메뉴 건너뛰기




Volumn 19, Issue 2, 2008, Pages 113-121

Progress in the genetics of common obesity: Size matters

Author keywords

Candidate gene; Genetic epidemiology; Genome wide association; Genome wide linkage; Obesity

Indexed keywords

ADIPONECTIN; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; GNB3 PROTEIN; HTR2C PROTEIN; LEP PROTEIN; LEPR PROTEIN; MELANOCORTIN 4 RECEPTOR; NR3C1 PROTEIN; PPARG PROTEIN; PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

EID: 41649092481     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e3282f6a7f3     Document Type: Review
Times cited : (41)

References (53)
  • 1
    • 41649087364 scopus 로고    scopus 로고
    • World Health Organization, Geneva, Switzerland: World Health Organization;
    • World Health Organization. Obesity and overweight: fact sheet no 311. Geneva, Switzerland: World Health Organization; 2006.
    • (2006) Obesity and overweight: Fact sheet , Issue.311
  • 2
    • 41649099493 scopus 로고    scopus 로고
    • The National Audit Office: Tackling obesity in England. London, UK: The National Audit Office; 2001.
    • The National Audit Office: Tackling obesity in England. London, UK: The National Audit Office; 2001.
  • 4
    • 0032577404 scopus 로고    scopus 로고
    • Environmental contributions to the obesity epidemic
    • Hill JO, Peters JC. Environmental contributions to the obesity epidemic. Science 1998; 280:1371-1374.
    • (1998) Science , vol.280 , pp. 1371-1374
    • Hill, J.O.1    Peters, J.C.2
  • 5
    • 0035010297 scopus 로고    scopus 로고
    • Environmental influences on eating and physical activity
    • French SA, Story M, Jeffery RW. Environmental influences on eating and physical activity. Annu Rev Public Health 2001; 22:309-335.
    • (2001) Annu Rev Public Health , vol.22 , pp. 309-335
    • French, S.A.1    Story, M.2    Jeffery, R.W.3
  • 6
    • 0023879112 scopus 로고
    • Stone-agers in the fast lane: Chronic degenerative diseases in evolutionary perspective
    • Eaton SB, Konner M, Shotak M. Stone-agers in the fast lane: chronic degenerative diseases in evolutionary perspective. Am J Med 1988; 84: 739-749.
    • (1988) Am J Med , vol.84 , pp. 739-749
    • Eaton, S.B.1    Konner, M.2    Shotak, M.3
  • 7
    • 0030843960 scopus 로고    scopus 로고
    • Genetic and environmental factors in relative body weight and human obesity
    • Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human obesity. Behav Genet 1997; 27:325-351.
    • (1997) Behav Genet , vol.27 , pp. 325-351
    • Maes, H.H.1    Neale, M.C.2    Eaves, L.J.3
  • 8
    • 33749017409 scopus 로고    scopus 로고
    • The Human Obesity Gene Map: The 2005 Update
    • This is the last yearly update of the Human Obesity Gene Map; the initiators of the map have now terminated this project. This has been an easily accessible resource that lists all obesity-related genes and loci reported in the literature
    • Rankinen T, Zuberi A, Chagnon YC, et al. The Human Obesity Gene Map: The 2005 Update. Obes Res 2006; 14:529-644. This is the last yearly update of the Human Obesity Gene Map; the initiators of the map have now terminated this project. This has been an easily accessible resource that lists all obesity-related genes and loci reported in the literature.
    • (2006) Obes Res , vol.14 , pp. 529-644
    • Rankinen, T.1    Zuberi, A.2    Chagnon, Y.C.3
  • 9
    • 34547625955 scopus 로고    scopus 로고
    • Scuteri A, Sanna S, Chen W-M, et al. Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLos Genetics 2007; 3:e115. This is the first large-scale high-density genome-wide association study for obesity, which identified FTO as an obesity susceptibility gene.
    • Scuteri A, Sanna S, Chen W-M, et al. Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLos Genetics 2007; 3:e115. This is the first large-scale high-density genome-wide association study for obesity, which identified FTO as an obesity susceptibility gene.
  • 10
    • 34248594090 scopus 로고    scopus 로고
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316:889-894. This is the first study that unequivocally established the association between the FTO gene and obesity through a genome-wide association study for type 2 diabetes.
