Chapter 2.2 Molecular regulation of the CRF system

Techniques in the Behavioral and Neural Sciences

Volumn 15, Issue PART 1, 2005, Pages 133-154

  Roseboom, P H ^a,b   Kalin, N H ^a,b   Steckler, T ^c   Dautzenberg, F M ^c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956689514     PISSN: 09210709     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0921-0709(05)80011-2     Document Type: Chapter

References (184)

1. Aguilera G., Harwood J.P., Wilson J.X., Morell J., Brown J.H., and Catt K.J. Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells. J. Biol. Chem. 258 (1983) 8039-8045
2. Aguilera G., Jessop D.S., Harbuz M.S., Kiss A., and Lightman S.L. Differential regulation of hypothalamic pituitary corticotropin releasing hormone receptors during development of adjuvant-induced arthritis in the rat. J. Endocrinol. 153 (1997) 185-191
3. Aguilera G., Rabadan-Diehl C., and Nikodemova M. regulation of pituitary corticotropin releasing hormone receptors. Peptides 22 (2001) 769-774
4. Albeck D.S., McKittrick C.R., Blanchard D.C., Blanchard R.J., Nikulina J., McEwen B.S., and Sakai R.R. Chronic social stress alters levels of corticotropin-releasing factor and arginine vasopressin mRNA in rat brain. J. Neurosci. 17 (1997) 4895-4903
5. Andrews M.W., and Rosenblum L.A. The development of affiliative and agonistic social patterns in differentially reared monkeys. Child Dev. 65 (1994) 1398-1404
6. Anisman H., Zaharia M.D., Meaney M.J., and Merali Z. Do early-life events permanently alter behavioral and hormonal responses to stressors?. Int. J. Dev. Neurosci. 16 (1998) 149-164
7. Arase K., York D.A., Shimizu H., Shargill N., and Bray G.A. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am. J. Physiol. 255 (1988) E255-E259
8. Arborelius L., Owens M.J., Plotsky P.M., and Nemeroff C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol. 160 (1999) 1-12
9. Aubry J.M., Pozzoli G., and Vale W.W. Chronic treatment with the antidepressant amitriptyline decreases CRF-R1 receptor mRNA levels in the rat amygdala. Neurosci. Lett. 266 (1999) 197-200
10. Bakshi V.P., and Kalin N.H. Corticotropin-releasing hormone and animal models of anxiety: gene-environment interactions. Biol. Psychiatry 48 (2000) 1175-1198
11. 1 receptors in amygdala. J. Neurosci. 22 (2002) 2926-2935
12. Bale T.L., Contarino A., Smith G.W., Chan R., Gold L.H., Sawchenko P.E., Koob G.F., Vale W.W., and Lee K.F. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet. 24 (2000) 410-414
13. Bale T.L., Picetti R., Contarino A., Koob G.F., Vale W.W., and Lee K.F. Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J. Neurosci. 22 (2002) 193-199
14. Bartanusz V., Jezova D., Bertini L.T., Tilders F.J., Aubry J.M., and Kiss J.Z. Stress-induced increase in vasopressin and corticotropin-releasing factor expression in hypophysiotrophic paraventricular neurons. Endocrinology 132 (1993) 895-902
15. Battaglia G., Webster E.L., and DeSouza E.B. Characterization of corticotropin-releasing factor receptor-mediated adenylate cyclase activity in the rat central nervous system. Synapse 1 (1987) SYN1
16. Blank T., Nijholt I., Grammatopoulos D.K., Randeva H.S., Hillhouse E.W., and Spiess J. Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning. J. Neurosci. 23 (2003) 700-707
17. Bonaz B., and Rivest S. Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain. Am. J. Physiol. 275 (1998) R1438-R1449
18. Bowlby J. Attachment and Loss, Vol. II: Separation (1973), Basic Books, Amsterdam
19. Brady L.S., Gold P.W., Herkenham M., Lynn A.B., and Whitfield Jr. H.J. The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain Res. 572 (1992) 117-125
20. Brady L.S., Whitfield Jr. H.J., Fox R.J., Gold P.W., and Herkenham M. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. J. Clin. Invest. 87 (1991) 831-837
21. 1 ) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. Exp. Neurol 176 (2002) 75-86
22. Carlson M., and Earls F. Psychological and neuroendocrinological sequelae of early social deprivation in institutionalized children in Romania. Ann. N. Y. Acad. Sci. 807 (1997) 419-428
