A role for CD44 in the production of IFN-γ and immunopathology during infection with Toxoplasma gondii

Journal of Immunology

Volumn 166, Issue 9, 2001, Pages 5726-5732

  Blass, S L ^a   Pure E ^a   Hunter, C A ^a  

^a UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 12; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; INFLAMMATORY CELL; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 0035339916     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.9.5726     Document Type: Article

References (62)

1. CD44 and its interaction with extracellular matrix
2. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation
3. CD44: A model for regulated adhesion function
4. CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation
5. TNF-α induction of CD44-mediated leukocyte adhesion by sulfation
6. TNF-α and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44
7. Degradation of hyaluronic acid, poly- and monosaccharides, and model compounds by hypochlorite: Evidence for radical intermediates and fragmentation
8. Depolymerization products of hyaluronic acid after exposure to oxygen-derived free radicals
9. Enzymic pathways of hyaluronan catabolism
10. Cytokine regulation of human lung fibroblast hyaluronan (hyaluronic acid) production: Evidence for cytokine-regulated hyaluronan (hyaluronic acid) degradation and human lung fibroblast-derived hyaluronidase
11. A new alternatively spliced exon between v9 and v10 provides a mo lecular basis for synthesis of soluble CD44
12. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H
13. CD44 contributes to T cell activation
14. Dual role of the CD44 molecule in T cell adhesion and activation
15. Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44
16. Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation
17. Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages
18. Enhancement of natural killer activity by an antibody to CD44
19. CD44 involvement in experimental collagen-induced arthritis (CIA)
20. Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2
21. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii
22. In the absence of endogenous IFN-γ, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection
23. Interferon-γ: The major mediator of resistance against Toxoplasma gondii
24. + T cell-dependent, IFN-γ-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii
25. Strategies of anti-cytokine monoclonal antibody development: Immunoassay of IL-10 and IL-5 in clinical samples
26. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen: Cytokine detection by immunoassay and intracellular immunostaining
27. CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells
28. Requirements for hyaluronic acid binding by CD44: A role for the cytoplasmic domain and activation by antibody
29. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
30. 4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment
31. CD44 supports T cell proliferation and apoptosis by apposition of protein kinases
32. Adhesive and/or signaling functions of CD44 isoforms in human dendritic cells
33. Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
34. Hyaluronan fragments activate an NF-κB/I-κBα autoregulatory loop in murine macrophages
35. Mechanisms of hyaluronan-induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells: Hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-κB and activating protein-1
36. Signaling pathways regulating CD44-dependent cytolysis in natural killer cells
37. Hyaluronan fragments synergize with interferon-γ to induce the C-X-C chemokines Mig and IFN-γ inducible protein-10 in mouse macrophages
38. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages: The role of HA size and CD44
39. Requirement for CD44 in activated T cell extravasation into an inflammatory site
40. Immunocytochemical detection of cytokines in the lymph nodes and brains of mice resistant or susceptible to toxoplasmic encephalitis
41. Role of TNF and IL-1 in infections with Toxoplasma gondii
42. lck in T lymphocytes
43. The NF-κB family member Re1B is required for innate and adaptive immunity to Toxoplasma gondii
44. The balance of protein kinase C and calcium signaling directs T cell subset development
45. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type I cells and regulates IFN-γ production in human T lymphocytes
46. Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii
47. Regulation of IFN-γ production by IL-12 and IL-18
48. IGIF does not drive Thl development but synergizes with IL-12 for IFN-γ production and activates IRAK and NF-κB
49. IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice
50. CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway
51. IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway
52. Interleukin-12-induced adhesion molecule expression in murine liver
53. P- and E-selectin mediate recruitment of T-helper-I but not T-helper-2 cells into inflamed tissues
54. Interferon-γreceptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation
55. The role of donor and recipient B7-1 (CD80) in allograft rejection
56. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival
57. + T cells
58. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
59. Measurement of an adhesion molecule as an indicator of inflammatory disease activity: Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis
60. Administration of anti-bodies to hyaluronan receptor (CD44) delays the start and ameliorates the severity of collagen II arthritis
61. Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease
62. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7)