Thermoregulatory and thermal control in the human cutaneous circulation

Frontiers in Bioscience - Scholar

Volumn 2 S, Issue 3, 2010, Pages 825-853

  Johnson, John M ^a   Kellogg Jr , Dean L ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Active vasodilation; Adrenergic function; Human; Laser doppler flowmetry; Local cooling; Local heating; Microdialysis; Nitric oxide; Reflex vasoconstriction; Review; Skin circulation

Indexed keywords

BOTULINUM TOXIN A; NEUROPEPTIDE Y; NITRIC OXIDE; NORADRENALIN; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADRENERGIC SYSTEM; ANIMAL; DRUG EFFECT; FEMALE; HUMAN; IN VITRO STUDY; INNERVATION; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; PHYSIOLOGY; REFLEX; REVIEW; SKIN; SWEATING; THERMOREGULATION; VASCULARIZATION; VASOCONSTRICTION; VASODILATATION;

ANIMALS; BODY TEMPERATURE REGULATION; BOTULINUM TOXIN TYPE A; FEMALE; HUMANS; IONTOPHORESIS; LASER-DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; NEUROPEPTIDE Y; NITRIC OXIDE; NOREPINEPHRINE; REFLEX; SKIN; SUBSTANCE P; SWEATING; SYMPATHETIC NERVOUS SYSTEM; VASOACTIVE INTESTINAL PEPTIDE; VASOCONSTRICTION; VASODILATION;

EID: 77956630521     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Article

References (192)

1. JM Johnson, DW Proppe. Cardiovascular adjustments to heat stress. In: Handbook of Physiology, Section 4 Environmental Physiology. Eds: MJ Fregly, CM Blatteis Oxford University Press, New York (1996)
2. ADM Greenfield. The circulation through the skin In: Handbook of Physiology, Section 2 Circulation Eds: WF Hamilton, p Dow Am Physiol Soc, Washington, DC (1963)
3. DL Kellogg Jr., In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans. J Appl Physiol, 100, 1709-1718 (2006)
4. IC Roddie. Circulation to skin and adipose tissue In: Handbook of Physiology, Section 2 The Cardiovascular System. Ed JT Shepherd, FM Abboud Am Physiol Soc, Bethesda, MD (1983)
5. LB Rowell. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev, 54, 75-159 (1974)
6. LB Rowell. Cardiovascular adjustments to thermal stress. In. Handbook of Physiology. The Cardiovascular System Eds: J T Shepherd, F M Abboud Am Physiol Soc, Bethesda, MD (1983)
7. PÂ Öberg. Laser-Doppler flowmetry. Crit Rev BiomedEng, 18, 125-163 (1990)
8. MD Stern, DL Lappe, PD Bowen, JE Chimosky, GA Holloway, HR Keiser, RL Bowman. Contiuous measurement of tissue blood flow by laser-Doppler spectroscopy. Am J Physiol Heart Circ Physiol, 232, H441-H448 (1977)
9. JL Saumet, DL Kellogg Jr, WF Taylor, JM Johnson. Cutaneous laser-Doppler flowmetry. influence of underlying muscle blood flow. J Appl Physiol, 65, 478-481 (1988)
10. JM Johnson. The cutaneous circulation. In: Laser Doppler Blood Flowmetry Eds: AP Shepherd, PÂ Öberg Kluwer Academic Publishers, Boston MA (1990)
11. JM Johnson, WF Taylor, AP Shepherd, MK Park. Laser-Doppler measurement of skin blood flow, comparison with plethysmography. J Appl Physiol, 56, 798-803 (1984) (Pubitemid 14149493)
12. JM Johnson. Nonthermoregulatory control of human skin blood flow. J Appl Physiol, 61, 1613-1622(1986)
13. DL Kellogg Jr, JM Johnson, WL Kenney, PE Pergola, WA Kosiba. Mechanisms of control of skin blood flow during prolonged exercise in humans. Am J Physiol Heart Circ Physiol, 265, H562-H568 (1993) (Pubitemid 23273592)
14. Y Tabuchi, M Nakamaru, H Rakugi, M Nagano, H Mikami, T Ogihara. Endothelin inhibits presynaptic neurotransmission in rat mesenteric artery. Biochem Biophys Res Commun, 161(2), 803-808 (1989) (Pubitemid 19162705)
15. WF Taylor, JM Johnson, D O'Leary, MK Park. Effect of high local temperature on reflex cutaneous vasodilation. J Appl Physiol, 57, 191-196 (1984) (Pubitemid 14098698)
16. DL Kellogg Jr, Y Liu, IF Kosiba, D O'Donnell. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol, 86, 1185-1190 (1999) (Pubitemid 29172150)
17. CT Minson, LT Berry, MJ Joyner. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol, 91, 1619-1626 (2001) (Pubitemid 32900352)
18. GJ Hodges, WA Kosiba, K Zhao, GE Alvarez, JM Johnson. The role of baseline in the cutaneous vasoconstrictor responses during combined local and whole body cooling in humans. Am J Physiol Heart Circ Physiol, 293, H3187-H3192 (2007) (Pubitemid 350106546)
19. GJ Hodges, K Zhao, WA Kosiba, JM Johnson. The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans. J Physiol (Lond), 573, 849-857 (2006) (Pubitemid 44089075)