23. Catalano R.D., Kyriakou T., Chen J., Easton A., and Hillhouse E.W. Regulation of corticotropin-releasing hormone type 2 receptors by multiple promoters and alternative splicing: identification of multiple splice variants. Mol. Endocrinol. 17 (2003) 395-410
24. Chen A., Vaughan J., and Vale W.W. Glucocorticoids regulate the expression of the mouse urocortin II gene: a putative connection between the corticotropin releasing factor receptor pathways. Mol. Endocrinol. 17 (2003) 1622-1639
25. Chen F.M., Bilezikjian L.M., Perrin M.H., Rivier J., and Vale W. Corticotropin releasing factor receptor-mediated stimulation of adenylate cyclase activity in the rat brain. Brain Res. 381 (1986) 49-57
26. Chen R., Lewis K.A., Perrin M.H., and Vale W.W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl. Acad. Sci. USA 90 (1993) 8967-8971
27. Chen Y., Hatalski C.G., Brunson K.L., and Baram T.Z. Rapid phosphorylation of the CRE binding protein precedes stress-induced activation of the corticotropin releasing hormone gene in medial parvocellular hypothalamic neurons of the immature rat. Brain Res. Mol. Brain Res. 96 (2001) 39-49
28. Colantuoni C., Purcell A.E., Bouton C.M., and Pevsner J. high throughput analysis of gene expression in the human brain. J. Neurosci. Res. 59 (2000) 1-10
29. Contarino A., Dellu F., Koob G.F., Smith G.W., Lee K.F., Vale W., and Gold L.H. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Res. 835 (1999) 1-9
30. Coplan J.D., Andrews M.W., Rosenblum L.A., Owens M.J., Friedman S., Gorman J.M., and Nemeroff C.B. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc. Natl. Acad. Sci. USA 93 (1996) 1619-1623
31. Coplan J.D., Smith E.L., Trost R.C., Scharf B.A., Altemus M., Bjornson L., Owens M.J., Gorman J.M., Nemeroff C.B., and Rosenblum L.A. Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Res. 95 (2000) 93-102
32. Coste S.C., Heldwein K.A., Stevens S.L., Tobar-Dupres E., and Stenzel-Poore M.P. IL-1alpha and TNFalpha down-regulate CRH receptor-2 mRNA expression in the mouse heart. Endocrinology 142 (2001) 3537-3545
33. Coste S.C., Kesterson R.A., Heldwein K.A., Stevens S.L., Heard A.D., Hollis J.H., Murray S.E., Hill J.K., Pantely G.A., Hohimer A.R., Hatton D.C., Phillips T.J., Finn D.A., Low M.J., Rittenberg M.B., Stenzel P., and Stenzel-Poore M.P. Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat. Genet. 24 (2000) 403-409
34. Dautzenberg F.M., and Hauger R.L. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci. 23 (2002) 71-77
35. 1 receptors: a potential mechanism regulating stress adaptation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2001) R935-R946
36. Dautzenberg F.M., Higelin J., and Teichert U. Functional characterization of corticotropin-releasing factor type 1 receptor endogenously expressed in human embryonic kidney 293 cells. Eur. J. Pharmacol. 390 (2000) 51-59
37. (2alpha) receptors and the role of position 185 for receptor-ligand selectivity. Neuropharmacology 39 (2000) 1368-1376
38. Dautzenberg F.M., Kilpatrick G.J., Hauger R.L., and Moreau J. Molecular biology of the CRH receptors - in the mood. Peptides 22 (2001) 753-760
39. 1 receptor desensitization. Biochem. Biophys. Res. Commun. 298 (2002) 303-308
40. De Souza E.B. Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology 20 (1995) 789-819
41. Dent G.W., Smith M.A., and Levine S. Rapid induction of corticotropin-releasing hormone gene transcription in the paraventricular nucleus of the developing rat. Endocrinology 141 (2000) 1593-1598
42. Diamond M.I., Miner J.N., Yoshinaga S.K., and Yamamoto K.R. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249 (1990) 1266-1272
43. Dieterich K.D., and DeSouza E.B. Functional corticotropin-releasing factor receptors in human neuroblastoma cells. Brain Res. 733 (1996) 113-118
44. 1 receptor in stable transfected mouse fibroblast cells. Brain Res. 710 (1996) 287-292
45. Dunn A.J., and Berridge C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?. Brain Res. Brain Res. Rev. 15 (1990) 71-100
46. Fadda P., Pani L., Porcella A., and Fratta W. Chronic imipramine, L-sulpiride and mianserin decrease corticotropin releasing factor levels in the rat brain. Neurosci. Lett. 192 (1995) 121-123