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316:889-894. This is the first study that unequivocally established the association between the FTO gene and obesity through a genome-wide association study for type 2 diabetes.
  • 11
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88:131-141.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 12
    • 0037456768 scopus 로고    scopus 로고
    • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    • Farooqi IS, Keogh JM, Yeo GSH, et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003; 348:1085-1095.
    • (2003) N Engl J Med , vol.348 , pp. 1085-1095
    • Farooqi, I.S.1    Keogh, J.M.2    Yeo, G.S.H.3
  • 13
    • 33745036725 scopus 로고    scopus 로고
    • Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous propriomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist
    • Xiang Z, Litherland SA, Sorensen NB, et al. Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous propriomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry 2006; 45:7277-7288.
    • (2006) Biochemistry , vol.45 , pp. 7277-7288
    • Xiang, Z.1    Litherland, S.A.2    Sorensen, N.B.3
  • 14
    • 28544447162 scopus 로고    scopus 로고
    • Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys
    • Heid IM, Vollmert C, Hinney A, et al. Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys. J Med Genet 2005; 42:e21.
    • (2005) J Med Genet , vol.42
    • Heid, I.M.1    Vollmert, C.2    Hinney, A.3
  • 15
    • 34547831224 scopus 로고    scopus 로고
    • Young EH, Wareham NJ, Farooqi S, et al. The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29,563 individuals. Int J Obes 2007; 31:1437-1441. This study reports on a meta-analysis of the V103 MC4R variant and provides conclusive evidence for the association between this polymorphismand obesity risk.
    • Young EH, Wareham NJ, Farooqi S, et al. The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29,563 individuals. Int J Obes 2007; 31:1437-1441. This study reports on a meta-analysis of the V103 MC4R variant and provides conclusive evidence for the association between this polymorphismand obesity risk.
  • 16
    • 34547839796 scopus 로고    scopus 로고
    • Stutzmann F, Vatin V, Cauchi S, et al. Nonsynonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 2007; 16:1837-1844. This is a large-scale study that provides conclusive evidence for the association between the V103I and I251L polymorphisms in MC4R and obesity risk.
    • Stutzmann F, Vatin V, Cauchi S, et al. Nonsynonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 2007; 16:1837-1844. This is a large-scale study that provides conclusive evidence for the association between the V103I and I251L polymorphisms in MC4R and obesity risk.
  • 17
    • 23044493861 scopus 로고    scopus 로고
    • Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    • Meyre D, Bouatia-Naji N, Tounian A, et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005; 37:863-867.
    • (2005) Nat Genet , vol.37 , pp. 863-867
    • Meyre, D.1    Bouatia-Naji, N.2    Tounian, A.3
  • 18
    • 33845488945 scopus 로고    scopus 로고
    • ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children
    • Bottcher Y, Korner A, Reinehr T, et al. ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children. J Clin Endocrinol Metab 2006; 91:4948-4952.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4948-4952
    • Bottcher, Y.1    Korner, A.2    Reinehr, T.3
  • 19
    • 34548502192 scopus 로고    scopus 로고
    • Meyre D, Bouatia-Naji N, Vatin V, et al. ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study. Diabetologia 2007; 50:2090-2096. This is a large-scale study (more than 5000 men and women) that refutes the association between the ENPP1 K121Q polymorphism and obesity.
    • Meyre D, Bouatia-Naji N, Vatin V, et al. ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study. Diabetologia 2007; 50:2090-2096. This is a large-scale study (more than 5000 men and women) that refutes the association between the ENPP1 K121Q polymorphism and obesity.
  • 20
    • 33845434199 scopus 로고    scopus 로고
    • Weedon MN, Shields B, Hitman G, et al. No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians. Diabetes 2006; 55:3175-3179. This is a second large-scale study (more than 8000 men and women) that refutes the association between the ENPP1 K121Q polymorphism and obesity.
    • Weedon MN, Shields B, Hitman G, et al. No Evidence of Association of ENPP1 Variants With Type 2 Diabetes or Obesity in a Study of 8,089 U.K. Caucasians. Diabetes 2006; 55:3175-3179. This is a second large-scale study (more than 8000 men and women) that refutes the association between the ENPP1 K121Q polymorphism and obesity.
