Bacteriol. 72 (1992) 139-145