20. L Ekenvall, LE Lindblad, O Norbeck, BM Etzell. a-Adrenoceptors and cold-induced vasoconstriction in human finger skin. Am J Physiol Heart Circ Physiol, 255, H1000-H1003 (1988)
21. LE Lindblad, L Ekenvall. Alpha-adrenoreceptors in the vessels of human finger skin. Acta Physiol Scand, 128, 219-222 (1986) (Pubitemid 16032353)
22. LE Lindblad, L Ekenvall, K Ancker, H Rohman, PÂ Öberg. Laser Doppler flow-meter assessment of iontophoretically applied norepinephrine on human finger skin circulation. J Invest Dermatol, 87, 634-636 (1986) (Pubitemid 17178896)
23. DL Kellogg Jr, JM Johnson, WA Kosiba. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol, 257
24. Heart Circ Physiol, H1599-1606 (1989)
25. S Durand, B Fromy, P Bouye, JL Saumet, P Abraham. Current-induced vasodilation during water iontophoresis (5 min, 0.10 mA) is delayed from current onset and involves aspirin sensitive mechanisms. J Vase Res, 39, 59-71 (2002) (Pubitemid 34158360)
26. M Grossmann, MJ Jamieson, DL Kellogg, WA Kosiba, PE Pergola, CG Crandall, AMM Shepherd. The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia. Microvasc Res, 50, 444-452 (1995)
27. CG Crandall, RA Etzel, JM Johnson. Evidence of functional Beta-adrenoceptors in the cutaneous vasculature. Am J Physiol Heart Circ Physiol, 273, H1038-H1043 (1997)
28. DP Stephens, K Aoki, WA Kosiba, JM Johnson. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol, 280, H1496-H1504 (2001)
29. DP Stephens, LAT Bennett, K Aoki, WA Kosiba, N Charkoudian, JM Johnson. Sympathetic nonnoradrenergic cutaneous vasoconstriction in women is associated with reproductive hormone status. Am J Physiol Heart Circ Physiol, 282, H264-H272 (2002) (Pubitemid 34654158)
30. DP Stephens, AR Saad, LAT Bennett, WA Kosiba, JM Johnson. Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol, 287, H1401-H1409 (2004)
31. GA Holloway Jr., Cutaneous blood flow responses to injection trauma measured by laser-Doppler velocimetry. J Invest Dermatol, 74, 1-4 (1980) (Pubitemid 10134589)
32. GJ Hodges, WA Kosiba, K Zhao, JM Johnson. The involvement of norepinephrine, neuropeptide Y, and nitric oxide in the cutaneous vasodilator response to local heating in humans. J Appl Physiol, 105, 233-240 (2008)
33. C Anderson, T Andersson, K Wardell. Changes in skin circulation after insertion of a microdialysis probe visualized by laser-Doppler perfusion imaging. J Invest Dermatol, 102, 808-811 (1994)
34. DL Kellogg Jr, JL Zhao, Y Wu. Neuronal nitric oxide synthase mechanisms in the cutaneous vasculature of humans in vivo. J Physiol (Lond), 586, 847-857 (2008) (Pubitemid 351194122)
35. S Shastry, MJ Joyner. Geldanamycin attenuates NO-mediated dilation in human skin. Am J Physiol Heart Circ Physiol, 282, H232-H236 (2002) (Pubitemid 34654154)
36. DA Low, M Shibasaki, SL Davis, DM Keller, CG Crandall. Does local heating-induced nitric oxide production attenuate vasoconstrictor responsiveness to lower body negative pressure in human skin? J Appl Physiol, 102, 1839-1843 (2007) (Pubitemid 46701952)
37. M Shibasaki, DA Low, SL Davis, CG Crandall. Nitric Oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine. J Appl Physiol, 105, 1504-1508 (2008)
38. JE Wingo, DA Low, DM Keller, RM Brothers, M Shibasaki, CG Crandall. Effect of elevated local temperature on cutaneous vasoconstrictor responsiveness in humans. J Appl Physiol, 106, 571-575 (2009)
39. JM Johnson, DS O'Leary, WF Taylor, W Kosiba. Effect of local warming on forearm reactive hyperaemia. Clin Physiol, 6, 337-346 (1986) (Pubitemid 16005910)
40. GL Brengelmann, MV Savage. Temperature regulation in the neutral zone. Ann N Y Acad Sci, 813, 39-50 (1997) (Pubitemid 27189868)
41. JM Johnson, GL Brengelmann, JRS Hales, PM Vanhoutte, CB Wenger. Regulation of the cutaneous circulation. Fed Proc, 45, 2841-2850 (1986) (Pubitemid 17233717)
42. MV Savage, GL Brengelmann. Control of skin blood flow in the neutral zone of human body temperature regulation. J Appl Physiol, 80, 1249-1257(1996) (Pubitemid 26118528)
43. N Charkoudian, JM Johnson. Female reproductive hormones and thermoregulatory control of skin blood flow. Exerc Sport Sci Rev, 28, 108-112 (2000)
44. OG Edholm, RH Fox, R K MacPherson. Vasomotor control of the cutaneous blood vessels in the human forearm. J Physiol (Lond), 139, 455-465 (1957)
45. IC Roddie, JT Shepherd, RF Whelan. The contribution of constrictor and dilator nerves to the skin vasodilation during body heating. J Physiol (Lond), 136, 489-497 (1957)
