Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms

Preventive Veterinary Medicine

Volumn 31, Issue 1-2, 1997, Pages 95-112

  Bager, F ^a   Madsen, M ^a   Christensen, J ^a   Aarestrup, F M ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Antibiotic resistance; Avoparcin; Enterococcus faecium; Growth promoter; VRE

Indexed keywords

ANIMALIA; ENTEROCOCCUS; ENTEROCOCCUS FAECIUM; SUS SCROFA; VISCUM ALBUM;

ANTIINFECTIVE AGENT; AVOPARCIN; BACTERIUM ANTIBODY; GLYCOPEPTIDE; GROWTH PROMOTOR; VANCOMYCIN;

ANIMAL; ANIMAL DISEASE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; BIRD DISEASE; CHICKEN; COHORT ANALYSIS; DENMARK; DISEASE PREDISPOSITION; DRUG EFFECT; ENTEROCOCCUS FAECIUM; FEMALE; GERMFREE ANIMAL; IMMUNOLOGY; MALE; MICROBIOLOGY; POULTRY; RETROSPECTIVE STUDY; SWINE; SWINE DISEASE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; CHICKENS; COHORT STUDIES; DENMARK; DISEASE SUSCEPTIBILITY; DRUG RESISTANCE, MICROBIAL; ENTEROCOCCUS FAECIUM; FEMALE; GLYCOPEPTIDES; GRAM-POSITIVE BACTERIAL INFECTIONS; GROWTH SUBSTANCES; MALE; POULTRY; POULTRY DISEASES; RETROSPECTIVE STUDIES; SPECIFIC PATHOGEN-FREE ORGANISMS; SWINE; SWINE DISEASES; VANCOMYCIN;

EID: 0031178855     PISSN: 01675877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5877(96)01119-1     Document Type: Article

References (36)

