Severe asthma with fungal sensitization in a child: Response to itraconazole therapy

Pediatrics

Volumn 125, Issue 5, 2010, Pages

  Vicencio, Alfin G ^a   Muzumdar, Hiren ^a   Tsirilakis, Kalliope ^a   Kessel, Aaron ^a   Nandalike, Kiran ^a   Goldman, David L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Airway; Fungal; Inflammation

Indexed keywords

IMMUNOGLOBULIN E; ITRACONAZOLE;

AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CASE REPORT; CHILD; DISEASE SEVERITY; DRUG WITHDRAWAL; FUNGUS; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LUNG INFILTRATE; MALE; NONHUMAN; PRIORITY JOURNAL; SCHOOL CHILD; SENSITIZATION; TREATMENT RESPONSE;

ANTIFUNGAL AGENTS; ASPERGILLOSIS, ALLERGIC BRONCHOPULMONARY; ASTHMA; BASEMENT MEMBRANE; BIOPSY; BRONCHI; BRONCHOSCOPY; CHILD; FUNGI; HUMANS; IMMUNOGLOBULIN E; ITRACONAZOLE; MALE; PULMONARY EOSINOPHILIA; RHINITIS, ALLERGIC, PERENNIAL;

EID: 77951856336     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2009-2443     Document Type: Article

References (25)

1. Tariq SM, Matthews SM, Stevens M, Hakim EA. Sensitization to Alternaria and Cladosporium by the age of 4 years. Clin Exp Allergy. 1996;26(7):794-798 (Pubitemid 26266425)
2. Ezeamuzie CI, Al-Ali S, Khan M, et al. IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment. Int Arch Allergy Immunol. 2000;121(4):300-307 (Pubitemid 30229642)
3. Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet J, Neukirch F; European Community Respiratory Health Survey. Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community Respiratory Health Survey. BMJ. 2002;325(7361):411-414
4. Dharmage S, Bailey M, Raven J, et al. Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure. Am J Respir Crit Care Med. 2001;164(1):65-71 (Pubitemid 33151299)
5. Denning DW, O'Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: the Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med. 2009;179(1):11-18
6. Ward GW Jr, Woodfolk JA, Hayden ML, Jackson S, Platts-Mills TA. Treatment of late-onset asthma with fluconazole. J Allergy Clin Immunol. 1999;104(3 pt 1):541-546
7. Hürlimann A, Fäh J. Asthma, rhinitis and dermatitis triggered by fungal infection: therapeutic effects of terbinafine. Dermatology. 2001;202(4):330-332 (Pubitemid 32664529)
8. Katzenstein AL, Sale SR, Greenberger PA. Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol. 1983;72(1):89-93
9. Ward GW Jr, Karlsson G, Rose G, Platts-Mills TA. Trichophyton asthma: sensitisation of bronchi and upper airways to dermatophyte antigen. Lancet. 1989;1(8643): 859-862 (Pubitemid 19107874)
10. Schwartz HJ, Ward GW. Onychomycosis, trichophyton allergy and asthma: a causal relationship? Ann Allergy Asthma Immunol. 1995;74(6):523-524
11. Thia LP, Balfour LI. Diagnosing allergic bronchopulmonary aspergillosis in children with cystic fibrosis. Paediatr Respir Rev. 2009;10(1):37-42
12. Agarwal R. Allergic bronchopulmonary aspergillosis. Chest. 2009;135(3):805-826
13. Malde B, Greenberger PA. Allergic bronchopulmonary aspergillosis. Allergy Asthma Proc. 2004;25(4 suppl 1):S38-S39
14. Stevens DA, Moss RB, Kurup VP, et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis: state of the art-Cystic Fibrosis Foundation Consensus Conference. Clin Infect Dis. 2003;37(suppl 3):S225-S264
15. Denning DW, O'Driscoll BR, Hogaboam CM, Bowyer P, Niven RM. The link between fungi and severe asthma: a summary of the evidence. Eur Respir J. 2006;27(3):615-626 (Pubitemid 43372538)
16. Littman ML, Schneierson SS. Cryptococcus neoformans in pigeon excreta in New York City. Am J Hyg. 1959;69(1):49-59
17. Campbell GD. Primary pulmonary cryptococcosis. Am Rev Respir Dis. 1966;94(2): 236-243
18. Haugen RK, Baker RD. The pulmonary lesions in cryptococcosis with special reference to subpleural nodules. Am J Clin Pathol. 1954;24(12):1381-1390
19. Goldman DL, Khine H, Abadi J, et al. Serologic evidence for Cryptococcus neoformans infection in early childhood. Pediatrics. 2001;107(5). Available at: www. pediatrics.org/cgi/content/full/107/5/e66
20. - individuals. Clin Exp Immunol. 1995;99(3):425-432
21. Davis J, Zheng WY, Glatman-Freedman A, et al. Serologic evidence for regional differences in pediatric cryptococcal infection. Pediatr Infect Dis J. 2007;26(6):549-551 (Pubitemid 46847323)
22. Goldman DL, Davis J, Bommarito F, Shao X, Casadevall A. Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma. J Infect Dis. 2006;193(8):1178-1186
23. Vicencio AG, Narain S, Du Z, et al. Pulmonary cryptococcosis induces chitinase in the rat. Respir Res. 2008;9:40
24. Zhu Z, Zheng T, Homer RJ, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science. 2004;304(5677):1678-1682 (Pubitemid 38765861)
25. Saha DC, Xess I, Zeng WY, Goldman DL. Antibody responses to Cryptococcus neoformans in Indian patients with cryptococcosis. Med Mycol. 2008;46(5):457-463