Nitric oxide and cutaneous active vasodilation during heat stress in humans

Journal of Applied Physiology

Volumn 85, Issue 3, 1998, Pages 824-829

  Kellogg Jr , D L ^a,b   Crandall, C G ^c,d   Liu, Y ^b   Charkoudian, N ^b   Johnson, J M ^b  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Laser Doppler flowmetry; Microdialysis; Skin blood flow

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CONDUCTANCE; CONTROLLED STUDY; FEMALE; FOREARM; HEAT STRESS; HUMAN; HUMAN EXPERIMENT; HYPERTHERMIA; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN TEMPERATURE; SWEATING; VASODILATATION;

EID: 3543004059     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.3.824     Document Type: Article

References (26)

1. Anderson, C., T. Andersson, and K. Wardell. Changes in skin circulation after insertion of a microdialysis probe visualized by laser-Doppler perfusion imaging. J. Invest. Dermatol. 102: 808-811, 1994.
2. Brengelmann, G. L., P. R. Freund, L. B. Rowell, J. E. Olerud, and K. K. Kraning. Absence of active vasodilation associated with congenital absence of sweat glands in humans. Am. J. Physiol. 240 (Heart Circ. Physiol. 9): H571-H575, 1981.
3. G-nitro-L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ. Res. 72: 387-395, 1993.
4. Coffman, J. D. Effects of endothelium-derived nitric oxide on skin and digital blood flow in humans. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H2087-H2090, 1994.
5. Dietz, N. M., J. M. Rivera, D. O. Warner, and M. J. Joyner. Is nitric oxide involved in cutaneous vasodilation during body heating in humans? J. Appl. Physiol. 76: 2047-2053, 1994.
6. Edholm, O. G., R. H. Fox, and R. K. MacPherson. Vasomotor control of the cutaneous blood vessels in the human forearm. J. Physiol. (Lond.) 139: 455-465, 1957.
7. Farrell, D. M., and V. S. Bishop. Permissive role for nitric oxide in active thermoregulatory vasodilation in rabbit ear. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H1613-H1618, 1995.
8. Fox, R. H., and S. M. Hilton. Bradykinin formation in human skin as a factor in heat vasodilation. J. Physiol. (Lond.) 142: 219-232, 1958
9. Goldsmith, P. C., T. A. Leslie, N. A. Hayes, N. J. Levell, P. M. Dowd, and J. C. Fremont. Inhibitors of nitric oxide synthase in human skin. J. Invest. Dermatol. 106: 113-118, 1996.
10. Grant, R. T., and H. E. Holling. Further observations on the vascular responses of the human limb to body warming; evidence for sympathetic vasodilator nerves in the normal subject. Clin. Sci. (Colch.) 3: 273-285, 1938.
11. Johnson, J. M., and M. K. Park. Effect of upright exercise on the threshold for cutaneous vasodilation and sweating. J. Appl. Physiol. 50: 814-818, 1981.
12. Johnson, J. M., P. E. Pérgola, F. K. Liao, D. L. Kellogg, Jr., and C. G. Crandall. The skin of the dorsal aspects of human fingers and hands possesses an active vasodilator system. J. Appl. Physiol. 78: 948-954, 1995.
13. Johnson, J. M., and D. W. Proppe. Cardiovascular adjustments to heat stress. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, vol. 1, chapt. 11, p. 215-243.
14. Kellogg, D. L., Jr., W. L. Kenney, J. M. Johnson, and W. A. Kosiba. Mechanisms of control of skin blood flow during prolonged exercise. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H562-H568, 1993.
15. Kellogg, D. L., Jr., Y. Liu, I. F. Kosiba, J. M. Johnson, C. G. Crandall, D. O'Donnell, and A. M. M. Shepherd. Nitric oxide mediates increases in skin blood flow during local warming in humans (Abstract). FASEB J. 11: A43, 1997.
16. Kellogg, D. L., Jr., P. E. Pérgola, K. L. Piest, W. A. Kosiba, C. G. Crandall, M. Grossmann, and J. M. Johnson. Cutaneous active vasodilation in humans is mediated by cholinergic nerve co-transmission. Circ. Res. 77: 1222-1228, 1995.
17. Lindblad, L. R., and L. Ekenvall. Alpha-adrenoreceptors in the vessels of human finger skin. Acta Physiol. Scand. 128: 219-222, 1986.
18. Noon, J. P., W. G. Haynes, D. J. Webb, and A. C. Shore. Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin. J. Physiol. (Lond.) 490: 501-508, 1996.
19. Rajfer, J., W. J. Aronson, P. A. Bush, F. J. Dorey, and L. J. Ignarro. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic noncholinergic neurotransmission. N. Engl. J. Med. 3236: 90-94, 1992.
20. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. The contribution of constrictor and dilator nerves to the skin vasodilation during body heating. J. Physiol. (Lond.) 136: 489-497, 1957.
21. Rowell, L. B., J. A. Murray, G. L. Brengelmann, and K. K. Kraning II. Human cardiovascular adjustments to rapid changes in skin temperature during exercise. Circ. Res. 24: 711-724, 1969.
22. Saumet, J. L., D. L. Kellogg, Jr., W. F. Taylor, and J. M. Johnson. Cutaneous laser-Doppler flowmetry: influence of underlying muscle blood flow. J. Appl. Physiol. 65: 478-481, 1988.
23. Shastry, S., A. S. Reed, J. R. Halliwill, N. M. Dietz, and M. J. Joyner. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J. Appl. Physiol. 85: 830-834, 1998.
24. Taylor, W. F., J. M. Johnson, D. O'Leary, and M. K. Park. Effect of high local temperature on reflex cutaneous vasodilation. J. Appl. Physiol. 57: 191-196, 1984.
25. Toda, N., and T. Okamura. Role of nitric oxide in neurally induced cerebroarterial relaxation. J. Pharmacol. Exp. Ther. 258: 1027-1032, 1991.
26. Warren, J. B. Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light. FASEB J. 8: 247-251, 1994.