Depression and obesity: Do shared genes explain the relationship?

Depression and Anxiety

Volumn 27, Issue 9, 2010, Pages 799-806

  Afari, Niloofar ^a,b   Noonan, Carolyn ^c   Goldberg, Jack ^c,d   Roy Byrne, Peter ^e   Schur, Ellen ^c   Golnari, Golnaz ^a   Buchwald, Dedra ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Vietnam Era Twin Registry   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Depression; Genetics; Heritability; Obesity; Twins

Indexed keywords

ADULT; ARTICLE; BIVARIATE ANALYSIS; BODY HEIGHT; BODY WEIGHT; DEPRESSION; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; FEMALE; GENETIC CORRELATION; HUMAN; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; OBESITY; PRIORITY JOURNAL; SELF REPORT; UNITED STATES; UNIVARIATE ANALYSIS;

ADULT; BODY MASS INDEX; DEPRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; MIDDLE AGED; MODELS, GENETIC; OBESITY; PHENOTYPE; REGISTRIES; RISK FACTORS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; WASHINGTON; YOUNG ADULT;

EID: 77956826852     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.20704     Document Type: Article

References (79)

1. Stunkard AJ, Faith MS, Allison KC. Depression and obesity. Biol Psychiatry 2003;54:330-337.
2. Kress AM, Peterson MR, Hartzell MC. Association between obesity and depressive symptoms among U.S. military active duty service personnel, 2002. J Psychosom Res 2006;60:263-271.
3. Simon GE, Von Korff M, Saunders K et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry 2006;63:824-830.
4. Kessler RC, McGonagle KA, Zhao S et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994;51:8-19.
5. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. J Am Med Assoc 2002;288:1723-1727.
6. Wyatt SB, Winters KP, Dubbert PM. Overweight and obesity: Prevalence, consequences, and causes of a growing public health problem. Am J Med Sci 2006;331:166-174.
7. Katon W, Lin EH, Kroenke K. The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 2007;29:147-155.
8. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults-the evidence report. Obes Res 1998;6: 51S-209S.
9. Schulz R, Beach SR, Ives DG et al. Association between depression and mortality in older adults: The Cardiovascular Health Study. Arch Intern Med 2000;160:1761-1768.
10. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care 2001;24:1069-1078.
11. Pohjasvaara T, Vataja R, Leppavuori A, Kaste M, Erkinjuntti T. Depression is an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol 2001;8:315-319.
12. Robbins J, Hirsch C, Whitmer R, Cauley J, Harris T. The association of bone mineral density and depression in an older population. J Am Geriatr Soc 2001;49:732-736.
13. Koenig HG, George LK, Larson DB et al. Depressive symptoms and nine-year survival of 1,001 male veterans hospitalized with medical illness. Am J Geriatr Psychiatry 1999;7:124-131.
14. Abramson J, Berger A, Krumholz HM, Vaccarino V. Depression and risk of heart failure among older persons with isolated systolic hypertension. Arch Intern Med 2001;161:1725-1730. (Pubitemid 32679547)
15. Kasen S, Cohen P, Chen H, Must A. Obesity and psychopathology in women: A three decade prospective study. Int J Obes (Lond) 2008;32:558-566.
16. Pine DS, Goldstein RB, Wolk S, Weissman MM. The association between childhood depression and adulthood body mass index. Pediatrics 2001;107:1049-1056.
17. Roberts RE, Kaplan GA, Shema SJ, Strawbridge WJ. Are the obese at greater risk for depression? Am J Epidemiol 2000;152:163-170.
18. Roberts RE, Deleger S, Strawbridge WJ, Kaplan GA. Prospective association between obesity and depression: Evidence from the Alameda County Study. Int J Obes Relat Metab Disord 2003;27:514-521.
19. Friedman MA, Brownell KD. Psychological correlates of obesity: Moving to the next research generation. Psychol Bull 1995;117:3-20.
20. Faubel M. Body image and depression in women with early and late onset obesity. J Psychol 1989;123:385-395.
21. Hallstrom T, Noppa H. Obesity in women in relation to mental illness, social factors and personality traits. J Psychosom Res 1981;25:75-82.
