Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of β-amyloid plaques in Alzheimer's disease

Journal of Medicinal Chemistry

Volumn 52, Issue 20, 2009, Pages 6394-6401

  Ono, Masahiro ^a,b   Watanabe, Rumi ^a   Kawashima, Hidekazu ^b   Yan, Cheng ^b   Kimura, Hiroyuki ^b   Watanabe, Hiroyuki ^a   Haratake, Mamoru ^a   Saji, Hideo ^b   Nakayama, Morio ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROPHENYL) 3 (4 METHYLAMINOPHENYL) 2 PROPEN 1 ONE; 1 (4 FLUOROPHENYL) 3 (4 NITROPHENYL) 2 PROPEN 1 ONE; 1 [4 (2 FLUOROETHOXY)PHENYL] 3 (4 NITROPHENYL) 2 PROPEN 1 ONE; 1 [4 (2 FLUOROETHOXY)PHENYL] 3 [4 (METHYLAMINO)PHENYL] 2 PROPEN 1 ONE; 1 [4 (2 FLUOROETHOXY)PHENYL]ETHANONE; 1 [4 (2 HYDROXYETHOXY)PHENYL]ETHANONE; 1 [4 [2 (2 FLUOROETHOXY)ETHOXY]PHENYL]ETHANONE; 1 [4 [2 (2 HYDROXYETHOXY)ETHOXY]PHENYL]ETHANONE; 1 [4 [2 (FLUOROETHOXY)ETHOXY]PHENYL] 3 (4 NITROPHENYL) 2 PROPEN 1 ONE; 1 [4 [2 (FLUOROETHOXY)ETHOXY]PHENYL] 3 [4 (METHYLAMINO) PHENYL] 2 PROPEN 1 ONE; 1 [4 [2 [(FLUOROETHOXY)ETHOXY]ETHOXY]PHENYL] 3 (4 NITROPHENYL) 2 PROPEN 1 ONE; 1 [4 [2 [(FLUOROETHOXY)ETHOXY]ETHOXY]PHENYL] 3 [4 (METHYAMINO)PHENYL] 2 PROPEN 1 ONE; 1 [4 [2 [2 (2 FLUOROETHOXY)ETHOXY]ETHOXY]PHENYL]ETHANONE; 1 [4 [2 [2 (2 HYDROXYETHOXY)ETHOXY]ETHOXY]PHENYL]ETHANONE; 2 [2 [2 [4 [3 [4 (DIMETHYLAMINO)PHENYL]ACRYLOYL]PHENOXY]ETHOXY]ETHOXY]ETHYL 4 METHYLBENZENESULFONATE; 3 (4 AMINOPHENYL) 1 (4 FLUOROPHENYL) 2 PROPEN 1 ONE; 3 (4 AMINOPHENYL) 1 [4 (2 FLUOROETHOXY)PHENYL] 2 PROPEN 1 ONE; 3 (4 AMINOPHENYL) 1 [4 [2 (FLUOROETHOXY)ETHOXY]PHENYL] 2 PROPEN 1 ONE; 3 (4 AMINOPHENYL) 1 [4 [2 [(FLUOROETHOXY)ETHOXY]ETHOXY]PHENYL] 2 PROPEN 1 ONE; 3 (4 DIMETHYLAMINOPHENYL) 1 (4 FLUOROPHENYL) 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 (4 HYDROXYPHENYL) 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 [4 (2 FLUOROETHOXY)PHENYL] 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 [4 (2 HYDROXYETHOXY)PHENYL] 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 [4 [2 (FLUOROETHOXY)ETHOXY] PHENYL] 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 [4 [2 (HYDROXYETHOXY)ETHOXY] PHENYL] 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 [4 [2 [(FLUOROETHOXY)ETHOXY] ETHOXY]PHENYL] 2 PROPEN 1 ONE; 3 [4 (DIMETHYLAMINO)PHENYL] 1 [4 [2 [(HYDROXYETHOXY)ETHOXY] ETHOXY]PHENYL] 2 PROPEN 1 ONE; CHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN BINDING;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CHALCONES; DRUG DESIGN; FEMALE; FLUORINE RADIOISOTOPES; HALOGENATION; HUMANS; ISOTOPE LABELING; MALE; MICE; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION;

EID: 70350075454     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901057p     Document Type: Article

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