메뉴 건너뛰기




Volumn 37, Issue 6, 1998, Pages 429-435

The pharmacological role of P-glycoprotein in the intestinal epithelium

Author keywords

Intestinal secretion; Intestine; Oral bioavailability; P glycoprotein; Reversal agents

Indexed keywords

CARRIER PROTEIN; CYCLOSPORIN A; GLYCOPROTEIN P;

EID: 0032101275     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1998.0326     Document Type: Article
Times cited : (118)

References (40)
  • 1
    • 0343488673 scopus 로고    scopus 로고
    • Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
    • 1. Hunter J, Hirst BH. Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv Drug Deliv Rev 1997; 25: 129-57.
    • (1997) Adv Drug Deliv Rev , vol.25 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 3
    • 0029782485 scopus 로고    scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • 3. Tsuji A, Tamai I. Carrier-mediated intestinal transport of drugs. Pharm Res 1996; 13: 963-77.
    • (1996) Pharm Res , vol.13 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 4
    • 0031022120 scopus 로고    scopus 로고
    • Applications of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium
    • 4. Gan L-SL, Thakker DR. Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium. Adv Drug Deliv Rev 1997; 23: 77-98.
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 77-98
    • Gan, L.-S.L.1    Thakker, D.R.2
  • 5
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • 5. Aungst BJ. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J Pharm Sci 1993; 82: 979-87.
    • (1993) J Pharm Sci , vol.82 , pp. 979-987
    • Aungst, B.J.1
  • 6
    • 0025944972 scopus 로고
    • Pharmacokinetics of 2′,3′-dideoxyinosine in patients with severe human immunodeficiency infection. II. The effects of different oral formulations and the presence of other medications
    • 6. Hartman NR, Yarchoan R, Pluda JM, Thomas RV, Wyvill KM, Flora KP, Broder S, Johns DG. Pharmacokinetics of 2′,3′-dideoxyinosine in patients with severe human immunodeficiency infection. II. The effects of different oral formulations and the presence of other medications. Clin Pharmacol Ther 1991; 50: 278-85.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 278-285
    • Hartman, N.R.1    Yarchoan, R.2    Pluda, J.M.3    Thomas, R.V.4    Wyvill, K.M.5    Flora, K.P.6    Broder, S.7    Johns, D.G.8
  • 7
    • 0020900115 scopus 로고
    • Elimination of drugs by passive diffusion from blood to intestinal lumen: Factors influencing nonbiliary excretion by the intestinal tract
    • 7. Dayton PG, Israili ZH, Henderson JD. Elimination of drugs by passive diffusion from blood to intestinal lumen: factors influencing nonbiliary excretion by the intestinal tract. Drug Metab Rev 1983; 14: 1193-206.
    • (1983) Drug Metab Rev , vol.14 , pp. 1193-1206
    • Dayton, P.G.1    Israili, Z.H.2    Henderson, J.D.3
  • 8
    • 0021737426 scopus 로고
    • Enhancement of xenobiotic elimination: Role of intestinal excretion
    • 8. Israili ZH, Dayton PG. Enhancement of xenobiotic elimination: role of intestinal excretion. Drug Metab Rev 1984; 15: 1123-59.
    • (1984) Drug Metab Rev , vol.15 , pp. 1123-1159
    • Israili, Z.H.1    Dayton, P.G.2
  • 9
    • 0018307205 scopus 로고
    • Elimination of drugs by active intestinal transport
    • 9. George CF, Gruchy BS. Elimination of drugs by active intestinal transport. J Pharm Pharmacol 1979; 31: 643-4.
    • (1979) J Pharm Pharmacol , vol.31 , pp. 643-644
    • George, C.F.1    Gruchy, B.S.2
  • 11
    • 0001152155 scopus 로고
    • The gastric secretion of drugs: A pH partition hypothesis
    • 11. Shore PA, Brodie BB, Hogben CAM. The gastric secretion of drugs: a pH partition hypothesis. J Pharmacol Exp Ther 1957; 119: 361-9.
    • (1957) J Pharmacol Exp Ther , vol.119 , pp. 361-369
    • Shore, P.A.1    Brodie, B.B.2    Hogben, C.A.M.3
  • 12
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • 12. Ford JM, Hait WN. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 1990; 42: 155-99.
    • (1990) Pharmacol Rev , vol.42 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 13
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • 13. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993; 62: 385-427.
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 15
    • 0029860174 scopus 로고    scopus 로고
    • Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdrla P-glycoprotein
    • 15. Mayer U, Wagenaar E, Beijnen JH, Smit JW, Meijer DKF, van Asperen J, Borst P, Schinkel AH. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdrla P-glycoprotein. Br J Pharmacol 1996; 119: 1038-44.
    • (1996) Br J Pharmacol , vol.119 , pp. 1038-1044