22. Onyike CU, Crum RM, Lee HB, Lyketsos CG, Eaton WW. Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2003;158:1139-1147.
23. Dragan A, Akhtar-Danesh N. Relation between body mass index and depression: A structural equation modeling approach. BMC Med Res Methodol 2007;7:17.
24. Palinkas LA, Wingard DL, Barrett-Connor E. Depressive symptoms in overweight and obese older adults: A test of the "jolly fat" hypothesis. J Psychosom Res 1996;40:59-66.
25. Stewart AL, Brook RH. Effects of being overweight. Am J Public Health 1983;73:171-178.
26. Crisp AH, Queenan M, Sittampaln Y, Harris G. "Jolly fat" revisited. J Psychosom Res 1980;24:233-241.
27. Crisp AH, McGuiness B. Jolly fat: Relation between obesity and psychoneurosis in general population. Br Med J 1976;1:7-9.
28. Barry D, Pietrzak RH, Petry NM. Gender differences in associations between body mass index and DSM-IV mood and anxiety disorders: Results from the national epidemiologic survey on alcohol and related conditions. Ann Epidemiol 2008;18:458-466.
29. Simon GE, Ludman EJ, Linde JA et al. Association between obesity and depression in middle-aged women. Gen Hosp Psychiatry 2008;30:32-39.
30. Sachs-Ericsson N, Burns AB, Gordon KH et al. Body mass index and depressive symptoms in older adults: The moderating roles of race, sex, and socioeconomic status. Am J Geriatr Psychiatry 2007;15:815-825.
31. Erickson SJ, Robinson TN, Haydel KF, Killen JD. Are overweight children unhappy? Body mass index, depressive symptoms, and overweight concerns in elementary school children. Arch Pediatr Adolesc Med 2000;154:931-935.
32. Carpenter KM, Hasin DS, Allison DB, Faith MS. Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: Results from a general population study. Am J Public Health 2000;90:251-257.
33. Istvan J, Zavela K, Weidner G. Body weight and psychological distress in NHANES I. Int J Obes Relat Metab Disord 1992;16:999-1003.
34. Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry 2006;163:109-114.
35. Cummings DE, SchwartzMW. Genetics and pathophysiology of human obesity. Annu Rev Med 2003;54:453-471.
36. Challis BG, Luan J, Keogh J et al. Genetic variation in the corticotrophin-releasing factor receptors: Identification of singlenucleotide polymorphisms and association studies with obesity in UK Caucasians. Int J Obes Relat Metab Disord 2004;28: 442-446.
37. Lerer B, Macciardi F, Segman RH et al. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Mol Psychiatry 2001;6: 579-585.
38. Lin RC, Wang XL, Dalziel B, Caterson ID, Morris BJ. Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obes Res 2003;11: 802-808.
39. Liu Z, Zhu F, Wang G et al. Association study of corticotropinreleasing hormone receptor 1 gene polymorphisms and antidepressant response in major depressive disorders. Neurosci Lett 2007;414:155-158.
40. Lopez Leon S, Croes EA, Sayed-Tabatabaei FA et al. The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: A meta-analysis. Biol Psychiatry 2005;57: 999-1003.
41. Poston 2nd WS, Ericsson M, Linder J et al. D4 dopamine receptor gene exon III polymorphism and obesity risk. Eat Weight Disord 1998;3:71-77.
42. Rosmond R, Bouchard C, Bjorntorp P. 5-HT2A receptor gene promoter polymorphism in relation to abdominal obesity and cortisol. Obes Res 2002;10:585-589. (Pubitemid 135688255)
43. vanWest D, Van Den Eede F, Del-Favero J et al. Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression. Neuropsychopharmacology 2006;31:620-627.
44. Afari N, Noonan C, Goldberg J et al. University of Washington Twin Registry: Construction and characteristics of a communitybased twin registry. Twin Res Hum Genet 2006;9:1023-1029.
45. Eisen S, Neuman R, Goldberg J, Rice J, True W. Determining zygosity in the Vietnam era twin registry: An approach using questionnaires. Clin Genet 1989;35:423-432.
46. Magnus P, Berg K, NanceWE. Predicting zygosity in Norwegian twin pairs born 1915-1960. Clin Genet 1983;24:103-112.
