Securing genome stability by orchestrating DNA repair: Removal of radiation-induced clustered lesions in DNA

BioEssays

Volumn 23, Issue 8, 2001, Pages 745-749

  Dianov, Grigory L ^a   O'Neill, Peter ^a   Goodhead, Dudley T ^a  

^a MRC Radiation And Genome Stability Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE IV; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA GLYCOSYLTRANSFERASE; GLYCOSIDASE; LYASE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; DNA DAMAGE; DNA REPAIR; GENOME; HUMAN; METABOLISM; RADIATION EXPOSURE;

ANIMALS; CARBON-OXYGEN LYASES; DEOXYRIBONUCLEASE IV (PHAGE T4-INDUCED); DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; GENOME; HUMANS; MODELS, BIOLOGICAL; N-GLYCOSYL HYDROLASES;

EID: 0034876617     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.1104     Document Type: Article

References (39)

1. Primary Radical Process in DNA
2. Detection and repair of DNA base damages produced by ionizing radiation
3. Effects of radiations of different qualities on cells: Molecular mechanism of damage and repair
4. Computational modeling of low-energy electron-induced DNA damage by early physical and chemical events
5. DNA double-strand break repair determines the RBE of a particles
6. The induction and joining of DNA double strand breaks in V79-4 mammalian cells under aerobic and hypoxic conditions by γ and α radiations
7. Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA
8. The complexity of DNA damage: Relevance to biological consequences
9. The complexity of radiation-induced DNA damage as revealed by exposure to cell extracts
10. Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
11. Generation of single-nucleotide repair patches following excision of uracil residues from DNA
12. Quality Control by DNA Repair
13. Base excision repair of oxidative DNA damage activated by XPG protein
14. Passing the baton in base excision repair
15. Holding damaged DNA together
16. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
17. Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1
18. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
19. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis
20. Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase β and the XRCC1 protein
21. XRCC1 polypeptide interacts with DNA polymerase β and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular "nick-sensor" in vitro
22. The action of Escherichia coli endonuclease III on multiply damaged sites in DNA
23. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins
24. Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein
25. Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA
26. Multiply damaged sites in DNA: Interactions with Escherichia coli endonucleases III and VIII
27. In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites
28. Nucleases involved in DNA repair
29. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
30. Supression of spontaneous mutagenesis in human cells by DNA base excision repair
31. Single and double-strand break formation in DNA irradiated in aqueous solution: Dependence on dose and OH radical scavender concentration
32. Instability and decay of the primary structure of DNA
33. The molecular basis of the origin of complete and mosaic mutants
34. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation
35. Illegitimate recombination induced by benzo-a-pyren diol epoxide in Escherichia coli
36. Mutation in Escherichia coli and mammalian cells induced by closely spaced 1-methylpyrene-deoxyadenosine adducts in opposite DNA strands
37. Mechanism of mutation on DNA templates containing synthetic abasic sites: Study with a double stranded vector
38. DNA glycosylases in the base excision repair of DNA