A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 5, 2009, Pages 1554-1559

  Russo, Ilaria ^a   Oksman, Anna ^a   Vaupel, Barbara ^a   Goldberg, Daniel E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; Cysteine protease; Essentiality; Inducible; Malaria

Indexed keywords

CALPAIN; CYSTEINE PROTEINASE; HYBRID PROTEIN;

ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CODON; DRUG TARGETING; GENE DISRUPTION; GENE FUNCTION; GENE IDENTIFICATION; IMMUNOPRECIPITATION; MISSENSE MUTATION; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; WESTERN BLOTTING; ANIMAL; CELL CYCLE G1 PHASE; CLASSIFICATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALVEOLATA; PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES;

ANIMALS; BLOTTING, WESTERN; CALPAIN; FLOW CYTOMETRY; G1 PHASE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLASMODIUM FALCIPARUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S PHASE;

EID: 60849106255     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806926106     Document Type: Article

References (25)

1. Rosenthal PJ (2004) Cysteine proteases of malaria parasites. Int J Parasitol 34:1489-1499.
2. Wu Y, Wang X, Liu X, Wang Y (2003) Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite. Genome Res 13:601-616.
3. Croall DE, Ersfeld K (2007) The calpains: Modular designs and functional diversity. Genome Biol 8:218.
4. Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83:731-801.
5. Sorimachi H (2004) Handbook of Proteolytic Enzymes (Elsevier, London), pp 1206-1225.
6. Sorimachi H, Suzuki K (2001) The structure of calpain. J Biochem (Tokyo) 129:653-664.
7. Perrin BJ, Huttenlocher A (2002) Calpain. Int J Biochem Cell Biol 34:722-725.
8. lanchard H, et al. (1997) Structure of a calpain Ca2+-binding domain reveals a novel EF-hand and Ca2+-induced conformational changes. Nat Struct Biol 4:532-538.
9. Bozdech Z, et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 1:E5.
10. Le Roch KG, et al. (2003) Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301:1503-1508.
11. Duraisingh MT, Triglia T, Cowman AF (2002) Negative selection of lasmodium falciparum reveals targeted gene deletion by double cross-over recombination. Int J Parasitol 32:81-89.
12. Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ (2006) A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126:995-1004.
13. Armstrong CM, Goldberg DE (2007) An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods 4:1007-1009.
14. Janossy J, et al. (2004) Calpain as a multi-site regulator of cell cycle. Biochem Pharmacol 67:1513-1521.
15. Zhang W, Lu Q, Xie ZJ, Mellgren RL (1997) Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: Evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition. Oncogene 14:255-263.
16. Janse CJ, et al. (2003) Malaria parasites lacking eEF1a have a normal S/M phase yet grow more slowlydue to a longer G1 phase. MolMicrobiol50:1539-1551.
17. Boisvert FM, van Koningsbruggen S, Navascues J, Lamond AI (2007) The multifunctional nucleolus. Nat Rev Mol Cell Biol 8:574-585.
18. Francis SE, et al. (1994) Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase. EMBO J13:306-317.
19. Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193:673-675.
20. LambrosC, Vanderberg JP (1979)Synchronization of Plasmodium falciparumerythro- cytic stages in culture. J Parasitol65:418-420.
21. Dluzewski AR, Ling IT, Rangachari K, Bates PA, Wilson RJ (1984) A simple method for isolating viable mature parasites of Plasmodium falciparum from cultures. Trans R Soc Trop Med Hyg 78:622-624.
22. Paul F, Roath S, Melville D, Warhurst DC, Osisanya JO (1981) Separation of malaria- infected erythrocytes from whole blood: Use of a selective high-gradient magnetic separation technique. Lancet 2:70-71.
23. Fidock DA, Wellems TE (1997) Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but dos not affect the intrinsic activity of proguanil. ProcNatl Acad Sci USA94:10931-10936.
24. Wu Y, Kirkman LA, Wellems TE (1996) Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci USA 93:1130-1134.
25. Klemba M, Beatty W, Gluzman I, Goldberg DE (2004) Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum. J Cell Biol 164:47-56.