Active site-directed double mutants of dihydrofolate reductase

Cancer Research

Volumn 56, Issue 18, 1996, Pages 4142-4145

  Ercikan Abali, Emine A ^a   Mineishi, Shin ^a   Tong, Youzhi ^b   Nakahara, Saori ^a   Waltham, Mark C ^a   Banerjee, Debabrata ^a   Chen, Wen ^c   Sadelain, Michel ^a   Bertino, Joseph R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

^c Box 78 ^*

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; METHOTREXATE;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER RESISTANCE; CATALYSIS; DRUG BINDING; ENZYME ACTIVITY; GENE THERAPY; GENE TRANSFER; HUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ANIMALS; BINDING SITES; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; POINT MUTATION; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE; TYROSINE; VARIATION (GENETICS);

EID: 0029832419     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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