46. P Drummond. The effect of noradrenaline, angiotensin II and vasopressin on blood flow and sensitivity to heat in capsaicin-treated skin. Clin Auton Res, 8, 87-93 (1998) (Pubitemid 28200718)
47. SM Frank, SN Raja, PK Wu, N el-Gamal. Alpha-adrenergic mechanisms of thermoregulation in humans. Ann N Y Acad Sci, 813, 101-110 (1997)
48. SM Frank, N el-Gamal, SN Raja, PK Wu, O Afifi. Role of alpha-adrenoceptors in the maintenance of core temperature in humans. Clin Sci, 89, 219-225 (1995)
49. N Shibahara, H Matsuda, K Umeno, Y Shimada, T Itoh, K Terasawa. The responses of skin blood flow, mean arterial pressure and R-R interval induced by cold stimulation with cold wind and ice water. J Auton Nerv Syst, 61, 109-115 (1996) (Pubitemid 26384332)
50. TM Hökfelt, O Johansson, A Ljungdahl, JM Lundberg, M Schultzberg. Peptidergic neurons. Nature, 284, 515-521 (1980)
51. JM Lundberg, A Franco-Cerecda, Y Lou, A Modin, J Pernow. Differential release of classical transmitters and peptides In: Molecular and Cellular Mechanisms of Neurotransmitter Release Eds: L Stjârne, p Greengard, S Grillner, T Hökfelt, D Ottoson Raven Press, Ltd, New York (1994)
52. JM Lundberg, A Rudehill, A Sollevi, G Fried, G Wallin. Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation, and resupply by axonal transport. Neuroscience, 28, 475-486 (1989) (Pubitemid 19053088)
53. E Valassi, M Scacchi, F Cavagnini. Neuroendocrine control of food intake. Nutr Metab CardivascDis, 18, 158-168 (2008) (Pubitemid 351282471)
54. L Yang, KA Scott, J Hyun, KL Tamashiro, N Tray, TH Moran, S Bi. Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance. J Neurosci, 29, 179-190 (2009)
55. J Ballesta, SR Bloom, JM Polak. Distribution and localization of regulatory peptides. Crit Rev Clin Lab Sci, 22, 185-218 (1985)
56. JM Lundberg, A Franco-Cereceda, JS Lacroix, J Pernow. Neuropeptide Y and sympathetic neurotransmission. Ann N Y Acad Sci, 611, 166-174 (1990)
57. G Haeusler, W Haefely, A Huerlimann. On the mechanism of the adrenergic nerve blocking action of bretylium. Naunyn-Schmiedeberg's Arch Pharmacol, 265, 260-277(1979)
58. C Wahlestedt, L Grundemar, R Hakanson, M Heilig, GH Shen, Z Zukowska-Grojec, DJ Reis. Neuropeptide Y receptor subtypes, Yl and Y2. Ann N Y Acad Sci, 611, 7-26 (1990)
59. JL O'Conner, MF Wade, DW Brann, VB Mahesh. Evidence that progesterone modulates anterior pituitary neuropeptide Y levels during the progesterone-induced gonadotropin surge in the estrogen-primed intact immature female rat. J Steroid Biochem Mol Biol, 52, 497-504 (1995)
60. CS Thompson-Torgerson, LA Holowatz, WL Kenney. Altered mechanisms of thermoregulatory vasoconstriction in aged human skin. Exerc Sport Sci Rev, 36, 122-127(2008)
61. CS Thompson, WL Kenney. Altered neurotransmitter control of reflex vasoconstriction in aged human skin. J Physiol (Lond), 558, 697-704 (2004) (Pubitemid 39117612)
62. N Charkoudian, JM Johnson. Reflex control of cutaneous vasoconstrictor system is reset by exogenous female reproductive hormones. J Appl Physiol, 87, 381-385 (1999) (Pubitemid 29330704)
63. K Aoki, DP Stephens, AR Saad, JM Johnson. Cutaneous vasoconstrictor response to whole body skin cooling is altered by time of day. J Appl Physiol, 94, 930-934 (2003) (Pubitemid 36232005)
64. A Cagnacci, K Kräuchi, A Wirz-Justice. Homeostatic versus circadian effects of melatonin on body temperature in humans. J Biol Rhythms, 12, 509-517(1997) (Pubitemid 127477088)
65. A Cagnacci, JA Elliot, SSC Yen. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol Metab, 75, 447-452 (1992)
66. SS Gilbert, CJ van den Heuvel, D Dawson. Daytime melatonin and temezapam in young adult humans, equivalent effects on sleep latency and body temperature. J Physiol (Lond), 514, 905-914 (1999) (Pubitemid 29060334)
67. K Kräuchi, C Cajochen, A Wirz-Justice. A relationship between heat loss and sleepiness, effects of postural change and melatonin administration. J Appl Physiol, 83, 134-139 (1997) (Pubitemid 27304741)
68. K Aoki, K Zhao, F Yamazaki, R Sone, GE Alvarez, WA Kosiba, JM Johnson. Exogenous melatonin administration modifies cutaneous vasoconstrictor response to whole body skin cooling in humans. J Pineal Res, 44, 141-148(2008) (Pubitemid 351252916)
69. T Lewis, GW Pickering. Vasodilatation in the limbs in response to warming the body; with evidence for sympathetic vasodilator nerves in man. Heart, 16, 33-51 (1931)
