-
1
-
-
0026355025
-
The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli
-
J.A. Adams, C.A. Fierke, and S.J. Benkovic The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli Biochemistry 30 1991 11046 11054
-
(1991)
Biochemistry
, vol.30
, pp. 11046-11054
-
-
Adams, J.A.1
Fierke, C.A.2
Benkovic, S.J.3
-
2
-
-
27744451421
-
Specific recognition and cleavage of the plus-strand primer by reverse transcriptase
-
A. Atwood-Moore, K. Ejebe, and H.L. Levin Specific recognition and cleavage of the plus-strand primer by reverse transcriptase J. Virol. 79 2005 14863 14875
-
(2005)
J. Virol.
, vol.79
, pp. 14863-14875
-
-
Atwood-Moore, A.1
Ejebe, K.2
Levin, H.L.3
-
3
-
-
33748195107
-
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
-
L.A. Banaszynski, L.C. Chen, L.A. Maynard-Smith, A.G. Ooi, and T.J. Wandless A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules Cell 126 2006 995 1004
-
(2006)
Cell
, vol.126
, pp. 995-1004
-
-
Banaszynski, L.A.1
Chen, L.C.2
Maynard-Smith, L.A.3
Ooi, A.G.4
Wandless, T.J.5
-
4
-
-
53549129978
-
Chemical control of protein stability and function in living mice
-
L.A. Banaszynski, M.A. Sellmyer, C.H. Contag, T.J. Wandless, and S.H. Thorne Chemical control of protein stability and function in living mice Nat. Med. 14 2008 1123 1127
-
(2008)
Nat. Med.
, vol.14
, pp. 1123-1127
-
-
Banaszynski, L.A.1
Sellmyer, M.A.2
Contag, C.H.3
Wandless, T.J.4
Thorne, S.H.5
-
5
-
-
0018100877
-
The penetration of antibiotics into cerebrospinal fluid and brain tissue
-
R.W. Barling, and J.B. Selkon The penetration of antibiotics into cerebrospinal fluid and brain tissue J. Antimicrob. Chemother. 4 1978 203 227
-
(1978)
J. Antimicrob. Chemother.
, vol.4
, pp. 203-227
-
-
Barling, R.W.1
Selkon, J.B.2
-
6
-
-
0031443372
-
Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant
-
C.E. Cameron, and S.J. Benkovic Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant Biochemistry 36 1997 15792 15800
-
(1997)
Biochemistry
, vol.36
, pp. 15792-15800
-
-
Cameron, C.E.1
Benkovic, S.J.2
-
7
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
P. Carmeliet, V. Ferreira, G. Breier, S. Pollefeyt, L. Kieckens, M. Gertsenstein, M. Fahrig, A. Vandenhoeck, K. Harpal, and C. Eberhardt Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele Nature 380 1996 435 439
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
Pollefeyt, S.4
Kieckens, L.5
Gertsenstein, M.6
Fahrig, M.7
Vandenhoeck, A.8
Harpal, K.9
Eberhardt, C.10
-
8
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G. Rasmussen, F.S. Thian, T.S. Kobilka, H.J. Choi, P. Kuhn, W.I. Weis, and B.K. Kobilka High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science 318 2007 1258 1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
-
9
-
-
13144276290
-
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity
-
T. Clackson, W. Yang, L.W. Rozamus, M. Hatada, J.F. Amara, C.T. Rollins, L.F. Stevenson, S.R. Magari, S.A. Wood, and N.L. Courage Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity Proc. Natl. Acad. Sci. USA 95 1998 10437 10442
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10437-10442
-
-
Clackson, T.1
Yang, W.2
Rozamus, L.W.3
Hatada, M.4
Amara, J.F.5
Rollins, C.T.6
Stevenson, L.F.7
Magari, S.R.8
Wood, S.A.9
Courage, N.L.10
-
10
-
-
0028213449
-
Heat-inducible degron: A method for constructing temperature-sensitive mutants
-
R.J. Dohmen, P. Wu, and A. Varshavsky Heat-inducible degron: a method for constructing temperature-sensitive mutants Science 263 1994 1273 1276
-
(1994)
Science
, vol.263
, pp. 1273-1276
-
-
Dohmen, R.J.1
Wu, P.2
Varshavsky, A.3
-
11
-
-
33847636046
-
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis
-
M.G. Dominguez, V.C. Hughes, L. Pan, M. Simmons, C. Daly, K. Anderson, I. Noguera-Troise, A.J. Murphy, D.M. Valenzuela, and S. Davis Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis Proc. Natl. Acad. Sci. USA 104 2007 3243 3248
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 3243-3248
-
-
Dominguez, M.G.1
Hughes, V.C.2
Pan, L.3
Simmons, M.4
Daly, C.5
Anderson, K.6
Noguera-Troise, I.7
Murphy, A.J.8
Valenzuela, D.M.9
Davis, S.10
-
12
-
-
77952378704
-
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes
-
J.D. Dvorin, D.C. Martyn, S.D. Patel, J.S. Grimley, C.R. Collins, C.S. Hopp, A.T. Bright, S. Westenberger, E. Winzeler, and M.J. Blackman A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes Science 328 2010 910 912
-
(2010)
Science
, vol.328
, pp. 910-912
-
-
Dvorin, J.D.1
Martyn, D.C.2
Patel, S.D.3
Grimley, J.S.4
Collins, C.R.5
Hopp, C.S.6
Bright, A.T.7
Westenberger, S.8
Winzeler, E.9
Blackman, M.J.10
-
13
-
-
0028071115
-
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter
-
P.A. Furth, L. St. Onge, H. Boger, P. Gruss, M. Gossen, A. Kistner, H. Bujard, and L. Hennighausen Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter Proc. Natl. Acad. Sci. USA 91 1994 9302 9306
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9302-9306
-
-
Furth, P.A.1
St. Onge, L.2
Boger, H.3
Gruss, P.4
Gossen, M.5
Kistner, A.6
Bujard, H.7
Hennighausen, L.8
-
14
-
-
33847658304
-
Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases
-
C. Gaveriaux-Ruff, and B.L. Kieffer Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases Pharmacol. Ther. 113 2007 619 634
-
(2007)
Pharmacol. Ther.