1. Aalbæk, B., Rasmussen, J., Nielsen, B. and Olsen, J.E., 1991. Prevalence of antibiotic-resistant Escherichia coli in Danish pigs and cattle. APMIS, 99: 1103-1110.
2. Aarestrup, F.M., 1995. Occurrence of glycopeptide resistance among Enterococcus faecium isolates from conventional and ecological poultry farms. Microb. Drug Resist., 1: 255-257.
3. Anonymous, 1995. Recommendations for preventing the spread of vancomycin resistance. EID, 1: 66.
4. Arthur, M., Molinas, C., Depardieu, F. and Courvalin, P., 1993. Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriology, 175: 117-127.
5. Bates, J., Jordens, J.Z. and Griffiths, D.T., 1994. Farm animals as a putative reservoir for vancomycin-resistant enterococcal infection in man. J. Antimicrob. Chemother., 34: 507-516.
6. Bingen, E.H., Denamur, E., Lambert-Zechovsky, N.Y. and Elion, J., 1991. Evidence for the genetic unrelatedness of nosocomial vancomycin-resistant Enterococcus faecium strains in a pediatric hospital. J. Clin. Microbiol., 29: 1888-1892.
7. Casals, J.B. and Pringler, N., 1991. Antibacterial Sensitivity Testing using Neo-Sensitabs. Rosco Diagnostica, Taastrup, Denmark.
8. Courvalin, P., 1990. Resistance of enterococci to glycopeptides. Antimicrob. Agents Chemother., 34: 2291-2296.
9. Dean, A.G., Dean, J.A., Coulombier, D., Brendel, K.A., Smith, D.C., Burton, A.H., Dicker, R.C., Sullivan, K., Fagan, R.F. and Arner, T.G., 1994. Epi Info, Version 6: A Word Processing, Database, and Statistics Program for Epidemiology on Microcomputers. Centres for Disease Control and Prevention, Atlanta, GA.
10. Devriese, L.A., Pot, B. and Collins, M.D., 1993. Phenotypic identification of the genus Enterococcus and differentiation of phylogenetically distinct enterococcal species and species groups. J. Appl. Bacteriol., 75: 399-408.
11. Donner, A., 1993. The comparison of proportions in the presence of litter effects. Prev. Vet. Med., 18: 17-26.
12. Dutta, G.N. and Devriese, L.A., 1982. Susceptibility of faecal streptococci of poultry origin to nine growth-promoting agents. Appl. Environ. Microbiol., 44: 832-837.
13. Dutta, G.N. and Devriese, L.A., 1984. Observations on the in vitro sensitivity and resistance of Gram-positive intestinal bacteria of farm animals to growth-promoting antimicrobial agents. J. Appl. Bacteriol., 56: 117-123.
14. Frieden, T.R., Munsiff, S.S., Low, D.E., Willey, B.M., Williams, G., Faur, Y., Eisner, W., Warren, S. and Kreiswirth, B., 1993. Emergence of vancomycin-resistant enterococci in New York City. Lancet, 342: 76-79.
15. Goldmann, D.A., 1992. Vancomycin-resistant Enterococcus faecium: Headline news. Infect. Control Hosp. Epidemiol., 13: 695-699.
16. Grayson, M.L., Eliopoulos, G.M., Wennerstein, C.B., Ruoff, K.L., De Girolami, P.C., Ferraro, M.J. and Moellering, R.C., 1991. Increasing resistance to β-lactam antibiotics among clinical isolates of Enterococcus faecium. Antimicrob. Agents Chemother., 35: 2180-2184.
17. Greko, C. and Lindblad, J., 1996. Vancomycin sensitivity of enterococci from Swedish poultry and pigs. Proc. Food Associated Pathogens, Uppsala, Sweden, 6-8 May.
18. Jay, J.M., 1978 Modem Food Microbiology. 2nd edn. Van Nostrand Reinhold, New York, pp. 299-302.
19. Johnson, A.P., Uttly, A.H.C., Woodford, N. and George, R.C., 1990. Resistance to vancomycin and teicoplanin: An emerging clinical problem. Clin. Microbiol. Rev., 3: 280-291.
20. Jordens, J.Z., Bates, J. and Griffiths, D.T., 1994. Faecal carriage and nosocomial spread of vancomycin-resistant Enterococcus faecium. J. Antimicrob. Chemother., 34: 515-528.
21. Kaukas, A., Hinton, M. and Linton, A.H., 1988. The effect of growth-promoting antibiotics on the faecal enterococci of healthy young chickens. J. Appl. Bacteriol., 64: 57-64.
22. Klare, I., Heier, H., Claus, H., Reissbrodt, R. and Witte, W., 1995. vanA-mediated high-level glycopeptide resistance in Enterococcus faecium from animal husbandry. FEMS Microbiol. Lett., 125: 165-172.
23. Kruse, H., 1995. The use of avoparcin as a feed additive and the occurrence of vancomycin-resistant Enterococcus spp. in poultry production. Report, Norwegian College of Veterinary Medicine and the State Veterinary Laboratories, Oslo, August 1995.
24. Lai, M.H. and Kirsch, D.R., 1996. Induction signals for vancomycin resistance encoded by the vanA gene cluster in Enterococcus faecium. Antimicrob. Agents Chemother., 40: 1645-1648.
25. Leclerc, R., Derlot, E., Duval, J. and Courvalin, P., 1988. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N. Engl. J. Med., 319: 157-161.
26. Linton, A.H., Hinton, M.H. and Al-Chalaby, Z.A.M., 1985. Monitoring for antibiotic resistance in enterococci consequent upon feeding growth promoters active against Gram-positive bacteria. J. Vet. Pharmacol. Therap., 8: 62-70.
27. Moellering, R.C., 1990. The enterococci: An enigma and a continuing therapeutic challenge. Eur. J. Clin. Microbiol. Infect, Dis., 9: 73-74.
28. Murray, B.E., 1990. The life and times of the enterococcus. Clin. Microbiol. Rev., 3: 46-65.
29. Paul, S.M., Finelli, L., Crane, G. and Spitalny, K.C., 1995. Statewide surveillance for antibiotic-resistant bacteria-New Jersey, 1992-1994. MMWR, 44: 504-506.
30. Rubin, L.G., Tucci, V., Cercenado, E., Eliopoulos, G. and Isenberg, H.D., 1992. Vancomycin-resistant Enterococcus faecium in hospitalized children. Infect. Control Hosp. Epidemiol., 13: 700-705.
31. Sahm, D.F. and Washington II, J.A., 1991. Antibacterial susceptibility tests: Dilution methods. In: A. Balows (Editor), Manual of Clinical Microbiology. American Society for Microbiology, Washington, DC, pp. 1105-1116.
32. Schaberg, D.R., Culver, D.H.R. and Gayes, R.P., 1991. Major trends in the microbial etiology of nosocomial infection. Am. J. Med., 91: 72-76.
33. Spera, R.V. and Farber, B.F., 1994. Multidrug-resistant Enterococcus faecium. An untreatable nosocomial pathogen. Drugs, 48: 678-688.
34. Statistical Analysis Systems Institute, 1989. SAS User's Guide. SAS Institute, Cary, NC.
35. Walton, J.R., 1978. The effect of dietary avoparcin on the antibiotic resistance patterns of enteric and pharyngeal bacteria isolated from broiler chickens. Zbl. Vet. Med. B, 25: 290-300.
36. Whitman, M.S., Pitsakis, P.G., DeJesus, E., Osborne, A.J., Levison, M.E. and Johnson, C.C., 1996. Gastrointestinal tract colonization with vancomycin-resistant Enterococcus faecium in an animal model. Antimicrob. Agents Chemother., 40: 1526-1530.