Neuropeptide Y antagonism reduces reflex cutaneous vasoconstriction in humans

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 3 56-3, 2004, Pages

  Stephens, Dan P ^a   Saad, Adham R ^a   Bennett, Lee Ann T ^a   Kosiba, Wojciech A ^a   Johnson, John M ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Cold stress; Cotransmitters; Skin blood flow; Sympathetic nervous system

Indexed keywords

NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; PROPRANOLOL; RINGER SOLUTION; YOHIMBINE;

ADRENERGIC SYSTEM; ADULT; ARTICLE; BLOOD FLOWMETRY; COLD STRESS; CONTROLLED STUDY; COOLING; DOPPLER FLOWMETER; HEMODYNAMIC MONITORING; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; MALE; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN TEMPERATURE; SYMPATHETIC TONE; VASOCONSTRICTION; VASOMOTOR REFLEX;

ADULT; ARGININE; BLOOD VESSELS; COLD; DRUG COMBINATIONS; FINGERS; HUMANS; ISOTONIC SOLUTIONS; MALE; NEUROPEPTIDE Y; NOREPINEPHRINE; PROPRANOLOL; REFLEX; REGIONAL BLOOD FLOW; SKIN; SKIN PHYSIOLOGY; SKIN TEMPERATURE; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS; VASOMOTOR SYSTEM; YOHIMBINE;

EID: 4143076887     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00061.2004     Document Type: Article

References (41)

