Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells

European Journal of Immunology

Volumn 40, Issue 9, 2010, Pages 2643-2654

  Kersseboom, Rogier ^a   Kil, Laurens ^a   Flierman, Roelof ^b   Van Der Zee, Marten ^a   Dingjan, Gemma M ^a   Middendorp, Sabine ^a,c   Maas, Alex ^a   Hendriks, Rudi W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Antibodies; Autoimmunity; B cell development; B cells; Signal transduction

Indexed keywords

AGAMMAGLOBULINAEMIA TYROSINE KINASE; ANTIGEN ANTIBODY COMPLEX; ANTINUCLEAR ANTIBODY; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; MUTANT PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL; ANTIGEN ANTIBODY COMPLEX; B LYMPHOCYTE; BIOSYNTHESIS; BLOOD; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PATHOLOGY; PLASMA CELL; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGEN-ANTIBODY COMPLEX; B-LYMPHOCYTE SUBSETS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; IMMUNE TOLERANCE; IMMUNOGLOBULIN M; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MUTANT PROTEINS; PLASMA CELLS; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; TRANSGENES;

EID: 77956462586     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040521     Document Type: Article

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