Effects of atropine and L-NAME on cutaneous blood flow during body heating in humans

Journal of Applied Physiology

Volumn 88, Issue 2, 2000, Pages 467-472

  Shastry, Shubha ^a   Minson, Christopher T ^b   Wilson, Shurea A ^b   Dietz, Niki M ^b   Joyner, Michael J ^a,b  

^a MAYO CLINIC   (United States)

^b DEPARTMENT OF UROLOGY   (United States)

Author keywords

Muscarinic; Nitric oxide; Sudomotor

Indexed keywords

ACETYLCHOLINE; ATROPINE; MUSCARINIC RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ADULT; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORE TEMPERATURE; FEMALE; HUMAN; HUMAN EXPERIMENT; LASER FLOWMETER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SKIN BLOOD FLOW; SWEAT GLAND; SWEATING; VASODILATATION;

EID: 0033975934     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.2.467     Document Type: Article

References (20)

1. Dietz, N. M., J. M. Rivera, S. E. Eggener, R. T. Fix, D. O. Warner, and M. J. Joyner. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J. Physiol. (Lond.) 480: 361-368, 1994.
2. Dietz, N. M., J. M. Rivera, D. O. Warner, and M. J. Joyner. Is nitric oxide involved in cutaneous vasodilation during body heating in humans? J. Appl. Pkysiol. 76: 2047-2053, 1994.
3. Engelke, K. A., J. R. Halliwill, D. N. Proctor, N. M. Dietz, and M. J. Joyner. Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm. J. Appl. Physiol. 81: 1807-1814, 1996.
4. Farrell, D. M., and V. S. Bishop. Permissive role for nitric oxide in active thermoregulatory vasodilation in rabbit ear. Am. J. Physiol Heart Circ. Physiol. 269: H1613-H1618, 1995.
5. Farrell, D. M., and V. S. Bishop. The roles of cGMP and cAMP in active thermoregulatory vasodilation. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 272: R975-R981, 1997.
6. Fox, R. H., and S. M. Hilton. Bradykinin formation in human skin as a factor in heat vasodilatation. J. Physiol. (Lond.) 142: 219-232, 1958.
7. Johnson, J. M., W. F. Taylor, A. P. Shepherd, and M. K. Park. Laser-Doppler measurement of skin blood flow: comparison with plethysmography. J. Appl. Physiol. 56: 798-803, 1984.
8. Joyner, M. J., and N. M. Dietz. Nitric oxide and vasodilation in human limbs. J. Appl. Physiol. 83: 1785-1796, 1997.
9. Kellogg, D. L., Jr., C. G. Crandall, Y. Liu, N. Charkoudian, and J. M. Johnson. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J. Appl. Physiol. 85: 824-829, 1998.
10. Kellogg, D. L., Jr., Y. Liu, I. F. Kosiba, and D. O'Donnell. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J. Appl. Physiol. 86: 1185-1190, 1999.
11. Kellogg, D. L., Jr., P. E. Pergola, K. L. Piest, W. A. Kosiba, C. G. Crandall, M. Grossmann, and J. M. Johnson. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ. Res. 77: 1222-1228, 1995.
12. Kolka, M. A., and L. A. Stephenson. Cutaneous blood flow and local sweating after systemic atropine administration. Pflügers Arch. 410: 524-529, 1987.
13. Martin, C. M., A. Beltran-del-Rio, A. Albrecht, R. R. Lorenz., and M. J. Joyner. Local cholinergic mechanisms mediate nitric oxide-dependent flow-induced vasorelaxation in vitro. Am. J. Physiol. Heart Circ. Physiol. 270: H442-H446, 1996.
14. Mugge, A., J. A. G. Lopez, D. J. Piegors, K. R. Breese, and D. D. Heistad. Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogs of L-arginine. Am. J. Physiol. 160: H242-H247, 1991.
15. Roddie, I. C. Circulation to skin and adipose tissue. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 1, chapt. 10, p. 285-317.
16. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. The contribution of constrictor and dilator nerves to the skin vasodilation during body heating. J. Physiol. (Lond.) 136: 489-497, 1957.
17. Rubanyi, G. M., J. C. Romero, and P. M. Vanhoutte. Flow-induced release of endothelium-derived relaxing factor. Am. J. Physiol. Heart Circ. Physiol. 250: H1145-H1149, 1986.
18. Shastry, S., N. M. Dietz, J. R. Halliwill, A. S. Reed, and M. J. Joyner. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J. Appl. Physiol. 85: 830-834, 1998.
19. Shepherd, J. T., and Z. S. Katusic. Endothelium-derived vasoactive factors. I. Endothelium-dependent relaxation. Hypertension 18, Suppl. III: III-76-III-85, 1991.
20. Taylor, W. F., and V. S. Bishop. A role for nitric oxide in active thermoregulatory vasodilation. Am. J. Physiol. Heart Circ. Physiol. 264: H1355-H1359, 1993.