70. RT Grant, HE Holling. Further observations on the vascular responses of the human limb to body warming; evidence for sympathetic vasodilator nerves in the normal subject. Clin Sci, 3, 273-285 (1938)
71. IC Roddie. Sympathetic vasodilatation in human skin J Physiol (Lond), 548, 336-337 (2003) (Pubitemid 36527457)
72. IC Roddie, JT Shepherd, RF Whelan. The vasomotor nerve supply of the human forearm. Clin Sei, 16, 67-74 (1957)
73. P Gaskell. Are there sympathetic vasodilator nerves to the vessels of the hands? J Physiol (Lond), 131, 647-656 (1956)
74. JM Johnson, PE Pergola, FK Liao, DL Kellogg Jr, CG Crandall. Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system. J Appl Physiol, 78(3), 948-954 (1995)
75. DL Kellogg Jr, PE Pergola, WA Kosiba, M Grossmann, JM Johnson. Cutaneous active vasodilation in humans is mediated by cholinergic nerve co-transmission. Circ Res, 77, 1222-1228 (1995)
76. S Shastry, CT Minson, SA Wilson, NK Dietz, MJ Joyner. Effects of atropine and L-NAME on cutaneous blood flow during body heating in humans. J Appl Physiol, 88, 467-472 (2000) (Pubitemid 30097088)
77. MA Kolka, LA Stephenson. Cutaneous blood flow and local sweating after systemic atropine administration. Pfluegers Arch, 410, 524-529 (1987) (Pubitemid 18029407)
78. MA Kolka, LA Stephenson. Atropine-induced cutaneous vasodilation decreases esophageal temperature during exercise. Am J Physiol Regul Integr Comp Physiol, 257, R1089-1095 (1989)
79. PE Pergola, JM Johnson, DL Kellogg Jr, WA Kosiba. Control of skin blood flow by whole body and local skin cooling in exercising humans. Am J Physiol Heart Circ Physiol 270, H208-H215 (1996)
80. PE Pérgola, DL Kellogg, Jr, JM Johnson, WA Kosiba. Reflex control of active cutaneous vasodilation by skin temperature in humans. Am J Physiol Heart Circ Physiol, 266, H1979-H1984 (1994)
81. M Shibasaki, TE Wilson, J Cui, CG Crandall. Acetylcholine released from cholinergic nerves contributes to cutaneous vasodilation during heat stress. J Appl Physiol, 93, 1947-1951 (2002) (Pubitemid 35379318)
82. JO Dolly, KR Aoki. The structure and mode of action of different botulinum toxins. Eur J Neurol 13 Suppl 4, 1-9 (2006) (Pubitemid 44748278)
83. LL Simpson. The origin, structure and pharmacological activity of botulinum toxin. Pharmacol Rev, 33, 155-188 (1981)
84. J Jankovic. Botulinum toxin in clinical practice. J Neurol Neurosurg Psychiatry, 75, 951-957 (2004) (Pubitemid 38869604)
85. WJ Schulte-Mattler. Use of botulinum toxin A in adult neurological disorders, efficacy, tolerability and safety. CNS Drugs, 22, 725-738 (2008)
86. MA Breidenbach, AT Brunger. New insights into clostridial neurotoxin-SNARE interactions. Trends Mol Med, 11, 377-381 (2005) (Pubitemid 41080579)
87. AT Brunger, R Jin, MA Breidenbach. Highly specific interactions between botunlinum neurotoxins and synaptic vesicle proteins. Cell Mol Life Sei, 65, 2296-2306 (2008)
88. JL Morris, P Jobling, IL Gibbins. Botulinum neurotoxin A attenuates release of norepinephrine but not NPY from vasoconstrictor nerves. Am J Physiol Heart Circ Physiol, 283, H2627-H2635 (2002) (Pubitemid 35345972)
89. M Shibasaki, SL Davis, J Cui, DA Low, DM Keller, S Durand, CG Crandall. Neurally mediated vasoconstriction is capable of decreasing skin blood flow during orthostasis in the heat-stressed human. J Physiol (Lond), 575(3), 953-959 (2006) (Pubitemid 44323754)
90. M Shibasaki, S Durand, SL Davis, J Cui, DA Low, DM Keller, CG Crandall. Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction. J Physiol (Lond), 585(2), 627-634 (2007) (Pubitemid 350193930)
91. JL Morris, P Jobling, IL Gibbins. Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons. Am J Physiol Heart Circ Physiol, 281, H2124-H2132 (2001)
92. J Lundberg. Evidence for coexistence of vasoactive intestinal polypeptide (VIP) in neurons of cat exocrine glands. Acta Physiol Scand, 112 (Suppl 496), 1-57(1981)
93. JM Lundberg, A Ânggârd, J Fahrenkrug. Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for submandibular gland blood flow and secretion. Acta Physiol Scand, 113, 329-336 (1981) (Pubitemid 12235754)
94. JM Lundberg, A Ânggârd, J Fahrenkrug, T Hokfelt, V Mutt. Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands. Functional significance of co-existing transmitters for vasodilation and secretion. Proc Natl Acad Sci USA, 11, 1651-1655 (1980) (Pubitemid 10073819)