  • 21
    • 33845428756 scopus 로고    scopus 로고
    • Lyon HN, Florez JC, Bersaglieri T, et al. Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes 2006; 55:3180-3184. This is a third large-scale study (more than 8000 men and women) that refutes the association between the ENPP1 K121Q polymorphism and obesity.
    • Lyon HN, Florez JC, Bersaglieri T, et al. Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes 2006; 55:3180-3184. This is a third large-scale study (more than 8000 men and women) that refutes the association between the ENPP1 K121Q polymorphism and obesity.
  • 22
    • 34548768914 scopus 로고    scopus 로고
    • Qi L, Zhang C, van Dam RM, et al. Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab 2007; 92:3618-3625. This meta-analysis includes almost 30 000 individuals, but it found no association between the -174C→G IL6 variant and obesity.
    • Qi L, Zhang C, van Dam RM, et al. Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab 2007; 92:3618-3625. This meta-analysis includes almost 30 000 individuals, but it found no association between the -174C→G IL6 variant and obesity.
  • 23
    • 33749844675 scopus 로고    scopus 로고
    • Variants in the 5′ region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects
    • Torekov S, Larsen L, Andersen G, et al. Variants in the 5′ region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects. Diabetologia 2006; 49:2653-2658.
    • (2006) Diabetologia , vol.49 , pp. 2653-2658
    • Torekov, S.1    Larsen, L.2    Andersen, G.3
  • 24
    • 34248154742 scopus 로고    scopus 로고
    • Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: A possible role for NPY2R as a candidate gene for type 2 diabetes in men
    • Campbell CD, Lyon HN, Nemesh J, et al. Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. Diabetes 2007; 56:1460-1467.
    • (2007) Diabetes , vol.56 , pp. 1460-1467
    • Campbell, C.D.1    Lyon, H.N.2    Nemesh, J.3
  • 25
    • 16944362008 scopus 로고    scopus 로고
    • Genomewide search for genes influencing percentage body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22
    • Norman A, Thompson DB, Foroud T, et al. Genomewide search for genes influencing percentage body fat in Pima Indians: Suggestive linkage at chromosome 11q21-q22. Am J Hum Genet 1997; 60:166-173.
    • (1997) Am J Hum Genet , vol.60 , pp. 166-173
    • Norman, A.1    Thompson, D.B.2    Foroud, T.3
  • 26
    • 35548952185 scopus 로고    scopus 로고
    • Saunders CL, Chiodini BD, Sham P, et al. Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity 2007; 15:2263-2275. The first large-scale meta-analyses 37 genome-wide linkage studies, including more than 31 000 individuals from more than 10 000 families. None of the QTLs, however, exhibited convincing evidence for linkage with obesity.
    • Saunders CL, Chiodini BD, Sham P, et al. Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity 2007; 15:2263-2275. The first large-scale meta-analyses 37 genome-wide linkage studies, including more than 31 000 individuals from more than 10 000 families. None of the QTLs, however, exhibited convincing evidence for linkage with obesity.
  • 27
    • 0035865087 scopus 로고    scopus 로고
    • A physical map of the human genome
    • The International Human Genome Mapping Consortium
    • The International Human Genome Mapping Consortium. A physical map of the human genome. Nature 2001; 409:934-941.
    • (2001) Nature , vol.409 , pp. 934-941
  • 28
    • 35348983887 scopus 로고    scopus 로고
    • The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449:851-861. This paper reports on the characteristics of the second phase of the International HapMap Project.
    • The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449:851-861. This paper reports on the characteristics of the second phase of the International HapMap Project.
  • 29
    • 34547092673 scopus 로고    scopus 로고
    • Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation
    • This study evaluateshow much of the genetic variation of the International HapMap is captured by commercially available SNPchips for genome-wide association studies
    • Magi R, Pfeufer A, Nelis M, et al. Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. BMC Genomics 2007; 8:159. This study evaluateshow much of the genetic variation of the International HapMap is captured by commercially available SNPchips for genome-wide association studies.
    • (2007) BMC Genomics , vol.8 , pp. 159
    • Magi, R.1    Pfeufer, A.2    Nelis, M.3
  • 30
    • 34249777814 scopus 로고    scopus 로고
    • Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39:724-726. The study identified FTO as an obesity gene by serendipity while testing for population stratification.
    • Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39:724-726. The study identified FTO as an obesity gene by serendipity while testing for population stratification.