47. Reed T, Plassman BL, Tanner CMet al. Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later. Twin Res Hum Genet 2005;8:362-367.
48. Torgersen S. The determination of twin zygosity by means of a mailed questionnaire. Acta Genet Med Gemellol (Roma) 1979;28:225-236.
49. Neale M, Cardon L. Methodology for the Study of Twins and Families. Dordrecht, The Netherlands: Kluwer Academic Press; 1992.
50. Akaike H. Factor analysis and AIC. Psychometrika 1987;52: 327-332.
51. Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: Review and meta-analysis. Am J Psychiatry 2000;157:1552-1562.
52. Perusse L. Genetics of human obesity: Results from genetic epidemiology studies. Ann Endocrinol (Paris) 2000;61:24-30.
53. Barsh GS, Farooqi IS, O'Rahilly S. Genetics of body-weight regulation. Nature 2000;404:644-651.
54. Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 2008;13:772-785.
55. Christiansen L, Tan QH, Iachina M et al. Candidate gene polymorphisms in the serotonergic pathway: Influence on depression symptomatology in an elderly population. Biol Psychiatry 2007;61:223-230.
56. Lesch KP, Bengel D, Heils A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
57. Caspi A, Sugden K, Moffitt TE et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-389.
58. Bouchard C. Genetics of obesity in humans: Current issues. Ciba Found Symp 1996;201:108-115; discussion 115-107, 188-193.
59. Yang W, Kelly T, He J. Genetic epidemiology of obesity. Epidemiol Rev 2007;29:49-61.
60. Rankinen T, Zuberi A, Chagnon YC et al. The human obesity gene map: The 2005 update. Obesity (Silver Spring) 2006;14:529-644.
61. Li S, Loos RJ. Progress in the genetics of common obesity: Size matters. Curr Opin Lipidol 2008;19:113-121.
62. Thorleifsson G, Walters GB, Gudbjartsson DF et al. Genomewide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41:18-24.
63. Willer CJ, Speliotes EK, Loos RJ et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
64. Scuteri A, Sanna S, Chen WM et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
65. Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894.
66. Blaine B. Does depression cause obesity? A meta-analysis of longitudinal studies of depression and weight control. J Health Psychol 2008;13:1190-1197.
67. Atlantis E, Baker M. Obesity effects on depression: Systematic review of epidemiological studies. Int J Obes (Lond) 2008;32: 881-891.
68. Choy WC, Lopez-Leon S, Aulchenko YS et al. Role of shared genetic and environmental factors in symptoms of depression and body composition. Psychiatr Genet 2009;19:32-38.
69. Bonisch H, Bruss M. The norepinephrine transporter in physiology and disease. Handb Exp Pharmacol 2006:485-524.
70. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;44:151-162.
71. Noble EP. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet 2003;116B:103-125.
72. Bornstein SR, Schuppenies A,Wong ML, Licinio J. Approaching the shared biology of obesity and depression: The stress axis as the locus of gene-environment interactions. Mol Psychiatry 2006;11:892-902.
73. Dallman M, Pecoraro N, la Fleur S. Chronic stress and comfort foods: Self-medication and abdominal obesity. Brain Behav Immun 2005;19:275-280.
74. Wise L, Adams-Campbell L, Palmer J, Rosenberg L. Leisure time physical activity in relation to depressive symptoms in the Black Women's Health Study. Ann Behav Med 2006;32: 68-76.
75. Strine TW, Mokdad AH, Dube SR et al. The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. Gen Hosp Psychiatry 2008;30:127-137.
76. Fan AZ, Strine TW, Huang Y et al. Self-rated depression and physician-diagnosed depression and anxiety in Florida adults: Behavioral risk factor surveillance ystem, 2006. Prev Chronic Dis 2009;6:A10.
77. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence. J Affect Disord 1993;29:85-96.
78. Jeffery RW, Finch EA, Linde JA et al. Does clinical depression affect the accuracy of self-reported height and weight in obese women? Obesity (Silver Spring) 2008;16:473-475.
79. Drewnowski A, Rehm CD, Solet D. Disparities in obesity rates: Analysis by ZIP code area. Soc Sci Med 2007;65:2458-2463.