Acetaminophen toxicity revisited: Is drug-induced hepatotoxity immune mediated?

Journal of Pediatric Gastroenterology and Nutrition

Volumn 40, Issue 4, 2005, Pages 528-529

  O'Connor, Judith A ^a   Bennett, Sean ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLUTATHIONE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; RNA;

ANIMAL MODEL; ANTIGEN EXPRESSION; IMMUNE SYSTEM; INFLAMMATION; LIVER TOXICITY; LYMPHOCYTE DEPLETION; NATURAL KILLER CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; T LYMPHOCYTE; TOXIC HEPATITIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; HUMANS; KILLER CELLS, NATURAL; LIVER; LIVER DISEASES; MICE;

ANIMALIA;

EID: 16844386470     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MPG.0000137880.41925.2F     Document Type: Note

References (6)

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2. Laskin DI, Gardner CR. Nonparenchymal cells inflammatory macrophages and hepatoxicity. In: Kaplowitz N, DeLeve LD, eds. Drug Induced Liver Diseases. New York: Marcel Dekker; 2003:183-212.
3. Michael SI, Pumford NR, Mayeux PR, Niesman MR, Hinson JA. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and formation of reactive oxygen and nitrogen species. Hepatology 1999;30:186-95.
4. Ishida Y, Kondo T, Ohshima T, et al. A pivotal involvement of IFN gamma in the pathogenesis of acetaminophcn-induced acute liver injury. FASEB J 2002;16:1227-36.
5. Bourrdi M, Masubuchi Y, Teilly TP, et al. Protection against acetaminophen induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 2002;35:289-98.
6. Boess F, Bopst M, Althaus R, et al. Acetaminophen toxicity in tumor necrosis factor/lymphotoxin-a gene knockout mice. Hepatology 1998;27:1021.