47. Ferguson S.S. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53 (2001) 1-24
48. Francis D., Diorio J., Liu D., and Meaney M.J. nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286 (1999) 1155-1158
49. Francis D.D., Caldji C., Champagne F., Plotsky P.M., and Meaney M.J. The role of corticotropin-releasing factor - norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol. Psychiatry 46 (1999) 1153-1166
50. Fuchs E., and Flugge G. Modulation of binding sites for corticotropin-releasing hormone by chronic psychosocial stress. Psychoneuroendocrinology 20 (1995) 33-51
51. Gentles A.J., and Karlin S. Why are human G-protein-coupled receptors predominantly intronless?. Trends Genet. 15 (1999) 47-49
52. Giardino L., Puglisi-Allegra S., and Ceccatelli S. CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress. Brain Res. Mol. Brain Res. 40 (1996) 310-314
53. Gonzalez G.A., and Montminy M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59 (1989) 675-680
54. Gould E., Tanapat P., Rydel T., and Hastings N. Regulation of hippocampal neurogenesis in adulthood. Biol. Psychiatry 48 (2000) 715-720
55. Guardiola-Diaz H.M., Boswell C., and Seasholtz A.F. The cAMP-responsive element in the corticotropin-releasing hormone gene mediates transcriptional regulation by depolarization. J. Biol. Chem. 269 (1994) 14784-14791
56. Guillemin R., and Rosenberg B. Humoral hypothalamic control of anterior pituitary: a study with combined tissue cultures. Endocrinology 57 (1955) 599-607
57. Hatalski C.G., Guirguis C., and Baram T.Z. Corticotropin releasing factor mRNA expression in the hypothalamic paraventricular nucleus and the central nucleus of the amygdala is modulated by repeated acute stress in the immature rat. J. Neuroendocrinol. 10 (1998) 663-669
58. Hauger R.L., and Dautzenberg F.M. Regulation of the stress response by corticotropin-releasing factor receptors. In: Conn P.M., and Freeman M.E. (Eds). Neuroendocrinology in Physiology and Medicine (1999), Humana Press, New York 261-286
59. Hauger R.L., Dautzenberg F.M., Flaccus A., Liepold T., and Spiess J. Regulation of corticotropin-releasing factor receptor function in human Y-79 retinoblastoma cells: rapid and reversible homologous desensitization but prolonged recovery. J. Neurochem. 68 (1997) 2308-2316
60. Hauger R.L., Grigoriadis D.E., Dallman M.F., Plotsky P.M., Vale W.W., and Dautzenberg F.M. International union of pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. Pharmacol. Rev. 55 (2003) 21-26
61. Hauger R.L., Irwin M.R., Lorang M., Aguilera G., and Brown M.R. High intracerebral levels of CRH result in CRH receptor downregulation in the amygdala and neuroimmune desensitization. Brain Res. 616 (1993) 283-292
62. 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation. J. Pharmacol. Exp. Ther. 306 (2003) 794-803
63. Hauger R.L., Smith R.D., Braun S., Dautzenberg F.M., and Catt K.J. Rapid agonist-induced phosphorylation of the human CRF receptor, type 1: a potential mechanism for homologous desensitization. Biochem. Biophys. Res. Commun. 268 (2000) 572-576
64. Heilig M., McLeod S., Brot M., Heinrichs S.C., Menzaghi F., Koob G.F., and Britton K.T. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8 (1993) 357-363
65. Heim C., and Nemeroff C.B. The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biol. Psychiatry 46 (1999) 1509-1522
66. Heldwein K.A., Duncan J.E., Stenzel P., Rittenberg M.B., and Stenzel-Poore M.P. Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle. Mol. Cell Endocrinol. 131 (1997) 167-172
67. Herman J.P., Schafer M.K., Thompson R.C., and Watson S.J. Rapid regulation of corticotropin-releasing hormone gene transcription in vivo. Mol. Endocrinol. 6 (1992) 1061-1069
68. Heuser I., Bissette G., Dettling M., Schweiger U., Gotthardt U., Schmider J., Lammers C.H., Nemeroff C.B., and Holsboer F. Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment. Depress Anxiety 8 (1998) 71-79
69. Ho S.P., Takahashi L.K., Livanov V., Spencer K., Lesher T., Maciag C., Smith M.A., Rohrbach K.W., Hartig P.R., and Arneric S.P. Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor. Brain Res. Mol. Brain Res. 89 (2001) 29-40
