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Volumn 411, Issue 21-22, 2010, Pages 1735-1740

The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels

Author keywords

Ezetimibe; Fatty acid component; Insulin resistance; Lipid metabolism; Metabolic syndrome; Nonalcoholic fatty liver disease

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; CHOLESTEROL ESTER; EZETIMIBE; GAMMA LINOLENIC ACID; LINOLEOYL COENZYME A DESATURASE; PALMITIC ACID; PALMITOLEIC ACID;

EID: 77956485145     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.07.012     Document Type: Article
Times cited : (39)

References (40)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002, 18:1221-1231.
    • (2002) N Engl J Med , vol.18 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 3
    • 0037299949 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?
    • Farrell G.C. Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?. J Gastroenterol Hepatol 2003, 18:124-138.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 124-138
    • Farrell, G.C.1
  • 4
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S., Abeygunasekera S., Farrell G.C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 5
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    • Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 6
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • Day C.P., James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterology 1998, 114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 7
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: when tissues overeat
    • Schaffer J. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 2003, 14:281-287.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 281-287
    • Schaffer, J.1
  • 8
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor dubstrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C.C.Y., Cline G.W., Zong H., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor dubstrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002, 277:50230-50236.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.C.Y.1    Cline, G.W.2    Zong, H.3
  • 9
    • 34548746833 scopus 로고    scopus 로고
    • Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
    • Joshi-Barve S., Barve S.S., Amancherla K., et al. Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 2007, 46:823-830.
    • (2007) Hepatology , vol.46 , pp. 823-830
    • Joshi-Barve, S.1    Barve, S.S.2    Amancherla, K.3
  • 10
    • 54249093047 scopus 로고    scopus 로고
    • Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
    • Park T., Hu Y., Noh H., et al. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res 2008, 49:2101-2112.
    • (2008) J Lipid Res , vol.49 , pp. 2101-2112
    • Park, T.1    Hu, Y.2    Noh, H.3
  • 11
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • Haus J., Kashyap S., Kasumov T., et al. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 2009, 58:337-344.
    • (2009) Diabetes , vol.58 , pp. 337-344
    • Haus, J.1    Kashyap, S.2    Kasumov, T.3
  • 12
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri P., Baillie R.A., Wiest M.M., et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007, 46:1081-1090.
    • (2007) Hepatology , vol.46 , pp. 1081-1090
    • Puri, P.1    Baillie, R.A.2    Wiest, M.M.3
  • 13
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya J., Rodrigo R., Videla L.A., et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2004, 106:635-643.
    • (2004) Clin Sci (Lond) , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3
  • 15
    • 0038507384 scopus 로고    scopus 로고
    • ARIC Study Investigators. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study
    • Wang L., Folsom A.R., Zheng Z.J., Pankow J.S. ARIC Study Investigators. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 2003, 78:91-98.
    • (2003) Am J Clin Nutr , vol.78 , pp. 91-98
    • Wang, L.1    Folsom, A.R.2    Zheng, Z.J.3    Pankow, J.S.4
  • 16
    • 0035985217 scopus 로고    scopus 로고
    • Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men
    • Laaksonen D.E., Lakka T.A., Lakka H.M., et al. Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 2002, 19:456-464.
    • (2002) Diabet Med , vol.19 , pp. 456-464
    • Laaksonen, D.E.1    Lakka, T.A.2    Lakka, H.M.3
  • 17
    • 0037312745 scopus 로고    scopus 로고
    • Dietary fat, fatty acid composition in plasma and the metabolic syndrome
    • F
    • Vessby B. Dietary fat, fatty acid composition in plasma and the metabolic syndrome. Curr Opin Lipidol Feb 2003, 14:15-19.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 15-19
    • Vessby, B.1
  • 18
    • 33644881910 scopus 로고    scopus 로고
    • Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women
    • M
    • Warensjö E., Ohrvall M., Vessby B. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis Mar 2006, 16:128-136.
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , pp. 128-136
    • Warensjö, E.1    Ohrvall, M.2    Vessby, B.3
  • 19
    • 73149094543 scopus 로고    scopus 로고
    • The plasma lipidomic signature of nonalcoholic steatohepatitis
    • Puri P., Wiest M.M., Cheung O., et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 2009, 50:1827-1838.
    • (2009) Hepatology , vol.50 , pp. 1827-1838
    • Puri, P.1    Wiest, M.M.2    Cheung, O.3
  • 20
    • 0036330904 scopus 로고    scopus 로고
    • Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis
    • de Almeida I.T., Cortez-Pinto H., Fidalgo G., Rodrigues D., Camilo M.E. Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. Clin Nutr 2002, 21:219-223.
    • (2002) Clin Nutr , vol.21 , pp. 219-223
    • de Almeida, I.T.1    Cortez-Pinto, H.2    Fidalgo, G.3    Rodrigues, D.4    Camilo, M.E.5
  • 21
    • 57349106472 scopus 로고    scopus 로고
    • Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice
    • Labonté E.D., Camarota L.M., Rojas J.C., et al. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am J Physiol Gastrointest Liver Physiol 2008, 295:G776-G783.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Labonté, E.D.1    Camarota, L.M.2    Rojas, J.C.3
  • 22
    • 20044374023 scopus 로고    scopus 로고
    • Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 23