95. JM Lundberg, A Ânggârd, J Fahrenkrug, C Lundgren, B Homstedt. Co-release of VIP and acetylcholine in relation to blood flow and salivary secretion in cat submandibular salivary gland. Acta Physiol Scand, 115, 525-528 (1982) (Pubitemid 12019443)
96. RH Fox, OG Edholm. Nervous control of the cutaneous circulation. Br Med Bull, 19, 110-114 (1963)
97. LAT Bennett, JM Johnson, DP Stephens, AR Saad, DL Kellogg. Evidence for a role for vasoactive intestinal peptide in active vasodilation in the cutaneous vasculature in humans. J Physiol (Lond), 552, 223-232 (2003) (Pubitemid 37265480)
98. JR Grider. Identification of neurotransmitters by selective protection of postjunctional receptors. Am J Physiol Gastrointest Liver Physiol, 258, G103-G106 (1990) (Pubitemid 20068806)
99. RJ Henning, DR Sawmiller. Vasoactive intestinal peptide, cardiovascular effects. Cardiovasc Res, 49, 27-37(2001)
100. DR Sawmiller, M Ashtari, H Urueta, M Leschinsky, RJ Henning. Mechanisms of vasoactive intestinal pepide-elicited coronary vasodilation in the isolated perfused rat heart. Neuropeptides, 40, 349-355 (2006) (Pubitemid 44634709)
101. MA Summers, MS O'Dorisio, MO Cox, M Lara-Marquez, EJ Goetzl. A lymphocyte-generated fragment of vasointestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effects. J Pharmacol Exp Ther, 306, 638-645 (2003) (Pubitemid 36886163)
102. D Roosterman, T George, SW Schneider, NW Bunnett, M Steinhoff. Neuronal control of skin function, the skin as a neuroendocrine organ. Physiol Rev, 86, 1309-1379(2006) (Pubitemid 44523706)
103. BW Wilkins, B J Wong, N J Tublitz, M G R, C T Minson. Vasoactive intestinal peptide fragment VIP10-28 and active vasodilation in human skin. J Appl Physiol, 99, 2284-2301 (2005)
104. MV Savage, GL Brengelmann, A M J Buchan, P R Freund. Cystic fibrosis, vasoactive intestinal polypeptide, and active cutaneous vasodilation. J Appl Physiol, 69, 2149-2154 (1990)
105. P Heinz-Erian, RD Dey, M Flux, SI Said. Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients. Science, 229, 1407-1408 (1985) (Pubitemid 16222386)
106. DJ Kellogg J.r., GJ Hodges, CR Orozco, TM Phillips, JL Zhao, JM Johnson. Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis. J Appl Physiol, 103, 963-968 (2007) (Pubitemid 47358881)
107. BW Wilkins, EA Martin, SK Roberts, MJ Joyner. Preserved reflex vasodilation in cystic fibrosis does not include an enhanced nitric oxide-dependent mechanism. J Appl Physiol, 102, 2301-2306 (2007) (Pubitemid 47080764)
108. BW Wilkins, LH Chung, NJ Tublitz, BJ Wong, CT Minson. Mechanisms of vasoactive intestinal peptide-mediated vasodilation in human skin. J Appl Physiol, 97, 1291-1298 (2004) (Pubitemid 39299343)
109. BJ Wong, CT Minson. Neurokinin-1 receptor desensitization attenuates cutaneous active vasodilatation in humans. J Physiol (Lond), 577, 1043-1051 (2006) (Pubitemid 44882611)
110. BJ Wong, NJ Tublitz, CT Minson. Neurokinin-1 receptor desensitization to consecutive microdialysis infusions of substance p in humans. J Physiol (Lond), 568, 1047-1056 (2005) (Pubitemid 41646041)
111. S Harrison, P Geppetti. Substance P. Int J Biochem Cell Biol, 33, 555-576 (2001) (Pubitemid 32510811)
112. P Hölzer. Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol, 30, 5-11 (1998) (Pubitemid 27497213)
113. P Milner, P Bodin, S Guiducci, AD Rosso, MB Kahaleh, M Matucci-Cerinic, G Burnstock. Regulation of substance p mRNA expression in human dermal microvascular endothelial cells. Clin Exp Rheumatol, 22 Suppl 33, S24-S27 (2004) (Pubitemid 39162030)
114. DL Kellogg Jr, CG Crandall, Y Liu, N Charkoudian, JM Johnson. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol, 85, 824-829 (1998) (Pubitemid 28413257)
115. S Shastry, AS Reed, JR Halliwill, NM Dietz, MJ Joyner. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J Appl Physiol, 85, 830-834 (1998) (Pubitemid 28413258)
116. GR McCord, J-L Cracowski, CT Minson. Prostanoids contribute to cutaneous active vasodilation in humans. Am J Physiol Regul Integr Comp Physiol, 291, R596-R602 (2006) (Pubitemid 44352341)
117. BJ Wong, BW Wilkins, CT Minson. HI but not H2 histamine receptor activation contributes to the rise in skin blood flow during whole body heating in humans. J Physiol (Lond), 560, 941-948 (2004) (Pubitemid 39530130)
118. DL Kellogg Jr, JL Zhao, Y Wu. Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. Am J Physiol Heart Circ Physiol, 295, H123-129 (2008)