70. Hoffman A.R., Ceda G., and Reisine T.D. Corticotropin-releasing factor desensitization of adrenocorticotropic hormone release is augmented by arginine vasopressin. J. Neurosci. 5 (1985) 234-242
71. Hogg J.E., Myers J., and Hutson P.H. The human neuroblastoma cell line, IMR-32, expresses functional corticotropin-releasing factor receptors. Eur. J. Pharmacol. 312 (1996) 257-261
72. Hsu D.T., Chen F.L., Takahashi L.K., and Kalin N.H. Rapid stress-induced elevations in corticotropin-releasing hormone mRNA in rat central amygdala aucleus and hypothalamic paraventricular nucleus: an in situ hybridization Analysis. Brain Res. 788 (1998) 305-310
73. Hsu D.T., Lombardo K.A., Herringa R.J., Bakshi V.P., Roseboom P.H., and Kalin N.H. Corticotropin-releasing hormone messenger RNA distribution and stress-induced activation in the thalamus. Neuroscience 105 (2001) 911-921
74. Iredale P.A., Terwilliger R., Widnell K.L., Nestler E.J., and Duman R.S. Differential regulation of corticotropin-releasing factor (1) receptor expression by stress and agonist treatments in brain and cultured cells. Mol. Pharmacol. 50 (1996) 1103-1110
75. Jensen J.B., Jessop D.S., Harbuz M.S., Mork A., Sanchez C., and Mikkelsen J.D. Acute and long-term treatments with the selective serotonin reuptake inhibitor citalopram modulate the HPA axis activity at different levels in male rats. J. Neuroendocrinol. 11 (1999) 465-471
76. Kageyama K., Bradbury M.J., Zhao L., Blount A.L., and Vale W.W. Urocortin messenger ribonucleic acid: tissue distribution in the rat and regulation in thymus by lipopolysaccharide and glucocorticoids. Endocrinology 140 (1999) 5651-5658
77. Kageyama K., Gaudriault G.E., Bradbury M.J., and Vale W.W. Regulation of corticotropin-releasing factor receptor type 2 beta messenger ribonucleic acid in the rat cardiovascular system by urocortin, glucocorticoids, and cytokines. Endocrinology 141 (2000) 2285-2293
78. Kageyama K., Gaudriault G.E., Suda T., and Vale W.W. Regulation of corticotropin-releasing factor receptor type 2beta mRNA via cyclic AMP pathway in A7r5 aortic smooth muscle cells. Cell Signal 15 (2002) 17-25
79. Kalin N.H. Behavioral effects of ovine corticotropin-releasing factor administered to rhesus monkeys. Fed. Proc. 44 (1985) 249-253
80. Kalin N.H. The neurobiology of fear. Sci. Am, Mysteries of the Mind (1997) 76-83
81. Kalin N.H., Shelton S.E., Kraemer G.W., and McKinney W.T. Corticotropin-Releasing factor administered intraventricularly to rhesus monkeys. Peptides 4 (1983) 217-220
82. Kalin N.H., Shelton S.E., Rickman M., and Davidson R.J. Individual differences in freezing and cortisol in infant and mother rhesus monkeys. Behav. Neurosci. 112 (1998) 251-254
83. Kalin N.H., Takahashi L.K., and Chen F.L. Restraint stress increases corticotropin-releasing hormone mRNA content in the amygdala and paraventricular nucleus. Brain Res. 656 (1994) 182-186
84. Kaplan N.M. The adrenal glands. In: Griffin J.E., and Ojeda S.R. (Eds). Textbook of Endocrine Physiology (1992), Oxford University Press, Totowa, NJ 247-275
85. Kasckow J.W., Regmi A., Sheriff S., Mulchahey J., and Geracioti Jr. T.D. Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell line. Life. Sci. 65 (1999) 2709-2714
86. Kemp C.F., Woods R.J., and Lowry P.J. The corticotrophin-releasing factor-binding protein: an act of several parts. Peptides 19 (1998) 1119-1128
87. Kiang J.G. Corticotropin-releasing factor increases [Ca2+]i via receptor-mediated Ca2+ channels in human epidermoid A-431 cells. Eur. J. Pharmacol. 267 (1994) 135-142
88. Kiang J.G., Ding X.Z., Gist I.D., Jones R.R., and Tsokos G.C. Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cells. Eur. J. Pharmacol. 363 (1998) 203-210
89. Kiang J.G., Wang X., and McClain D.E. Corticotropin-releasing factor increases protein kinase C activity by elevating membrane-bound alpha and beta isoforms. Chin J Physiol. 37 (1994) 105-110
90. Kino T., and Chrousos G.P. Glucocorticoid effects on gene expression. In: Steckler T., Kalin N., and Reul J.M.H.M. (Eds). Handbook of Stress and the Brain, Part 1 (2005), Elsevier, New York 295-312