  • 31
    • 36749041363 scopus 로고    scopus 로고
    • Gerken T, Girard CA, Tung YCL, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318:1469-1472. This is a follow-up study on the function of FTO; bioinformatics analyses and experiments in mice showed that FTO has DNA demythelation activity, is expressed in the hypothalamus of mice and is regulated by fasting and feeding.
    • Gerken T, Girard CA, Tung YCL, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318:1469-1472. This is a follow-up study on the function of FTO; bioinformatics analyses and experiments in mice showed that FTO has DNA demythelation activity, is expressed in the hypothalamus of mice and is regulated by fasting and feeding.
  • 32
    • 39049154918 scopus 로고    scopus 로고
    • The FTO (fat mass and obesity associated) gene codes for a novel member of the nonheme dioxygenase superfamily
    • This is a follow-up study on the function of FTO; bioinformatics analyses showed that FTO is a member of the nonheme dioxygenase superfamily
    • Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the nonheme dioxygenase superfamily. BMC Biochem 2007; 8:23. This is a follow-up study on the function of FTO; bioinformatics analyses showed that FTO is a member of the nonheme dioxygenase superfamily.
    • (2007) BMC Biochem , vol.8 , pp. 23
    • Sanchez-Pulido, L.1    Andrade-Navarro, M.A.2
  • 33
    • 35848938196 scopus 로고    scopus 로고
    • Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans
    • This is a follow-up study on the function of FTO; this study suggests that FTO may confer obesity through cerebrocortical insulin resistance in humans
    • Tschritter O, Preissl H, Yokoyama Y, et al. Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans. Diabetologia 2007; 50:2602-2603. This is a follow-up study on the function of FTO; this study suggests that FTO may confer obesity through cerebrocortical insulin resistance in humans.
    • (2007) Diabetologia , vol.50 , pp. 2602-2603
    • Tschritter, O.1    Preissl, H.2    Yokoyama, Y.3
  • 34
    • 41649108830 scopus 로고    scopus 로고
    • Wahlen K, Sjolin E, Hoffstedt J. The common rs9939609 gene variant of the fat mass and obesity associated gene (FTO) is related to fat cell lipolysis. J Lipid Res 2007; M700448-M701200. This is a follow-up study on the function of FTO; it suggests that FTO may confer obesity through a reduced lipolytic activity in women.
    • Wahlen K, Sjolin E, Hoffstedt J. The common rs9939609 gene variant of the fat mass and obesity associated gene (FTO) is related to fat cell lipolysis. J Lipid Res 2007; M700448-M701200. This is a follow-up study on the function of FTO; it suggests that FTO may confer obesity through a reduced lipolytic activity in women.
  • 35
    • 38449098674 scopus 로고    scopus 로고
    • Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    • This is a follow-up study on FTO regarding its interaction with environmental factors; it suggests that the risk associated with FTO is attenuated in physically active individuals
    • Andreasen CH, Stender-Petersen KL, Mogensen MS, et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 95-101. This is a follow-up study on FTO regarding its interaction with environmental factors; it suggests that the risk associated with FTO is attenuated in physically active individuals.
    • (2008) Diabetes , pp. 95-101
    • Andreasen, C.H.1    Stender-Petersen, K.L.2    Mogensen, M.S.3
  • 36
    • 38449097877 scopus 로고    scopus 로고
    • Li H, Wu Y, Loos RJF, et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 2008; 57:264-268. This is a follow-up study on FTO regarding its role in different ethnicities; it shows no significant association in Chinese Hans, despite being sufficiently powered to detect previously identified effect sizes.
    • Li H, Wu Y, Loos RJF, et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 2008; 57:264-268. This is a follow-up study on FTO regarding its role in different ethnicities; it shows no significant association in Chinese Hans, despite being sufficiently powered to detect previously identified effect sizes.
  • 37
    • 33645825830 scopus 로고    scopus 로고
    • Herbert A, Gerry NP, McQueen MB, et al. A common genetic variant is associated with adult and childhood obesity. Science 2006; 312:279-283. This is the first genome-wide association study for BMI using a 100K SNP chip in a small sample from the Framingham Heart Study. A SNP at about 10 kilobases upstream from the INSIG2 gene was identified and replicated in four independent samples.
