Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6803-6810

  Taniguchi, Yosuke ^a,b   Uchida, Yuko ^a   Takaki, Tomoko ^a   Aoki, Eriko ^a,b   Sasaki, Shigeki ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

5 Membered heterocycle; Anti parallel triplex; Antigene; CG interrupting site; Evaluation; Nucleoside analog; Synthesis; Triplex DNA; W shaped nucleoside analog (WNA)

Indexed keywords

DNA; N 1 ACETHYL 2 [3' DIMETHOXYTRITHYLOXYMETHYL 4' O (N,N DIISOPROPYL BETA CYANOETHYLPHOSPHORAMIDYL) 1' PHENYL 2',6' DIOXABICYCLO [3.3.0]OCT 7' YL] 4 METHYL 3 PYRAZOLIN 5 ONE; N 1 BENZOYL 2 [4' ACETOXY 1' PHENYL 3' (TERT BUTYLDIPHENYLSILYLOXYMETHYL) 2',6' DIOXABICYCLO[3.3.0]OCT 7' YL] 4 METHYL 3 PYRAZOLIN 5 ONE; N 2 BENZOYL 1 [4' ACETOXY 1' PHENYL 3' (TERT BUTYLDIPHENYLSILYLOXYMETHYL) 2',6' DIOXABICYCLO[3.3.0]OCT 7' YL] 4 METHYL 3 PYRAZOLIN 5 ONE; N 3 DIMETHYLAMINOMETHYLIDINE 1 [3' DIMETHOXYTRITHYLOXYMETHYL 4' O (N,N DIISOPROPYL BETA CYANOETHYLPHOSPHORAMIDYL) 1' PHENYL 2',6 DIOXABICYCLO [3.3.0]OCT 7' YL] 3 AMINOPYRAZOLE; N 3 DIMETHYLAMINOMETHYLIDINE 1 [4' ACETOXY 1' PHENYL 3' (TERT BUTYLDIPHENYLSILYLOXYMETHYL) 2',6' DIOXABICYCLO[3.3.0]OCT 7' YL] 3 AMINOPYRAZOLE; NUCLEOSIDE ANALOG; OLIGONUCLEOTIDE; PYRAZOLE; PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; DEPROTECTION REACTION; GLYCOSIDATION; HYDROGEN BOND; SUBSTITUTION REACTION; SYNTHESIS;

CYTOSINE; DNA; GUANINE; NUCLEIC ACID CONFORMATION; NUCLEOSIDES; PYRAZOLES;

EID: 69949143888     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.040     Document Type: Article

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