91. Kishimoto T., Radulovic J., Radulovic M., Lin C.R., Schrick C., Hooshmand F., Hermanson O., Rosenfeld M.G., and Spiess J. Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Nat. Genet 24 (2000) 415-419
92. Kohout T.A., and Lefkowitz R.J. Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol. Pharmacol. 63 (2003) 9-18
93. Koob G.F., and Heinrichs S.C. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res 848 (1999) 141-152
94. Koob G.F., Heinrichs S.C., Pich E.M., Menzaghi F., Baldwin H., Miczek K., and Britton K.T. The role of corticotropin-releasing factor in behavioural responses to stress. Ciba. Found Symp. 172 (1993) 277-289
95. 2gamma receptor. Mol. Endocrinol 12 (1998) 1077-1085
96. Kovalovsky D., Refojo D., Liberman A.C., Hochbaum D., Pereda M.P., Coso O.A., Stalla G.K., Holsboer F., and Arzt E. Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Mol. Endocrinol 16 (2002) 1638-1651
97. Krahn D.D., Gosnell B.A., Grace M., and Levine A.S. CRF antagonist partially reverses CRF- and stress-induced effects on feeding. Brain Res. Bull. 17 (1986) 285-289
98. Labrie F., Veilleux R., and LeFevre G. Corticotropin-releasing factor stimulates accumulation of adenosine 3′ × 5′-monophasphate in rat pituitary corticotrophs. Science 216 (1982) 1007-1008
99. research0019.0011-0019.0011. Landgrebe J., Wurst W., and Welzl G. Permutation-validated principal components analysis of microarray data. Genome. Biol. 3 (2002)
100. 2 receptor. Proc. Natl. Acad. Sci. USA 98 (2001) 7570-7575
101. Li P., He X., Gerrero M.R., Mok M., Aggarwal A., and Rosenfeld M.G. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes Dev. 7 (1993) 2483-2496
102. Liang K.C., and Lee E.H.Y. Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats. Psychopharmacology (Berl) 96 (1988) 232-236
103. Litvin Y., PasMantier R., Fleischer N., and Erlichman J. Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. J. Biol. Chem. 259 (1984) 10296-10302
104. Lombardo K.A., Herringa R.J., Balachandran J.S., Hsu D.T., Bakshi V.P., Roseboom P.H., and Kalin N.H. Effects of acute and repeated restraint stress on corticotropin-releasing hormone binding protein mRNA in rat amygdala and dorsal hippocampus. Neurosci. Lett. 302 (2001) 81-84
105. 2beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology 136 (1995) 4139-4142
106. Lovenberg T.W., Liaw C.W., Grigoriadis D.E., Clevenger W., Chalmers D.T., DeSouza E.B., and Oltersdorf T. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc. Natl. Acad. Sci. USA 92 (1995) 836-840
107. Ma X., Levy A., and Lightman S. Emergence of an isolated arginine vasopressin (AVP) response to stress after repeated restraint: a study of both AVP and corticotropin-releasing hormone messenger ribonucleic acid (RNA) and heteronuclear RNA. Endocrinology 138 (1997) 4351-4357
108. Ma X.M., Lightman S.L., and Aguilera G. Vasopressin and corticotropin-releasing hormone gene responses to novel stress in rats adapted to repeated restraint. Endocrinology 140 (1999) 3623-3632
109. Makino S., Asaba K., Nishiyama M., and Hashimoto K. Decreased type 2 corticotropin-releasing hormone receptor mRNA expression in the ventromedial hypothalamus during repeated immobilization stress. Neuroendocrinology 70 (1999) 160-167
110. Makino S., Schulkin J., Smith M., Pacak K., Palkovits M., and Gold P. Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress. Endocrinology 136 (1995) 4517-4525
111. Malkoski S.P., and Dorin R.I. Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene. Mol. Endocrinol. 13 (1999) 1629-1644
112. Malkoski S.P., Handanos C.M., and Dorin R.I. Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol. Cell Endocrinol. 127 (1997) 189-199
113. Mamalaki E., Kvetnansky R., Brady L.S., Gold P.W., and Herkenham M. Repeated immobilization stress alters tyrosine hydroxylase, corticotropin-releasing hormone and corticosteroid receptor messenger ribonucleic acid levels in rat brain. J. Neuroendocrinol. 4 (1992) 689-699
114. 1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr. Pharm. Des. 5 (1999) 289-315
115. McClennen S.J., and Seasholtz A.F. Transcriptional regulation of corticotropin-releasing hormone-binding protein gene expression in astrocyte cultures. Endocrinology 140 (1999) 4095-4103