, vol.113
, pp. 619-634
-
-
Gaveriaux-Ruff, C.1
Kieffer, B.L.2
-
15
-
-
36749062385
-
Rapid control of protein level in the apicomplexan Toxoplasma gondii
-
A. Herm-Götz, C. Agop-Nersesian, S. Munter, J.S. Grimley, T.J. Wandless, F. Frischknecht, and M. Meissner Rapid control of protein level in the apicomplexan Toxoplasma gondii Nat. Methods 4 2007 1003 1005
-
(2007)
Nat. Methods
, vol.4
, pp. 1003-1005
-
-
Herm-Götz, A.1
Agop-Nersesian, C.2
Munter, S.3
Grimley, J.S.4
Wandless, T.J.5
Frischknecht, F.6
Meissner, M.7
-
17
-
-
0034919257
-
Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers
-
J.D. Iuliucci, S.D. Oliver, S. Morley, C. Ward, J. Ward, D. Dalgarno, T. Clackson, and H.J. Berger Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers J. Clin. Pharmacol. 41 2001 870 879
-
(2001)
J. Clin. Pharmacol.
, vol.41
, pp. 870-879
-
-
Iuliucci, J.D.1
Oliver, S.D.2
Morley, S.3
Ward, C.4
Ward, J.5
Dalgarno, D.6
Clackson, T.7
Berger, H.J.8
-
18
-
-
0028951190
-
Methotrexate inhibits proteolysis of dihydrofolate reductase by the N-end rule pathway
-
J.A. Johnston, E.S. Johnson, P.R. Waller, and A. Varshavsky Methotrexate inhibits proteolysis of dihydrofolate reductase by the N-end rule pathway J. Biol. Chem. 270 1995 8172 8178
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 8172-8178
-
-
Johnston, J.A.1
Johnson, E.S.2
Waller, P.R.3
Varshavsky, A.4
-
19
-
-
0033555642
-
Analysis of a conditional degradation signal in yeast and mammalian cells
-
F. Lévy, J.A. Johnston, and A. Varshavsky Analysis of a conditional degradation signal in yeast and mammalian cells Eur. J. Biochem. 259 1999 244 252
-
(1999)
Eur. J. Biochem.
, vol.259
, pp. 244-252
-
-
Lévy, F.1
Johnston, J.A.2
Varshavsky, A.3
-
20
-
-
33847405867
-
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice
-
K.J. Liu, J.R. Arron, K. Stankunas, G.R. Crabtree, and M.T. Longaker Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice Nature 446 2007 79 82
-
(2007)
Nature
, vol.446
, pp. 79-82
-
-
Liu, K.J.1
Arron, J.R.2
Stankunas, K.3
Crabtree, G.R.4
Longaker, M.T.5
-
21
-
-
11844252081
-
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: Scope and mechanism
-
T.J. Magliery, C.G. Wilson, W. Pan, D. Mishler, I. Ghosh, A.D. Hamilton, and L. Regan Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism J. Am. Chem. Soc. 127 2005 146 157
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 146-157
-
-
Magliery, T.J.1
Wilson, C.G.2
Pan, W.3
Mishler, D.4
Ghosh, I.5
Hamilton, A.D.6
Regan, L.7
-
22
-
-
0021989114
-
Dihydrofolate reductase. The stereochemistry of inhibitor selectivity
-
D.A. Matthews, J.T. Bolin, J.M. Blurridge, D.J. Filman, K.W. Volz, and J. Kraut Dihydrofolate reductase. The stereochemistry of inhibitor selectivity J. Biol. Chem. 260 1985 392 399
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 392-399
-
-
Matthews, D.A.1
Bolin, J.T.2
Blurridge, J.M.3
Filman, D.J.4
Volz, K.W.5
Kraut, J.6
-
23
-
-
61949341072
-
Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants
-
T.T. Nielsen, J. Jakobsson, N. Rosenqvist, and C. Lundberg Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants BMC Biotechnol. 9 2009 13
-
(2009)
BMC Biotechnol.