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 24
    • 39649112612 scopus 로고    scopus 로고
    • The alpha-glucosidase inhibitor acarbose reduces the net electronegative charge of low-density lipoprotein in patients with newly diagnosed type 2 diabetes
    • Hasegawa G., Kajiyama S., Tanaka T., et al. The alpha-glucosidase inhibitor acarbose reduces the net electronegative charge of low-density lipoprotein in patients with newly diagnosed type 2 diabetes. Clin Chim Acta 2008, 390:110-114.
    • (2008) Clin Chim Acta , vol.390 , pp. 110-114
    • Hasegawa, G.1    Kajiyama, S.2    Tanaka, T.3
  • 25
    • 0023213632 scopus 로고
    • Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL: correlation with changes in receptor-mediated catabolism
    • Steinbrecher U.P., Witztum J.L., Parthasarathy S., Steinberg D. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL: correlation with changes in receptor-mediated catabolism. Arteriosclerosis 1987, 7:135-143.
    • (1987) Arteriosclerosis , vol.7 , pp. 135-143
    • Steinbrecher, U.P.1    Witztum, J.L.2    Parthasarathy, S.3    Steinberg, D.4
  • 26
    • 0023221153 scopus 로고
    • Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products
    • Steinbrecher U.P. Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J Biol Chem 1987, 262:3603-3608.
    • (1987) J Biol Chem , vol.262 , pp. 3603-3608
    • Steinbrecher, U.P.1
  • 27
    • 0028071636 scopus 로고
    • Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein
    • Miyazaki A., Sakai M., Suginohara Y., et al. Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein. J Biol Chem 1994, 269:5264-5269.
    • (1994) J Biol Chem , vol.269 , pp. 5264-5269
    • Miyazaki, A.1    Sakai, M.2    Suginohara, Y.3
  • 28
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • Wei Y., Wang D., Topczewski F., Pagliassotti M.J. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 2006, 291:E275-E281.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 29
    • 34347223254 scopus 로고    scopus 로고
    • Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity
    • Pagliassotti M.J., Wei Y., Wang D. Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. Endocrinology 2007, 148:3338-3345.
    • (2007) Endocrinology , vol.148 , pp. 3338-3345
    • Pagliassotti, M.J.1    Wei, Y.2    Wang, D.3
  • 30
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H., Bronk S.F., Werneburg N.W., Gores G.J. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006, 281:12093-12101.
    • (2006) J Biol Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 31
    • 3142753961 scopus 로고    scopus 로고
    • Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases
    • Nakamura M.T., Nara T.Y. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004, 24:345-376.
    • (2004) Annu Rev Nutr , vol.24 , pp. 345-376
    • Nakamura, M.T.1    Nara, T.Y.2
  • 32
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • Miyazaki M., Kim Y.C., Gray-Keller M.P., Attie A.D., Ntambi J.M. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem 2000, 275:30132-30138.
    • (2000) J Biol Chem , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 33
    • 0036846245 scopus 로고    scopus 로고
    • Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    • Attie A.D., Krauss R.M., Gray-Keller M.P., et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res 2002, 43:1899-1907.
    • (2002) J Lipid Res , vol.43 , pp. 1899-1907
    • Attie, A.D.1    Krauss, R.M.2    Gray-Keller, M.P.3
  • 34
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty acid composition of skeletal-muscle phospholipids
    • Borkman M., Storlien L.H., Pan D.A., et al. The relation between insulin sensitivity and the fatty acid composition of skeletal-muscle phospholipids. N Engl J Med 1993, 328:238-244.
    • (1993) N Engl J Med , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, L.H.2    Pan, D.A.3
  • 35
    • 0028817921 scopus 로고
    • Skeletal muscle membrane lipid composition is related to adiposity and insulin action
    • Pan D.A., Lillioja S., Milner M.R., et al. Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J Clin Invest 1995, 96:2802-2808.
    • (1995) J Clin Invest , vol.96 , pp. 2802-2808
    • Pan, D.A.1    Lillioja, S.2    Milner, M.R.3
  • 36
    • 0036231890 scopus 로고    scopus 로고
    • Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures
    • Wahl H.G., Kausch C., Machicao F., Rett K., Stumvoll M., Häring H.U. Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures. Diabetes 2002, 51:1060-1065.
    • (2002) Diabetes , vol.51 , pp. 1060-1065
    • Wahl, H.G.1    Kausch, C.2    Machicao, F.3    Rett, K.4    Stumvoll, M.5    Häring, H.U.6
  • 37
    • 0034805897 scopus 로고    scopus 로고
    • Effects of diabetes and insulin on hepatic delta 6 desaturase gene expression
    • Rimoldi O.J., Finarelli G.S., Brenner R.R. Effects of diabetes and insulin on hepatic delta 6 desaturase gene expression. Biochem Biophys Res Commun 2001, 283:323-326.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 323-326
    • Rimoldi, O.J.1    Finarelli, G.S.2    Brenner, R.R.3
  • 38
    • 20444371945 scopus 로고    scopus 로고
    • The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
    • Garcia-Calvo M., Lisnock J., Bull H.G., et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci USA 2005, 102:8132-8137.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8132-8137
    • Garcia-Calvo, M.1    Lisnock, J.2    Bull, H.G.3
  • 39
    • 36549013633 scopus 로고    scopus 로고
    • Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome
    • Deushi M., Nomura M., Kawakami A., et al. Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Lett 2007, 581:5664-5670.
    • (2007) FEBS Lett , vol.581 , pp. 5664-5670
    • Deushi, M.1    Nomura, M.2    Kawakami, A.3
  • 40
    • 41149120450 scopus 로고    scopus 로고
    • Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
    • Zheng S., Hoos L., Cook J., et al. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur J Pharmacol 2008, 584:118-124.
    • (2008) Eur J Pharmacol , vol.584 , pp. 118-124
    • Zheng, S.1    Hoos, L.2    Cook, J.3


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