Rate dependency and role of nitric oxide in the vascular response to direct cooling in human skin

Journal of Applied Physiology

Volumn 100, Issue 1, 2006, Pages 42-50

  Yamazaki, Fumio ^a,b   Sone, Ryoko ^a,c   Zhao, Kun ^a   Alvarez, Guy E ^a   Kosiba, Wojciech A ^a   Johnson, John M ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c YAMAGUCHI UNIVERSITY   (Japan)

Author keywords

Bretylium; Laser Doppler flowmetry; Microdialysis; Skin blood flow; Skin temperature

Indexed keywords

BRETYLIUM TOSYLATE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; COOLING; FEMALE; HUMAN; LASER DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN TEMPERATURE; VASOCONSTRICTION; BLOOD FLOW VELOCITY; BODY TEMPERATURE; CLINICAL TRIAL; COLD; CONTROLLED CLINICAL TRIAL; HEMOSTASIS; METABOLISM; PHYSIOLOGY; SKIN; THERMOREGULATION; VASCULAR RESISTANCE; VASCULARIZATION;

ADULT; BLOOD FLOW VELOCITY; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; COLD; FEMALE; HEMOSTASIS; HUMANS; MALE; NITRIC OXIDE; SKIN; SKIN TEMPERATURE; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 33644825084     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00139.2005     Document Type: Article

References (45)