116. McKnight G.S., Clegg C.H., Uhler M.D., Chrivia J.C., Cadd G.G., Correll L.A., and Otten A.D. Analysis of the cAMP-Dependent protein kinase system using molecular genetic approaches. Recent Prog. Horm. Res. 44 (1988) 307-335
117. Menard L., Ferguson S.S., Zhang J., Lin F.T., Lefkowitz R.J., Caron M.G., and Barak L.S. Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol. Pharmacol. 51 (1997) 800-808
118. Merali Z., McIntosh J., Kent P., Michaud D., and Anisman H. Aversive and appetitive events evoke the release of corticotropin-releasing hormone and bombesin-like peptides at the central nucleus of the amygdala. J. Neurosci. 18 (1998) 4758-4766
119. Mitchell A.J. The role of corticotropin releasing factor in depressive illness: a critical review. Neurosci. Biobehav Rev. 22 (1998) 635-651
120. Mugele K., Kugler H.I., and Spiess J. Immortalization of a fetal rat brain cell line that expresses corticotropin-releasing factor mRNA. DNA Cell Biol. 12 (1993) 119-126
121. Nanda S.A., Jones S.G., Kalin N.H., and Roseboom P.H. Regulation of human urocortin II promoter activity. Soc. Neurosci. Abstract 28 (2002) 769.762
122. 2 receptor promoter activity. Soc. Neurosci. Abstract 27 (2001) 914.913
123. Nemeroff C.B. The role of corticotropin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry 21 (1988) 76-82
124. Nemeroff C.B., Widerlov E., Bissette G., Walleus H., Karlsson I., Eklund K., Kilts C.D., Loosen P.T., and Vale W. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226 (1984) 1342-1344
125. Nishikimi T., Miyata A., Horio T., Yoshihara F., Nagaya N., Takishita S., Yutani C., Matsuo H., Matsuoka H., and Kangawa K. Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H3031-H3039
126. Palchaudhuri M.R., Hauger R.L., Wille S., Fuchs E., and Dautzenberg F.M. Isolation and phamacological characterization of two functional splice variants of corticotropin-releasing factor type 2 receptor from tupaia belangeri. J. Neuroendocrinol. 11 (1999) 419-428
127. Park J.H., Lee Y.J., Na S.Y., and Kim K.L. Genomic organization and tissue-specific expression of rat urocortin. Neurosci. Lett. 292 (2000) 45-48
128. Pedersen W.A., Wan R., Zhang P., and Mattson M.P. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. J. Neurosci. 22 (2002) 404-412
129. Peeters P., Moechars D., Grohlmann H., Swagemakers S., Kass S., Langlois X., Stenzel-Poore M., Bakker M., and Steckler T. Gene expression profiling of CRF signaling. Soc. Neurosci. Abstract 28 (2002) 223.222
130. Penn R.B., and Benovic J.L. Mechanisms of receptor regulation. In: Conn P.M. (Ed). Handbook of physiology, section 7: Endocrinology (1998), American Physiological Society, Amsterdam 125-164
131. Perrin M., Donaldson C., Chen R., Blount A., Berggren T., Bilezikjian L., Sawchenko P., and Vale W. Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc. Natl. Acad. Sci. USA 92 (1995) 2969-2973
132. Pich E.M., Lorang M., Yeganeh M., Rodriguez de Fonseca F., Raber J., Koob G.F., and Weiss F. Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J. Neurosci. 15 (1995) 5439-5447
133. Plotsky P.M., and Meaney M.J. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res. Mol. Brain Res. 18 (1993) 195-200
134. Potter E., Behan D.P., Fischer W.H., Linton E.A., Lowry P.J., and Vale W.W. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature 349 (1991) 423-425
135. Pozzoli G., Bilezikjian L.M., Perrin M.H., Blount A.L., and Vale W.W. Corticotropin-Releasing factor (CRF) and glucocorticoids modulate the expression of type 1 CRF receptor messenger ribonucleic acid in rat anterior pituitary cell cultures. Endocrinology 137 (1996) 65-71
136. Raadsheer F., Hoogendijk W., Stam F., Tilders F., and Swaab D. Increased numbers of corticotropinreleasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocirnology 60 (1994) 436-444
137. Raber J., Koob G.F., and Bloom F.E. Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response. J. Pharmacol. Exp. Ther. 272 (1995) 815-824
138. Ramkumar T., and Adler S. A Requirement for the POU transcription factor, Brn-2, in corticotropin-releasing hormone expression in a neuronal Cell Line. Mol. Endocrinol 13 (1999) 1237-1248