119. WF Taylor, VS Bishop. A role for nitric oxide in active thermoregulatory vasodilation. Am J Physiol Heart Circ Physiol, 264, H1355-H1359 (1993) (Pubitemid 23154118)
120. WF Taylor, SE DiCarlo, VS Bishop. Neurogenic vasodilator control of rabbit ear blood flow. Am J Physiol Regul Integr Comp Physiol, 262, R766-R770 (1992)
121. DM Farrell, VS Bishop. Permissive role for nitric oxide in active thermoregulatory vasodilation in rabbit ear. Am J Physiol Heart Circ Physiol, 269, H1613-H1618 (1995) (Pubitemid 3005963)
122. DM Farrell, VS Bishop. The roles of cGMP and cAMP in active thermoregulatory vasodilation. Am J Physiol, Regul Integr Comp Physiol, 272, R975-R981 (1997)
123. BW Wilkins, LA Holowatz, BJ Wong, CT Minson. Nitric oxide is not permissive for cutaneous active vasodilation in humans. J Physiol (Lond), 548, 963-969 (2003) (Pubitemid 36592788)
124. LA Holowatz, WL Kenney. Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol, 106, 500-505 (2009)
125. RH Fox, SM Hilton. Bradykinin formation in human skin as a factor in heat vasodilatation. J Physiol (Lond), 142, 219-232 (1958)
126. GL Brengelmann, PR Freund, LB Rowell, JE Olerud, KK Kraning. Absence of active vasodilation associated with congenital absence of sweat glands in humans. Am J Physiol Heart Circ Physiol, 240, H571-H575 (1981) (Pubitemid 11150319)
127. DL Kellogg Jr, Y Liu, K McAllister, C Friel, PE Pergola. Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans. J ApplPhysiol, 93, 1215-1221 (2002)
128. JB Warren, RK Loi. Captopril increases skin microvascular blood flow secondary to bradykinin, nitric oxide, and prostaglandins. FASEB J, 9, 411-418 (1995)
129. CG Crandall, JM Johnson, WA Kosiba, DL Kellogg Jr., Baroreceptor control of the cutaneous active vasodilator system. J Appl Physiol, 81, 2192-2198(1996) (Pubitemid 26384549)
130. DL Kellogg Jr, JM Johnson, WA Kosiba. Baroreflex control of the cutaneous active vasodilator system in humans. Circ Res, 66, 1420-1426 (1990) (Pubitemid 20147758)
131. JM Johnson. Exercise and the cutaneous circulation. Exerc Sport Sci Rev, 20, 59-97 (1992)
132. WL Kenney, JM Johnson. Control of skin blood flow during exercise. Med Sci Sports Exerc, 24, 303-312 (1992)
133. WF Taylor, JM Johnson, WA Kosiba, CM Kwan. Cutaneous vascular responses to isometric handgrip exercise. J Appl Physiol, 66, 1586-1592 (1989) (Pubitemid 19112961)
134. CG Crandall, J Musick, JP Hatch, DL Kellogg Jr, JM Johnson. Cutaneous vascular and sudomotor responses to isometric exercise in humans. J Appl Physiol, 79, 1946-1950 (1995) (Pubitemid 26010564)
135. AR Saad, DP Stephens, LAT Bennett, N Charkoudian, WA Kosiba, JM Johnson. Influence of isometric exercise on blood flow and sweating in glabrous and nonglabrous human skin. J Appl Physiol, 91, 2487-2492 (2001) (Pubitemid 33108008)
136. CG Crandall, DP Stephens, JM Johnson. Muscle metaboreceptor modulation of cutaneous active vasodilation. Med Sci Sports Exerc, 30, 490-496 (1998) (Pubitemid 28193387)
137. K Aoki, DP Stephens, JM Johnson. Diurnal variation in cutaneous vasodilator and vasoconstrictor systems during heat stress. Am J Physiol Regul Integr Comp Physiol, 281, R591-R595 (2001)
138. N Charkoudian, JM Johnson. Modification of active cutaneous vasodilation by oral contraceptive hormones. J Appl Physiol, 83, 2012-2018 (1997) (Pubitemid 28006503)
139. LA Stephenson, MA Kolka. Thermoregulation in women. Exerc Sport Sci Rev, 21, 231-262 (1993)
140. LA Stephenson, MA Kolka. Menstrual cycle phase and time of day alter reference signal controlling arm blood flow and sweating. Am J Physiol Regul Integr Comp, 249, R186-R191 (1985) (Pubitemid 16239838)
141. K Aoki, DP Stephens, K Zhao, WA Kosiba, JM Johnson. Modification of cutaneous vasodilator response to heat stress by daytime exogenous melatonin administration. Am J Physiol Regul Integr Comp, 291, R619-R624 (2006) (Pubitemid 44352344)
142. WL Kenney, CG Tankersley, DL Newswanger, DE Hyde, SM Puhl, NL Turner. Age and hypohydration independently influence the peripheral vascular response to heat stress. J Appl Physiol, 68, 1902-1908 (1990) (Pubitemid 20183075)
143. LA Holowatz, CS Thompson, WL Kenney. L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J Physiol (Lond), 574, 573-581 (2006)
144. LA Holowatz, CS Thompson, WL Kenney. Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Am J Physiol Heart Circ Physiol, 291, H2965-H2970 (2006) (Pubitemid 44911034)