, vol.9
, pp. 13
-
-
Nielsen, T.T.1
Jakobsson, J.2
Rosenqvist, N.3
Lundberg, C.4
-
24
-
-
73349085934
-
An auxin-based degron system for the rapid depletion of proteins in nonplant cells
-
K. Nishimura, T. Fukagawa, H. Takisawa, T. Kakimoto, and M. Kanemaki An auxin-based degron system for the rapid depletion of proteins in nonplant cells Nat. Methods 6 2009 917 922
-
(2009)
Nat. Methods
, vol.6
, pp. 917-922
-
-
Nishimura, K.1
Fukagawa, T.2
Takisawa, H.3
Kakimoto, T.4
Kanemaki, M.5
-
25
-
-
0033558051
-
A cytomegalovirus glycoprotein re-routes MHC class i complexes to lysosomes for degradation
-
U. Reusch, W. Muranyi, P. Lucin, H.G. Burgert, H. Hengel, and U.H. Koszinowski A cytomegalovirus glycoprotein re-routes MHC class I complexes to lysosomes for degradation EMBO J. 18 1999 1081 1091
-
(1999)
EMBO J.
, vol.18
, pp. 1081-1091
-
-
Reusch, U.1
Muranyi, W.2
Lucin, P.3
Burgert, H.G.4
Hengel, H.5
Koszinowski, U.H.6
-
26
-
-
60849106255
-
A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development
-
I. Russo, A. Oksman, B. Vaupel, and D.E. Goldberg A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development Proc. Natl. Acad. Sci. USA 106 2009 1554 1559
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1554-1559
-
-
Russo, I.1
Oksman, A.2
Vaupel, B.3
Goldberg, D.E.4
-
27
-
-
3042660150
-
Structure, dynamics, and catalytic function of dihydrofolate reductase
-
J.R. Schnell, H.J. Dyson, and P.E. Wright Structure, dynamics, and catalytic function of dihydrofolate reductase Annu. Rev. Biophys. Biomol. Struct. 33 2004 119 140
-
(2004)
Annu. Rev. Biophys. Biomol. Struct.
, vol.33
, pp. 119-140
-
-
Schnell, J.R.1
Dyson, H.J.2
Wright, P.E.3
-
28
-
-
0015274059
-
Distribution and elimination of trimethoprim in pregnant and newborn rats
-
R. Schulz Distribution and elimination of trimethoprim in pregnant and newborn rats Naunyn Schmiedebergs Arch. Pharmacol. 272 1972 369 377
-
(1972)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.272
, pp. 369-377
-
-
Schulz, R.1
-
29
-
-
0025361947
-
Dihydrofolate reductase as a therapeutic target
-
B.I. Schweitzer, A.P. Dicker, and J.R. Bertino Dihydrofolate reductase as a therapeutic target FASEB J. 4 1990 2441 2452
-
(1990)
FASEB J.
, vol.4
, pp. 2441-2452
-
-
Schweitzer, B.I.1
Dicker, A.P.2
Bertino, J.R.3
-
30
-
-
0346156074
-
Conditional protein alleles using knockin mice and a chemical inducer of dimerization
-
K. Stankunas, J.H. Bayle, J.E. Gestwicki, Y.M. Lin, T.J. Wandless, and G.R. Crabtree Conditional protein alleles using knockin mice and a chemical inducer of dimerization Mol. Cell 12 2003 1615 1624
-
(2003)
Mol. Cell
, vol.12
, pp. 1615-1624
-
-
Stankunas, K.1
Bayle, J.H.2
Gestwicki, J.E.3
Lin, Y.M.4
Wandless, T.J.5
Crabtree, G.R.6
-
31
-
-
33744991560
-
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors
-
D.M. Suter, L. Cartier, E. Bettiol, D. Tirefort, M.E. Jaconi, M. Dubois-Dauphin, and K.H. Krause Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors Stem Cells 24 2006 615 623
-
(2006)
Stem Cells
, vol.24
, pp. 615-623
-
-
Suter, D.M.1
Cartier, L.2
Bettiol, E.3
Tirefort, D.4
Jaconi, M.E.5
Dubois-Dauphin, M.6
Krause, K.H.7
-
33
-
-
0029869449
-
An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues
-
M. Zaccolo, D.M. Williams, D.M. Brown, and E. Gherardi An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues J. Mol. Biol. 255 1996 589 603
-
(1996)
J. Mol. Biol.
, vol.255
, pp. 589-603
-
-
Zaccolo, M.1
Williams, D.M.2
Brown, D.M.3
Gherardi, E.4
|