139. Reisine T., and Hoffman A. Desensitization of corticotropin-releasing factor receptors. Biochem. Biophys. Res. Commun. 111 (1983) 919-925
140. Reyes T.M., Lewis K., Perrin M.H., Kunitake K.S., Vaughan J., Arias C.A., Hogenesch J.B., Gulyas J., Rivier J., Vale W.W., and Sawchenko P.E. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc. Natl. Acad. Sci. USA 98 (2001) 2843-2848
141. Roseboom P.H., Bakshi V.P., Herringa R.J., and Kalin N.H. Microarray analysis of restraint stress-induced gene expression changes in the rat septum. Soc. Neurosci. Abstract 27 (2001) 739.733
142. Roseboom P.H., Urben C.M., and Kalin N.H. Persistent corticotropin-releasing factorl receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32. Brain Res. Mol. Brain Res. 92 (2001) 115-127
143. Rossant C.J., Pinnock R.D., Hughes J., Hall M.D., and McNulty S. Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3′,5′- monophosphate response elementbinding protein and activation of p42/p44 mitogen-activated protein kinase. Endocrinology 140 (1999) 1525-1536
144. Rots N.Y., deJong J., Workel J.O., Levine S., Cools A.R., and DeKloet E.R. Neonatal maternally deprived rats have as adults elevated basal pituitary-adrenal activity and enhanced susceptibility to apomorphine. J. Neuroendocrinol. 8 (1996) 501-506
145. Saffran M., and Schally A.V. The release of corticotrophin by anterior pituitary tissue in vitro. Can. J. Biochem. Physiol. 33 (1956) 408-415
146. Sakai K., Yamada M., Horiba N., Wakui M., Demura H., and Suda T. The genomic organization of the human corticotropin-releasing factor type-1 receptor. Gene 219 (1998) 125-130
147. Sanchez M.M., Young L.J., Plotsky P.M., and Insel T.R. Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain. J. Comp. Neurol. 408 (1999) 365-377
148. Sandberg J.A., Parker V.P., Blanchard K.S., Sweedler D., Powell J.A., Kachensky A., Bellon L., Usman N., Rossing T., Borden E., and Blatt L.M. Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers. J. Clin. Pharmacol. 40 (2000) 1462-1469
149. 1 ) and CRF1 receptor mRNA expression in human neuroblastoma SH-SY5Y cells. Fundam. Clin. Pharmacol. 13 (1999) 484-489
150. Segre G.V., and Goldring S.R. Trends Endocrin. Metab. 4 (1993) 309-314
151. Shanks N., Larocque S., and Meaney M.J. Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress. J. Neurosci. 15 (1995) 376-384
152. Sheriff S., Dautzenberg F.M., Mulchahey J.J., Pisarska M., Hauger R.L., Chance W.T., Balasubramaniam A., and Kasckow J.W. Interaction of neuropeptide Y and corticotropin-releasing factor signaling pathways in AR-5 amygdalar cells. Peptides 22 (2001) 2083-2089
153. Sherman J.E., and Kalin N.H. Corticotropin releasing hormone: effects on stress-related behavior in rats. In: Moody T. (Ed). Neural. and Endocrine Peptides and Receptors (1986), Plenum Publ Co., Bethesda, MD 195-204
154. Simone N.L., Bonner R.F., Gillespie J.W., Emmert-Buck M.R., and Liotta L.A. Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet 14 (1998) 272-276
155. Skelton K.H., Nemeroff C.B., Knight D.L., and Owens M.J. Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. J. Neurosci. 20 (2000) 1240-1248
156. Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., Sawchenko P.E., Koob G.F., Vale W., and Lee K.F. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20 (1998) 1093-1102
157. Smith M.A., Kim S.Y., VanOers H.J.J., and Levine S. Maternal deprivation and stress induce immediate early genes in the infant rat brain. Endocrinology 138 (1997) 4622-4628
158. Spengler D., Rupprecht R., Van L.P., and Holsboer F. Identification and characterization of a 3′, 5′-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing gene promoter. Mol. Endocrinol. 6 (1992) 1931-1941
159. Spiess J., Dautzenberg F.M., Sydow S., Hauger R.L., Ruhmann A., and Radulowic J. Molecular properties of the CRF receptor. Trends Endocrin Metab. 9 (1998) 140-145
160. Spina M. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 273 (1996) 1561-1564
161. Steckler T. CRF antagonists as novel treatment strategies for stress-related disorders. In: Steckler T., Kalin N., and Reul J.M.H.M. (Eds). Handbook of Stress and the Brain, Part 1 (2005), Elsevier, New York 371-400