145. LA Holowatz, CS Thompson-Torgerson, WL Kenney. Altered mechanisms of vasodilation in aged human skin. Exercise Sports Sci Rev, 35, 119-125 (2007) (Pubitemid 47056548)
146. HL Martin, JL Loomis, WL Kenney. Maximal skin vascular conductance in subjects aged 5-85 yr. J Appl Physiol, 79, 297-301 (1995)
147. GA Rooke, MV Savage, GL Brengelmann. Maximal skin blood flow is decreased in elderly men. J Appl Physiol, 77, 11-14 (1994) (Pubitemid 24226108)
148. H Barcroft, OG Edholm. The effect of temperature on blood flow and deep temperature in the human forearm. J Physiol (Lond), 102, 5-20 (1943)
149. PM Vanhoutte. Physical factors of regulation. I: Handbook of Physiology Section 2. The Cardiovascular System Eds: DF Bohr, AP Somlyo, HV Sparks Amer Physiol Soc, Bethesda MD (1980)
150. PJ Boels, TJ Verbeuren, PM Vanhoutte. Moderate cooling depresses the accumulation and the release of newly synthesized catecholamines in isolated canine saphenous veins. Experientia, 41, 1374-1377(1985) (Pubitemid 16193745)
151. NA Flavahan. The role of vascular alpha-2-adrenoreceptors as cutaneous thermosensors. News Physiol Sci, 6, 251-255 (1991)
152. NA Flavahan, LE Lindblad, TJ Verbeuren, JT Shepherd, PM Vanhoutte. Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins, role of receptor reserve. Am J Physiol Heart Circ Physiol, 249, H950-955 (1985) (Pubitemid 16197335)
153. NA Flavahan, PM Vanhoutte. Effect of cooling on a-1 and a-2 adrenergic responses in canine saphenous and femoral veins. J Pharmacol Exp Ther, 238, 139-147(1986) (Pubitemid 16058307)
154. PM Vanhoutte, NA Flavahan. Effects of temperature on alpha adrenoceptors in limb veins, role of receptor reserve. Fed Proc, 45, 2347-2354 (1986) (Pubitemid 16028650)
155. PM Vanhoutte, VM Miller. Alpha-2 adrenoceptors and endothelium-derived relaxing factor. Am J Med, 87, 1S-5S (1989) (Pubitemid 19248359)
156. SR Bailey, AH Eid, S Mitra, S Flavahan, NA Flavahan. Rho kinase mediates cold-Induced constriction of cutaneous arteries. Circ Res, 94, 1367-1374(2004)
157. SR Bailey, S Mitra, S Flavahan, NA Flavahan. Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries. Am J Physiol Heart Circ Physiol, 289, H253-H250 (2005)
158. MA Chotani, S Flavahan, S Mitra, D Daunt, NA Flavahan. Silent alpha-2c-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol, 278, H1075-H1083 (2000) (Pubitemid 30235482)
159. SC Jeyaraj, MA Chotani, S Mitra, HE Gregg, NA Flavahan, KJ Morrison. Cooling evokes redistribution of alpha2C-adrenoceptors from Golgi to plasma membrane in transfected human embryonic kidney 293 cells. Mol Pharmacol, 60, 1195-1200 (2001) (Pubitemid 33144890)
160. CS Thompson-Torgerson, LA Holowatz, NA Flavahan, WL Kenney. Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin. Am J Physiol Heart Circ Physiol, 292, H1700-H1705 (2007) (Pubitemid 46572391)
161. F Yamazaki, R Sone, K Zhao, GE Alvarez, WA Kosiba, JM Johnson. Rate dependency and role of nitric oxide in the vascular response to direct cooling in human skin. J Appl Physiol, 100, 42-50 (2006) (Pubitemid 43671088)
162. PE Pergola, DL Kellogg Jr, JM Johnson, WA Kosiba. Role of sympathetic nerves in the vascular effects of local temperature in human forearm skin. Am J Physiol Heart Circ Physiol, 265, H785-H792 (1993) (Pubitemid 23296577)
163. G Venturini, M Colasanti, E Fioravanti, A Bianchini, P Pascenzi. Direct effect of temperature on the catalytic activity of nitric oxide synthases types I, II and III. Nitric Oxide, 3, 375-382 (1999) (Pubitemid 29531864)
164. GJ Hodges, JA Traeger, T Tang, WA Kosiba, K Zhao, JM Johnson. Role of sensory nerves in the cutaneous vasoconstrictor response to local cooling in humans. Am J Physiol Heart Circ Physiol, 293, H784-H789 (2007) (Pubitemid 47105142)
165. JM Johnson, TC Yen, K Zhao, WA Kosiba. Sympathetic, sensory, and nonneural contributions to the cutaneous vasoconstrictor response to local cooling. Am J Physiol Heart Circ Physiol, 288, 1573-1579 (2005)
166. DP Stephens, N Charkoudian, JM Benevento, JM Johnson, JL Saumet. The influence of topical capsaicin on the local thermal control of skin blood flow in humans. Am J Physiol Regul Integr Comp Physiol, 281, R894-R901 (2001)
167. RG Hallin, HE Torebjörk, Z Wiesenfeld. Nociceptors and warm receptors innervated by C fibers in human skin. J Neurol Neurosurg Psychiatry, 45, 313-319 (1982) (Pubitemid 12150147)