    • Mayer, U.1    Wagenaar, E.2    Beijnen, J.H.3    Smit, J.W.4    Meijer, D.K.F.5    Van Asperen, J.6    Borst, P.7    Schinkel, A.H.8
  • 16
    • 0030781139 scopus 로고    scopus 로고
    • Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833
    • 16. Mayer U, Wagenaar E, Dorobek B, Beijnen JH, Borst P, Schinkel AH. Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833. J Clin Invest 1997; 100: 2430-6.
    • (1997) J Clin Invest , vol.100 , pp. 2430-2436
    • Mayer, U.1    Wagenaar, E.2    Dorobek, B.3    Beijnen, J.H.4    Borst, P.5    Schinkel, A.H.6
  • 17
    • 9044245300 scopus 로고    scopus 로고
    • Inhibition of the intestinal digoxin absorption and exsorption by quinidine
    • 17. Su S-F, Huang J-D. Inhibition of the intestinal digoxin absorption and exsorption by quinidine. Drug Metab Dispos 1996; 24: 142-7.
    • (1996) Drug Metab Dispos , vol.24 , pp. 142-147
    • Su, S.-F.1    Huang, J.-D.2
  • 18
    • 0029800447 scopus 로고    scopus 로고
    • Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
    • 18. Terao T, Hisanaga E, Sai Y, Tamai I, Tsuji A. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J Pharm Pharmacol 1996; 48: 1083-9.
    • (1996) J Pharm Pharmacol , vol.48 , pp. 1083-1089
    • Terao, T.1    Hisanaga, E.2    Sai, Y.3    Tamai, I.4    Tsuji, A.5
  • 19
    • 0002690481 scopus 로고    scopus 로고
    • Pharmacological treatment of heart failure
    • Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. USA: McGraw-Hill
    • 19. Kelly RA, Smith TW. Pharmacological treatment of heart failure. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. The pharmacological basis of therapeutics. USA: McGraw-Hill, 1996: 809-38.
    • (1996) The Pharmacological Basis of Therapeutics , pp. 809-838
    • Kelly, R.A.1    Smith, T.W.2
  • 20
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • 20. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJJ, Roden DM. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998; 101: 289-94.
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3    Leake, B.4    Wood, A.J.J.5    Roden, D.M.6
  • 24
    • 0026611746 scopus 로고
    • Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity
    • 24. Keller RP, Altermatt HJ, Donatsch P, Zihlmann H, Laissue JA, Hiestand PC. Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int J Cancer 1992; 51: 433-8.
    • (1992) Int J Cancer , vol.51 , pp. 433-438
    • Keller, R.P.1    Altermatt, H.J.2    Donatsch, P.3    Zihlmann, H.4    Laissue, J.A.5    Hiestand, P.C.6
  • 25
    • 0028801904 scopus 로고
    • Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
    • 25. Leu B-L, Huang J-D. Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother Pharmacol 1995; 35: 432-6.
    • (1995) Cancer Chemother Pharmacol , vol.35 , pp. 432-436
    • Leu, B.-L.1    Huang, J.-D.2
  • 26
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporinemetabolizing enzyme explains interactions of cyclosporine with other drugs
    • 26. Kronbach T, Fischer V, Meyer UA. Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporinemetabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 1988; 43: 630-5.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 27
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • 27. Wacher VJ, Wu C-Y, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995; 13: 129-34.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.-Y.2    Benet, L.Z.3
  • 28
    • 0030772347 scopus 로고    scopus 로고
    • Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters
    • 28. Tamai I, Saheki A, Saitoh R, Sai Y, Yamada I, Tsuji A. Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters. J Pharmacol Exp Ther 1997; 283: 108-15.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 108-115
    • Tamai, I.1    Saheki, A.2    Saitoh, R.3    Sai, Y.4    Yamada, I.5    Tsuji, A.6
  • 30
  • 32
    • 0029986277 scopus 로고    scopus 로고
    • Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro - In vivo correlation
    • 32. Fricker G, Drewe J, Huwyler J, Gutmann H, Beglinger C. Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro - in vivo correlation. Br J Pharmacol 1996; 118: 1841-7.
    • (1996) Br J Pharmacol , vol.118 , pp. 1841-1847
    • Fricker, G.1    Drewe, J.2    Huwyler, J.3    Gutmann, H.4    Beglinger, C.5
  • 38
    • 0030059953 scopus 로고    scopus 로고
    • Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
    • 38. Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996; 49: 311-18.
    • (1996) Mol Pharmacol , vol.49 , pp. 311-318
    • Schuetz, E.G.1    Beck, W.T.2    Schuetz, J.D.3
  • 40


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.