    • Herbert A, Gerry NP, McQueen MB, et al. A common genetic variant is associated with adult and childhood obesity. Science 2006; 312:279-283. This is the first genome-wide association study for BMI using a 100K SNP chip in a small sample from the Framingham Heart Study. A SNP at about 10 kilobases upstream from the INSIG2 gene was identified and replicated in four independent samples.
  • 38
    • 33846936809 scopus 로고    scopus 로고
    • Loos RJF, Barroso I, O'Rahilly S, et al. Comment on 'a common genetic variant is associated with adult and childhood obesity'. Science 2007; 315:187. This is a first follow-up report on the INSIG2 variant; the study found no association between INSIG2 variants and BMI or obesity in more than 6000 individuals.
    • Loos RJF, Barroso I, O'Rahilly S, et al. Comment on 'a common genetic variant is associated with adult and childhood obesity'. Science 2007; 315:187. This is a first follow-up report on the INSIG2 variant; the study found no association between INSIG2 variants and BMI or obesity in more than 6000 individuals.
  • 39
    • 33846903056 scopus 로고    scopus 로고
    • Dina C, Meyre D, Samson C, et al. Comment on 'a common genetic variant is associated with adult and childhood obesity'. Science 2007; 315:187. This is a second follow-up report on the INSIG2 variant; the study found no association between the INSIG2 variants and BMI or obesity in more than 10 000 individuals.
    • Dina C, Meyre D, Samson C, et al. Comment on 'a common genetic variant is associated with adult and childhood obesity'. Science 2007; 315:187. This is a second follow-up report on the INSIG2 variant; the study found no association between the INSIG2 variants and BMI or obesity in more than 10 000 individuals.
  • 40
    • 33846933276 scopus 로고    scopus 로고
    • Rosskopf D, Bornhorst A, Rimmbach C, et al. Comment on 'a common genetic variant is associated with adult and childhood obesity'. Science 2007; 315:187d. This is a third follow-up report on the INSIG2 variant; the study found no association between the INSIG2 variants and BMI or obesity in more than 4,000 individuals.
    • Rosskopf D, Bornhorst A, Rimmbach C, et al. Comment on 'a common genetic variant is associated with adult and childhood obesity'. Science 2007; 315:187d. This is a third follow-up report on the INSIG2 variant; the study found no association between the INSIG2 variants and BMI or obesity in more than 4,000 individuals.
  • 41
    • 34247576412 scopus 로고    scopus 로고
    • Lyon HN, Emilsson V, Hinney A, et al. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLos Genet 2007; 3:e61. This is a fourth follow-up report on the INSIG2 variant. Significant association between the INSIG2 variants and BMI or obesity was found in five studies examined in this report, whereas no association was observed in three other studies.
    • Lyon HN, Emilsson V, Hinney A, et al. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLos Genet 2007; 3:e61. This is a fourth follow-up report on the INSIG2 variant. Significant association between the INSIG2 variants and BMI or obesity was found in five studies examined in this report, whereas no association was observed in three other studies.
  • 42
    • 41649089967 scopus 로고    scopus 로고
    • Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents
    • Epub ahead of print
    • Reinehr T, Hinney A, Nguyen TT et al. Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents. Diabetes 2007 [Epub ahead of print].
    • (2007) Diabetes
    • Reinehr, T.1    Hinney, A.2    Nguyen, T.T.3
  • 43
    • 33845607272 scopus 로고    scopus 로고
    • INSIG-2 promoter polymorphism and obesity related phenotypes: Association study in 1428 members of 248 families
    • Hall D, Rahman T, Avery P, et al. INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. BMC Med Genet 2006; 7:83.
    • (2006) BMC Med Genet , vol.7 , pp. 83
    • Hall, D.1    Rahman, T.2    Avery, P.3
  • 44
    • 35648971173 scopus 로고    scopus 로고
    • INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects
    • Smith AJP, Cooper JA, Li LK, et al. INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects. Int J Obes 2007; 31:1753-1755.
    • (2007) Int J Obes , vol.31 , pp. 1753-1755
    • Smith, A.J.P.1    Cooper, J.A.2    Li, L.K.3
  • 45
    • 34248371252 scopus 로고    scopus 로고
    • The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population
    • Kumar J, Sunkishala RR, Karthikeyan G, et al. The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population. Clin Genet 2007; 71:415-418.
