The toxicity of prion protein fragment PrP(106-126) is not mediated by membrane permeabilization as shown by a M112W substitution

Biochemistry

Volumn 48, Issue 19, 2009, Pages 4198-4208

  Henriques, Sónia Troeira ^a   Pattenden, Leonard Keith ^b   Aguilar, Marie Isabel ^b   Castanho, Miguel A R B ^a  

^a INSTITUTO DE MEDICINA MOLECULAR JOÃO LOBO ANTUNES   (Portugal)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFORM; MEMBRANE PERMEABILIZATION; MEMBRANE PORES; PEPTIDE-MEMBRANE INTERACTIONS; PHYSIOLOGICAL CONDITION; PORE FORMATION; POST-TRANSLATIONAL MODIFICATIONS; PRION DISEASE; PRION PROTEIN; TOXIC EFFECT;

AMINES; LEAD; PORE SIZE; SCANDIUM; SURFACE PLASMON RESONANCE; TOXICITY;

MEMBRANES;

PEPTIDE FRAGMENT; PRION PROTEIN; PRION PROTEIN[106-126]; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONTROLLED STUDY; LIPID MEMBRANE; MEMBRANE BINDING; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL MEMBRANE; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; LIPID BILAYERS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PERMEABILITY; PRIONS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; STATIC ELECTRICITY; THERMODYNAMICS; TRYPTOPHAN; WATER;

EID: 66049086991     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900009d     Document Type: Article

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