The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice

Histology and Histopathology

Volumn 25, Issue 7, 2010, Pages 819-830

  Ćavar, Ivan ^a   Kelava, Tomislav ^b   Vukojević, Katarina ^a,c   Saraga Babić, Mirna ^c   Čulo, Filip ^a,b  

^a UNIVERSITY OF MOSTAR   (Bosnia and Herzegovina)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c UNIVERSITY OF SPLIT   (Croatia)

Author keywords

Acetaminophen; Immunohistochemistry; Liver injury; NF kB; Prostaglandin E2

Indexed keywords

ANIMALIA; MUS;

ALANINE AMINOTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2A PROTEIN, HUMAN; PARACETAMOL; PROSTAGLANDIN E2;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; CELL PROTECTION; DRUG EFFECT; DRUG TOXICITY; FEMALE; INTOXICATION; LIVER; LIVER FAILURE; MALE; METABOLISM; MOUSE; PATHOLOGY;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; CYTOPROTECTION; DINOPROSTONE; DRUG TOXICITY; FEMALE; LIVER; LIVER FAILURE, ACUTE; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OVERDOSE;

EID: 77956633418     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Araki H., Ukawa H., Sugawa Y., Yagi K., Suzuki K. and Takeuchi K. (2000). The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach. Aliment. Pharmacol. Ther. 14, 116-124.
2. Bauer I., Vollmar B., Jaeschke H., Rensing H., Kraemer T., Larsen R. and Bauer M. (2000). Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat. J. Hepatol. 33, 395-406.
3. Bernal W. (2003). Intensive care support therapy. Liver. Transpl. 9, 15-17.
4. Bourdi M., Masubuchi Y., Reilly T.P., Amouzadeh H.R., Martin J.L., George J.W., Shah A.G. and Pohl L.R. (2002). Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 35, 289-298.
5. Bourne R., Lichtenstein L.M., Melmon K.L., Henney C.S., Weinstein Y. and Shearer G.M. (1974). Modulation of Inflammation and Immunity by Cyclic AMP. Science 184, 119-128.
6. Cheon H., Rho Y.H., Choi S.J., Lee Y.H., Song G.G., Sohn J., Won N.H. and Ji J.D. (2006). Prostaglandin E2 augments IL-10 signaling and function. J. Immunol. 177, 1092-1100.
7. Čulo F., Renić M., Sabolović D., Radoš M., Bilić A. and Jagić V. (1995). Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. Eur. J. Gastroenterol. Hepatol. 7, 757-762.
8. Dambach D.M., Durham S.K., Laskin J.D. and Laskin D.L. (2006). Distinct roles of NF-kappaB p50 in the regulation of acetaminopheninduced inflammatory mediator production and hepatotoxicity. Toxicol. Appl. Pharmacol. 211, 157-165.
9. Decker K. (1990). Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192, 245-261.
10. Dey I., Lejeune M. and Chadee K. (2006). Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. Br. J. Pharmacol. 149, 611-623.
11. Enomoto A., Itoh K., Nagayoshi E., Haruta J., Kimura T., O'Connor T., Harada T. and Yamamoto M. (2001). High Sensitivity of Nrf2 Knockout Mice toAcetaminophen Hepatotoxicity Associated with Decreased Expression of Regulated Drug Metabolizing Enzymes and Antioxidant Genes. Toxicol. Sci. 59, 169-177.
12. Gardner C.R., Laskin J.D., Dambach D.M., Sacco M., Durham S.K., Bruno M.K., Cohen S.D., Gordon M.K., Gerecke D.R., Zhou P. and Laskin D.L. (2002). Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol. Appl. Pharmacol. 184, 27-36.
13. Guarner F., Boughton-Smith N.K., Blackwell G.J. and Moncada S. (1988). Reduction by prostacyclin of acetaminophen-induced liver toxicity in the mouse. Hepatology 8, 248-253.
14. Hao C.M. and Breyer M.D. (2008). Physiological regulation of prostaglandins in the kidney. Annu. Rev. Physiol. 70, 357-377.
15. Harris S.G., Padilla J., Koumas L., Ray D. and Phipps R.P. (2002). Prostaglandins as modulators of immunity. Trends Immunol. 23, 144-150.
16. Hata A.N. and Breyer R.M. (2004). Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103, 147-166.
17. Hinson J.A., Pike S.L., Pumford N.R. and Mayeux P.R. (1998). Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice. Chem. Res. Toxicol. 11, 604-607.
18. Ito Y., Abril E.R., Bethea N.W. and McCuskey R.S. (2003). Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 286, 60-67.
19. Jaeschke H. (2000). Reactive oxygen and mechanisms of inflammatory liver injury. J. Gastroenterol. Hepatol. 15, 718-724.