    • (2007) Clin Genet , vol.71 , pp. 415-418
    • Kumar, J.1    Sunkishala, R.R.2    Karthikeyan, G.3
  • 46
    • 35748970488 scopus 로고    scopus 로고
    • Fox C, Heard-Costa N, Cupples LA, et al. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. BMC Med Genet 2007; 8:S18. This is a report on an extended genome-wide scan in the Framingham Heart study, now in more than 1,300 individuals, using a 100K SNP chip. No replication was performed. The data from this study are publicly available on a website (http://www.ncbi.nlm.nih.gov/projects/gap/cgi- bin/study.cgi?id=phs000007).
    • Fox C, Heard-Costa N, Cupples LA, et al. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. BMC Med Genet 2007; 8:S18. This is a report on an extended genome-wide scan in the Framingham Heart study, now in more than 1,300 individuals, using a 100K SNP chip. No replication was performed. The data from this study are publicly available on a website (http://www.ncbi.nlm.nih.gov/projects/gap/cgi- bin/study.cgi?id=phs000007).
  • 47
    • 36248986199 scopus 로고    scopus 로고
    • Association of single-nucleotide polymorphisms in MTMR9 gene with obesity
    • This study on a genome-wide gene-based chip identifies variations in MTMR9 to be consistently associated with obesity risk in Japanese
    • Yanagiya T, Tanabe A, Iida A, et al. Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. Hum Mol Genet 2007; 16:3017-3026. This study on a genome-wide gene-based chip identifies variations in MTMR9 to be consistently associated with obesity risk in Japanese.
    • (2007) Hum Mol Genet , vol.16 , pp. 3017-3026
    • Yanagiya, T.1    Tanabe, A.2    Iida, A.3
  • 48
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium: Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447:661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 49
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • This study reports on a new method called imputation that determines individuals' genotypes for unobserved variants based the genotypes variants and on the haplotype structure from the HapMap
    • Marchini J, Howie B, Myers S, et al. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet 2007; 39:906-913. This study reports on a new method called imputation that determines individuals' genotypes for unobserved variants based the genotypes variants and on the haplotype structure from the HapMap.
    • (2007) Nat Genet , vol.39 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3
  • 50
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • This study reports on a pilot project of the ENCODE Project Consortium that aims to determine the functional characteristics of each base pair of the human genome through various functional studies. Thus far, the pilot project comprises 1% of the human genome. The ENCODE Project Consortium
    • The ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007; 447: 799-816. This study reports on a pilot project of the ENCODE Project Consortium that aims to determine the functional characteristics of each base pair of the human genome through various functional studies. Thus far, the pilot project comprises 1% of the human genome.
    • (2007) Nature , vol.447 , pp. 799-816
  • 51
    • 34548805282 scopus 로고    scopus 로고
    • Dixon AL, Liang L, Moffatt MF, et al. A genome-wide association study of global gene expression. Nat Genet 2007; 39:1202-1207. This is the first study that explored genome-wide gene expression. The data are publicly available. This study also provides useful software that allows searching of the dataset.
    • Dixon AL, Liang L, Moffatt MF, et al. A genome-wide association study of global gene expression. Nat Genet 2007; 39:1202-1207. This is the first study that explored genome-wide gene expression. The data are publicly available. This study also provides useful software that allows searching of the dataset.
  • 52
    • 34548738566 scopus 로고    scopus 로고
    • Stranger BE, Nica AC, Forrest MS, et al. Population genomics of human gene expression. Nat Genet 2007; 39:1217-1224. This is the second study that explored genome-wide gene expression. The data are publicly available. This study also provides useful software that allows searching of the dataset.
    • Stranger BE, Nica AC, Forrest MS, et al. Population genomics of human gene expression. Nat Genet 2007; 39:1217-1224. This is the second study that explored genome-wide gene expression. The data are publicly available. This study also provides useful software that allows searching of the dataset.
  • 53
    • 34548719076 scopus 로고    scopus 로고
    • Goring HHH, Curran JE, Johnson MP, et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 2007; 39:1208-1216. The third study that explored genome-wide gene expression. The data are publicly available. This study also provides useful software that allows searching of the dataset.
    • Goring HHH, Curran JE, Johnson MP, et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 2007; 39:1208-1216. The third study that explored genome-wide gene expression. The data are publicly available. This study also provides useful software that allows searching of the dataset.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.