1. Bailey SR, Eid AH, Mitra S, Flavahan S, and Flavahan NA. Rho kinase mediates cold-induced constriction on cutaneous arteries. Circ Res 94: 1367-1374, 2004.
2. Barbee JH. The effect of temperature on the relative viscosity of human blood. Biorheology 10: 1-5, 1973.
3. Bennett LAT, Johnson JM, Stephens DP, Saad AR, and Kellogg DL Jr. Evidence for a role for vasoactive intestinal peptide in active vasodilatation in the cutaneous vasculature of humans. J Physiol 552: 223-232, 2003.
4. Brodszki J, Gardiner HM, Eriksson A, Stale H, and Marsál K. Reproducibility of ultrasonic fetal volume blood flow measurements. Clin Physiol 18: 479-485, 1998.
5. Carlsson I, Sollevi A and Wennmalm Å. The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperaemia. J Physiol 389: 147-161, 1987.
6. Charkoudian N, Stephens DP, Pirkle KC, Kosiba WA, and Johnson JM. Influence of female reproductive hormones on local thermal control of skin blood flow. J Appl Physiol 87: 1719-1723, 1999.
7. 2C-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol 278: H1075-H1083, 2000.
8. Coffman JD. Effects of endothelium-derived nitric oxide on skin and digital blood flow in humans. Am J Physiol Heart Circ Physiol 267: H2087-H2090, 1994.
9. Corson MA, James NL, Latta SE, Nerem RM, Berk BC, and Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res 79: 984-991, 1996.
10. Durand S, Davis SL, Cui J, and Crandall CG. Exogenous nitric oxide inhibits sympathetically mediated vasoconstriction in human skin. J Physiol 562: 629-634, 2005.
11. Ekenvall L, Lindblad LE, Norbeck O, and Etzell BM. α-Adrenoceptors and cold-induced vasoconstriction in human finger skin. Am J Physiol Heart Circ Physiol 255: H1000-H1003, 1988.
12. Engelke KA, Halliwill JR, Proctor DN, Dietz NM, and Joyner MJ. Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm. J Appl Physiol 81: 1807-1814, 1996.
13. 2-adrenergic responses in cutaneous veins: role of receptor reserve. Am J Physiol Heart Circ Physiol 249: H950-H955, 1985.
14. Flavahan NA and Vanhoutte PM. Effect of cooling on alpha-1 and alpha-2 adrenergic responses in canine saphenous veins. J Pharmacol Exp Ther 238: 139-147, 1986.
15. Haeusler G, Haefely W, and Huerlimann A. On the mechanism of the adrenergic nerve blocking action of bretylium. Naunyn Schmiedebergs Arch Pharmacol 265: 260-277, 1979.
16. Harker CT and Vanhoutte PM. Cooling the central ear artery of the rabbit: myogenic and adrenergic responses. J Pharmacol Exp Ther 245: 89-93, 1988.
17. Holzer P. Neurogenic vasodilation and plasma leakage in the skin. Gen Pharmacol 30: 5-11, 1998.
18. Johnson JM. The cutaneous circulation. In: Laser Doppler Blood Flowmetry. Boston, MA: Kluwer Academic, 1990, p. 121-140.
19. Johnson JM, Brengelmann GL, and Rowell LB. Interactions between local and reflex influences on human forearm skin blood flow. J Appl Physiol 41: 826-831, 1976.
20. Johnson JM and Proppe DW. Cardiovascular adjustments to heat stress. In: Handbook of Physiology. Environmental Physiology. Bethesda MD: Am. Physiol. Soc., 1996, sect. 4, vol. 1, chapt. 11, p. 215-243.
21. Johnson JM, Yen TC, Zhao K, and Kosiba WA. Sympathetic, sensory, and nonneuronal contributions to the cutaneous vasoconstrictor response to local cooling. Am J Physiol Heart Circ Physiol 288: H1573-H1579, 2005.
22. Kellogg DL Jr, Crandall CG, Liu Y, Charkoudian N, and Johnson JM. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol 85: 824-829, 1998.
23. Kellogg DL Jr, Johnson JM, and Kosiba WA. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol Heart Circ Physiol 257: H1599-H1606, 1989.
24. Kellogg DL Jr, Liu Y, Kosiba IF, and O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 86: 1185-1190, 1999.
25. Kellogg DL Jr, Zhao JL, Friel C, and Roman LJ. Nitric oxide concentration increases in the cutaneous interstitial space during heat stress in humans. J Appl Physiol 94: 1971-1977, 2003.
26. Langille BL. Hemodynamic factors and vascular disease. In: Cardiovascular Pathology. New York: Churchill Livingstone, 1991, vol. 1, chapt. 4, p. 131-154.
27. Minson CT, Berry LT, and Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 91: 1619-1626, 2001.
28. Mangiafico RA, Malatino LS, Santonocite M, Spada RS, and Tamburino G. Plasma endothelin-1 concentrations during cold exposure in essential acrocyanosis. Angiology 47: 1033-1038, 1996.
29. Mustafa S and Thulesius O. Cooling is a potent vasodilator of deep vessels in the rat. Can J Physiol Pharmacol 79: 899-904, 2001.
30. Mustafa S and Thulesius O. Cooling-induced gastrointestinal smooth muscle contractions in the rat. Fundam Clin Pharmacol 15: 349-354, 2001.
31. Öberg PA. Laser-Doppler flowmetry. Crit Rev Biomed Eng 18: 125-163, 1990.
32. Pérgola PE, Johnson JM, Kellogg DL Jr, and Kosiba WA. Control of skin blood flow by whole body and local skin cooling in exercising humans. Am J Physiol Heart Circ Physiol 270: H208-H215, 1996.
33. Pérgola PE, Kellogg DL Jr, Johnson JM, Kosiba WA, and Solomon DE. Role of sympathetic nerves in the vascular effects of local temperature in human forearm skin. Am J Physiol Heart Circ Physiol 265: H785-H792, 1993.
34. Saumet JL, Kellogg DL Jr, Taylor WF, and Johnson JM. Cutaneous laser-Doppler flowmetry: influence of underlying muscle blood flow. J Appl Physiol 65: 478-481, 1988.
35. Schmelz M, Luz O, Averbeck B, and Bickel A. Plasma extravasation and neuropeptide release in human skin as measured by intradermal microdialysis. Neurosci Lett 230: 117-120, 1997.
36. Shastry S, Dietz NM, Halliwill JR, Reed AS, and Joyner MJ. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J Appl Physiol 85: 830-834, 1998.
37. Spilt A, Box FM, Van der Geest RJ, Reiber JH, Kunz P, Kamper AM, Blauw GJ, and Van Buchem MA. Reproducibility of total cerebral blood flow measurements using phase contrast magnetic resonance imaging. J Magn Reson Imaging 16: 1-5, 2002.
38. Stephens DP, Aoki K, Kosiba WA, and Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol 280: H1496-H1504, 2001.
39. Stephens DP, Saad AR, Bennett LAT, Kosiba WA, and Johnson JM. Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans. Am J Physiol Heart Circ Physiol 287: H1404-H1409, 2004.
40. Taylor WF, Johnson JM, O'Leary D, and Park MK. Effect of high local temperature on reflex cutaneous vasodilation. J Appl Physiol 57: 191-196, 1984.
41. Vanhoutte PM. Physical factors of regulation. In: Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle. Bethesda, MD: Am. Physiol. Soc., 1980, sect. 2, vol. II, chapt. 16, p. 443-474.
42. Vanhoutte PM, Cooke JP, Lindblad LE, Shepherd JT, and Flavahan NA. Modulation of postjunctional alpha-adrenergic responsiveness by local changes in temperature. Clin Sci (Lond) 68, Suppl: 10: 121s-123s, 1985.
43. Venturini G, Colasanti M, Fioravanti E, Bianchini A, and Ascenzi P. Direct effect of temperature on the catalytic activity of nitric oxide synthases type I, II, and III. Nitric Oxide 3: 375-382, 1999.
44. Wong BJ, Wilkins BW, Holowatz LA, and Minson CT. Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation. J Appl Physiol 95: 504-510, 2003.
45. Zamora MR, O'Brien RF, Rutherford RB, and Weil JV. Serum endothelin-1 concentrations and cold provocation in primary Raynaud's phenomenon. Lancet 336: 1144-1147, 1990.