1. Bennett LAT, Johnson JM, Stephens DP, Saad AR, and Kellogg DL Jr. Evidence for a role for vasoactive intestinal peptide in active vasodilatation in the cutaneous vasculature in humans. J Physiol 552: 223-232, 2003.
2. Bini G, Hagbarth KE, Hynninen P, and Wallin BG. Regional similarities and differences in thermoregulatory vaso- and sudomotor tone. J Physiol 306: 553-565, 1980.
3. Brengelmann GL and Savage MV. Temperature regulation in the neutral zone. Ann NY Acad Sci 813: 39-50, 1997.
4. Burnstock G. Purinergic cotransmission. Brain Res Bull 50: 355-357, 1999.
5. Charkoudian N and Johnson JM. Female reproductive hormones and thermoregulatory control of skin blood flow. Exerc Sport Sci Rev 28: 108-112, 2000.
6. Clarke J, Benjamin N, Larkin S, Webb D, Maseri A, and Davies G. Interaction of neuropeptide Y and the sympathetic nervous system in vascular control in man. Circulation 83: 774-777, 1991.
7. Cortés V, Donoso MV, Brown N, Fanjul R, López C, Fournier A, and Huidobro-Toro JP. Synergism between neuropeptide Y and norepinephrine highlights sympathetic cotransmission: studies in rat arterial mesenteric bed with neuropeptide Y, analogs, and BIBP 3226. J Pharmacol Exp Ther 289: 1313-1322, 1999.
8. Coutts AA, Jorizzo JL, Eady RA, Greaves MW, and Burnstock G. Adenosine triphosphate-evoked vascular changes in human skin: mechanism of action. Eur J Pharmacol 76: 391-401, 1981.
9. Crandall CG, Etzel RA, and Johnson JM. Evidence of functional β-adrenoceptors in the cutaneous vasculature. Am J Physiol Heart Circ Physiol 273: H1038-H1043, 1997.
10. Delius W, Hagbarth KE, Hongell A, and Wallin BG. Manoeuvres affecting sympathetic outflow in human skin nerves. Acta Physiol Scand 84: 177-186, 1972.
11. 1 receptor antagonist: a review of its pharmacological properties. Regul Pept 65: 71-77, 1996.
12. Doods HN, Wienen W, Entzeroth M, Rudolf K, Eberlein W, Engel W, and Wieland HA. Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226. J Pharmacol Exp Ther 275: 136-142, 1995.
13. Duff F, Patterson GC, and Shepherd JT. A quantitative study of the response to adenosine triphosphate of the blood vessels of the human hand and forearm. J Physiol 125: 581-589, 1954.
14. Edvinsson L, Ekblad E, Håkanson R, and Wahlestedt C. Neuropeptide Y potentiates the effects of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol 83: 519-525, 1984.
15. 2-adrenoreceptor. Pharmacol Rev 35: 143-180, 1983.
16. Grundemar L and Ekelund M. Effects of the neuropeptide Y (NPY)-receptor antagonist BIBP3226 on vascular NPY-receptors with different ligand requirements. Pharmacol Toxicol 79: 266-269, 1996.
17. Hashim MA and Tadepalli AS. Cutaneous vasomotor effects of neuropeptide Y. Neuropeptides 29: 263-271, 1995.
18. 1 receptor agonists increase blood flow through arteriovenous anastomoses in rat tail. J Appl Physiol 85: 301-309, 1998.
19. Holtbäck U, Brismar H, DiBona GF, Fu M, Greengard P, and Aperia A. Receptor recruitment: a mechanism for interactions between G protein-coupled receptors. Proc Natl Acad Sci USA 96: 7271-7275, 1999.
20. 1 receptor mediated facilitatory, modulatory cotransmission by NPY in the rat anococcygeus muscle. J Pharmacol Exp Ther 294: 38-44, 2000.
21. Johnson JM and Proppe DW. Cardiovascular adjustments to heat stress. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, vol. 1, chapt. 11, p. 215-243.
22. Kahan T, Taddei S, Pedrinelli R, Hjemdahl P, and Salvetti A. Non-adrenergic sympathetic vascular control of the human forearm in hypertension: possible involvement of neuropeptide Y. J Cardiovasc Pharmacol 19: 587-592, 1992.
23. Kellogg DL Jr, Johnson JM, and Kosiba WA. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am J Physiol Heart Circ Physiol 257: H1599-H1606, 1989.
24. Kellogg DL Jr, Liu Y, Kosiba IF, and O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 86: 1185-1190, 1999.
25. Kellogg DL Jr, Pérgola PE, Piest KL, Kosiba WA, Crandall CG, Grossmann M, and. Johnson JM. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res 77: 1222-1228, 1995.
26. Lundberg JM. Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol Rev 48: 113-178, 1996.
27. Lundberg JM, Torssell L, Sollevi A, Pernow J, Theodorsson-Norheim E, Änggard A, and Hamberger B. Neuropeptide Y and sympathetic vascular control in man. Regul Pept 13: 41-52, 1985.
28. Malmström RE and Lundberg JM. Neuropeptide Y accounts for sympathetic vasoconstriction in guinea-pig vena cava: evidence using BIBP 3226 and 3435. Eur J Pharmacol 294: 661-668, 1995.
29. Morris JL. Cotransmission from sympathetic vasoconstrictor neurons to small cutaneous arteries in vivo. Am J Physiol Heart Circ Physiol 277: H58-H64, 1999.
30. Nilsson T, Erlinge D, Gantera L, and Edvinsson L. Contractile effects of neuropeptide Y in human subcutaneous resistance arteries are mediated by Y1 receptors. J Cardiovasc Pharmacol 28: 764-768, 1996.
31. Nilsson T, Lind H, Brunkvall J, and Edvinsson L. Vasodilation in human subcutaneous arteries induced by neuropeptide Y is mediated by neuropeptide Y Y1 receptors and is nitric oxide dependent. Can J Physiol Pharmacol 78: 251-255, 2000.
32. Parati G, Casadei R, Groppelli A, Di Rienzo M, and Mancia G. Comparison of finger and intra arterial blood pressure monitoring at rest and during laboratory testing. Hypertension 13: 647-655, 1989.
33. Pernow J, Lundberg JM, Kaijser L, Hjemdahl P, Theodorsson-Norheim E, Martinsson A, and Pernow B. Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man. Clin Physiol 6: 561-578, 1986.
34. Racchi H, Irarrázabal MJ, Howard M, Morán S, Zalaquett R, and Huidobro-Toro JP. Adenosine 5′-triphosphate and neuropeptide Y are co-transmitters in conjunction with noradrenaline in the human saphenous vein. Br J Pharmacol 126: 1175-1185, 1999.
35. 1 receptor antagonist: BIBP3226. Eur J Pharmacol 271: R11-R13, 1994.
36. 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C. and arachidonic acid production. J Biol Chem 270: 11789-11796, 1995.
37. Stephens DP, Aoki K, Kosiba WA, and Johnson JM. Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men. Am J Physiol Heart Circ Physiol 280: H1496-H1504, 2001.
38. Stephens DP, Bennett LAT, Aoki K, Kosiba WA, Charkoudian N, and Johnson JM. Sympathetic nonnoradrenergic cutaneous vasoconstriction in women is associated with female reproductive hormone status. Am J Physiol Heart Circ Physiol 282: H264-H272, 2002.
39. Taddei S, Pedrinelli R, and Salvetti A. Sympathetic nervous system-dependent vasoconstriction in humans. Evidence for mechanistic role for endogenous purine compounds. Circulation 82: 2061-2067, 1990.
40. Taylor WF, Johnson JM, Kosiba WA, and Kwan CM. Cutaneous vascular responses to isometric handgrip exercise. J Appl Physiol 66: 1586-1592, 1989.
41. Wahlestedt C, Håkanson R, Vaz CA, and Zukowska-Grojec Z. Norepinephrine and neuropeptide Y: vasoconstrictor cooperation in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol 258: R736-R742, 1990.