162. Stenzel-Poore M.P., Cameron V.A., Vaughan J., Sawchenko P.E., and Vale W. Development of cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130 (1992) 3378-3386
163. Stenzel-Poore M.P., Heinrichs S.C., Rivest S., Koob G.F., and Vale W.W. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J. Neurosci. 14 (1994) 2579-2584
164. Stout S.C., Owens M.J., and Nemeroff C.B. Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment. J. Pharmacol. Exp. Ther. 300 (2002) 1085-1092
165. 2alpha receptors. Eur. J. Pharmacol. 379 (1999) 219-227
166. Timofeeva E., Deshaies Y., Picard F., and Richard D. Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) zucker rats. Am. J. Physiol. 277 (1999) R1749-R1759
167. Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., and Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat. Genet. 19 (1998) 162-166
168. Tsai-Morris C.H., Buczko E., Geng Y., Gamoa-Pinto A., and Dufau M.L. The genomic structure of the rat corticotropin releasing factor receptor. J. Biol. Chem. 271 (1996) 14519-14525
169. Valdenaire O., Giller T., Breu V., Gottowik J., and Kilpatrick G. A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. Biochim. Biophys. Acta. 1352 (1997) 129-132
170. Vale W., Spiess J., Rivier C., and Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and betaendorphin. Science 213 (1981) 1394-1397
171. van der Meer M., Baumans V., Olivier B., and van Zutphen B.L. Impact of transgenic procedures on behavioral and physiological responses in postweaning mice. Physiol. Behav. 73 (2001) 133-143
172. van Gaalen M.M., Stenzel-Poore M.P., Holsboer F., and Steckler T. Effects of transgenic overproduction of CRH on anxiety-like behaviour. Eur. J. Neurosci. 15 (2002) 2007-2015
173. van Oers H.J., de Kloet E.R., and Levine S. Early vs. late maternal deprivation differentially alters the endocrine and hypothalamic responses to stress. Brain Res. Dev. Brain Res. 111 (1998) 245-252
174. Vaughan J., Donaldson C., Bittencourt J., Perrin M.H., Lewis K., Sutton S., Chan R., Turnbull A.V., Lovejoy D., Rivier C., et al. Urocortin, a mammalian seuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378 (1995) 287-292
175. Weninger S.C., Dunn A.J., Muglia L.J., Dikkes P., Miczek K.A., Swiergiel A.H., Berridge C.W., and Majzoub J.A. Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH. Proc. Natl. Acad. Sci. USA 96 (1999) 8283-8288
176. Weninger S.C., Peters L.L., and Majzoub J.A. Urocortin expression in the edinger-westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Endocrinology 141 (2000) 256-263
177. Wigger A., and Neumann I.D. Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats. Physiol. Behav. 66 (1999) 293-302
178. Wong L.F., and Murphy D. Adenoviral-mediated overexpression of Brn2 in the rat paraventricular nucleus: no effect on vasopressin or corticotrophin releasing factor RNA levels. Mol. Cell Endocrinol. 200 (2003) 165-175
179. Wynn P.C., Hauger R.L., Holmes M.C., Millan M.A., Catt K.J., and Aguilera G. Brain and pituitary receptors for corticotropin releasing factor: localization and differential regulation after adrenalectomy. Peptides 5 (1984) 1077-1084
180. Xiong Y., Xie L.Y., and Abou-Samra A.B. Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptor. Endocrinology 136 (1995) 1828-1834
181. Yuan P.X., Zhou R., Farzad N., Gray N.A., Du J., and Manji H.K. Enhancing resilience to stress: the role of signaling cascades. In: Steckler T., Kalin N., and Reul J.M.H.M. (Eds). Handbook of Stress and the Brain, Part 1 (2005), Elsevier, Amsterdam 751-772
182. Zhang X.K., Dong J.M., and Chiu J.F. Regulation of alpha-fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site. J. Biol. Chem. 266 (1991) 8248-8254
183. Zhao L., Donaldson C.J., Smith G.W., and Vale W.W. The structures of the mouse and human urocortin genes (Ucn and UCN). Genomics 50 (1998) 23-33
184. Zobel A.W., Nickel T., Kunzel H.E., Ackl N., Sonntag A., Ising M., and Holsboer F. Effects of the highaffinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatr. Res. 34 (2000) 171-181