168. KM Gooding, MM Hanneman, JE Tooke, GF Clough, AC Shore. Maximum skin hyperaemia induced by local heating, possible mechanisms. J Vase Res, 43, 270-277 (2005) (Pubitemid 44257045)
169. JM Stewart, MS Medow, CT Minson, I Taneja. Cutaneous neuronal nitric
170. WK Alderton, CE Cooper, RG Knowles. Nitric oxide synthases.structure, function and inhibition. Biochem J, 357, 593-615 (2001) (Pubitemid 32735142)
171. GR Cooper, A Barr, DJ Wolff. Neuronal nitric oxide synthase is refractory to mechanism-based inactivation in GH3 pituitary cells. Arch Biochem Biophysics, 357, 195-206 (1998) (Pubitemid 28419201)
172. P K Stricklett, AK Hughes, DE Kohan. Endothelin-1 stimulates NO production and inhibits cAMP accumulation in rat inner medullary collecting duct through independent pathways. Am J Physiol Renal Physiol, 290, F1315-F1319 (2005) (Pubitemid 43830755)
173. DJ Wolff, A Lubeskie. Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine. Arch Biochem Biophys, 325, 227-234 (1996)
174. EP Erdal, EA Litzinger, J Seo, Y Zhu, H J.i., RB Silverman. Selective neuronal nitric oxide synthase inhibitors. Curr Top Med Chem, 5, 603-624 (2005) (Pubitemid 41179723)
175. H Huang, P Martesek, LJ Roman, RB Silverman. Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. J Med Chem, 43, 2938-2945 (2000) (Pubitemid 30599652)
176. S Durand, SL Davis, J Cui, CG Crandall. Exogenous nitric oxide inhibits sympathetically mediated vasoconstriction in human skin. J Physiol (Lond), 562, 629-634 (2005)
177. TE Wilson, J Cui, CG Crandall. Effect of whole-body and local heating on cutaneous vasoconstrictor responses in humans. Auton Neurosci, 97, 122-128 (2002) (Pubitemid 34603136)
178. WF Taylor, JM Johnson, D O'Leary, MK Park. Modification of the cutaneous vascular response to exercise by local skin temperature. J Appl Physiol, 57, 1878-1884 (1984) (Pubitemid 15191391)
179. GJ Hodges, WA Kosiba, K Zhao, JM Johnson. The involvement of heating rate and vasoconstrictor nerves in the cutaneous vasodilator response to skin warming. Am J Physiol Heart Circ Physiol, 296, H51-56(2009)
180. BL Houghton, JR Meendering, BJ Wong, CT Minson. Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin. J Physiol (Lond), 572, 811-820 (2006)
181. JA Angus, TM Cocks, K Satoh. The alpha adrenoceptors on endothelial cells. Fed Proc, 45, 2355-2359 (1986)
182. TM Cocks, JA Angus. Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin. Nature, 305, 627-630 (1983) (Pubitemid 13013451)
183. T Nilsson, H Lind, J Brunkvall, L Edvinsson. Vasodilation in human subcutaneous arteries induced by neuropeptide Y is mediated by neuropeptide Y Yl receptors and is nitric oxide dependent. Can J Physiol Pharmacol, 78, 251-255 (2000) (Pubitemid 30163458)
184. TA Munce, WL Kenney. Age-specific modification of local cutaneous vasodilation by capsaicin-sensitive primary afférents. J Appl Physiol, 95, 1016-1024 (2003) (Pubitemid 37033996)
185. CT Minson, LA Holowatz, BJ Wong, WL Kenney, BW Wilkins. Decreased nitric oxide- and axon reflex-mediated cutaneous vasodilation with age during local heating. J Appl Physiol, 93, 1644-1649 (2002) (Pubitemid 36082975)
186. JM Stewart, AJ Ocon, D Clarke, I Taneja, MS Medow. Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin- (1-7) production in postural tachycardia syndrome. Hypertension, 53, 767-774 (2009)
187. GL Brengelmann. Body temperature regulation in heart failure. Cardiologia, 41, 1033-1043 (1996)
188. J Cui, A Arbab-Zadeh, A Prasad, S Durand, BD Levine, CG Crandall. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation, 112, 2286-2292 (2005) (Pubitemid 41464571)
189. DJ Green, AJ Malorana, JH Siong, V Burke, M Erikson, CT Minson, W Bilsborough, G O'Driscoll. Impaired skin blood flow response to environmental heating in chronic heart failure. Eur Heart J, 27, 338-343 (2006) (Pubitemid 43100030)
190. PG Fegan, AC Shore, D Mawson, JE Tooke, KM MacLeod. Microvascular endothelial function in subjects with Type 2 diabetes and the effect of lipid-lowering therapy. DiabetMed, 22, 1670-1676 (2005) (Pubitemid 43046466)
191. A Koitka, P Abraham, B Bouhanick, D Sigaudo-Roussel, C Demiot, JL Saumet. Impaired pressure-induced vasodilation at the foot in young adults with type I diabetes. Diabetes, 53, 721-725 (2004) (Pubitemid 38270642)
192. LA Sokolnicki, NA Strom, SK Roberts, SA Kingsley-Berg, A Basu, N Charkoudian. Skin blood flow during body heating in type 2 diabetes mellitus. J Appl Physiol, 106, 566-570 (2009)