20. Jaeschke H., Knight T.R. and Bajt M.L. (2003). The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol. Lett. 144, 279-288.
21. James L.P., Mayeux P.R. and Hinson J. A. (2003). Acetaminopheninduced hepatotoxicity. Drug. Metab. Dispos. 31, 1499-1506.
22. Janssen-Heininger Y.M., Poynter M.E. and Baeuerle P.A. (2000). Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic. Biol. Med. 28, 1317-1327.
23. Kamanaka Y., Kawabata A., Matsuya H., Taga C., Sekiguchi F. and Kawao N. (2003). Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat. Life Sci. 74, 793-802.
24. Laskin J.D., Heck D.E., Gardner C.R. and Laskin D.L. (2001). Prooxidant and antioxidant functions of nitric oxide in liver toxicity. Antioxid. Redox Signal. 3, 261-271.
25. Lee W.M. (2003). Acute liver failure in the United States. Semin. Liver Dis. 23, 217-226.
26. Matsuoka T. and Narumiya S. (2007). Prostaglandin receptor signaling in disease. Scientific World J. 7, 1329-1347.
27. Mazer M. and Perrone J. (2008). Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J. Med. Toxicol. 4, 2-6.
28. Morio L.A., Chiu H., Sprowles K.A., Zhou P., Heck D.E., Gordon M.K. and Laskin D.L. (2001). Distinct roles of tumor necrosis factor-alpha and nitric oxide in acute liver injury induced by carbon tetrachloride in mice. Toxicol. Appl. Pharmacol. 172, 44-51.
29. Muntané J., Rodríguez F.J., Segado O., Quintero A., Lozano J.M., Siendones E., Pedraza C.A., Delgado M., O'Valle F., García R., Montero J.L., De La Mata M. and Miño G. (2000). TNF-alpha dependent production of inducible nitric oxide is involved in PGE(1) protection against acute liver injury. Gut 47, 553-562.
30. Nakano H., Monden M., Umeshita K., Murata M., Miyoshi H., Kanai T., Gotoh M. and Mori T. (1994). Cytoprotective effect of prostaglandin I2 analogues on superoxide-induced hepatocyte injury. Surgery 116, 883-889. (Pubitemid 24347198)
31. O'Connor J.A. and Bennett S. (2005). Acetaminophen toxicity revisited: is drug-induced hepatotoxity immune mediated? J. Pediatr. Gastroenterol. Nutr. 40, 528-529.
32. Oh-ishi S., Utsunomiya I., Yamamoto T., Komuro Y. and Hara Y. (1996). Effects of prostaglandins and cyclic AMP on cytokine production in rat leukocytes. Eur. J. Pharmacol. 300, 255-259.
33. Ogawa M., Suzuki J., Kosuge H., Takayama K., Nagai R. and Isobe M. (2009). The mechanism of antiinflammatory effects of prostaglandin E2 receptor 4 activation in murine cardiac transplantation. Transplantation 87, 1645-1653.
34. Quiroga J. and Prieto J. (1993). Liver cytoprotection by prostaglandins. Pharmacol. Ther. 58, 67-91.
35. Reilly T.P., Brady J.N., Marchick M.R., Bourdi M., George J.W., Radonovich M.F., Pise-Masison C.A. and Pohl L.R. (2001). A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. Chem. Res. Toxicol. 14, 1620-1628.
36. Renić M., Čulo F. and Sabolović D. (1995). Protection of acute hepatotoxicity in mice by intrleukin-1a2. Periodicum Biologorum 97, 55-60.
37. Schroer K., Ying Z., Saunders M.A., Deng W.G., Xu X.M., Meyer-Kirchrath J. and Wu K.K. (2002). Obligatory Role of Cyclic Adenosine Monophosphate Response Element in Cyclooxygenase-2 Promoter Induction and Feedback Regulation by Inflammatory Mediators. Circulation 105, 2760-2765.
38. Silva V.M., Chen C., Hennig G.E., Whiteley H.E. and Manautou J.E. (2001). Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green. Food Chem. Toxicol. 39, 271-278.
39. Suzuki K., Araki H., Mizoguchi H., Furukawa O. and Takeuchi K. (2001). Prostaglandin E inhibits indomethacin-induced gastric lesions through EP-1 receptors. Digestion 63, 92-101.
40. Tran-Thi T.A., Decker K. and Baeuerle P.A. (1995). Differential activation of transcription factors NF-kappa B and AP-1 in rat liver macrophages. Hepatology 22, 613-619.
41. Willuweit A., Sass G., Schöneberg A., Eisel U., Tiegs G. and Clauss M. (2001). Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. J. Immunol. 167, 3944-3952.
42. Yin H., Cheng L., Langenbach R. and Ju C. (2007). Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury. Hepatology 45, 159-169.