Targeting of an interrupted polypurine: Polypyrimidine sequence in mammalian cells by a triplex-forming oligonucleotide containing a novel base analogue

Biochemistry

Volumn 49, Issue 36, 2010, Pages 7867-7878

  Semenyuk, A ^a   Darian, E ^b   Liu, J ^a   Majumdar, A ^a   Cuenoud, B ^d   Miller, P S ^c   MacKerell, A D ^b   Seidman, M M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MERCK SERONO S A   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DUPLEXES; GENE TARGETING; LIVING CELL; MAMMALIAN CELL LINES; MAMMALIAN CELLS; METHYLCYTOSINE; POLYPYRIMIDINE; PURINE BASIS; SECOND GENERATION; TARGET SEQUENCES; TRIPLE HELIXES; TRIPLEX-FORMING OLIGONUCLEOTIDES;

CELL CULTURE; DNA; GENES; GENETIC ENGINEERING; MAMMALS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; SUGAR (SUCROSE);

HYDROGEN BONDS;

CYTOSINE; GUANIDINE DERIVATIVE; NUCLEIC ACID; OLIGONUCLEOTIDE; POLYPURINE; POLYPYRIMIDINE; PSORALEN; TRIPLE HELIX FORMING OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; DNA; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIPLEX DNA;

ARTICLE; BINDING AFFINITY; GENETIC ENGINEERING; MAMMAL CELL; NUCLEIC ACID STRUCTURE; NUCLEIC ACID SYNTHESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; CHO CELL LINE; CONFORMATION; CRICETULUS; HAMSTER; HUMAN; METABOLISM;

ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; CRICETULUS; DNA; HUMANS; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PURINES; PYRIMIDINES;

MAMMALIA;

EID: 77956407750     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100797z     Document Type: Article

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